Effects of the oceans on polar motion: Extended investigations

A method was found for expressing the tide current velocities in terms of the tide height (with all variables expanded in spherical harmonics). All time equations were then combined into a single, nondifferential matrix equation involving only the unknown tide height. The pole tide was constrained so that no tidewater flows across continental boundaries. The constraint was derived for the case of turbulent oceans; with the tide velocities expressed in terms of the tide height. The two matrix equations were combined. Simple matrix inversion then yielded the constrained solution. Programs to construct and invert the matrix equations were written. Preliminary results were obtained and are discussed

Ocean tide models for satellite geodesy and Earth rotation

A theory is presented which predicts tides in turbulent, self-gravitating, and loading oceans possessing linearized bottom friction, realistic bathymetry, and continents (at coastal boundaries no-flow conditions are imposed). The theory is phrased in terms of spherical harmonics, which allows the tide equations to be reduced to linear matrix equations. This approach also allows an ocean-wide mass conservation constraint to be applied. Solutions were obtained for 32 long and short period luni-solar tidal constituents (and the pole tide), including the tidal velocities in addition to the tide height. Calibrating the intensity of bottom friction produces reasonable phase lags for all constituents; however, tidal amplitudes compare well with those from observation and other theories only for long-period constituents. In the most recent stage of grant research, traditional theory (Liouville equations) for determining the effects of angular momentum exchange on Earth's rotation were extended to encompass high-frequency excitations (such as short-period tides)

Effects of the oceans on polar motion: Extended investigations

Matrix formulation of the tide equations (pole tide in nonglobal oceans); matrix formulation of the associated boundary conditions (constraints on the tide velocity at coastlines); and FORTRAN encoding of the tide equations excluding boundary conditions were completed. The need for supercomputer facilities was evident. Large versions of the programs were successfully run on the CYBER, submitting the jobs from SUNY through the BITNET network. The code was also restructured to include boundary constraints

Parasites on parasites:Coupled fluctuations in stacked contact processes

We present a model for host-parasite dynamics which incorporates both vertical and horizontal transmission as well as spatial structure. Our model consists of stacked contact processes (CP), where the dynamics of the host is a simple CP on a lattice while the dynamics of the parasite is a secondary CP which sits on top of the host-occupied sites. In the simplest case, where infection does not incur any cost, we uncover a novel effect: a non-monotonic dependence of parasite prevalence on host turnover. Inspired by natural examples of hyperparasitism, we extend our model to multiple levels of parasites and identify a transition between the maintenance of a finite and infinite number of levels, which we conjecture is connected to a roughening transition in models of surface growth

Report of the panel on earth rotation and reference frames, section 7

Objectives and requirements for Earth rotation and reference frame studies in the 1990s are discussed. The objectives are to observe and understand interactions of air and water with the rotational dynamics of the Earth, the effects of the Earth's crust and mantle on the dynamics and excitation of Earth rotation variations over time scales of hours to centuries, and the effects of the Earth's core on the rotational dynamics and the excitation of Earth rotation variations over time scales of a year or longer. Another objective is to establish, refine and maintain terrestrial and celestrial reference frames. Requirements include improvements in observations and analysis, improvements in celestial and terrestrial reference frames and reference frame connections, and improved observations of crustal motion and mass redistribution on the Earth

Ariel - Volume 2 Number 6

Editors Richard J. Bonanno Robin A. Edwards Associate Editors Steven Ager Stephen Flynn Shep Dickman Tom Williams Lay-out Editor Eugenia Miller Contributing Editors Michael J. Blecker W. Cherry Light James J. Nocon Lynne Porter Editors Emeritus Delvyn C. Case, Jr. Paul M. Fernhof

Endocrine Effects of Inhaled Corticosteroids in Children

Inhaled corticosteroids (ICSs) are widely used as first-line treatment for various chronic respiratory illnesses. Advances in devices and formulations have reduced their local adverse effects. However, as delivery of ICSs to the lungs improves, the systemic absorption increases, and an adverse effect profile similar to, although milder than, oral corticosteroids has emerged. The most serious potential adverse effect is adrenal insufficiency, which can be life threatening. Adrenal insufficiency occurs most in patients taking the highest doses of ICSs but is reported with moderate or even low doses as well. Our recommendations include greater vigilance in testing adrenal function than current standard practice. In patients with diabetes mellitus (types 1 and 2), an increase in glucose levels is likely, and diabetes medication adjustment may be needed when initiating or increasing ICSs. The risk of linear growth attenuation and adverse effects on bone mineral density is generally low but should be considered in the face of additional risk factors. On behalf of the Pediatric Endocrine Society Drugs and Therapeutics Committee, we present a review of the endocrine adverse effects of ICSs in children and offer recommendations relating to testing and referral. Limited data in particular realms diminish the strength of certain recommendations, and clinical judgment continues to be paramount

Lifting the Dusty Veil With Near- and Mid-Infrared Photometry: I. Description and Applications of the Rayleigh-Jeans Color Excess Method

