Improving the Knowledge on Seismogenic Sources in the Lower Tagus Valley for Seismic Hazard Purposes

The Lower Tagus Valley, that includes the metropolitan area of Lisbon, has been struck by several earthquakes which produced significant material damage and loss of lives. Their exact location remains unknown. Our goal is to shed some light into the seismogenic sources in the area using seismic reflection and geological data. In areas with no seismic coverage, potential-field data interpretation was carried out. Seismicity was overlaid to the potential seismogenic structures and high-resolution data was acquired in order to confirm which structures have been active into the Quaternary. Three major fault-zones affecting the Neogene were identified: V. F. Xira, Samora-Alcochete and Pinhal Novo. For the first fault, strong evidences suggest it is active. The other two fault-zones and other structures previously unknown can be correlated with several epicentres. Empirical relationships between maximum moment magnitude and fault area indicate that MW > 6.5 earthquakes can be expected for the larger structures

Trends of case-fatality rate by acute coronary syndrome in Portugal : impact of a fast track to the coronary unit

© The Author(s) 2019. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons AttributionNonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).Introduction: Efforts were made to improve management of coronary disease as the fast-track system to the Coronary Unit. We aim to analyse case-fatality rates by acute coronary syndrome in Portugal from 2000 to 2016, mainly the impact of the fast-track system and the proportion of patients that activate the fast-track system. Methods: We analysed monthly acute coronary syndrome case-fatality before and after the implementation of the fasttrack system in 2007. Impact of the system was assessed through regression models for interrupted time-series. We calculated annual proportion of fast-track system admissions. Results: After 2007 case-fatality by acute coronary syndrome decreased (b¼1.27, p-value < 0.01). The estimates obtained for ST Elevation Myocardial Infarction suggest a reduction of nearly 86 monthly deaths prevented after 2007. The highest percentage of patients admitted through the fast-track system was 35%. Conclusions: Our results suggest fast-track system may have contributed to a decline in acute coronary syndrome case-fatality. However, more than half of patients were not admitted through the system. This should encourage health authorities to make efforts to ensure compliance.info:eu-repo/semantics/publishedVersio

Ghrelin and obestatin: Different role in fetal lung development?

Ghrelin and obestatin are two proteins that originate from post-translational processing of the preproghrelin peptide. Various authors claim an opposed role of ghrelin and obestatin in several systems. Preproghrelin mRNA is significantly expressed in airway epithelium throughout lung development, predominantly during the earliest stages. The aim of this study was to evaluate the role of ghrelin and obestatin in fetal lung development in vitro. Immunohistochemistry studies were performed at different gestational ages in order to clarify the expression pattern of ghrelin, GHS-R1a, obestatin and GPR39 during fetal lung development. Fetal rat lung explants were harvested at 13.5 days post-conception (dpc) and cultured during 4 days with increasing doses of total ghrelin, acylated ghrelin, desacyl-ghrelin, ghrelin antagonist (D-Lys(3)-GHRP-6) or obestatin. Immunohistochemistry studies demonstrated that ghrelin, GHS-R1a, obestatin and GPR39 proteins were expressed in primitive rat lung epithelium throughout all studied gestational ages. Total and acylated ghrelin supplementation significantly increased the total number of peripheral airway buds, whereas desacyl-ghrelin induced no effect. Moreover, GHS-R1a antagonist significantly decreased lung branching. Finally, obestatin supplementation induced no significant effect in the measured parameters. The present study showed that ghrelin has a positive effect in fetal lung development through its GHS-R1a receptor, whereas obestatin has no effect on lung branching

Local fetal lung renin-angiotensin system as a target to treat congenital diaphragmatic hernia

Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the literature demonstrated a possible involvement of renin-angiotensin system (RAS) during fetal lung development. Thus, the expression pattern of renin, angiotensin-converting enzyme, angiotensinogen, type 1 (AT₁) and type 2 (AT₂) receptors of angiotensin II (ANGII) was assessed by immunohisto-chemistry throughout gestation, whereas the function of RAS in the fetal lung was evaluated using fetal rat lung explants. These were morphometrically analyzed and intracellular pathway alterations assessed by Western blot. In nitrofen-induced CDH model, pregnant rats were treated with saline or PD-123319. In pups, lung growth, protein/DNA ratio, radial saccular count, epithelial differentiation and lung maturation, vascular morphometry, right ventricular hypertrophy and overload molecular markers, gasometry and survival time were evaluated. Results demonstrated that all RAS components were constitutively expressed in the lung during gestation and that ANGII had a stimulatory effect on lung branching, mediated by AT₁ receptor, through p44/42 and Akt phosphorylation. This stimulatory effect on lung growth was mimicked by AT₂-antagonist (PD-123319) treatment. In vivo antenatal PD-123319 treatment increased lung growth, ameliorated indirect parameters of pulmonary hypertension, improved lung function and survival time in nonventilated CDH pups, without maternal or fetal deleterious effects. Therefore, this study demonstrated a local and physiologically active RAS during lung morphogenesis. Moreover, selective inhibition of AT₂ receptor is presented as a putative antenatal therapy for CDH

Produção integrada de melão no Vale do São Francisco: manejo e aspectos socioeconômicos.

