7 research outputs found
Réflexivité, pouvoirs et transformation des pratiques
Dans le domaine de lâintervention sociale, on assiste aujourdâhui Ă des appels multiples Ă la rĂ©flexivitĂ© des acteurs comme des institutions, dans le cadre de politiques publiques devenues « activantes », et dans le contexte plus global dâune sociĂ©tĂ© dite « rĂ©flexive ». Lâobjectif de cet article est de montrer comment lâoutillage conceptuel de Foucault permet de problĂ©matiser ces divers usages de la rĂ©flexivitĂ© et leurs relations au pouvoir dans les pratiques, et dâen dĂ©gager certains enjeux et potentialitĂ©s Ă©thiques dans la transformation des pratiques dâintervention sociale.In the field of social intervention there are currently numerous expectations from both individual actors and institutions to become âreflexiveâ. This is related to public policies that have become âactivatingâ and to the more global context of a so-called âreflexiveâ society. This article aims to show how Foucaultâs conceptual tools allow us to problematize these various uses of reflexivity and their relationship to power in practices, and to identify on that basis certain ethical issues and possibilities in transforming social intervention
Penser les conditions et enjeux de la rĂ©flexivitĂ© dans les pratiques professionnelles aujourdâhui
Les controverses suscitĂ©es par la multiplication des rĂ©fĂ©rentiels dans le secteur de lâintervention sociale, comme dans celui de lâĂ©ducation et de la formation des professionnels, sont vives aujourdâhui. On sâinterroge sur la portĂ©e et sur les enjeux des transformations en cours dans lâaction sociale et dans les services publics, et sur les formes de professionnalisation que ces rĂ©fĂ©rentiels promeuvent dans ces secteurs Ă©galement. Si plusieurs modĂšles de professionnalisme sâaffrontent (Demail..
Dynamiques du travail social en pays francophones
Dans un contexte professionnel et organisationnel en tension, notamment avec l'Ă©tablissement de nouvelles normes de gouvernance de l'intervention sociale, le travail social connaĂźt de profondes mutations. Les professions et les formations qui le structurent, se trouvent engagĂ©es dans des situations paradoxales entre prescription et autonomie. On relĂšvera par exemple, l'augmentation des exigences alors que les ressources diminuent ; l'injonction d'insĂ©rer des personnes prĂ©carisĂ©es dans un systĂšme Ă©conomique gĂ©nĂ©rant lui-mĂȘme de la prĂ©carisation. Dans le champ de la formation, les diffĂ©rents cursus et l'accent mis notamment sur le dĂ©veloppement des compĂ©tences engendrent l'ajustement des programmes et l'adaptation des formateurs et des enseignants-chercheurs. Les contributions rĂ©unies dans Dynamiques du travail social en pays francophones permettent d'entrevoir les conditions de renouvellement des mĂ©tiers du social et les rĂ©gulations mises en Ćuvre dans chacun des cinq pays francophones convoquĂ©s (Belgique, France, Luxembourg, QuĂ©bec, Suisse). En dĂ©peignant des paysages contrastĂ©s et en soulevant des questions ouvertes issues d'expĂ©riences hĂ©tĂ©rogĂšnes, l'ouvrage vise Ă alimenter la rĂ©flexion et les dĂ©bats des praticiens, des Ă©tudiants, des professeurs-chercheurs et des usagers au sein du travail social
Inflammatory gene expression profile and defective IFN-Îł and granzyme K in natural killer cells of systemic juvenile idiopathic arthritis patients
Systemic juvenile idiopathic arthritis (sJIA) is an immune-inflammatory disease characterized by arthritis and systemic features. The role of natural killer (NK) cells in sJIA pathogenesis remains unclear. Therefore, we performed a comprehensive analysis of NK cell phenotype and functionality in sJIA patients.status: publishe
Inflammatory gene expression profile and defective interferon-Îł and granzyme K in natural killer cells from systemic juvenile idiopathic arthritis patients
Objective: Systemic juvenile idiopathic arthritis (JIA) is an immunoinflammatory disease characterized by arthritis and systemic manifestations. The role of natural killer (NK) cells in the pathogenesis of systemic JIA remains unclear. The purpose of this study was to perform a comprehensive analysis of NK cell phenotype and functionality in patients with systemic JIA.
Methods: Transcriptional alterations specific to NK cells were investigated by RNA sequencing of highly purified NK cells from 6 patients with active systemic JIA and 6 age-matched healthy controls. Cytokines (NK cell-stimulating and others) were quantified in plasma samples (n=18). NK cell phenotype and cytotoxic activity against tumor cells were determined (n=10), together with their interferon-gamma (IFN gamma)-producing function (n=8).
Results: NK cells from the systemic JIA patients showed an altered gene expression profile compared to cells from the healthy controls, with enrichment of immunoinflammatory pathways, increased expression of innate genes including TLR4 and S100A9, and decreased expression of immune-regulating genes such as IL10RA and GZMK. In the patients' plasma, interleukin-18 (IL-18) levels were increased, and a decreased ratio of IFN gamma to IL-18 was observed. NK cells from the patients exhibited specific alterations in the balance of inhibitory and activating receptors, with decreased killer cell lectin-like receptor G1 and increased NKp44 expression. Although NK cells from the patients showed increased granzyme B expression, consistent with intact cytotoxicity and degranulation against a tumor cell line, decreased granzyme K expression in CD56(bright) NK cells and defective IL-18-induced IFN gamma production and signaling were demonstrated.
Conclusion: NK cells are active players in the inflammatory environment typical of systemic JIA. Although their cytotoxic function is globally intact, subtle defects in NK-related pathways, such as granzyme K expression and IL-18-driven IFN gamma production, may contribute to the immunoinflammatory dysregulation in this disease