59 research outputs found
A First Look at the Abundance Pattern -- O/H, C/O, Ne/O, and Fe/O -- in Galaxies with JWST/NIRSpec
We analyze the rest-frame near-UV and optical nebular spectra of three z > 7
galaxies from the Early Release Observations taken with the Near-Infrared
Spectrograph (NIRSpec) on the James Webb Space Telescope (JWST). These three
high-z galaxies show the detection of several strong-emission nebular lines,
including the temperature-sensitive [O III] 4363 line, allowing us to
directly determine the nebular conditions and gas-phase abundances for O/H,
C/O, Ne/O, and Fe/O. We derive O/H abundances and ionization parameters that
are generally consistent with other recent analyses. The lowest-mass galaxy has
a large O/H uncertainty, which as a significant effect on anchoring the
mass-metallicity relationship (i.e., slope) and tests of its redshift
evolution. We also detect the C III] 1907,1909 emission in a
z > 8 galaxy from which we determine the most distant C/O abundance to date.
This valuable detection provides the first test of C/O redshift evolution out
to high-redshift. For neon, we use the high-ionization [Ne III] 3869
line to measure the first Ne/O abundances at z>7, finding no evolution in this
-element ratio. To investigate the Fe abundance, we explore the
tentative detection of weak [Fe II] and [Fe III] lines in a z>8 galaxy, which
would indicate a rapid build up of metals. Importantly, we demonstrate that
properly flux-calibrated and higher S/N spectra are crucial to robustly
determine the abundance pattern in z>7 galaxies with NIRSpec/JWST.Comment: Submitted to The Astrophysical Journal Letters. Comments welcom
Scary Barbie: An Extremely Energetic, Long-Duration Tidal Disruption Event Candidate Without a Detected Host Galaxy at z = 0.995
We report multi-wavelength observations and characterization of the
ultraluminous transient AT 2021lwx (ZTF20abrbeie; aka ``Barbie'') identified in
the alert stream of the Zwicky Transient Facility (ZTF) using a Recommender
Engine For Intelligent Transient Tracking (REFITT) filter on the ANTARES alert
broker. From a spectroscopically measured redshift of 0.995, we estimate a peak
observed pseudo-bolometric luminosity of log (L) = 45.7 from slowly fading ztf- and ztf-
light curves spanning over 1000 observer-frame days. The host galaxy is not
detected in archival Pan-STARRS observations ( mag), implying a lower
limit to the outburst amplitude of more than 5 mag relative to the quiescent
host galaxy. Optical spectra from Lick and Keck Observatories exhibit strong
emission lines with narrow cores from the H Balmer series and ultraviolet
semi-forbidden lines of Si III] 1892, C III] 1909, and C II]
2325. Typical nebular lines in AGN spectra from ions such as [O II]
and [O III] are not detected. These spectral features, along with the smooth
light curve that is unlike most AGN flaring activity, and the luminosity that
exceeds any observed or theorized supernova, lead us to conclude that AT
2021lwx is most likely an extreme tidal disruption event (TDE). Modeling of ZTF
photometry with MOSFiT suggests that the TDE was between a star and a supermassive black hole of mass
. Continued monitoring of the still-evolving light curve
along with deep imaging of the field once AT 2021lwx has faded can test this
hypothesis and potentially detect the host galaxy.Comment: 15 pages, 4 figures, 1 Table; Version as published in The
Astrophysical Journal Letters. Observations of AT 2021lwx published in the
paper can be found at https://bsubraya.github.io/research
Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial
Background
Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy
The Physical Conditions of Emission-Line Galaxies at Cosmic Dawn from JWST/NIRSpec Spectroscopy in the SMACS 0723 Early Release Observations
We present rest-frame optical emission-line flux ratio measurements for five
galaxies observed by the JWST Near-Infared Spectrograph (NIRSpec) in the
SMACS 0723 Early Release Observations. We add several quality-control and
post-processing steps to the NIRSpec pipeline reduction products in order to
ensure reliable relative flux calibration of emission lines that are closely
separated in wavelength, despite the uncertain \textit{absolute}
spectrophotometry of the current version of the reductions. Compared to
galaxies in the literature, the galaxies have similar
[OIII]5008/H ratios, similar [OIII]4364/H
ratios, and higher (0.5 dex) [NeIII]3870/[OII]3728
ratios. We compare the observations to MAPPINGS V photoionization models and
find that the measured [NeIII]3870/[OII]3728,
[OIII]4364/H, and [OIII]5008/H emission-line
ratios are consistent with an interstellar medium that has very high ionization
(, units of cm~s), low metallicity (), and very high pressure (, units of
cm). The combination of [OIII]4364/H and
[OIII](4960+5008)/H line ratios indicate very high electron
temperatures of , further implying metallicities of
with the application of low-redshift calibrations for
``-based'' metallicities. These observations represent a tantalizing new
view of the physical conditions of the interstellar medium in galaxies at
cosmic dawn.Comment: Accepted for publication in AAS Journals. 14 pages, 6 figures, 3
table
Paternity of Subordinates Raises Cooperative Effort in Cichlids
Background
In cooperative breeders, subordinates generally help a dominant breeding pair to raise offspring. Parentage studies have shown that in several species subordinates can participate in reproduction. This suggests an important role of direct fitness benefits for cooperation, particularly where groups contain unrelated subordinates. In this situation parentage should influence levels of cooperation. Here we combine parentage analyses and detailed behavioural observations in the field to study whether in the highly social cichlid Neolamprologus pulcher subordinates participate in reproduction and if so, whether and how this affects their cooperative care, controlling for the effect of kinship.
