1,345 research outputs found

    The role of inclusions in ALS pathogenesis

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    Disrupting Disability: Social Practice Art

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    Visuality and imagery are two powerful mechanisms embedded within cultures that perpetuate as well as reflect structural violence. Despite the serious harm caused by unchecked cultural violence, it is often overlooked, particularly as it appears or is absent in image. This study examines how images both creates institutional violence exercised through discrimination against aging and disabled populations and how socially engaged art, curation, and performance are being used to disrupt and reverse oppression, discrimination, and exclusion.https://digitalcommons.library.umaine.edu/ccids_posters/1019/thumbnail.jp

    Produksi Gas Hidrogen Dari Limbah Alumunium Dan Uji Daya Listrik Dengan Fuel Cell

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    Teknologi Fuel Cell adalah teknologi masa depan yang ramah lingkungan. Bahan baku untuk fuel cell adalah hidrogen. Produksi hidrogen dari limbah alumunium dan storage telah dilakukan. Penelitian ini bertujuan untuk memanfaatkan limbah alumunium (alumunium foil dan kaleng minuman) yang direaksikan dengan larutan beralkalin untuk menghasilkan hidrogen. Hidrogen yang dihasilkan sebanding dengan tekanan yang terukur yang diukur dengan CASSY LAB Version 1.41. Hasilnya adalah: a. Semakin tinggi konsentrasi NaOH (5 %, 10 % dan 15 %) semakin cepat reaksi produksi hidrogen berlangsung. b. Jumlah limbah alumunium yang berbeda (0,01 g, 0,05 g dan 0,10 g) kurang berpengaruh terhadap waktu reaksi jika konsentrasi NaOHnya sama. c. Temperatur yang dihasilkan berkisar antara 27 oC - 33,7 oC, semakin banyak jumlah alumunium yang direaksikan semakin tinggi temperatur yang dihasilkan. d. Daya listrik yang dihasilkan dari 0,10 gram alumunium foil adalah sebesar 45-51 watt dengan daya rata-rata 0,08 watt per detik. e. Daya listrik yang dihasilkan dengan kaleng Coca Cola adalah sebesar 12,13 watt dengan daya rata-rata 0,009 watt per detik

    The role of inclusions in ALS pathogenesis

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    Cardiovascular risk prediction in the Netherlands

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    Background: In clinical practice, Systematic COronary Risk Evaluation (SCORE) risk prediction functions and charts are used to identify persons at high risk for cardiovascular diseases (CVD), who are considered eligible for drug treatment of elevated blood pressure and serum cholesterol. These functions use classical risk factors (age, gender, smoking, blood pressure and the ratio of total-to-HDL-cholesterol) to predict absolute 10-year risk of CVD mortality rather than total (fatal plus nonfatal) CVD. The aim of this thesis was to improve cardiovascular risk prediction in the Netherlands and to correctly classify high-risk persons. Methods: We primarily used data from the Monitoring Project on Chronic Disease Risk Factors (MORGEN project) of the National Institute for Public Health and the Environment (RIVM). Risk factor data of more than 20,000 men and women aged 20-65 years were collected between 1993 and 1997. Ten-year follow up data on CVD mortality and morbidity were obtained from Statistics Netherlands and the National Hospital Discharge Register, respectively. Risk functions were developed using multivariable Cox proportional hazard models. Results: The SCORE risk function for low-risk countries was the best predictor of CVD mortality in the Netherlands. Total CVD was approximately four times higher than CVD mortality. Obesity (BMI ≥30 kg/m2) and parental history of myocardial infarction before age 70 were independent predictors of total CVD. Risk functions predicting risk of CVD mortality and total CVD, and their ability to discriminate between future cases and non-cases, did not differ. Of the high-risk persons with a CVD mortality risk of at least 5%, approximately 20% developed a nonfatal or fatal CVD event during 10 years of follow-up. When a cut-off point of 2% CVD mortality was used, approximately 10% of the high-risk persons developed a CVD event. When obesity and parental history of MI were added to the classical risk factor function, correct risk classification improved by 5%. This improvement in risk prediction was mainly due to obesity. Conclusions: Discrimination between future cases and non-cases did not improve by expanding the endpoint of risk prediction from fatal CVD to total CVD. Adding obesity and parental history to the classical risk factor functions slightly increased the number of correctly classified persons. </p

    Effect of the amount of battery charge on tube voltage in different hand-held dental x-ray systems

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    The role of inclusions in ALS pathogenesis

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    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that primarily afflicts motor neurons, leading to paralysis and death within 3 to 5 years after diagnosis. Genetic studies have uncovered multiple genetic defects causing familial forms of ALS and mutations occurring in proteins with a variety of functions, including RNA metabolism (TDP43, FUS) and oxygen free radical homeostasis (SOD1). A commonality among all ALS forms is the presence of intracellular inclusions that primarily consist of insoluble protein aggregates. These inclusions indicate that protein aggregation is a central pathogenic event shared by multiple ALS forms. The research of the present thesis focuses on the role of protein aggregation and inclusion formation in two types of ALS: 1) ALS caused by mutations in the superoxide dismutase 1 (SOD1) gene (ALS1); and 2) ALS caused by mutations in the vesicle-associated membrane protein (VAMP)-associated protein B (VAPB) gene (ALS8)

    Growing with Students

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    Domesticating digital game-based learning

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    This paper analyses the use of digital game-based learning (DGBL) in schools in Norway. It investigates the types of games used in Norwegian schools and how pupils experience that practice. Digital game-based learning is being widely employed throughout Norway as a result of the increased focus on digital skills in Norwegian education. This paper analyses that development by way of focus group interviews with a total of sixty-four pupils at four schools. Drawing upon domestication and actor-network theory, the paper provides a novel approach to the study of DGBL. The broad empirical investigation into DGBL practices furthermore provides a contribution to scholarly literature on the subject. A noteworthy finding of this study is the diversity of games employed in schools—around 30 different titles— indicating that the choice of games lies at the discretion of individual teachers. Findings from this research show that the domestication of digital game-based learning occurs through the construction of complex game-based learning assemblages. This includes the classroom and home as gaming sites, group work and individual assignments as practices, and PCs and iPads as platforms
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