The relationships between distances covered above generic andrelative speed thresholds by male soccer players in EnglishPremier League matches across two competitive seasons.The effects of positional demands and possession

The aims of this study were to: a) examine the relationships between high-intensity distances covered above generic and relative speed thresholds in English Premier League (EPL) matches across two consecutive seasons and b) analyze the effects of playing position and team possession. Sixteen elite male soccer players (seven defenders, six midfielders and three forwards) participated in this study (age 27.8 ± 3.5 years, height 183.7 ± 5.4 cm, body mass 83.9 ± 7.1 kg). An Optical Tracking System was used to collect the following variables: total distance covered; high-speed running distance (HSRD) (> 5.5 m/s); high-intensity running distance (HIRD) (5.5–7 m/s); sprint distance (> 7 m/s); total distance covered above Maximal Aerobic Speed (MAS); distance covered > 85% peak speed (PS); and distance > 30% Anaerobic Speed Reserve (ASR). All measures were analyzed as whole match totals and as distances covered in the periods of the team in possession (TIP), opponent team in possession (OTIP), and ball out of play (BOP). Analysis by position based on defenders, midfielders and forwards was also performed. Distance > 30% ASR was almost perfectly correlated with HSRD (r = 0.98), while distances > MAS were highly correlated with both HIRD (r = 0.91) and HSRD (r = 0.91), and distance > 85% PS were highly correlated with SD (r = 0.70). Although the generic and relative speed thresholds show almost perfect correlation, the differences between HSRD, HIRD and distance > MAS indicate that players may be exposed to more HIRD when using relative thresholds.info:eu-repo/semantics/publishedVersio

EFFECTS OF FATIGUE ON KINEMATICS AND SHOCK ATTENUATION DURING DOWNHILL TRAIL RUNNING

This study assessed the effects of a competitive trail run on running kinematics and shock attenuation in well-trained trail runners. Nine male runners performed a simulated short trail running race. Prior and 5-min after the race, participants completed a 290-m downhill run at pre-determined preferred speed. Inertial measurement units were used to assessselected kinematic parameters. The contact time showed a moderate increase in the fatigued condition (pre: 0.215 (0.024) s vs. post: 0.226 (0.219) s; p2vs. post: 49.1 (11.9) m/s2; p=0.038; d=0.56), while peak tibial acceleration and shock attenuation showed no change (p\u3e0.05). These findings confirm that running-induced fatigue impacts running kinematics, although shock attenuation was unaltered with the present fatiguing protocol. This study assessed the effects of a competitive trail run on running kinematics and shock attenuation in well-trained trail runners. Nine male runners performed a simulated short trail running race. Prior and 5-min after the race, participants completed a 290-m downhill run at pre-determined preferred speed. Inertial measurement units were used to assessselected kinematic parameters. The contact time showed a moderate increase in the fatigued condition (pre: 0.215 (0.024) s vs. post: 0.226 (0.219) s; p2vs. post: 49.1 (11.9) m/s2; p=0.038; d=0.56), while peak tibial acceleration and shock attenuation showed no change (p\u3e0.05). These findings confirm that running-induced fatigue impacts running kinematics, although shock attenuation was unaltered with the present fatiguing protocol

Breaking Symmetry Rules Enhance the Options for Stereoselective Propene Polymerization Catalysis

An example of breaking "Ewen's symmetry rule" for olefin catalysis polymerization is proposed by DFT calculations. Catalyst precursors with Cs symmetry are suggested to promote the isotactic propene polymerization by a modification of the active site geometry obtained via coordination with AlH-alkyl species in solution. The origin of stereocontrol in olefin polymerization is due to a dual mechanism dictated by the chiral catalyst. These findings may expand the toolbox for promoting stereoselective olefin polymerization by transition metal catalysts

Rhythm outcomes of minimally-invasive off-pump surgical versus catheter ablation in atrial fibrillation: A meta-analysis of reconstructed time-to-event data

Background: Mid- and long-term rhythm outcomes of catheter ablation (CA) for atrial fibrillation (AF) are reported to be suboptimal. Minimally invasive surgical off-pump ablation (MISOA), including both thoracoscopic and trans-diaphragmatic approaches, has been developed to reduce surgical invasiveness and overcome on-pump surgery drawbacks. We sought to compare the efficacy and safety of MISOA and CA for AF treatment. Methods: A systematic review and meta-analysis of the literature was performed including studies comparing MISOA and CA. The primary endpoint was survival freedom from AF at follow-up after a 3-month blanking period. Subgroup analysis of the primary endpoint was performed according to the type of surgical incision and hybrid approach. Results: Freedom from AF at 4 years was 52.1% ± 3.2% vs 29.1% ± 3.5%, between MISOA and CA respectively (log-rank p < 0.001; Hazard Ratio: 0.60 [95%Confidence Interval (CI):0.50-0.72], p < 0.001). At landmark analysis, a significant improvement in rhythm outcomes was observed in the MISOA group after the 5th month of follow-up (2 months from the blanking period). The Odds Ratio between MISOA and CA of postoperative cerebrovascular accident incidence and postoperative permanent pacemaker implant (PPM) were 2.00 (95%CI:0.91-4.40, p = 0.084) and 1.55 (95%CI:0.61-3.95, p = 0.358), respectively. The incidence rate ratio of late CVA between MISOA and CA was 0.86 (95%CI:0.28-2.65, p = 0.787), while for late PPM implant was 0.45 (95%CI:0.11-1.78, p = 0.256). Conclusions: The current meta-analysis suggests that MISOA provides superior rhythm outcomes when compared to CA in terms of sinus rhythm restoration. Despite the rhythm outcome superiority of MISOA, it is associated to higher postoperative complications compared to CA

