Estimating the import content of Argentine exports

Despite recent efforts toward collecting evidence of vertical specialization for developed economies, scarce work has been dedicated to developing economies and to Argentina, in particular. The key contribution of this paper is to provide comparable estimates of vertical specialization as reflected in the imported content of exports in Argentina. Drawing on the 1997 input-output matrix for Argentina, the authors estimate that the imported content of the country’s exports is about 14.5 percent of total exports, lower than for other emerging economies. They also provide estimates of imported content for more disaggregated product categories.Water and Industry,Transport Economics Policy&Planning,Commodities,Agribusiness&Markets,Rural Development Knowledge&Information Systems

Impact on soil degradation factors of changes in rain intensity patterns in southern Spain

In southern of Spain, the torrential nature of the rainfalls alters the soil water availability for vegetation and, consequently, its spatially and temporally pattern. This fact, combined with the current global warming, raises a modification of the eco-geomorphological processes dynamics in Mediterranean areas

Smart Stop: Paradero Inteligente que reduce el miedo a consecuencia de la inseguridad ciudadana en Lima Metropolitana

El Perú es un país bastamente afectado por la inseguridad ciudadana. En Lima, la problemática se manifiesta a través de robos callejeros en jóvenes entre 15 y 33 años y el sistema de transporte público es uno de los elementos de la ciudad más afectados por esta. La inseguridad ciudadana genera consecuencias físicas y psicológicas, y el miedo es una de las emociones más perjudiciales. En la presente investigación, se analizan distintos productos y servicios enfocados en la inseguridad ciudadana y se destaca la necesidad de un diseño de mobiliario público que reduzca el miedo por consecuencia de la inseguridad ciudadana. Se identifican a la iluminación, la buena apariencia física y la tecnología como elementos claves en el diseño. Los 6 estudios realizados con participantes de 3 universidades en Lima brindan resultados que complementarios. Se concluye que el paradero inteligente Smart Stop es un mobiliario público que reduce el miedo de los usuarios de sufrir un robo durante su espera del transporte público. Por último, se propone un trabajo a futuro en el que se implemente la propuesta para medir si el paradero también reduce el riesgo de los ciudadanos de sufrir un robo producto de la inseguridad ciudadana

Análisis del mercado kosher, diseño del packaging, creación de nueva gama kosher en bodega Peces-Barba y desarrollo del plan de marketing MIX

Análisis del mercado Kosher para desarrollar una nueva gama de producto de la bodega toledana Peces - Barba. Además se ha desarrollado un plan de marketing donde se detalla el precio, la promoción, el producto y la distribución del mismo.Grado en Publicidad y Relaciones Pública

IWARN: A people-centered approach for early warning

Early warning is the activity of the mitigation phase concerned with monitoring precursors of a potential hazard to decide whether it is evolving to real risk and eventually initiate an early response. The first step consists of collecting updated and reliable data to support situational awareness from emergency operators. Data-centered Early Warning Systems (EWS) are focused on gathering data and run simulations to support decision-makers. A more sustainable approach consists of a people-centered EWS that takes profit from citizens who act as intelligent sensors collecting and sharing purposeful information. This people-centered approach can contribute to raising community awareness of the local environment and its vulnerabilities. In this paper, we introduce iWarn, a system relying upon mobile to integrate citizens in this process. The system has been developed following an action research approach to involve different stakeholders, including professionals, volunteers and citizens

Control Policies for a Dynamic Storage System With Multiple Lifts and Shuttles

New types of Automated Storage and Retrieval Systems, able to achieve high throughput levels, are continuously being developed and require new control polices to take full advantage of the developed system. In this paper we study a dynamic storage system as developed by Vanderlande Industries consisting of a conveyor, two lifts, multiple transfer shuttles, and a storage rack. One of the decision problems for this system is the scheduling problem of the two lifts. In other words, which lift is going to handle which request and in which order. In this paper, we derive an integrated look-ahead heuristic based on enumeration to simultaneously assign a set of pre-defined requests to the lifts and to schedule the lifts. As main performance measure we use the total time required to serve all requests

Disease-causing mutations in BEST1 gene are associated with altered sorting of bestrophin-1 protein

