CRITERION VALIDITY OF THE LOWER LIMB ISOKINETIC POWER-FORCE-VELOCITY PROFILING PARAMETERS IN ELITE ATHLETES

The purpose of this study was to investigate the criterion validity of isokinetic leg press Power-Force-velocity (P-F-v) parameters. Forty elite athletes with diverse sporting backgrounds performed a maximal vertical squat jump test and an isokinetic leg press P-F-v profile test. The isokinetic leg press P-F-v profile consisted of leg-extension against 4 given velocity conditions: 0.1, 0.3, 0.7, and 1.2 m/s. Criterion validity was evaluated using correlation between squat jump height and each isokinetic P-F-v parameter (F0, v0, Pmax and, Sfv). Nearly “good” (r \u3e 0.815) correlations were found for Pmax, whereas correlations between the remaining P-F-v parameters ranged from “poor” to “impractical” (r = 0.702– 0.159). This result may fit the previous assumption of P-F-v profiles, that individuals express variable contributions of F0 and v0 for similar Pmax values. Consequently evaluating criterion validity for these parameters (F0 and v0) is likely difficult would be contrary to this P-F-v assumption

Explosive strength of the knee extensors : The influence of criterion trial detection methodology on measurement reproducibility

The present study was conducted to assess test-retest reproducibility of explosive strength measurements during single-joint isometric knee extension using the IsoMed 2000 dynamometer. Thirty-one physically active male subjects (mean age: 23.7 years) were measured on two occasions separated by 4872 h. The intraclass correlation coefficient (ICC 2,1) and the coefficient of variation (CV) were calculated for (i) maximum torque (MVC), (ii) the peak rate of torque development (RTDpeak) as well as for (iii) the average rate of torque development (RTD) and the impulse taken at several predefined time intervals (030 to 0300 ms); thereby explosive strength variables were derived in two conceptually different versions: on the one hand from the MVC-trial (version I), on the other hand from the trial showing the RTDpeak (version II). High ICC-values (0.800.99) and acceptable CV-values (1.98.7%) could be found for MVC as well as for the RTD and the impulse taken at time intervals of 100 ms, regardless of whether version I or II was used. In contrast, measurements of the RTDpeak as well as the RTD and the impulse taken during the very early contraction phase (i.e. RTD/impulse030ms and RTD/impulse050ms) showed clearly weaker reproducibility results (ICC: 0.530.84; CV: 7.316.4%) and gave rise to considerable doubts as to clinical usefulness, especially when derived using version I. However, if there is a need to measure explosive strength for earlier time intervals in practice, it is, in view of stronger reproducibility results, recommended to concentrate on measures derived from version II, which is based on the RTDpeak-trial.(VLID)214855

Journal of Human Kinetics / Isokinetic Strength profile of elite female handball players

Systematic assessment of muscle strength of the lower extremities throughout the annual training cycle in athletes is crucial from a performance perspective for the optimization of the training process, as well as a health perspective with regard to injury prevention. The main aim of the present study was to determine isokinetic muscle strength of the knee flexors and extensors in female handball players at the beginning of a preparatory period and to assess whether there were any differences between players of different performance levels. The performance level was expressed by means of membership of the Womens Junior National Handball Team (JNT, n=8) or the Womens National Handball Team (NT, n=9). The isokinetic peak torque during concentric and eccentric single-joint knee flexion and extension was measured at angular velocities of 60, 180, 240/s (concentric) and 60/s (eccentric). The Mann- Whitney test showed no significant differences in the peak torques or ipsilateral ratios between the two groups. The bilateral force deficit (BFD) for concentric extension at 240/s was significantly higher in the JNT compared with the NT (p=0.04; d=1.02). However, the results of individual evaluation show that the BFD was more frequent in the NT in most measurements. A high BFD was evident in the eccentric mode in both groups highlighting a need for particular strengthening. With regard to low strength ratios a prevention programme should be suggested for both observed groups of professional female handball players to reduce the risk of injury.(VLID)179426

Long-term outcomes from the Phase II L-MIND study of tafasitamab (MOR208) plus lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma

Tafasitamab (MOR208), an Fc-modified, humanized, anti-CD19 monoclonal antibody, combined with the immunomodulatory drug lenalidomide was clinically active with a good tolerability profile in the open-label, single-arm, phase II L-MIND study of patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) ineligible for autologous stem-cell transplantation. To assess long-term outcomes, we report an updated analysis with ≥35 months' follow-up. Patients were aged >18 years, had received one to three prior systemic therapies (including ≥1 CD20-targeting regimen) and Eastern Cooperative Oncology Group performance status 0-2. Patients received 28-day cycles of tafasitamab (12 mg/kg intravenously), once weekly during cycles 1-3, then every 2 weeks during cycles 4-12. Lenalidomide (25 mg orally) was administered on days 1-21 of cycles 1-12. After cycle 12, progression-free patients received tafasitamab every 2 weeks until disease progression. The primary endpoint was best objective response rate. After ≥35 months' follow-up (data cut-off: October 30, 2020), the objective response rate was 57.5% (n=46/80), including a complete response in 40.0% of patients (n=32/80) and a partial response in 17.5% of patients (n=14/80). The median duration of response was 43.9 months (95% confidence interval [95% CI]: 26.1-not reached), the median overall survival was 33.5 months (95% CI: 18.3-not reached) and the median progression-free survival was 11.6 months (95% CI: 6.3-45.7). There were no unexpected toxicities. Subgroup analyses revealed consistent long-term efficacy results across most subgroups of patients. This extended follow-up of L-MIND confirms the long duration of response, meaningful overall survival, and well-defined safety profile of tafasitamab plus lenalidomide followed by tafasitamab monotherapy in patients with relapsed/refractory diffuse large B-cell lymphoma ineligible for autologous stem cell transplantation. ClinicalTrials.gov identifier: NCT02399085

