Effect of manidipine-simvastatin combination on fibrinolysis, adhesion molecules and C-reactive protein in hypertensive hypercholesterolemic patients

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Euclid Space Mission: building the sky survey

The Euclid space mission proposes to survey 15000 square degrees of the extragalactic sky during 6 years, with a step-and-stare technique. The scheduling of observation sequences is driven by the primary scientific objectives, spacecraft constraints, calibration requirements and physical properties of the sky. We present the current reference implementation of the Euclid survey and on-going work on survey optimization.Comment: to appear in Proceedings IAU Symposium No. 306, "Statistical Challenges in 21st Century Cosmology", A.F. Heavens, J.-L. Starck & A. Krone-Martins, ed

Therapeutic Drug Monitoring of Imatinib in Gist Patients

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Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes

<b>Background:</b> Adiponectin is secreted by adipose tissue and may play a role in cardiovascular disease. We examined adiponectin levels in patients with type 2 diabetes who participated in the Telmisartan vs. Ramipril in Renal Endothelial Dysfunction (TRENDY) study. <b>Methods</b> A total of 87 patients were assessed at baseline and following 9 weeks treatment with the angiotensin-receptor blocker telmisartan (final dose, 80 mg; n = 45) or the angiotensin-converting enzyme inhibitor ramipril (final dose, 10 mg; n = 42). Adiponectin levels were measured in plasma by radioimmunoassay. <b>Results:</b> Adiponectin levels were inversely correlated with systolic (SBP; r = -0.240, P < 0.05) and diastolic (DBP; r = -0.227, P < 0.05) blood pressure at baseline and following treatment with telmisartan or ramipril (SBP: r = -0.228, P < 0.05; DBP: r = -0.286, P < 0.05). Changes in adiponectin levels were related to changes in SBP (r = -0.357, P < 0.01) and DBP (r = -0.286, P < 0.01). There was a significant increase in adiponectin levels in the telmisartan (0.68 (95% confidence interval (CI), 0.27 to 1.10) <sup>µ</sup>g/ml, P < 0.01) but not in the ramipril group (0.17 (95% CI, -0.56 to 0.90) <sup>µ</sup>g/ml, P = 0.67). Blood pressure reduction in the telmisartan group (DeltaSBP: -13.5 (95% CI, -17.0 to -10.0) mm Hg; ΔDBP: -7.6 (95% CI, -9.8 to -5.3) mm Hg, each P < 0.001) was significantly (P less than or equal to 0.01 for SBP and P < 0.01 for DBP) greater than in the ramipril group (ΔSBP: -6.1 (95% CI, -6.2 to -2.0) mm Hg; ΔDBP: -2.7 (95% CI, -5.0 to -0.5) mm Hg; P < 0.01 and P < 0.05, respectively). <b>Conclusion:</b> Adiponectin is correlated with blood pressure in patients with type 2 diabetes. Whether increased adiponectin contributes to the blood pressure–lowering effect of telmisartan needs further study

New Prognostic factors for second-line targeted therapy (TT) in metastatic renal cell carcinoma (mRCC).

No abstract availabl

The relation between stellar magnetic field geometry and chromospheric activity cycles – II The rapid 120-day magnetic cycle of <i>τ</i> Bootis

One of the aims of the BCool programme is to search for cycles in other stars and to understand how similar they are to the Sun. In this paper, we aim to monitor the evolution of τ Boo’s large-scale magnetic field using high-cadence observations covering its chromospheric activity maximum. For the first time, we detect a polarity switch that is in phase with τ Boo’s 120-day chromospheric activity maximum and its inferred X-ray activity cycle maximum. This means that τ Boo has a very fast magnetic cycle of only 240 days. At activity maximum τ Boo’s large-scale field geometry is very similar to the Sun at activity maximum: it is complex and there is a weak dipolar component. In contrast, we also see the emergence of a strong toroidal component which has not been observed on the Sun, and a potentially overlapping butterfly pattern where the next cycle begins before the previous one has finished

Feasibility and efficacy of 223Ra-dichloride (223Ra) to treat bone metastases in patients (pts) with castration resistant prostate cancer (mCRPC)

Aim: To share the Tuscany single-centre experience about the employing of the novel therapeutic radiopharmaceutical 223Ra in the treatment planning of mCRPC pts

Euclid space mission: a cosmological challenge for the next 15 years

Euclid is the next ESA mission devoted to cosmology. It aims at observing most of the extragalactic sky, studying both gravitational lensing and clustering over $\sim$15,000 square degrees. The mission is expected to be launched in year 2020 and to last six years. The sheer amount of data of different kinds, the variety of (un)known systematic effects and the complexity of measures require efforts both in sophisticated simulations and techniques of data analysis. We review the mission main characteristics, some aspects of the the survey and highlight some of the areas of interest to this meetingComment: to appear in Proceedings IAU Symposium No. 306, 2014, "Statistical Challenges in 21st Century Cosmology", A.F. Heavens, J.-L. Starck & A. Krone-Martins, ed

The Open Flux Problem

The heliospheric magnetic field is of pivotal importance in solar and space physics. The field is rooted in the Sun's photosphere, where it has been observed for many years. Global maps of the solar magnetic field based on full-disk magnetograms are commonly used as boundary conditions for coronal and solar wind models. Two primary observational constraints on the models are (1) the open field regions in the model should approximately correspond to coronal holes (CHs) observed in emission and (2) the magnitude of the open magnetic flux in the model should match that inferred from in situ spacecraft measurements. In this study, we calculate both magnetohydrodynamic and potential field source surface solutions using 14 different magnetic maps produced from five different types of observatory magnetograms, for the time period surrounding 2010 July. We have found that for all of the model/map combinations, models that have CH areas close to observations underestimate the interplanetary magnetic flux, or, conversely, for models to match the interplanetary flux, the modeled open field regions are larger than CHs observed in EUV emission. In an alternative approach, we estimate the open magnetic flux entirely from solar observations by combining automatically detected CHs for Carrington rotation 2098 with observatory synoptic magnetic maps. This approach also underestimates the interplanetary magnetic flux. Our results imply that either typical observatory maps underestimate the Sun's magnetic flux, or a significant portion of the open magnetic flux is not rooted in regions that are obviously dark in EUV and X-ray emission

Small scale energy release driven by supergranular flows on the quiet Sun

In this article we present data and modelling for the quiet Sun that strongly suggest a ubiquitous small-scale atmospheric heating mechanism that is driven solely by converging supergranular flows. A possible energy source for such events is the power transfer to the plasma via the work done on the magnetic field by photospheric convective flows, which exert drag of the footpoints of magnetic structures. In this paper we present evidence of small scale energy release events driven directly by the hydrodynamic forces that act on the magnetic elements in the photosphere, as a result of supergranular scale flows. We show strong spatial and temporal correlation between quiet Sun soft X-ray emission (from &lt;i&gt;Yohkoh&lt;/i&gt; and &lt;i&gt;SOHO&lt;/i&gt; MDI-derived flux removal events driven by deduced photospheric flows. We also present a simple model of heating generated by flux submergence, based on particle acceleration by converging magnetic mirrors. In the near future, high resolution soft X-ray images from XRT on the &lt;i&gt;Hinode&lt;/i&gt; satellite will allow definitive, quantitative verification of our results