Achieving sub-diffraction imaging through bound surface states in negative-refracting photonic crystals at the near-infrared

We report the observation of imaging beyond the diffraction limit due to bound surface states in negative refraction photonic crystals. We achieve an effective negative index figure-of-merit [-Re(n)/Im(n)] of at least 380, ~125x improvement over recent efforts in the near-infrared, with a 0.4 THz bandwidth. Supported by numerical and theoretical analyses, the observed near-field resolution is 0.47 lambda, clearly smaller than the diffraction limit of 0.61 lambda. Importantly, we show this sub-diffraction imaging is due to the resonant excitation of surface slab modes, allowing refocusing of non-propagating evanescent waves

Morphological and structural evidences concerning the origin of sheet fractures

[Abstract] Sheet fractures are well and widely developed in massive rocks, i.e., rocks lacking other partings, and they have been discussed in the literature for more than a century. Yet there is no agreement as to their origino Two contrasted interpretations hold sway. Almost without exception, geologist adhere to the pressure release or erosional offloading hypothesis. Engineers and engineering geologist, on the other hand, interpret sheet partings as buckling, i.e., crumpling or bending out of plane, related to compressive stresses, particularly lateral stresses. After a review of nomenclature and a description of the characteristics of sheet fractures, a critique ofprevious explanations of their origin is presented. What are perceived to be critical Enes of structural and morphological evidence. bearing on the origin ofsheet fracture are next reviewed, and this is followed by a discusion of the possible origins of the structures

Combining Static and Dynamic Contract Checking for Curry

Static type systems are usually not sufficient to express all requirements on function calls. Hence, contracts with pre- and postconditions can be used to express more complex constraints on operations. Contracts can be checked at run time to ensure that operations are only invoked with reasonable arguments and return intended results. Although such dynamic contract checking provides more reliable program execution, it requires execution time and could lead to program crashes that might be detected with more advanced methods at compile time. To improve this situation for declarative languages, we present an approach to combine static and dynamic contract checking for the functional logic language Curry. Based on a formal model of contract checking for functional logic programming, we propose an automatic method to verify contracts at compile time. If a contract is successfully verified, dynamic checking of it can be omitted. This method decreases execution time without degrading reliable program execution. In the best case, when all contracts are statically verified, it provides trust in the software since crashes due to contract violations cannot occur during program execution.Comment: Pre-proceedings paper presented at the 27th International Symposium on Logic-Based Program Synthesis and Transformation (LOPSTR 2017), Namur, Belgium, 10-12 October 2017 (arXiv:1708.07854

Engagement And Solidarity While Learning

2020 and 2021 were difficult years for students attending higher education and secondary education especially if they were preparing to enter higher education. Teaching was adapted, and assessments were the possible ones according to what we lived and experienced. Thus, students need innovative and stimulating teaching and learning practices that motivate and involve them in the teaching/learning processes. Information and Communication Technologies (ICT) and digital platforms have seen their indiscriminate use, not without sometimes, teachers and students questioning whether they were being used in the best conceivable way or taken full advantage of. Face-to-face group work and involvement with the needs of colleagues lost some space for achievement and effectiveness. The preference for individual work and the visible reduction in solidarity among colleagues was an issue/question posed at the beginning of this study. An activity was proposed over a semester to students of Statistical Methods from Informatics Engineering. This curricular unit enrols 533 students, 85 on an after-work basis. The objective of this proposal was to create a collaborative learning platform where students could interact with each other within the scope of the curricular unit. Cumulatively, it was an objective that students deepen the topics taught in class, including references provided, and reviewing exercises conducted by their colleagues. Regularly professors corrected the materials proposed by the students. All students who participated had access to all the work developed. The evaluation of students\u27 involvement, collaboration, and solidarity in addition to the results will be discussed and presented

Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans

Acknowledgments We are grateful to the Ian Fraser Cytometry Centre and our Mass Spetrometry and qPCR Facilities for help with the flow cytometry, glutathione and qRT-PCR assays, respectively. We also thank our many colleagues in the CRISP Consortium and in the medical mycology and systems biology communities for insightful discussions. Funding: This work was supported by the CRISP project (Combinatorial Responses In Stress Pathways), which was funded by the UK Biotechnology and Biological Research Council (www.bbsrc.ac.uk): AJPB, KH, CG, ADM, NARG, MT, MCR. (Research Grants; BB/F00513X/1, BB/F005210/1-2). AJPB and JQ received additional support from the BBSRC (Research Grants; BB/K016393/1; BB/K017365/1). NARG and AJPB were also supported by the Wellcome Trust (www.wellcome.ac.uk), (Grants: 080088; 097377). AJPB was also supported by the European Research Council (http://erc.europa.eu/), (STRIFE Advanced Grant; ERC-2009-AdG-249793). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites:an open resource

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. Secondary confirmatory and orthogonal intracellular anti-parasiticidal assays were conducted, and the potential for non-specific cytotoxicity determined. Hit compounds were chemically clustered and triaged for desirable physicochemical properties. The hypothetical biological target space covered by these diversity sets was investigated through bioinformatics methodologies. Consequently, three anti-kinetoplastid chemical boxes of ~200 compounds each were assembled. Functional analyses of these compounds suggest a wide array of potential modes of action against kinetoplastid kinases, proteases and cytochromes as well as potential host–pathogen targets. This is the first published parallel high throughput screening of a pharma compound collection against kinetoplastids. The compound sets are provided as an open resource for future lead discovery programs, and to address important research questions.The support and funding of Tres Cantos Open Lab Foundation is gratefully acknowledgedPeer reviewe

