Using late-time optical and near-infrared spectra to constrain Type Ia supernova explosion properties

The late-time spectra of Type Ia supernovae (SNe Ia) are powerful probes of the underlying physics of their explosions. We investigate the late-time optical and near-infrared spectra of seven SNe Ia obtained at the VLT with XShooter at $>$200 d after explosion. At these epochs, the inner Fe-rich ejecta can be studied. We use a line-fitting analysis to determine the relative line fluxes, velocity shifts, and line widths of prominent features contributing to the spectra ([Fe II], [Ni II], and [Co III]). By focussing on [Fe II] and [Ni II] emission lines in the ~7000-7500 \AA\ region of the spectrum, we find that the ratio of stable [Ni II] to mainly radioactively-produced [Fe II] for most SNe Ia in the sample is consistent with Chandrasekhar-mass delayed-detonation explosion models, as well as sub-Chandrasekhar mass explosions that have metallicity values above solar. The mean measured Ni/Fe abundance of our sample is consistent with the solar value. The more highly ionised [Co III] emission lines are found to be more centrally located in the ejecta and have broader lines than the [Fe II] and [Ni II] features. Our analysis also strengthens previous results that SNe Ia with higher Si II velocities at maximum light preferentially display blueshifted [Fe II] 7155 \AA\ lines at late times. Our combined results lead us to speculate that the majority of normal SN Ia explosions produce ejecta distributions that deviate significantly from spherical symmetry.Comment: 17 pages, 12 figure, accepted for publication in MNRA

Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump

The small size (58 residues) and simple structure of the B domain of staphylococcal protein A (BdpA) have led to this domain being a paradigm for theoretical studies of folding. Experimental studies of the folding of BdpA have been limited by the rapidity of its folding kinetics. We report the folding kinetics of a fluorescent mutant of BdpA (G29A F13W), named F13W*, using nanosecond laser-induced temperature jump experiments. Automation of the apparatus has permitted large data sets to be acquired that provide excellent signal-to-noise ratio over a wide range of experimental conditions. By measuring the temperature and denaturant dependence of equilibrium and kinetic data for F13W*, we show that thermodynamic modeling of multidimensional equilibrium and kinetic surfaces is a robust method that allows reliable extrapolation of rate constants to regions of the folding landscape not directly accessible experimentally. The results reveal that F13W* is the fastest-folding protein of its size studied to date, with a maximum folding rate constant at 0 M guanidinium chloride and 45°C of 249,000 (s-1). Assuming the single-exponential kinetics represent barrier-limited folding, these data limit the value for the preexponential factor for folding of this protein to at least ≈2 x 10(6) s(-1)

The late-time light curve of the type Ia supernova SN 2011fe

We present late-time optical $R$-band imaging data from the Palomar Transient Factory (PTF) for the nearby type Ia supernova SN 2011fe. The stacked PTF light curve provides densely sampled coverage down to $R\simeq22$ mag over 200 to 620 days past explosion. Combining with literature data, we estimate the pseudo-bolometric light curve for this event from 200 to 1600 days after explosion, and constrain the likely near-infrared contribution. This light curve shows a smooth decline consistent with radioactive decay, except over ~450 to ~600 days where the light curve appears to decrease faster than expected based on the radioactive isotopes presumed to be present, before flattening at around 600 days. We model the 200-1600d pseudo-bolometric light curve with the luminosity generated by the radioactive decay chains of $^{56}$Ni, $^{57}$Ni and $^{55}$Co, and find it is not consistent with models that have full positron trapping and no infrared catastrophe (IRC); some additional energy escape other than optical/near-IR photons is required. However, the light curve is consistent with models that allow for positron escape (reaching 75% by day 500) and/or an IRC (with 85% of the flux emerging in non-optical wavelengths by day 600). The presence of the $^{57}$Ni decay chain is robustly detected, but the $^{55}$Co decay chain is not formally required, with an upper mass limit estimated at 0.014 M$_{\odot}$. The measurement of the $^{57}$Ni/$^{56}$Ni mass ratio is subject to significant systematic uncertainties, but all of our fits require a high ratio >0.031 (>1.3 in solar abundances).Comment: 17 pages, 12 figures; accepted for publication in MNRA

Nebular Spectroscopy of Kepler's Brightest Supernova

We present late-time ($\sim$240-260 days after peak brightness) optical photometry and nebular (+236 and +264 days) spectroscopy of SN 2018oh, the brightest Type Ia supernova (SN Ia) observed by the Kepler telescope. The Kepler/K2 30-minute cadence observations started days before explosion and continued past peak brightness. For several days after explosion, SN 2018oh had blue "excess" flux in addition to a normal SN rise. The flux excess can be explained by the interaction between the SN and a Roche-lobe filling non-degenerate companion star. Such a scenario should also strip material from the companion star, that would emit once the SN ejecta become optically thin, imprinting relatively narrow emission features in its nebular spectrum. We search our nebular spectra for signs of this interaction, including close examination of wavelengths of hydrogen and helium transitions, finding no significant narrow emission. We place upper limits on the luminosity of these features of $2.6,\ 2.9\ \mathrm{and}\ 2.1\times10^{37}\ \mathrm{erg\ s^{-1}}$ for H$\alpha$, He I $\lambda$5875, and He I $\lambda$6678, respectively. Assuming a simple model for the amount of swept-up material, we estimate upper mass limits for hydrogen of $5.4\times10^{-4}\ \mathrm{M_{\odot}}$ and helium of $4.7\times10^{-4}\ \mathrm{M_{\odot}}$. Such stringent limits are unexpected for the companion-interaction scenario consistent with the early data. No known model can explain the excess flux, its blue color, and the lack of late-time narrow emission features.Comment: 10 pages, 5 figures, accepted for publication in APJ Letter