Mitral valve surgery in acute infective endocarditis: long-term outcomes of mitral valve repair versus replacement

AimsTiming and surgical strategies in acute infective endocarditis are still questionable. We sought to investigate clinical outcomes of patients undergoing mitral valve repair (MVR) compared with mitral valve replacement [mitral valve prosthesis (MVP)] for acute infective endocarditis.MethodsFrom 2004 to 2019, 109 consecutive patients with acute mitral valve infective endocarditis were retrospectively investigated. Patients were divided into two groups according to surgical strategy: MVR 53/109 (48.6%) versus MVP 56/109 (51.4%). Primary end points were in-hospital mortality and overall survival at 10 years. Secondary end point was the freedom from infective endocarditis relapse.ResultsOur institutional surgical approach for infective endocarditis allowed us to achieve MVR in 48.6% of patients. Hospital mortality was comparable between the two groups [MVR: 1/53 (1.9%) versus MVP: 2/56 (3.6%), P = 1.000]. Overall 10-year survival was 80.0 +/- 14.1 and 77.2 +/- 13.5% for MVR and MVP, respectively (P = 0.648). MVR showed a lower incidence of infective endocarditis relapse compared with MVP (MVR: 93.6 +/- 7.1 versus MVP: 80.9 +/- 10.8%, P = 0.041). At Cox regression, infective endocarditis relapse was an independent risk factor for death (hazard ratio 4.03; 95% confidence interval 1.41-11.52; P = 0.009).ConclusionThe tendency to postpone surgery in stable patients with mitral infective endocarditis allowed achievement of MVR in almost 50% of patients. Although repair remains the approach of choice in our institution, no differences between MVR and MVP were reported in terms of early/late survival. However, MVP had a higher incidence of infective endocarditis relapse that represents an independent risk of mortality

The physical demands of match-play in academy and senior soccer players from the Scottish Premiership

The present study aimed to assess the physical match performance among senior and youth soccer players from an elite Scottish Premiership club during the 2021/2022 season. Twenty-two first team (25.9 ± 4.5 years, 78.3 ± 8.2 kg, 1.82 ± 0.07 cm) and 16 youth players (16.8 ± 0.9 years, 70.1 ± 6.8 kg, 177 ± 5.8 cm) were examined. A selection of physical match performance variables were measured using a global positioning system. Linear mixed-effect regressions revealed for all examined variables no significant differences between first team and U-18 players and no significant differences between playing level by position interaction. Across both teams, Centre Backs compared to Wing Backs, showed a 295 m (p &lt; 0.01) lower high-intensity distance, and performed on average 36 fewer very-high intensity decelerations (p = 0.03). Comparing to Wide Midfielders, Centre Backs showed lower total (1297 m, p = 0.01), high-intensity (350 m, p = 0.01), and sprint (167 m, p &lt; 0.01) distances. Sprint distance was also lower in Centre Backs vs. Strikers (118 m, p = 0.03), and in Central Midfielders vs. both Strikers (104 m, p = 0.03) and Wide Midfielders (154 m, p = 0.01). The present findings highlight the physical match performance of elite Scottish players and provide useful information within the context of understanding how methods of physical development of youth soccer are implemented in different countries

Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients

To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations

Protective effects of Lactobacillus paracasei F19 in a rat model of oxidative and metabolic hepatic injury

The liver is susceptible to such oxidative and metabolic stresses as ischemia-reperfusion (I/R) and fatty acid accumulation. Probiotics are viable microorganisms that restore the gut microbiota and exert a beneficial effect on the liver by inhibiting bacterial enzymes, stimulating immunity, and protecting intestinal permeability. We evaluated Lactobacillus paracasei F19 (LP-F19), for its potential protective effect, in an experimental model of I/R (30 min ischemia and 60 min reperfusion) in rats fed a standard diet or a steatogen [methionine/choline-deficient (MCD)] diet. Both groups consisted of 7 sham-operated rats, 10 rats that underwent I/R, and 10 that underwent I/R plus 8 wk of probiotic dietary supplementation. In rats fed a standard diet, I/R induced a decrease in sinusoid perfusion (P &lt; 0.001), severe liver inflammation, and necrosis besides an increase of tissue levels of malondialdehyde (P &lt; 0.001), tumor necrosis factor-alpha (P &lt; 0.001), interleukin (IL)-1beta (P &lt; 0.001), and IL-6 (P &lt; 0.001) and of serum levels of transaminase (P &lt; 0.001) and lipopolysaccharides (P &lt; 0.001) vs. sham-operated rats. I/R also induced a decrease in Bacterioides, Bifidobacterium, and Lactobacillus spps (P &lt; 0.01, P &lt; 0.001, and P &lt; 0.001, respectively) and an increase in Enterococcus and Enterobacteriaceae (P &lt; 0.01 and P &lt; 0.001, respectively) on intestinal mucosa. The severity of liver and gut microbiota alterations induced by I/R was even greater in rats with liver inflammation and steatosis, i.e., MCD-fed animals. LP-F19 supplementation significantly reduced the harmful effects of I/R on the liver and on gut microbiota in both groups of rats, although the effect was slightly less in MCD-fed animals. In conclusion, LP-F19 supplementation, by restoring gut microbiota, attenuated I/R-related liver injury, particularly in the absence of steatosis

