Nutritional management of lactose intolerance : the importance of diet and food labelling

Worldwide, 70% of the adult population has limited expression of lactase enzyme with a wide variation among different regions and countries. Lactase deficiency may lead to lactose intolerance (LI). Depending both on the amount of lactose ingested and on the lactase activity, people who suffer from lactose malabsorption might experience numerous gastrointestinal and extra-intestinal symptoms and manifestations. Treatment of LI mainly consists of reducing or eliminating lactose from the diet until the symptoms disappear as well as supplementing lactase, and inducing colon microbiome adaptation by probiotics. Cow's milk is one of the major source of calcium and several other vitamins and minerals. Thus, a complete exclusion of dairy products may favor the development of bone diseases such as osteopenia and osteoporosis. Therefore, the dietetic approach has a crucial role in the management of LI patients. Additionally, the use of lactose and milk-derived products in non-dairy products (e.g., baked goods, breakfast cereals, drinks, and processed meat) has become widespread in the modern industry (the so-called "hidden lactose"). In this regard, a strict adherence to the lactose-free diet becomes challenging for LI patients, forced to continuous check of all products and food labels. In fact, lactose-free product labeling is still controversial. Considering that nowadays a specific cut-off value establishing "lactose-free" labeling policy is lacking and that there is no universal law regulating the production and commercialization of "delactosed" products, identification of specific safe and suitable products with a well-recognized lactose-free logo might help consumers. This narrative review aims to identify the dietary management for lactose intolerant people, avoiding symptoms and nutrients deficiencies, helped by the use of specific labelling to guide them to choose the safer product on the market

Natural zeolites chabazite/phillipsite/analcime increase blood levels of antioxidant enzymes

Imbalance between reactive oxygen species generation and antioxidant capacity induces a condition known as oxidative stress which is implicated in numerous pathological processes. In this study we evaluated whether natural zeolites chabazite/phillipsite/analcime may affect the levels of different antioxidant enzymes (gluthatione peroxidase, superoxide dismutase, gluthatione reductase), total antioxidant status and oxidative stress in 25 clinically healthy men, both non-smokers and smokers. Measurements were performed on whole blood or on plasma samples before (T0) and after 4-weeks zeolites intake (T1). At T1, gluthatione peroxidase, superoxide dismutase and gluthatione reductase increased compared to T0 levels, both considering all subjects as joint and after subdivision in non-smokers and smokers. Differently, a reduction in total antioxidant status was observed at T1. Anyway, total antioxidant status resulted higher than the reference values in both groups at each time point. A decrease in lipid peroxidation, a major indicator of oxidative stress assessed by monitoring thiobarbituric acid reactive substances, was also observed in all subjects at T1. Our results suggested that chabazite/phillipsite/analcime may help to counteract oxidative stress in apparently healthy subjects exposed to different oxidative stress risk factors, such as smoking, thus representing a particular kind of food with potential antioxidant properties

A SWIR based algorithm to retrieve total suspended matter in extremely turbid waters