Segmentation of vestibular schwannoma from MRI, an open annotated dataset and baseline algorithm

Automatic segmentation of vestibular schwannomas (VS) from magnetic resonance imaging (MRI) could significantly improve clinical workflow and assist patient management. We have previously developed a novel artificial intelligence framework based on a 2.5D convolutional neural network achieving excellent results equivalent to those achieved by an independent human annotator. Here, we provide the first publicly-available annotated imaging dataset of VS by releasing the data and annotations used in our prior work. This collection contains a labelled dataset of 484 MR images collected on 242 consecutive patients with a VS undergoing Gamma Knife Stereotactic Radiosurgery at a single institution. Data includes all segmentations and contours used in treatment planning and details of the administered dose. Implementation of our automated segmentation algorithm uses MONAI, a freely-available open-source framework for deep learning in healthcare imaging. These data will facilitate the development and validation of automated segmentation frameworks for VS and may also be used to develop other multi-modal algorithmic models

DGP Cosmology with a Non-Minimally Coupled Scalar Field on the Brane

We construct a DGP inspired braneworld scenario where a scalar field non-minimally coupled to the induced Ricci curvature is present on the brane. First we investigate the status of gravitational potential with non-minimal coupling and observational constraints on this non-minimal model. Then we further deepen the idea of embedding of FRW cosmology in this non-minimal setup. Cosmological implications of this scenario are examined with details and the quintessence and late-time expansion of the universe within this framework are examined. Some observational constraints imposed on this non-minimal scenario are studied and relation of this model with dark radiation formalism is determined with details.Comment: 26 pages, 3 eps figure

Three year experience with the cochlear BAHA attract implant: a systematic review of the literature

Background Bone conduction devices are widely used and indicated in cases of conductive, mixed or single sided deafness where conventional hearing aids are not indicated or tolerated. Percutaneous bone-conduction devices gave satisfactory hearing outcomes but were frequently complicated by soft tissue reactions. Transcutaneous bone conduction devices were developed in order to address some of the issues related to the skin-penetrating abutment. The aim of this article is to present a systematic review of the indications, surgical technique and audiological, clinical and functional outcomes of the BAHA Attract device reported so far. Methods A systematic computer-based literature search was performed on the PubMed database as well as Scopus, Cochrane and Google Scholar. Out of 497 articles, 10 studies and 89 reported cases were finally included in our review. Results The vast majority of implanted patients were satisfied with the aesthetics of the device scoring highly at the Abbreviated Profile of Hearing Aid Benefit, Glasgow Benefit Inventory and Client Oriented Scale of Improvement. Overall, hearing outcomes, tested by various means including speech in noise, free field hearing testing and word discrimination scores showed a significant improvement. Complications included seroma or haematoma formation, numbness around the area of the flap, swelling and detachment of the sound processor from the external magnet. Conclusions The functional and audiological results presented so far in the literature have been satisfactory and the complication rate is low compared to the skin penetrating Bone Conduction Devices. Further robust trials will be needed to study the long-term outcomes and any adverse effects

Male obesity associated gonadal dysfunction and the role of bariatric surgery

Obesity is an ever growing pandemic and a prevalent problem among men of reproductive age that can both cause and exacerbate male-factor infertility by means of endocrine abnormalities, associated comorbidities, and direct effects on the precision and throughput of spermatogenesis. Robust epidemiologic, clinical, genetic, epigenetic, and preclinical data support these findings. Clinical studies on the impact of medically induced weight loss on serum testosterone concentrations and spermatogenesis is promising but may show differential and unsustainable results. In contrast, literature has demonstrated that weight loss after bariatric surgery is correlated with an increase in serum testosterone concentrations that is superior than that obtained with only lifestyle modifications, supporting a further metabolic benefit from surgery that may be specific to the male reproductive system. The data on sperm and semen parameters is controversial to date. Emerging evidence in the burgeoning field of genetics and epigenetics has demonstrated that paternal obesity can affect offspring metabolic and reproductive phenotypes by means of epigenetic reprogramming of spermatogonial stem cells. Understanding the impact of this reprogramming is critical to a comprehensive view of the impact of obesity on subsequent generations. Furthermore, conveying the potential impact of these lifestyle changes on future progeny can serve as a powerful tool for obese men to modify their behavior. Healthcare professionals treating male infertility and obesity need to adapt their practice to assimilate these new findings to better counsel men about the importance of paternal preconception health and the impact of novel non-medical therapeutic interventions. Herein, we summarize the pathophysiology of obesity on the male reproductive system and emerging evidence regarding the potential role of bariatric surgery as treatment of male obesity-associated gonadal dysfunction