Predicción de la potencialidad de los bosques esclerófilos españoles mediante redes neuronales artificiales

Holm oak and cork oak forests are between the most important sclerophyllous formations in the Mediterranean Iberia. In order to study their potentiality, an artificial neural network model, with a feedforward BP algorithm, has been applied. The elevation, continentality, insolation, annual rainfall, annual mean temperature, mean temperature of the coldest month and mean temperature of the warmest month are the used bioclimatic variables with a 10 km resolution. The neural networks seem a highly predictive powerful tool. Different patterns in the response of the studied forests have been shown. The holm oak presents a continuous and wide potential simulate range. Meanwhile the cork oak potential area is fragmented and restricted, in accordance with its actual distribution area. The lack of both forests in the eastern and southern warm zones of Iberian Peninsula is the main discrepancy with previous potential vegetation proposals.Encinares y alcornocales son dos de las formaciones esclerófilas más importantes de la Iberia mediterránea. Para conocer cual es su potencialidad en el territorio español se ha empleado un modelo generado mediante redes neuronales artificiales con un algoritmo de retropropagación de errores que conduce la información siempre hacia delante. Las variables bioclimáticas empleadas como predictores son: altitud, continentalidad, insolación, precipitación total, temperatura media anual, temperatura media de las mínimas del mes más frío y temperatura media de las máximas del mes más cálido, con una resolución de 10 km. Las redes neuronales se perfilan como una herramienta de gran poder predictivo. Se aprecian patrones de respuesta diferente para las formaciones estudiadas. Mientras que para la encina se simula un área potencial continua y extensa, para el alcornoque se obtiene un área fragmentada y restringida, que se ajusta bastante a su presencia actual. La principal discrepancia del modelo presentado con esquemas de vegetación potencial anteriores radica en la ausencia de encinares y alcornocales en zonas térmicas del Levante y sur peninsular

Food and beverage intakes according to physical activity levels in European children: The IDEFICS (Identification and prevention of Dietary and lifestyle induced health EFfects in Children and infantS) study

Objective Physical activity (PA) levels and dietary habits are considered some of the most important factors associated with obesity. The present study aimed to examine the association between PA level and food and beverage consumption in European children (2-10 years old).Design/Setting/Subjects A sample of 7229 children (49·0 % girls) from eight European countries participating in the IDEFICS (Identification and prevention of Dietary and lifestyle induced health EFfects In Children and infantS) study was included. Moderate-to-vigorous PA (MVPA) was assessed objectively with accelerometers. FFQ was used to register dietary habits. ANCOVA and binary logistic regression were applied.Results Boys who spent less time in MVPA reported lower consumption of vegetables, fruits, cereals, yoghurt, milk, bread, pasta, candies and sugar-sweetened beverages (SSB) than boys who spent more time in MVPA (P<0·05). Moreover, boys who spent less time in MVPA were more likely to consume fast foods and water than those in the highest MVPA tertile (P<0·05). Girls who spent less time in MVPA reported lower consumption frequencies of vegetables, pasta, bread, yoghurt, candies, jam/honey and SSB than girls in the highest MVPA tertile (P<0·05). Also, girls in the lowest MVPA tertile were more likely to consume fast foods and water than those with high levels of MVPA (P<0·05).Conclusions Food intake among European children varied with different levels of daily MVPA. Low time spent in MVPA was associated with lowest consumption of both high- and low-energy-dense foods and high fast-food consumption

NFV Orchestration over Disaggregated Metro Optical Networks with End-to-End Multi-Layer Slicing enabling Crowdsourced Live Video Streaming

Network infrastructure must support emerging applications, fulfill 5G requirements, and respond to the sudden increase of societal need for remote communications. Remarkably, crowdsourced live video streaming (CLVS) challenges operators' infrastructure with tides of users attending major sport or public events that demand high bandwidth and low latency jointly with computing capabilities at the networks' edge. The Metro-Haul project entered the scene proposing a cost-effective, agile, and disaggregated infrastructure for the metro segment encompassing optical and packet resources jointly with computing capabilities. Recently, a major Metro-Haul outcome took the form of a field trial of network function virtualization (NFV) orchestration over the multi-layer packet and disaggregated optical network testbed that demonstrated a CLVS use case. We showcased the average service creation time below 5 min, which met the key performance indicator as defined by the 5G infrastructure public private partnership. In this paper, we expand our field trial demonstration with a detailed view of the Metro-Haul testbed for the CLVS use case, the employed components, and their performance. The throughput of the service is increased from approximately 9.6 Gbps up to 35 Gbps per virtual local area network with high-performance VNFs based on single-root input/output virtualization technology

Neuromapping: Inflight Evaluation of Cognition and Adaptability

In consideration of the health and performance of crewmembers during flight and postflight, we are conducting a controlled prospective longitudinal study to investigate the effects of spaceflight on the extent, longevity and neural bases of sensorimotor, cognitive, and neural changes. Previous studies investigating sensorimotor adaptation to the microgravity environment longitudinally inflight have shown reduction in the ability to perform complex dual tasks. In this study we perform a series of tests investigating the longitudinal effects of adaptation to the microgravity environment and how it affects spatial cognition, manual visuo-motor adaption and dual tasking