The Milky Way (MW) remains a primary laboratory for understanding the structure and evolution of spiral galaxies, but typically we are denied clear views of MW stellar populations at low Galactic latitudes because of extinction by interstellar dust. However, the combination of 2MASS near-infrared (NIR) and Spitzer-IRAC mid-infrared (MIR) photometry enables a powerful method for determining the line of sight reddening to any star: the sampled wavelengths lie in the Rayleigh-Jeans part of the spectral energy distribution of most stars, where, to first order, all stars have essentially the same intrinsic color. Thus, changes in stellar NIR-MIR colors due to interstellar reddening are readily apparent, and (under an assumed extinction law) the observed colors and magnitudes of stars can be easily and accurately restored to their intrinsic values, greatly increasing their usefulness for Galactic structure studies. In this paper we explore this "Rayleigh-Jeans Color Excess" (RJCE) method and demonstrate that use of even a simple variant of the RJCE method based on a single reference color, (H-[4.5um]), can rather accurately remove dust effects from previously uninterpretable 2MASS color-magnitude diagrams of stars in fields along the heavily reddened Galactic mid-plane, with results far superior to those derived from application of other dereddening methods. We also show that "total" Galactic midplane extinction looks rather different from that predicted using 100um emission maps from the IRAS/ISSA and COBE/DIRBE instruments as presented by Schlegel et al. Instead, the Galactic mid-plane extinction strongly resembles the distribution of 13-CO (J=1->0) emission. Future papers will focus on refining the RJCE method and applying the technique to understand better not only dust and its distribution, but the distribution of stars intermixed with the dust in the low-latitude Galaxy.Comment: Accepted to ApJ; 21 pages, 17 figure

A Gateway MultiSite Recombination Cloning Toolkit

The generation of DNA constructs is often a rate-limiting step in conducting biological experiments. Recombination cloning of single DNA fragments using the Gateway system provided an advance over traditional restriction enzyme cloning due to increases in efficiency and reliability. Here we introduce a series of entry clones and a destination vector for use in two, three, and four fragment Gateway MultiSite recombination cloning whose advantages include increased flexibility and versatility. In contrast to Gateway single-fragment cloning approaches where variations are typically incorporated into model system-specific destination vectors, our Gateway MultiSite cloning strategy incorporates variations in easily generated entry clones that are model system-independent. In particular, we present entry clones containing insertions of GAL4, QF, UAS, QUAS, eGFP, and mCherry, among others, and demonstrate their in vivo functionality in Drosophila by using them to generate expression clones including GAL4 and QF drivers for various trp ion channel family members, UAS and QUAS excitatory and inhibitory light-gated ion channels, and QUAS red and green fluorescent synaptic vesicle markers. We thus establish a starter toolkit of modular Gateway MultiSite entry clones potentially adaptable to any model system. An inventory of entry clones and destination vectors for Gateway MultiSite cloning has also been established (www.gatewaymultisite.org)

Synaptic Dysbindin-1 Reductions in Schizophrenia Occur in an Isoform-Specific Manner Indicating Their Subsynaptic Location

Background: An increasing number of studies report associations between variation in DTNBP1, a top candidate gene in schizophrenia, and both the clinical symptoms of the disorder and its cognitive deficits. DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases. This study determined whether such synaptic reductions are isoform-specific. Methodology/Principal Findings: Using Western blotting of tissue fractions, we first determined the synaptic localization of the three major dysbindin-1 isoforms (A, B, and C). All three were concentrated in synaptosomes of multiple brain areas, including auditory association cortices in the posterior half of the superior temporal gyrus (pSTG) and the hippocampal formation (HF). Tests on the subsynaptic tissue fractions revealed that each isoform is predominantly, if not exclusively, associated with synaptic vesicles (dysbindin-1B) or with postsynaptic densities (dysbindin-1A and -1C). Using Western blotting on pSTG (n = 15) and HF (n = 15) synaptosomal fractions from schizophrenia cases and their matched controls, we discovered that synaptic dysbindin-1 is reduced in an isoform-specific manner in schizophrenia without changes in levels of synaptophysin or PSD-95. In pSTG, about 92% of the schizophrenia cases displayed synaptic dysbindin-1A reductions averaging 48% (p = 0.0007) without alterations in other dysbindin-1 isoforms. In the HF, by contrast, schizophrenia cases displayed normal levels of synaptic dysbindin-1A, but 67% showed synaptic reductions in dysbindin-1B averaging 33% (p = 0.0256), while 80% showed synaptic reductions in dysbindin-1C averaging 35% (p = 0.0171). Conclusions/Significance: Given the distinctive subsynaptic localization of dysbindin-1A, -1B, and -1C across brain regions, the observed pSTG reductions in dysbindin-1A are postsynaptic and may promote dendritic spine loss with consequent disruption of auditory information processing, while the noted HF reductions in dysbindin-1B and -1C are both presynaptic and postsynaptic and could promote deficits in spatial working memory