Preferential sulfoxidation of the methionine residues of glycophorin A

AbstractCarbon-13 nuclear magnetic resonance spectroscopy was used to monitor the preferential sulfoxidation of the two methionine residues (8 and 81) of glycophorin A. In urea Met-8 is readily oxidized. However, Met-81 can only be oxidized in trifluoroacetic acid containing hydrogen peroxide. Our results also give some insight into the reagent accessibility of different portions of the protein molecule and the general stability of this glycoprotein

Sensor Deployment Mechanism for Surfer Satellite

SURFER, the Stanford University Radio Frequency Emissions Receiver, is a small, free flying, spin stabilized satellite. It will take measurements of the earth’s ionosphere during the joint US/Italian Shuttle tether experiment. To obtain these measurements several sensors must be extended from the satellite to Specified positions. This will increase the resolution of the instruments and decrease the electromagnetic interference from the satellite electronics. The primary requirements for the deployment mechanism are: 1) The sensors must be positioned at least 60 inches from the satellite with ± 5% on the known deployed length and a ±1 degree tolerance on the known angular position. 2) Opposing sensors must be deployed simultaneously to within 10% of the total deployment time. 3) Full piece part redundancy is desired to eliminate single point failure

Hydrological model LSDM for operational earth rotation and gravity field variations

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Traffic Collision Avoidance System: False Injection Viability

Safety is a simple concept but an abstract task, specifically with aircraft. One critical safety system, the Traffic Collision Avoidance System II (TCAS), protects against mid-air collisions by predicting the course of other aircraft, determining the possibility of collision, and issuing a resolution advisory for avoidance. Previous research to identify vulnerabilities associated with TCAS’s communication processes discovered that a false injection attack presents the most comprehensive risk to veritable trust in TCAS, allowing for a mid-air collision. This research explores the viability of successfully executing a false injection attack against a target aircraft, triggering a resolution advisory. Monetary constraints precluded access to a physical TCAS unit; instead, this research creates a novel program, TCAS-False Injection Environment (TCAS-FIE), that incorporates real-world distributed computing systems to simulate a ground-based attacker scenario which explores how a false injection attack could target an operational aircraft. TCAS-FIEs’ simulation models are defined by parameters to execute tests that mimic real-world TCAS units during Mode S message processing. TCAS-FIE simulations execute tests over applicable ranges (5–30 miles), altitudes (25–45K ft), and bearings standard for real-world TCAS tracking. The comprehensive tests compare altitude, measure range closure rate, and measure signal strength from another aircraft to determine the delta in bearings over time. In the attack scenario, the ground-based adversary falsely injects a spoofed aircraft with characteristics matching a Boeing 737-800 aircraft, targeting an operational Boeing 737-800 aircraft. TCAS-FIE completes 555,000 simulations using the various ranges, altitudes, and bearings. The simulated success rate to trigger a resolution advisory is 32.63%, representing 181,099 successful resolution advisory triggers out of 555,000 total simulations. The results from additional analysis determine the required ranges, altitudes, and bearing parameters to trigger future resolution advisories, yielding a predictive threat map for aircraft false injection attacks. The resulting map provides situational awareness to pilots in the event of a real-world TCAS anomaly

Atmospheric Contributions to Global Ocean Tides for Satellite Gravimetry

To mitigate temporal aliasing effects in monthly mean global gravity fields from the GRACE and GRACE‐FO satellite tandem missions, both tidal and non‐tidal background models describing high‐frequency mass variability in atmosphere and oceans are needed. To quantify tides in the atmosphere, we exploit the higher spatial (31 km) and temporal (1 hr) resolution provided by the latest atmospheric ECMWF reanalysis, ERA5. The oceanic response to atmospheric tides is subsequently modeled with the general ocean circulation model MPIOM (in a recently revised TP10L40 configuration that includes the feedback of self‐attraction and loading to the momentum equations and has an improved bathymetry around Antarctica) as well as the shallow water model TiME (employing a much higher spatial resolution and more elaborate tidal dissipation than MPIOM). Both ocean models consider jointly the effects of atmospheric pressure variations and surface wind stress. We present the characteristics of 16 waves beating at frequencies in the 1–6 cpd band and find that TiME typically outperforms the corresponding results from MPIOM and also FES2014b as measured from comparisons with tide gauge data. Moreover, we note improvements in GRACE‐FO laser ranging interferometer range‐acceleration pre‐fit residuals when employing the ocean tide solutions from TiME, in particular, for the S1 spectral line with most notable improvements around Australia, India, and the northern part of South America

Boolean implication networks derived from large scale, whole genome microarray datasets

A method for analysis of microarray data is presented that extracts statistically significant Boolean implication relationships between pairs of genes

Modelling spatial covariances for terrestrial water storage variations verified with synthetic GRACE-FO data