In ocean colour remote sensing, the use of Near Infra Red (NIR) spectral bands for the retrieval of Total Suspended Matter (TSM) concentration in turbid and highly turbid waters has proven to be successful. In extremely turbid waters (TSMN 100 mgL−1) however, these bands are less sensitive to increases in TSM. Here it is proposed to use Short Wave Infra Red (SWIR) spectral bands between 1000 and 1300 nm for these extreme cases. This SWIR spectral region is subdivided into two regions, SWIR-I (1000 nm to 1200 nm) and SWIR-II (1200 nm to 1300 nm) which correspond to local minima in the pure water absorption spectrum. For both spectral regions the water reflectance signal was measured in situ with an ASD spectrometer in three different extremely turbid estuarine sites: Scheldt (Belgium), Gironde (France), and Río de la Plata (Argentina), along with the TSMconcentration.A measurable water reflectance was observed for all sites in SWIR-I, while in the SWIR-II region the signal was not significant compared to the Signal-to-Noise Ratio (SNR) of current Ocean Colour (OC) sensors. For the spectral band at 1020 nm (present in Ocean and Land Colour Instrument ? OLCI, onboard Sentinel-3) and at 1071 nm, an empirical single band TSM algorithm is defined which is valid for both the Gironde and Scheldt estuarine sites. This means that a single algorithm can be applied for both sites without expensive recalibration.The relationship between TSM and SWIR reflectance at 1020 and 1071 nm is linear and did not show any saturation for the concentrations measured here (up to 1400 mg L−1), while saturation was observed for the NIR wavelengths, as expected. Hence, for extremely turbid waters it is advised to switch from NIR to SWIR-I wavelengths to estimate TSM concentration. This was demonstrated for an airborne hyperspectral dataset (Airborne Prism Experiment, APEX) from the Gironde estuary having several spectral bands in the SWIR-I. The empirical single band SWIR TSM algorithm was applied to the atmospherically corrected scene providing a TSM concentration map of the Gironde from mouth to more upstream with concentrations expected in this region ranging from a few to several hundreds mg L−1. These results, i.e. the existence of a single relationship for the Scheldt and Gironde, not showing any decrease of sensitivity, highlights the importance of having SWIR bands in future ocean colour sensors for studying extremely turbid rivers, coastal areas and estuaries in the world. A further implication of these results is that there is a TSMlimit for application of atmospheric correction algorithms which assume zero SWIR marine reflectance. That limit is defined here as function of wavelength and sensor noise level.Fil: Knaeps, E.. Flemish Institute for Technological Research (VITO); BélgicaFil: Ruddick, K. G.. Flemish Institute for Technological Research ; BélgicaFil: Doxaran, D.. Laboratoire d; FranciaFil: Dogliotti, Ana Inés. Consejo Nacional de Investigaciónes Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Nechad, B.. Royal Belgian Institute for Natural Sciences (RBINS); BélgicaFil: Raymaekers, D.. Flemish Institute for Technological Research; BélgicaFil: Sterckx, S.. Flemish Institute for Technological Research; Bélgic

Potential clinical value of circulating chromogranin A in patients with prostate carcinoma

n/

Sustainability transition pathways through ecological intensification: an assessment of vegetable food systems in Chile

Ecological intensification has been proposed as a promising lever for a transition towards more sustainable food systems. Various food systems exist that are based on ecological intensification and may have potential for a sustainability transition. Little is known, however, about their diversity and about how they perform against dominant systems in terms of the multiple societal goals. The aim of this study is to contribute to knowledge about sustainability transitions in food systems through an empirical analysis of vegetable food systems in Chile. The study (i) characterizes the diversity of vegetable food systems in Chile (ii) evaluates the food systems in terms of multiple societal goals, and (iii) assesses their potential for supporting sustainability transition pathways from the perspective of ecological intensification. Results indicate that among the five vegetable food system types, the agroecological and the small organic have potential to foster a sustainability transition. Nevertheless, these systems are small and localized, and scaling them requires actions to remove barriers in the relations with the agri-food regime and among themselves. The broader relevance of this analysis is that there needs to be awareness in research on transitions about the diversity of food systems present in countries and how they interact.</p

Molecular basis of anti-inflammatory action of platelet rich plasma on human chondrocytes : mechanisms of NF-kB inhibition via HGF

Loss of articular cartilage through injury or disease presents major clinical challenges also because cartilage has very poor regenerative capacity, giving rise to the development of biological approaches. As autologous blood product, platelet-rich plasma (PRP) provides a promising alternative to surgery by promoting safe and natural healing. Here we tested the possibility that PRP might be effective as an anti-inflammatory agent, providing an attractive basis for regeneration of articular cartilage, and two principal observations were done. First, activated PRP in chondrocytes reduced the transactivating activity of NF-kB, critical regulator of the inflammatory process, and decreased the expression of COX2 and CXCR4 target genes. By analyzing a panel of cytokines with different biological significance, in activated PRP we observed increases in hepatocyte growth factor (HGF), interleukin-4 and tumor necrosis factor-alpha (TNF-alpha). HGF and TNF-alpha, by disrupting NF-kB-transactivating activity, were important for the anti-inflammatory function of activated PRP. The key molecular mechanisms involved in PRP-inhibitory effects on NF-kB activity were for HGF the enhanced cellular IkBalpha expression, that contributed to NF-kB-p65 subunit retention in the cytosol and nucleo-cytoplasmic shuttling, and for TNF-alpha the p50/50 DNA-binding causing inhibition of target-gene expression. Second, activated PRP in U937-monocytic cells reduced chemotaxis by inhibiting chemokine transactivation and CXCR4-receptor expression, thus possibly controlling local inflammation in cartilage. In conclusion, activated PRP is a promising biological therapeutic agent, as a scaffold in micro-invasive articular cartilage regeneration, not only for its content of proliferative/differentiative growth factors, but also for the presence of anti-inflammatory agents including HGF