Doumanov, Jordan A. et al.Mutations in BEST1 gene, encoding the bestrophin-1 (Best1) protein are associated with macular dystrophies. Best1 is predominantly expressed in the retinal pigment epithelium (RPE), and is inserted in its basolateral membrane. We investigated the cellular localization in polarized MDCKII cells of disease-associated Best1 mutant proteins to study specific sorting motifs of Best1. Real-time PCR and western blots for endogenous expression of BEST1 in MDCK cells were performed. Best1 mutant constructs were generated using site-directed mutagenesis and transfected in MDCK cells. For protein sorting, confocal microscopy studies, biotinylation assays and statistical methods for quantification of mislocalization were used. Analysis of endogenous expression of BEST1 in MDCK cells revealed the presence of BEST1 transcript but no protein. Confocal microscopy and quantitative analyses indicate that transfected normal human Best1 displays a basolateral localization in MDCK cells, while cell sorting of several Best1 mutants (Y85H, Q96R, L100R, Y227N, Y227E) was altered. In contrast to constitutively active Y227E, constitutively inactive Y227F Best1 mutant localized basolaterally similar to the normal Best1 protein. Our data suggest that at least three basolateral sorting motifs might be implicated in proper Best1 basolateral localization. In addition, non-phosphorylated tyrosine 227 could play a role for basolateral delivery. © 2013 by the authors; licensee MDPI, Basel, Switzerland.This work was supported by Agence Nationale de la Recherche (Chaire d’Excellence to Shomi S. Bhattacharya), Fondation Voir et Entendre (Young Investigator Grants to Christina Zeitz and Emeline F. Nandrot), Centre National de la Recherche Scientifique (CNRS) and Fondation Bettencourt Schueller (to Emeline F. Nandrot), Université Pierre et Marie Curie-Paris6 (Bonus Qualité Recherche to Christina Zeitz), Foundation Fighting Blindness (grant number CD-CL-0808-0466-CHNO to Isabelle Audo), Centre d’Investigation Clinique 503 recognized as a Foundation Fighting Blindness Center (grant number C-CMM-0907-0428-INSERM04), Fundacion Progreso y Salud (to Shomi S. Bhattacharya, Maria Luz Bellido Diaz, Abhay Krishna and Paloma Dominguez Gimenez), Instituto de Salud Carlos III (grant number CM06/00183 to Maria Luz Bellido Diaz) and Bulgarian National Science Fund (grant number DDVU 02/10). Additionally, the Institut de la Vision is funded by Institut National de la Santé et de la Recherche Médicale, Université Pierre et Marie Curie-Paris 6, Centre National de la Recherche Scientifique and Départment de Paris.Peer Reviewe

Extracellular Tumor-Related mRNA in Plasma of Lymphoma Patients and Survival Implications

BACKGROUND: We studied anomalous extracellular mRNAs in plasma from patients with diffuse large B-cell lymphoma (DLBCL) and their survival implications. mRNAs studied have been reported in the literature as markers of poor (BCL2, CCND2, MYC) and favorable outcome (LMO2, BCL6, FN1) in tumors. These markers were also analyzed in lymphoma tissues to test possible associations with their presence in plasma. METHODOLOGY/PRINCIPAL FINDINGS: mRNA from 42 plasma samples and 12 tumors from patients with DLBCL was analyzed by real-time PCR. Samples post-treatment were studied. The immunohistochemistry of BCL2 and BCL6 was defined. Presence of circulating tumor cells was determined by analyzing the clonality of the immunoglobulin heavy-chain genes by PCR. In DLBCL, MYC mRNA was associated with short overall survival. mRNA targets with unfavorable outcome in tumors were associated with characteristics indicative of poor prognosis, with partial treatment response and with short progression-free survival in patients with complete response. In patients with low IPI score, unfavorable mRNA targets were related to shorter overall survival, partial response, high LDH levels and death. mRNA disappeared in post-treatment samples of patients with complete response, and persisted in those with partial response or death. No associations were found between circulating tumor cells and plasma mRNA. Absence of BCL6 protein in tumors was associated with presence of unfavorable plasma mRNA. CONCLUSIONS/SIGNIFICANCE: Through a non-invasive procedure, tumor-derived mRNAs can be obtained in plasma. mRNA detected in plasma did not proceed from circulating tumor cells. In our study, unfavorable targets in plasma were associated with poor prognosis in B-cell lymphomas, mainly MYC mRNA. Moreover, the unfavorable targets in plasma could help us to classify patients with poor outcome within the good prognosis group according to IPI

HIV and Substance Use in Latin America: A Scoping Review

This scoping review aims to explore the interplay between substance use (SU) and HIV in Latin America (LA). Database searches yielded 3481 references; 196 were included. HIV prevalence among people who used substances (PWUS) ranged from 2.8–15.2%. SU definitions were variable throughout studies, and thus data were not easily comparable. In 2019, only 2% of new HIV infections were attributed to injection drug use (IDU) in LA. Factors associated with HIV among PWUS included being female, IDU and homelessness, and PWUS were likely to engage in risky sexual behaviors, start antiretroviral treatment late, have poor adherence, have treatment failure, be lost to follow-up, have comorbidities, and experience higher mortality rates and lower quality of life, as has been reported in PLWH with SU in other regions. Five intervention studies were identified, and only one was effective at reducing HIV incidence in PWUS. Interventions in other regions have varying success depending on context-specific characteristics, highlighting the need to conduct more research in the LA region. Though progress has been made in establishing SU as a major concern in people living with HIV (PLWH), much more is yet to be done to reduce the burden of HIV and SU in LA