Study of rationality and utilization pattern of antimicrobials in ear, nose, throat outpatient department of Tertiary Care Hospital, Nanded

Background: Antimicrobials are most commonly prescribed drugs worldwide. Around 50% of the prescriptions of antimicrobial drugs are either not needed, inappropriate or in wrong doses. With the widespread use of antimicrobial agents (AMAs), the prevalence of resistance has increased. To evaluate the prescription pattern and utilization of AMA in ear, nose, throat (ENT) outpatient department (OPD) of Tertiary Care Hospital, Nanded.Methods: This prospective study was conducted in ENT OPD of Dr. Shankarrao Chavan Government Medical College, Nanded over a period of 3 months. During this period, approximately 1100 patients visited ENT OPD and 600 prescriptions were evaluated. The excluded patients were of post-operative follow-up and of patients undergoing medical examination for fitness and handicap certificate. Data were collected by using specially designed case report form. Appropriateness of AMA was assessed by Kunin’s modified criteria.Results: Total 600 prescriptions were analyzed out of which (91%) consist of AMA. Most of them reported with upper respiratory tract infections (URTI) (30.4%), chronic suppurative otitis media (21.4%), acute suppurative otitis media (10.4%), tonsillitis (3.3%), sinusitis (2.7%), and others (15%). Amoxicillin (43.9%) was preferred AMA followed by ciprofloxacin (30.6%), cotrimoxazole (5.8%), azithromycin (3.2%), doxycycline (3.2%) cefixime + clavulanate (3.2%), and amoxicillin + clavulanate (1.8%). Single antibiotic was preferred in all prescriptions. In the concomitant medications, antihistaminics were prescribed in 97.22% of patients, non-steroidal anti-inflammatory drugs in 94.96% of patients, and antacids in 87.76% of patients. Fixed-dose combinations were used in 10% of prescriptions. Brand names of AMA were used in 10% of prescriptions. As per the Kunin’s modified criteria, 83% of patients received AMA therapy appropriately, while 17% patients inappropriately.Conclusions: Amoxicillin is the most common AMA prescribed and URTI is the most common diagnosis made. All AMAs should be prescribed only when needed and should be used in proper dose and for proper duration. Institution wise antibiotic policy should be used to contain resistance. Proper training and regular orientation programs of the juniors’ doctors for judicial use of AMAs will foster the habit of rational prescribing of AMA

Bumper catch of silver pomfret Pampus argenteus at Satpati, Bombay

The article provies details about heavy catches of silver pomfret Pampus argenteus within a span of four days at Satpati, a fishing village in Thane District in Maharashtra during 1987

Occurrence of dusky sweeper Pempheris adusta Bleeker, 1877 in Ratnagiri waters, Maharashtra

Pempheris adusta Bleeker, 1877, commonly called ‘dusky sweeper’ (Fig. 1), generally live on coral reefs and form schools in large caves among rocks. On 19/08/2009, a good number of specimens of P. adusta were observed at Mirkarwada landing centre in Ratnagiri (Fig. 2). They had elliptical, compressed body with iridescent, coppery silver colouration, because of which they were spectacular in appearance

Knowledge, attitude, and practice of ‘P-drug concept’ among postgraduate residents and interns in a tertiary care teaching hospital in Maharashtra

Background: A P-drug is a clinician’s personal or preferred or priority choice drug. The study aims to evaluate the knowledge, awareness, and practice of P-drug, which helps postgraduates to prescribe medicines rationally. The objective of this study is to assess the knowledge, attitude, and practice of the P-drug concept among postgraduate students at a tertiary care teaching hospital. Methods: The study is a prospective, cross-sectional pre-validated questionnaire-based study conducted in the tertiary care teaching hospital. A total of 300 postgraduates, interns and consultants from Tertiary care teaching hospital from Maharashtra were enrolled and instructed to fill the questionnaire. These filled forms were collected, and data was analyzed. Results: Out of 300 members, 233 filled the questionnaire, and these forms are evaluated. About 49.7% among them are aware of P-drug, 43.4% are aware of P-treatment, 28.4% are not including fixed-dose combinations in their P-drug list, 42% are aware of the advantages of prescribing P-drug, and 48.4% felt that teaching programs are needed for preparing P-drug list. Conclusions: The P-drug concept is requisite for improving the quality of health care and practicing rational use of medicine. As only a few studies have been conducted on the P-drug idea in this institute, the institutional teaching review board should run teaching programs regarding the P-drug concept

Magnetotransport properties of individual InAs nanowires

We probe the magnetotransport properties of individual InAs nanowires in a field effect transistor geometry. In the low magnetic field regime we observe magnetoresistance that is well described by the weak localization (WL) description in diffusive conductors. The weak localization correction is modified to weak anti-localization (WAL) as the gate voltage is increased. We show that the gate voltage can be used to tune the phase coherence length ($l_\phi$) and spin-orbit length ($l_{so}$) by a factor of $\sim$ 2. In the high field and low temperature regime we observe the mobility of devices can be modified significantly as a function of magnetic field. We argue that the role of skipping orbits and the nature of surface scattering is essential in understanding high field magnetotransport in nanowires

Star formation in galaxies at z~4-5 from the SMUVS survey: a clear starburst/main-sequence bimodality for Halpha emitters on the SFR-M* plane