Meta-Analysis of Sustainable Transport Logistics Trends

In general, Austrian manufacturing companies need to catch up in terms of sustainable transport logistics. Awareness-raising on sustainability and a broad debate are necessary that companies rethink in this context. This paper, therefore, develops and applies a meta-analysis in order to analyze the development of transport logistics trends. This research integrates qualitative and quantitative elements of the content analysis. Firstly, existing trend analyses are evaluated and compared in order to subsequently define trend categories. Secondly, the identified trend categories are analyzed by a qualitative content analysis. Finally, a frequency analysis is performed to describe temporal developments. This meta-analysis evaluates how sustainability in terms of transport logistics has developed in comparison with other subject areas based on a prestigious, well-known international journal regarding logistics and traffic issues. Five relevant trends have been identified, their temporal development has been analyzed and a forecast has been created. Current transport logistics trend analyses usually do not challenge the topic of sustainability qualitatively by means of a meta-analysis. The validity of the definition whether a trend is relevant is increased, since the search items are analyzed in the context of previously defined trend categories. The meta-analysis is practically applicable, as in the period from 2014 to 2017 short-term and medium-term effects were tested in 171 editions of a subject-specific, but nonscientific international journal around logistics and traffic issues. This journal is published since 1945 and, therefore, comprehensively reflects the practical discussion about transport logistics

Digitized VMI – maturity model for the FMCG sector

Optimized stocks and lean processes are prerequisites in order to keep up with the increasing consumption of goods and limited storage areas in cities due to urbanization. This paper, therefore, develops a maturity model to increase the dissemination rate of Digitized VMI to optimize supply chains in the FMCG sector. Firstly, criteria for successful VMI application are identified by literature research and expert interviews. Moreover, the respective target state descriptions are defined. Secondly, an assessment scheme is integrated. Finally, a procedure model to identify company-specific operational factors is developed. The research establishes requirements for successful VMI application in the FMCG sector within four generic categories and a specific one. It has been found that company-specific operational factors are particularly relevant in this context. Therefore, the specific fifth category is described by a procedure model to identify those factors. Current VMI models are generalistic and describe potential components of VMI, contract contents and relevant processes. However, a model addressing the barriers for VMI application ex ante and taking company-specific operational factors into account is pending. The VMI Maturity Model is practically applicable, since it has been tested at a company in the FMCG sector. It turned out, that assessing the VMI Maturity Level supports companies in identifying specific areas for improvements in advance of VMI implementation

Producción inteligente: diseño de un modelo para el proceso de implementación de Cadenas de Suministros Inteligentes

Supply Chain Management and the technology adoption as a tool to increase efficiency is also known as Smart Supply Chain. This topic has become of importance in companies nowadays. Thus, this research analyzes this topic within two scenarios. The first one based on the process used by manufacturing companies in Costa Rica to their Supply Chain and the second was oriented to understand the implementation of a smart approach according to Austrian expert criteria. Based on the collected information a model for each scenario was designed with the most relevant characteristics. Finally, the analysis allowed to conclude that currently real-time information is essential for Supply Chain Management.La Administración de la Cadena de Suministros y la inclusión de la tecnología como una herramienta para su eficiencia, lo que hoy se denomina Cadenas de Suministro Inteligentes. Este tema es de alta importancia para las empresas en la actualidad, por esta razón el presente artículo hace una revisión de este bajo dos escenarios, el primero basado en el proceso utilizado por las empresas de manufactura en Costa Rica para su Cadena de Suministros y el segundo fue orientado a entender la implementación de un enfoque inteligente de acuerdo con el criterio de expertos austriacos. Tomando como base la información recolectada, el estudio diseña un modelo para la gestión de cadenas de suministro inteligentes con las características más relevantes para cada escenario. Finalmente, el análisis permitió concluir que actualmente la información en tiempo real es esencial para la Administración de la Cadena de Suministros

Producción inteligente: Diseño de un modelo para el proceso de implementación de Cadenas de Suministros Inteligentes

Supply Chain Management and the technology adoption as a tool to increase efficiency is alsoknown as Smart Supply Chain. This topic has become of importance in companies nowadays.Thus, this research analyzes this topic within two scenarios. The first one based on the processused by manufacturing companies in Costa Rica to their Supply Chain and the second wasoriented to understand the implementation of a smart approach according to Austrian expertcriteria. Based on the collected information a model for each scenario was designed with themost relevant characteristics. Finally, the analysis allowed to conclude that currently real-timeinformation is essential for Supply Chain Management.La Administración de la Cadena de Suministros y la inclusión de la tecnología como unaherramienta para su eficiencia, lo que hoy se denomina Cadenas de Suministro Inteligentes.Este tema es de alta importancia para las empresas en la actualidad, por esta razón el presenteartículo hace una revisión de este bajo dos escenarios, el primero basado en el procesoutilizado por las empresas de manufactura en Costa Rica para su Cadena de Suministros y elsegundo fue orientado a entender la implementación de un enfoque inteligente de acuerdo conel criterio de expertos austriacos. Tomando como base la información recolectada, el estudiodiseña un modelo para la gestión de cadenas de suministro inteligentes con las característicasmás relevantes para cada escenario. Finalmente, el análisis permitió concluir que actualmentela información en tiempo real es esencial para la Administración de la Cadena de Suministros