Gridded terrestrial water storage (TWS) variations observed by GRACE or GRACE-FO typically show a spatial correlation structure that is both anisotropic (direction-dependent) and non-homogeneous (latitude-dependent). We introduce a new correlation model to represent this structure. This correlation model allows GRACE and GRACE-FO data users to get realistic correlations of the TWS grids without the need to derive them from the formal spherical harmonic uncertainties. Further, we found that the modelled correlations fit the spatial structure of uncertainties to a greater extent in a simulation environment. The model is based on a direction-dependent Bessel function of the first kind which allows to model the longer correlation lengths in the longitudinal direction via a shape parameter, and also to account for residual GRACE striping errors that might remain after spatial filtering. The global scale and shape parameters vary with latitude by means of even Legendre polynomials. The correlation between two points transformed to covariance by scaling with the standard deviations of each point. The covariance model is valid on the sphere which is empirically verified with a Monte-Carlo approach. The covariance model is subsequently applied to 5 years of simulated GRACE-FO data which allow for immediate validation with true uncertainties from the differences between the input mass signal and the recovered gravity fields. Four different realisations of the point standard deviations were tested: two based on the formal errors provided with the simulated Stokes coefficients, and two based on empirical standard deviations, where the first is spatially variant and temporally invariant, and the second spatially invariant and temporally variant. These four different covariance models are applied to compute TWS time series uncertainties for both the fifty largest discharge basins and regular grid cells over the continents. These four models are compared with the true uncertainties available in the simulations. The two empirically-based covariance models provide more realistic TWS uncertainties than the ones based on the formal errors. Especially, the empirically-based covariance models are better in reflecting the spatial pattern of the uncertainties of the simulated GRACE-FO data including their latitude dependence. However, these modelled uncertainties are in general too large. But with only one global scaling factor, a statistical test confirms the equivalence between the empirically-based covariance model with temporally variable point standard deviations and the true uncertainties. Thus at the end, this covariance model represents the closest fit in the simulation environment. The simulated GRACE-FO data are assumed to be very realistic which is why we recommend the new covariance model to be further investigated for the characterisation of real GRACE and GRACE-FO terrestrial water storage data

Kinetic models for dilute solutions of dumbbells in non-homogeneous flows revisited

We propose a two fluid theory to model a dilute polymer solution assuming that it consists of two phases, polymer and solvent, with two distinct macroscopic velocities. The solvent phase velocity is governed by the macroscopic Navier-Stokes equations with the addition of a force term describing the interaction between the two phases. The polymer phase is described on the mesoscopic level using a dumbbell model and its macroscopic velocity is obtained through averaging. We start by writing down the full phase-space distribution function for the dumbbells and then obtain the inertialess limits for the Fokker-Planck equation and for the averaged friction force acting between the phases from a rigorous asymptotic analysis. The resulting equations are relevant to the modelling of strongly non-homogeneous flows, while the standard kinetic model is recovered in the locally homogeneous case

Gravitationally Consistent Mean Barystatic Sea Level Rise From Leakage‐Corrected Monthly GRACE Data

Gravitationally consistent solutions of the Sea Level Equation from leakage‐corrected monthly‐mean GFZ RL06 Gravity Recovery and Climate Experiment (GRACE) and GRACE Follow‐On (GRACE‐FO) Stokes coefficients reveal that barystatic sea level averaged over the whole global ocean was rising by 1.72 mm a−1 during the period April 2002 until August 2016. This rate refers to a truely global ocean averaging domain that includes all polar and semienclosed seas. The result corresponds to 2.02 mm a−1 mean barystatic sea level rise in the open ocean with a 1,000 km coastal buffer zone as obtained from a direct spatial integration of monthly GRACE data. The bias of +0.3 mm a−1 is caused by below‐average barystatic sea level rise in close proximity to coastal mass losses induced by the smaller gravitational attraction of the remaining continental ice and water masses. Alternative spherical harmonics solutions from CSR, JPL, and TU Graz reveal open‐ocean rates between 1.94 and 2.08 mm a−1, thereby demonstrating that systematic differences among the processing centers are much reduced in the latest release. We introduce in this paper a new method to approximate spatial leakage from the differences of two differently filtered global gravity fields. A globally constant and time‐invariant scale factor required to obtain full leakage from those filter differences is found to be 3.9 for GFZ RL06 when filtered with DDK3, and lies between 3.9 and 4.4 for other processing centers. Spatial leakage is estimated for every month in terms of global grids, thereby providing also valuable information of intrabasin leakage that is potentially relevant for hydrologic and hydrometeorological applications

Examining Factors in the Research Institute on Addictions Self-Inventory (RIASI): Associations with Alcohol Use and Problems at Assessment and Follow-Up

Impaired driving is a leading cause of alcohol-related deaths and injuries. Rehabilitation or remedial programs, involving assessment and screening of convicted impaired drivers to determine problem severity and appropriate programs, are an important component of society’s response to this problem. Ontario’s remedial program, Back on Track (BOT), involves an assessment process that includes administration of the Research Institute on Addictions Self-Inventory (RIASI) to determine assignment to an education or treatment program. The purpose of this study is to identify factors within the RIASI and examine how factor scores are associated with alcohol use and problem indicators at assessment and six-month follow-up. The sample included 22,298 individuals who completed BOT from 2000 to 2005. Principal component factor analysis with varimax rotation was conducted on RIASI data and an eight factor solution was retained: (1) Negative Affect, (2) Sensation Seeking, (3) Alcohol-Quantity, (4) Social Conformity, (5) High Risk Lifestyle, (6) Alcohol Problems, (7) Interpersonal Competence, and (8) Family History. Regression analyses were conducted to examine associations between factors and alcohol and problem measures obtained at assessment and at follow-up. Most factors, except for Interpersonal Competence, were associated with more alcohol use and problems at assessment. A similar pattern was observed at 6-month follow-up, but interestingly some factors (Negative Affect, Sensation Seeking, Alcohol-Quantity and Family History) predicted fewer days of alcohol use. The Interpersonal Competence factor was associated with significantly lower levels of alcohol use and problems at both assessment and follow-up. This work suggests that the RIASI provides information on several domains that have important relationships with alcohol problem severity and outcomes