We study a large galaxy sample from the Spitzer Matching Survey of the UltraVISTA ultra-deep Stripes (SMUVS) to search for sources with enhanced 3.6 micron fluxes indicative of strong Halpha emission at z=3.9-4.9. We find that the percentage of "Halpha excess" sources reaches 37-40% for galaxies with stellar masses log10(M*/Msun) ~ 9-10, and decreases to <20% at log10(M*/Msun) ~ 10.7. At higher stellar masses, however, the trend reverses, although this is likely due to AGN contamination. We derive star formation rates (SFR) and specific SFR (sSFR) from the inferred Halpha equivalent widths (EW) of our "Halpha excess" galaxies. We show, for the first time, that the "Halpha excess" galaxies clearly have a bimodal distribution on the SFR-M* plane: they lie on the main sequence of star formation (with log10(sSFR/yr^{-1})<-8.05) or in a starburst cloud (with log10(sSFR/yr^{-1}) >-7.60). The latter contains ~15% of all the objects in our sample and accounts for >50% of the cosmic SFR density at z=3.9-4.9, for which we derive a robust lower limit of 0.066 Msun yr^{-1} Mpc^{-3}. Finally, we identify an unusual >50sigma overdensity of z=3.9-4.9 galaxies within a 0.20 x 0.20 sq. arcmin region. We conclude that the SMUVS unique combination of area and depth at mid-IR wavelengths provides an unprecedented level of statistics and dynamic range which are fundamental to reveal new aspects of galaxy evolution in the young Universe.Comment: 18 pages, 11 figures, 1 table. Re-submitted to the ApJ, after addressing referee report. Main changes with respect to v1: a new section and a new appendix have been added to investigate further the origin and robustness of the sSFR bimodality. No conclusion change

PROSPECTS OF VEGETABLE OIL DERIVATIVES FOR RURAL AGRICULTURAL ENERGY IN INDIA

Svijet je suočen s dvojnom krizom: krizom nestajanja fosilnih goriva i krizom degradacije okoliša. Alternativna goriva, očuvanje i upravljanje energijom, energetska učinkovitost i zaštita okoliša posljednjih su godina dobili na značenju. Kao alternativa dizel gorivu dosta obećavaju esterificirana biljna ulja koja su ekološki vrlo pogodna. U ruralnoj Indiji potreba za naftom otpada na poljoprivrednu mehanizaciju poput traktora i vršilica. Poljoprivrednici koji posjeduju marginalna i velika zemljišta mogu ispuniti zahtjeve dizel goriva tako da siju uljarice na vlastitoj zemlji. U ovom radu procjenjuje se isplativost lokalne proizvodnje biljnih ulja u jednom malom oglednom selu u središnjoj Indiji. Analiziraju se metilni esteri masnih kiselina iz ulja pamukovog sjemena, sojinog ulja, ulja balanitesa i jatrofina ulja da bi se ustanovila njihova svojstva i radni učinak u dizel motoru, a procjenjuje se i potrebna površina zemljišta za uzgoj tih uljnih kultura kako bi se udovoljilo potrebama seoske poljoprivrede za gorivom. Rezultati pokazuju da kalorična vrijednost metilnih estera iznosi dizela, a i druga su svojstva posve usporediva s dizelom. Analiza radnog učinka metilnih estera u motoru pokazuje neznatno smanjenje toplinske učinkovitosti od oko , dok su emisije smanjene za do u usporedbi s dizelom. Izvršena je i ekonomska analiza te je ustanovljeno da je korištenje derivata biljnih ulja kao zamjene za dizel gorivo skuplje od korištenja mineralnog dizela.The world is confronting the twin crises of fossil fuel depletion and environmental degradation. Alternative fuels, energy conservation and management, energy efficiency and environmental protection have become increasingly import in recent years. Among alternative fuels, esterified vegetable oils hold good promise as eco-friendly alternatives to diesel fuel. In rural India, of the petroleum diesel requirement is for agricultural equipment such as tractors and threshers. Marginal farmers and large landholders can meet their diesel requirement by sowing oil yielding crops on their own lands. This paper evaluates the feasibility of the local production of vegetable oil for a small representative village in central India. Fatty acid methyl esters of cottonseed oil, soybean oil, balanites oil and jatropha oil were analyzed for their properties and performance in diesel engines. The land required to grow these oil crops in order to meet rural agricultural diesel requirements was estimated. The results indicate that the calorific value of these methyl esters is that of diesel and the other properties are quite comparable with diesel. Engine performance analysis of these methyl esters indicates that there is a slight decrease in thermal efficiency of approximately , while emissions are reduced by to as compared to diesel. Economic analysis was also performed and it was found that vegetable oil derivatives as diesel fuel substitutes are costlier than mineral diesel

Variability Studies in Soybean [Glycine max (L.) Merrill]

   Genetic variability, heritability and genetic advance were studied for thirty genotypes of soybean sown in RBD with three replications and data was analysed for eleven quantitative characters. It was observed that high amount of genetic variability with high heritability was present for most of the yield components studied

Wound healing activity of topical application of Aloe vera gel in experimental animal models

Aloe vera gel of 50% and 96.4% were tested for its wound healing activity by topical application in experimental rats. The effect of Aloe vera gel on wound healing was evaluated by wound excision model and histopathology was used to study the effect on wound healing. The effect produced by Aloe vera gel with reference to wound contraction, wound closure, decrease in surface area of wound, tissue regeneration at the wound site and histopathological characteristics were significant in treated rats. The effect of Aloe vera gel on biochemical studies revealed significant increase in collagen and decreased hexosamine content and malondialdehyde levels when compared with control. The present study thus provided scientific rationale for the traditional use of Aloe vera gel for management of wounds

Labour Market and Social Policy in Italy: Challenges and Changes. Bertelsmann Policy Brief #2016/02

vEight years after the outbreak of the financial crisis, Italy has still to cope with and overcome a plethora of economic and social challenges. On top of this, it faces an unfavourable demographic structure and severe disparities between its northern and southern regions. Some promising reforms have recently been enacted, specifically targeting poverty and social exclusion. However, much more remains to be done on the way towards greater economic stability and widely shared prosperity