Heart Transplantation Following Fontan Failure: Long-Term Survival Analysis

Objectives: Fontan circulation presents significant challenges for patients with congenital heart disease, often necessitating heart transplantation (HTX) due to deteriorating functionality across multiple organ systems. However, the impact of prior Fontan palliation on HTX outcomes remains poorly understood, with early mortality rates suggesting a heightened risk. The aim of our study is to evaluate the long-term results after heart transplantation in patients with univentricular congenital heart disease previously palliated with Fontan circulation. Methods: A retrospective analysis was conducted on patients who underwent HTX for congenital heart disease. Patients were categorized into two groups based on the pre-HTX circulation pathway: the Failing Fontan Group (FFG) and the Biventricular Congenital Group (BCG). Data were collected from patients between 1987 and 2018. Early and late outcomes, including survival rates, were assessed and critically analyzed. Results: Of the 66 patients, 29 (43%) had a failing Fontan palliation (FFG), and 37 had biventricular congenital diseases (BCG) before heart transplantation. Early mortality (30-day) was not statistically different between the two group. The overall survival rate was 82.6 +/- 13.9% at 1 year, 79.0 +/- 14.9% at 5 years, 67.2 +/- 17.6% at 10 years and 63.2 +/- 18.2 +/- at 15 years for the FFG, and 86.1 +/- 11.4% at 1 year, 79.5 +/- 13.7% at 5 years, 75.7 +/- 14.9% at 10 years, 75.7 +/- 14.9% at 15 years for the BCG, with no statistically significant difference (Mantel Cox p value: 0.69, 0.89, 0.52 and 0.39, respectively). Regarding Cox-regression analysis, the long-term survival rate was not affected either by previous Fontan surgery or by the era of heart transplantation (before vs. after the year 2000). Conclusions: Although heart transplantation after Fontan palliation showed a higher risk in the early post-operative period, the medium- and long-term survival rates are comparable with biventricular circulation patients. Despite the failing Fontan patients being a challenging set of candidates for transplantation, it is a reasonable option in their treatment

Renal Function in Kidney and Liver Transplant Recipients After A 130-km Road Cycling Race

Background: A few patients, after receiving solid organ transplantation, return to performing various sports and competitions; however, at present, data no study had evaluated the effects of endurance cycling races on their renal function. Methods: Race times and short form (36) health survey questionnaires of 10 kidney transplant recipients (KTR) and 8 liver transplant recipients (LTR) transplanted recipients involved in a road cycling race (130 km) were compared with 35 healthy control subjects (HCS), also taking laboratory blood and urine tests the day before the race, at the end of the race, and 18 to 24 hours after competing. Results: The 3 groups showed similar race times (KTR, 5 hours 59 minutes \ub1 0 hours 39 minutes; LTR, 6 hours 20 minutes \ub1 1 hour 11 minutes; HCS, 5 hours 40 minutes \ub1 1 hour 28 minutes), similar short form (36) health survey scores, and similar trend of laboratory parameters which returned to baseline after 18 to 24 hours. After the race, there was an increase in creatinine (0.24 mg/dL; effect size [ES] = 0.78; P &lt; 0.001), urea (22 mg/dL; ES = 1.42; P &lt; 0.001), and a decrease of estimated glomerular filtration rate ( 1217 mL/min; ES = 0.85; P &lt; 0.001). The increase of blood uric acid was more remarkable in HCS and KTR (2.3 mg/dL; ES = 1.39; P &lt; 0.001). The KTR showed an increase of microalbuminuria (167.4 mg/L; ES = 1.20; P &lt; 0.001) and proteinuria (175 mg/mL; ES = 0.97; P &lt; 0.001) similar to LTR (microalbuminuria: 176.0 mg/L; ES = 1.26; P &lt; 0.001; proteinuria: 213 mg/mL; ES = 1.18; P &lt; 0.001), with high individual variability. The HCS had a nonsignificant increase of microalbuminuria (4.4 mg/L; ES = 0.03; P = 0.338) and proteinuria (59 mg/mL; ES = 0.33; P = 0.084). Conclusions: Selected and well-trained KTR and LTR patients can participate to an endurance cycling race showing final race times and temporary modifications of kidney function similar to those of HCS group, despite some differences related to baseline clinical conditions and pharmacological therapies. Patients involved in this study represent the upper limit of performance currently available for transplant recipients and cannot be considered representative of the entire transplanted population