Early and late follow-up of untreated traumatic aortic lesion: a support to delayed surgery

Fuente Fuente, Carlos;Montes Gil, Antonio;Periel Piquer, Montserra

Improving plan quality and consistency by standardization of dose constraints in prostate cancer patients treated with CyberKnife.

Treatment plans for prostate cancer patients undergoing stereotactic body radiation therapy (SBRT) are often challenging due to the proximity of organs at risk. Today, there are no objective criteria to determine whether an optimal treatment plan has been achieved, and physicians rely on their personal experience to evaluate the plan's quality. In this study, we propose a method for determining rectal and bladder dose constraints achievable for a given patient's anatomy. We expect that this method will improve the overall plan quality and consistency, and facilitate comparison of clinical outcomes across different institutions. The 3D proximity of the organs at risk to the target is quantified by means of the expansion-intersection volume (EIV), which is defined as the intersection volume between the target and the organ at risk expanded by 5 mm. We determine a relationship between EIV and relevant dosimetric parameters, such as the volume of bladder and rectum receiving 75% of the prescription dose (V75%). This relationship can be used to establish institution-specific criteria to guide the treatment planning and evaluation process. A database of 25 prostate patients treated with CyberKnife SBRT is used to validate this approach. There is a linear correlation between EIV and V75% of bladder and rectum, confirming that the dose delivered to rectum and bladder increases with increasing extension and proximity of these organs to the target. This information can be used during the planning stage to facilitate the plan optimization process, and to standardize plan quality and consistency. We have developed a method for determining customized dose constraints for prostate patients treated with robotic SBRT. Although the results are technology specific and based on the experience of a single institution, we expect that the application of this method by other institutions will result in improved standardization of clinical practice

Cross-linkers both drive and brake cytoskeletal remodeling and furrowing in cytokinesis.

Cell shape changes such as cytokinesis are driven by the actomyosin contractile cytoskeleton. The molecular rearrangements that bring about contractility in nonmuscle cells are currently debated. Specifically, both filament sliding by myosin motors, as well as cytoskeletal cross-linking by myosins and nonmotor cross-linkers, are thought to promote contractility. Here we examined how the abundance of motor and nonmotor cross-linkers affects the speed of cytokinetic furrowing. We built a minimal model to simulate contractile dynamics in the Caenorhabditis elegans zygote cytokinetic ring. This model predicted that intermediate levels of nonmotor cross-linkers are ideal for contractility; in vivo, intermediate levels of the scaffold protein anillin allowed maximal contraction speed. Our model also demonstrated a nonlinear relationship between the abundance of motor ensembles and contraction speed. In vivo, thorough depletion of nonmuscle myosin II delayed furrow initiation, slowed F-actin alignment, and reduced maximum contraction speed, but partial depletion allowed faster-than-expected kinetics. Thus, cytokinetic ring closure is promoted by moderate levels of both motor and nonmotor cross-linkers but attenuated by an over-abundance of motor and nonmotor cross-linkers. Together, our findings extend the growing appreciation for the roles of cross-linkers in cytokinesis and reveal that they not only drive but also brake cytoskeletal remodeling

Performance of HPGe Detectors in High Magnetic Fields

A new generation of high-resolution hypernuclear gamma$-spectroscopy experiments with high-purity germanium detectors (HPGe) are presently designed at the FINUDA spectrometer at DAPhiNE, the Frascati phi-factory, and at PANDA, the antiproton proton hadron spectrometer at the future FAIR facility. Both, the FINUDA and PANDA spectrometers are built around the target region covering a large solid angle. To maximise the detection efficiency the HPGe detectors have to be located near the target, and therefore they have to be operated in strong magnetic fields B ~ 1 T. The performance of HPGe detectors in such an environment has not been well investigated so far. In the present work VEGA and EUROBALL Cluster HPGe detectors were tested in the field provided by the ALADiN magnet at GSI. No significant degradation of the energy resolution was found, and a change in the rise time distribution of the pulses from preamplifiers was observed. A correlation between rise time and pulse height was observed and is used to correct the measured energy, recovering the energy resolution almost completely. Moreover, no problems in the electronics due to the magnetic field were observed.Comment: submitted to Nucl. Instrum. Meth. Phys. Res. A, LaTeX, 19 pages, 9 figure

Risk of Hospitalization and Death for COVID-19 in People with Parkinson's Disease or Parkinsonism

The risk of COVID-19 and related death in people with Parkinson's disease or parkinsonism is uncertain. The aim of the study was to assess the risk of hospitalization for COVID-19 and death in a cohort of patients with Parkinson's disease or parkinsonism compared with a control population cohort, during the epidemic bout (March-May 2020) in Bologna, northern Italy

