Obtaining Extruded Quinoa (Chenopodium Quinoa Willd) Flavor to Vanilla, Chocolate, Passion Fruit and His Industrial Process

The main objective of this work was to design the industrial process for the elaboration of quinoa extruded (Chenopodium quinoa Willd) of vanilla, chocolate and passion fruit flavors. The first step was the physical, bromatological and microbiological characterization of the raw material according to the ‘NTE INEN 1673 (2013): Quinoa Requirements’. Next, both the laboratory and industrial processes were performed, in which the unitary operations suitable for precise design were determined, including extrusion, evaporation, mixing and drying. Simultaneously, data of the necessary processes were taken (humidity, temperature and time) which facilitated all engineering calculations essential to generate a daily production using 17 kg of natural quinoa extrude to obtain 22,702 kg of vanilla, 23,491 kg of chocolate or 24,137 kg of passion fruit values that were determined by mass balances. With these processed samples, a sensory evaluation was conducted using a preference test in which the vanilla flavor obtained a 63.03% acceptability, followed by passion fruit with 20.72%, and finally chocolate with 16.22%. Once it was completed, the design was validated through the ‘NTE INEN 2570 (2011): grain, cereal and seed snacks. Requirements’, recording values within the limits recommended by the norm. Thus, the product is suitable for human consumption. Keywords: Humidity, Extrusion, Mass balance, food safety, Statgraphycs (software). Resumen El presente trabajo tuvo por principal objetivo diseñar el proceso industrial para la elaboración de extruido de quinua (Chenopodium quinoa Willd) sabor a vainilla, chocolate y maracuyá, donde para cumplirlo se inició con la caracterización física, bromatológica y microbiológica de la materia prima acorde a la ‘NTE INEN 1673 (2013): Quinua. Requisitos.’, seguido a esto se desarrolló el proceso tanto a nivel de laboratorio como industrial en donde se determinaron las operaciones unitarias idóneas para un diseño preciso entre las que constan la extrusión, la evaporación, el mezclado y el secado, a la vez se tomaron los datos necesarios de las variables del proceso (humedad, temperatura y tiempo) que ayudarían a realizar todos los cálculos de ingeniería indispensables para generar una producción diaria que utiliza 17 kg de extruido de quinua natural para obtener 22,702 kg de vainilla, 23,491 de chocolate o 24,137 kg de maracuyá, valores que fueron determinados mediante balances de masa. Con las muestras elaboradas se procedió a realizar una ficha de evaluación sensorial utilizando una prueba de preferencia en la que el sabor de vainilla tuvo un 63,03% de aceptabilidad, seguido del de maracuyá con un 20,72% y por último el de chocolate con un 16,22%. Una vez se culminó el diseño se realizó su validación a través de la ‘NTE INEN 2570 (2011): Bocaditos de granos, cereales y semillas. Requisitos.’, registrando valores dentro de los límites recomendados por dicha norma, por lo tanto el producto es apto para el consumo humano. Palabras Clave: Humedad, Extrusión, Balance de masa, Seguridad alimentaria Statgraphycs (software)

Smart toys designed for detecting developmental delays

In this paper,we describe the design considerations and implementation of a smart toy system,a technology for supporting the automatic recording and analysis for detecting developmental delays recognition when children play using the smart toy. To achieve this goal,we take advantage of the current commercial sensor features (reliability,low consumption,easy integration,etc.) to develop a series of sensor-based low-cost devices. Specifically,our prototype system consists of a tower of cubes augmented with wireless sensing capabilities and a mobile computing platform that collect the information sent from the cubes allowing the later analysis by childhood development professionals in order to verify a normal behaviour or to detect a potential disorder. This paper presents the requirements of the toy and discusses our choices in toy design,technology used,selected sensors,process to gather data from the sensors and generate information that will help in the decision-making and communication of the information to the collector system. In addition,we also describe the play activities the system supportsAuthors would like to thank the National Programme for Research, Development and Innovation, oriented to Societal Challenges, of the Spanish Ministry for Economy and Competitiveness that supported the results of this paper through EDUCERE project (TIN2013-47803-C2-2-R), and to Universidad de Alcala that supported them through EDUSENS project (CCG2014/EXP-008