O cultivo do melão no pólo do Submédio São Francisco apresenta, no tocante à forma de exploração, um comportamento bem diferente do observado nas Regiões de Mossoró e Açu e do Baixo Jaguaribe

Casa de la Lhéngua: A set of language resources and natural language processing tools for Mirandese

This paper describes the efforts for the construction of Language Resources and NLP tools for Mirandese, a minority language spoken in North-eastern Portugal, now available on a community-led portal, Casa de la Lhéngua. The resources were developed in the context of a collaborative citizenship project led by Microsoft, in the context of the creation of the first TTS system for Mirandese. Development efforts encompassed the compilation of a corpus with over 1M tokens, the construction of a GTP system, syllable-division, inflection and a Part-of-Speech (POS) tagger modules, leading to the creation of an inflected lexicon of about 200.000 entries with phonetic transcription, detailed POS tagging, syllable division, and stress mark-up. Alongside these tasks, which were made easier through the adaptation and reuse of existing tools for closely related languages, a casting for voice talents among the speaking community was conducted and the first speech database for speech synthesis was recorded for Mirandese. These resources were combined to fulfil the requirements of a well-tested statistical parameter synthesis model, leading to an intelligible voice font. These language resources are available freely at Casa de la Lhéngua, aiming at promoting the development of real-life applications and fostering linguistic research on Mirandese.info:eu-repo/semantics/publishedVersio

Fecal Dipeptidyl Peptidase-4: An Emergent Biomarker in Inflammatory Bowel Disease

INTRODUCTION: Dipeptidyl peptidase-4 (DPP-4) is a membrane-bound glycoprotein that acts as a receptor but also exists in a soluble form. It has been recognized as a mediator of inflammation and considered a biomarker in inflammatory bowel disease (IBD). METHODS: We evaluated a prospectively recruited cohort, consisting of 101 patients with IBD, using validated clinical indexes; 22 patients with ulcerative colitis (UC) underwent endoscopic evaluation. Fecal DPP-4 (fDPP-4) levels were analyzed and correlated with clinical scores, Mayo endoscopic score (in UC patients), serum DPP-4, C-reactive protein, and fecal calprotectin. Immunohistochemical staining for DPP-4 in intestinal biopsies was also performed. RESULTS: When compared with remitters, median fDPP-4 levels were higher in patients with ileal Crohn's disease (CD) (7,584 [1,464-7,816] vs 2,104 [630-2,676] ng/mL, P = 0.015) and lower in patients with UC exhibiting clinical activity (1,213 [559-1,682] vs 7,814 [2,555-7,985] ng/mL, P < 0.001). Patients with UC presenting endoscopic activity also had lower levels than remitters (939 [559-1,420] vs 7,544 [4,531-7,940] ng/mL, P = 0.006). Fecal DPP-4 discriminated clinical activity from remission with areas under the curve of 0.76 (95% confidence interval [CI] 0.58-0.94, P = 0.015) and 0.80 (95% CI 0.68-0.93, P < 0.001) in CD and UC, respectively; it allowed to differentiate endoscopic activity in patients with UC, with areas under the curve of 0.84 (95% CI 0.63-1.00, P = 0.009). Immunohistochemical analysis revealed higher DPP-4 apical expression in UC remitters, but no statistically significant differences were revealed between patients with ileal CD. DISCUSSION: Our results suggest that fDPP-4 can be used as a biomarker of IBD activity, particularly in UC. The expression profiles in intestinal tissue might represent a functional compartmentalization of DPP-4 expression

Produtividade e qualidade de frutos de cultivares de melão no Submédio São Francisco.

Instalou-se um experimento no Campo Experimental de Mandacaru, Juazeiro-BA de setembro a dezembro de 2001, com o objetivo de identificar cultivares de melão mais produtivas e com frutos de melhor qualidade O delineamento foi de blocos ao acaso com 15 tratamentos ( cultivares) e quatro repetições. A produtividade comercial variou de 31 ,85 t/ha para cultivar Hy-Mark a 53,59 t/ha para a Sancho. Além da Hy-Mark, as cultivares KF-A com 32,27 t/ha e AF-682 com 33, 13 t/ha, foram as que apresentaram os rendimentos significativamente mais baixos. O peso médio de frutos e o teor de sólidos solúveis (brix) variaram de 1,10 a 2,48 kg, e de 12,6 a 15,4%, respectivamente. As cultivares Sancho, Frevo, Orange Country e Gold Street foram consideradas como novas alternativas de plantio para o Submédio São Francisco, por terem apresentado produtividades elevadas (acima de 34 t/ha) e bons índices de peso médio de fruto e sólidos solúveis.Suplemento 2. Edição do 42 Congresso Brasileiro de Olericultura; 11 Congresso Latino Americano de Horticultura, Uberlândia, jul. 2002

Towards elderly social integration using a multimodal human-computer interface

This paper presents a multimodal prototype application that aims to promote the social integration of the elderly. The application enables communication with their social network through conferencing and social media services, using natural interaction modalities, like speech, touch and gestures. We begin by discussing the requirements and design guidelines that were taken into account for the development of the prototype. We also present the key elements of the development stage and the results of a usability study conducted with ten elderly volunteers. The usability study reveals that such a multimodal solution can simplify accessibility to the considered services. Results indicate that this system is simpler, more natural and more enjoyable than the current user interfaces. Furthermore, the natural interaction modalities of the proposed prototype, allow elderly to be more efficient and have a better user experience, thus contributing with an easier and faster way for this population to join the information era.info:eu-repo/semantics/acceptedVersio