Methodology/Principal Findings
We show that: (i) male subordinates gained paternity in 27.8% of all clutches and (ii) if they participated in reproduction, they sired on average 11.8% of young. Subordinate males sharing in reproduction showed more defence against experimentally presented egg predators compared to subordinates not participating in reproduction, and they tended to stay closer to the breeding shelter. No effects of relatedness between subordinates and dominants (to mid-parent, dominant female or dominant male) were detected on parentage and on helping behaviour.
Conclusions/Significance
This is the first evidence in a cooperatively breeding fish species that the helping effort of male subordinates may depend on obtained paternity, which stresses the need to consider direct fitness benefits in evolutionary studies of helping behaviour
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Intelligence is highly heritable(1) and a major determinant of human health and well-being(2). Recent genome-wide meta-analyses have identified 24 genomic loci linked to variation in intelligence3-7, but much about its genetic underpinnings remains to be discovered. Here, we present a large-scale genetic association study of intelligence (n = 269,867), identifying 205 associated genomic loci (190 new) and 1,016 genes (939 new) via positional mapping, expression quantitative trait locus (eQTL) mapping, chromatin interaction mapping, and gene-based association analysis. We find enrichment of genetic effects in conserved and coding regions and associations with 146 nonsynonymous exonic variants. Associated genes are strongly expressed in the brain, specifically in striatal medium spiny neurons and hippocampal pyramidal neurons. Gene set analyses implicate pathways related to nervous system development and synaptic structure. We confirm previous strong genetic correlations with multiple health-related outcomes, and Mendelian randomization analysis results suggest protective effects of intelligence for Alzheimer's disease and ADHD and bidirectional causation with pleiotropic effects for schizophrenia. These results are a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.Peer reviewe
Author Correction:Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article
Rehabilitation versus surgical reconstruction for non-acute anterior cruciate ligament injury (ACL SNNAP): a pragmatic randomised controlled trial
BackgroundAnterior cruciate ligament (ACL) rupture is a common debilitating injury that can cause instability of the knee. We aimed to investigate the best management strategy between reconstructive surgery and non-surgical treatment for patients with a non-acute ACL injury and persistent symptoms of instability.MethodsWe did a pragmatic, multicentre, superiority, randomised controlled trial in 29 secondary care National Health Service orthopaedic units in the UK. Patients with symptomatic knee problems (instability) consistent with an ACL injury were eligible. We excluded patients with meniscal pathology with characteristics that indicate immediate surgery. Patients were randomly assigned (1:1) by computer to either surgery (reconstruction) or rehabilitation (physiotherapy but with subsequent reconstruction permitted if instability persisted after treatment), stratified by site and baseline Knee Injury and Osteoarthritis Outcome Score—4 domain version (KOOS4). This management design represented normal practice. The primary outcome was KOOS4 at 18 months after randomisation. The principal analyses were intention-to-treat based, with KOOS4 results analysed using linear regression. This trial is registered with ISRCTN, ISRCTN10110685, and ClinicalTrials.gov, NCT02980367.FindingsBetween Feb 1, 2017, and April 12, 2020, we recruited 316 patients. 156 (49%) participants were randomly assigned to the surgical reconstruction group and 160 (51%) to the rehabilitation group. Mean KOOS4 at 18 months was 73·0 (SD 18·3) in the surgical group and 64·6 (21·6) in the rehabilitation group. The adjusted mean difference was 7·9 (95% CI 2·5–13·2; p=0·0053) in favour of surgical management. 65 (41%) of 160 patients allocated to rehabilitation underwent subsequent surgery according to protocol within 18 months. 43 (28%) of 156 patients allocated to surgery did not receive their allocated treatment. We found no differences between groups in the proportion of intervention-related complications.InterpretationSurgical reconstruction as a management strategy for patients with non-acute ACL injury with persistent symptoms of instability was clinically superior and more cost-effective in comparison with rehabilitation management
Genomic investigations of unexplained acute hepatitis in children
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children
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