Respuestas emocionales, cuidado, autocuidado personal y SARS-CoV-2 (COVID-19)

Currently, the pandemic caused by COVID-19 and the various measures to stop the contagion has developed multiple crises in society. The work environment has been transformed, occupational diseases have increased, therefore, it was decided to analyze the information published on the current problem and it was found that according to statistics, depressive, panic, and stress disorders have increased, due to social isolation, the change in routine and new ways of exercising job responsibilities, leading to a decrease in people’s psychological well-being. By way of conclusion, it can be said that it is important and necessary for people to develop both individual and collective resources that allow them to properly manage emotions and that integral health can be established and guaranteed.Actualmente la pandemia ocasionada por el COVID-19 y las diversas medidas para detener el contagio han desarrollado múltiples crisis en la sociedad. El entorno laboral se ha transformado, las enfermedades laborales han aumentado, por lo anterior, se decidió analizar la información publicada sobre la problemática actual y se encontró que según las estadísticas los trastornos depresivos, de pánico y estrés han aumentado, debido al aislamiento social, el cambio de rutina y las nuevas formas de ejercer las responsabilidades laborales, conllevando a disminuir el bienestar psicológico de las personas. A modo de conclusión, se puede decir que es importante y necesario que las personas desarrollen recursos tanto individuales como colectivos que permitan gestionar adecuadamente las emociones y que permitan estabilizar y garantizar la salud integral

Predictors of Loss of Functional Independence in Parkinson’s Disease: Results from the COPPADIS Cohort at 2-Year Follow-Up and Comparison with a Control Group

Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson’s disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88.58 ± 10.19 to 84.26 ± 13.38; p < 0.0001; Cohen’s effect size = −0.519) was observed but not in controls (N = 124; from 98.87 ± 6.52 to 99.52 ± 2.15; p = 0.238). When only patients considered functional independent at baseline were included, 55 out of 463 (11.9%) converted to functional dependent at V2. To be a female (OR = 2.908; p = 0.009), have longer disease duration (OR = 1.152; p = 0.002), have a non-tremoric motor phenotype at baseline (OR = 3.574; p = 0.004), have a higher score at baseline in FOGQ (OR = 1.244; p < 0.0001) and BDI-II (OR = 1.080; p = 0.008), have a lower score at baseline in PD-CRS (OR = 0.963; p = 0.008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1.168; p = 0.0.29), FOGQ (OR = 1.348; p < 0.0001) and VAFS-Mental (OR = 1.177; p = 0.013) (adjusted R-squared 0.52; Hosmer and Lemeshow test = 0.94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term

Cluster analysis with cellwise trimming and applications to robust clustering of curves

In this work, we propose a robust Cluster Analysis methodology based on cell trimming as an extension to a recently introduced robust version of Principal Component Analysis. This new approach allows for cellwise trimming in cluster analysis, which is more reasonable than traditional casewise trimming when the problem's dimension is large. This type of trimming avoids an unnecessary loss of information when only a few cells of the entirely trimmed observations are atypical. An algorithm is proposed to apply this approach. This algorithm is particularized to the interesting case of functional cluster analysis. Simulations and applications to real data sets are given to illustrate the proposed methods.This research was partially supported by Spanish Ministerio de Economía y Competitividad, Grant MTM2017- 86061-C2-1-P, and by Consejería de Educación de la Junta de Castilla y León and FEDER, Grant VA005P17 and VA002G18

Diplopia is frequent and associated with motor and non-motor severity in Parkinson’s disease: results from the COPPADIS cohort at 2-year follow-up