Gamma-ray Tracking with Segmented HPGe Detectors

This paper gives a brief overview of the technical progress that can be achieved with the newly available segmented HPGe detectors. Gamma-ray tracking detectors are a new generation of HPGe detectors which are currently being developed to improve significantly the efficiency and resolving power of the 4 … germanium detectors arrays for high-precision ∞-ray spectroscopy. They consist of highly segmented HPGe detectors associated with fast digital front-end electronics. Through the pulse-shape analysis of the signals it is possible to extract the energy, timing and spatial information on the few interactions a ∞-ray undergoes in the HPGe detector. The tracks of the ∞-rays in the HPGe detector can then be reconstructed in three dimensions based on the Compton scattering formula. Such a detector has been used for the first time during an in-beam experiment. The ∞-decay of the Coulomb excitation of a 56 Fe nucleus was measured with the highly segmented MARS prototype positioned at 135 degree. The energy resolution has been improved by a factor of 3 as compared to standard HPGe detectors due to very precise Doppler correction based on knowledge of the ∞-ray track. I Introduction The future facilities for radioactive beams will allow, for the first time, the exploration of a new large area of the nuclear landscape. In connection with the study of the ∞-radiation, it is important to point out that the intensity of such radioactive beams is expected to be much smaller than that of stable beams, Doppler Effects in many experiments are expected to be much stronger and an intense background of X-rays could be present. Consequently, a new generation of powerful HPGe arrays with segmented detectors is being designed. Both in USA and in Europe several projects, based on segmented HPGe detectors, have already started and are in an advanced status of realization. The objective of the more recent R&D efforts is to improve the total efficiency by removing the BGO shields without affecting the P/T ratio with the use of the tracking technique, namely the reconstruction of the ∞-ray path to identify the ∞-incident direction (for the Doppler correction), the removal of the background and to check whether or not the ∞ was fully absorbed in the array. Such development implies unprecedented R&D efforts where completely new technology has to be applied, tested or developed in all the constituents of an HPGe array, from the detector to the front-end electronics. The typical feature of the energy deposition of a ∞-ray is that of interacting in a limited number of positions. ∞-tracking of this hits is a very challenging and ambitious task. First, one has to identify, isolate and localize each hit inside a segmented detector with pulse shape analysis based on the study of the physical mechanism of the pulse generation or with Artificial Intelligence techniques (like Neural Networks or Genetic Algorithm [1]) of the direct and induced electrical pulses produced by every interacting ∞-rays. Second, a tracking algorithm has to reconstruct the real trajectory from the list of interaction points through statistical techniques. The result is expected to be the complete reconstruction of the track of the incident ∞, namely the complete description of the interacting ∞-ray. Worldwide efforts have been done using simulations and proof-of-principle measurements and turned out to be successful. The feasibility of the entire process of ∞ray tracking is demonstrated in this paper based on an experiment, done at the LNL in Italy, using the MARS prototype detector

Deducing the \u3csup\u3e237\u3c/sup\u3eU(\u3cem\u3en,f\u3c/em\u3e) Cross Section Using the Surrogate Ratio Method

We have deduced the cross section for 237U(n, f) over an equivalent neutron energy range from 0 to 20 MeV using the surrogate ratio method. A 55 MeV4He beam from the 88 inch cyclotron at Lawrence Berkeley National Laboratory was used to induce fission in the following reactions: 238U(α, αf) and 236U(α, αf). The 238U reaction was a surrogate for 237U(n, f), and the 236U reaction was used as a surrogate for 235U(n, f). Scattered α particles were detected in a fully depleted segmented silicon telescope array over an angle range of 35° to 60° with respect to the beam axis. The fission fragments were detected in a third independent silicon detector located at backward angles between 106° and 131°

Risk of SARS-CoV-2 infection, hospitalization, and death for COVID-19 in people with Parkinson disease or parkinsonism over a 15-month period: A cohort study

Background and purpose: The patterns of long-term risk of SARS-CoV-2 infection, hospitalization for COVID-19, and related death are uncertain in people with Parkinson disease (PD) or parkinsonism (PS). The aim of the study was to quantify these risks compared to a control population cohort, during the period March 2020–May 2021, in Bologna, Northern Italy. Methods: ParkLink Bologna cohort (759 PD, 192 PS) and controls (9226) anonymously matched (ratio = 1:10) for sex, age, district, and comorbidity were included. Data were analysed in the whole period and in the two different pandemic waves (March–May 2020 and October 2020–May 2021). Results: Adjusted hazard ratio of SARS-CoV-2 infection was 1.3 (95% confidence interval [CI] = 1.04–1.7) in PD and 1.9 (95% CI = 1.3–2.8) in PS compared to the controls. The trend was detected in both the pandemic waves. Adjusted hazard ratio of hospitalization for COVID-19 was 1.1 (95% CI = 0.8–1.7) in PD and 1.8 (95% CI = 0.97–3.1) in PS. A higher risk of hospital admission was detected in PS only in the first wave. The 30-day mortality risk after hospitalization was higher (p = 0.048) in PS (58%) than in PD (19%) and controls (26%). Conclusions: Compared with controls, after adjustment for key covariates, people with PD and PS showed a higher risk of SARS-CoV-2 infection throughout the first 15 months of the pandemic. COVID-19 hospitalization risk was increased only in people with PS and only during the first wave. This group of patients was burdened by a very high risk of death after infection and hospitalization