Background and objective: Diplopia is relatively common in Parkinson’s disease (PD) but is still understudied. Our aim was to analyze the frequency of diplopia in PD patients from a multicenter Spanish cohort, to compare the frequency with a control group, and to identify factors associated with it. Patients and Methods: PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30 days follow-up (V2) from 35 centers of Spain from the COPPADIS cohort were included in this longitudinal prospective study. The patients and controls were classified as “with diplopia” or “without diplopia” according to item 15 of the Non-Motor Symptoms Scale (NMSS) at V0, V1 (1-year ± 15 days), and V2 for the patients and at V0 and V2 for the controls. Results: The frequency of diplopia in the PD patients was 13.6% (94/691) at V0 (1.9% in controls [4/206]; p < 0.0001), 14.2% (86/604) at V1, and 17.1% (86/502) at V2 (0.8% in controls [1/124]; p < 0.0001), with a period prevalence of 24.9% (120/481). Visual hallucinations at any visit from V0 to V2 (OR = 2.264; 95%CI, 1.269–4.039; p = 0.006), a higher score on the NMSS at V0 (OR = 1.009; 95%CI, 1.012–1.024; p = 0.015), and a greater increase from V0 to V2 on the Unified Parkinson’s Disease Rating Scale–III (OR = 1.039; 95%CI, 1.023–1.083; p < 0.0001) and Neuropsychiatric Inventory (OR = 1.028; 95%CI, 1.001–1.057; p = 0.049) scores were independent factors associated with diplopia (R2 = 0.25; Hosmer and Lemeshow test, p = 0.716). Conclusions: Diplopia represents a frequent symptom in PD patients and is associated with motor and non-motor severity

Extradural plasmacytoma mimicking a spinal meningioma : a case report

La papilomatosis mamaria es un proceso benigno poco frecuente, asociado con el desarrollo de cáncer de mama. El limitado número de series y casos publicados no ha permitido definir algunos aspectos de su manejo y seguimiento. Este artículo presenta los casos de dos mujeres (uno de estos casos corresponde a la variante juvenil mamaria), seguidos por la discusión de dicha patología. Se hace énfasis en los hallazgos imagenológicos y en su correlación con la patología.Reporte de caso4097-4100Plasmacytomas are frequent extradural manifestations in patients with history of multiple myeloma (MM). We present a case of a patient with past history of MM, who consulted due to neurologic symptoms. The magnetic resonance showed an extradural mass with typical features of a spinal meningioma: a narrow canal and compressive myelopathy. Hystopathological analysis confirmed a plasmacytoma

A novel method for automatic detection and classification of movement patterns in short duration playing activities

Autonomous devices able to evaluate diverse situations without external help have become especially relevant in recent years because they can be used as an important source of relevant information about the activities performed by people (daily habits, sports performance, and health-related activities). Specifically, the use of this kind of device in childhood games might help in the early detection of developmental problems in children. In this paper, we propose a method for the detection and classification of movements performed with an object, based on an acceleration signal. This method can automatically generate patterns associated with a given movement using a set of reference signals, analyze sequences of acceleration trends, and classify the sequences according to the previously established patterns. This method has been implemented, and a series of experiments has been carried out using the data from a sensor-embedded toy. For the validation of the obtained results, we have, in parallel, developed two other classification systems based on popular techniques, i.e., a similarity search based on Euclidean distances and machine-learning techniques, specifically a support vector machine model. When comparing the results of each method, we show that our proposed method achieves a higher number of successes and higher accuracy in the detection and classification of isolated movement signals as well as in sequences of movements

Spatial and temporal analysis of rainfall concentration using the Gini index and PCI

This study aims to determine if there is variation in precipitation concentrations in Chile. We analyzed daily and monthly records from 89 pluviometric stations in the period 1970–2016 and distributed between 29°12′ S and 39°30′ S. This area was divided into two climatic zones: arid–semiarid and humid–subhumid. For each station, the Gini coefficient or Gini Index (GI), the precipitation concentration index (PCI), and the maximum annual precipitation intensity in a 24-h duration were calculated. These series of annual values were analyzed with the Mann–Kendall test with 5% error. Overall, it was noted that positive trends in the GI are present in both areas, although most were not found to be significant. In the case of PCI, the presence of positive trends is only present in the arid–semiarid zone; in the humid–subhumid zone, negative trends were mostly observed, although none of them were significant. Although no significant changes in all indices are evident, the particular case of the GI in the humid–subhumid zone stands out, where mostly positive trends were found (91.1%), of which 35.6% were significant. This would indicate that precipitation is more likely to be concentrated on a daily scale