5,590 research outputs found
Quantifying the Drivers of Star Formation on Galactic Scales. I. The Small Magellanic Cloud
We use the star formation history of the Small Magellanic Cloud (SMC) to
place quantitative limits on the effect of tidal interactions and gas infall on
the star formation and chemical enrichment history of the SMC. The coincident
timing of two recent (< 4 Gyr) increases in the star formation rate and
SMC/Milky Way(MW) pericenter passages suggests that global star formation in
the SMC is driven at least in part by tidal forces due to the MW. The Large
Magellanic Cloud (LMC) is the other potential driver of star formation, but is
only near the SMC during the most recent burst. The poorly constrained LMC-SMC
orbit is our principal uncertainty. To explore the correspondence between
bursts and MW pericenter passages further, we model star formation in the SMC
using a combination of continuous and tidally-triggered star formation. The
behavior of the tidally-triggered mode is a strong inverse function of the
SMC-MW separation (preferred behavior ~ r^-5, resulting in a factor of ~100
difference in the rate of tidally-triggered star formation at pericenter and
apocenter). Despite the success of these closed-box evolutionary models in
reproducing the recent SMC star formation history and current chemical
abundance, they have some systematic shortcomings that are remedied by
postulating that a sizable infall event (~ 50% of the total gas mass) occured
about 4 Gyr ago. Regardless of whether this infall event is included, the
fraction of stars in the SMC that formed via a tidally triggered mode is > 10%
and could be as large as 70%.Comment: Accepted for publication in Ap
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Importance of food-demand management for climate mitigation
Recent studies show that current trends in yield improvement will not be sufficient to meet projected global food demand in 2050, and suggest that a further expansion of agricultural area will be required. However, agriculture is the main driver of losses of biodiversity and a major contributor to climate change and pollution, and so further expansion is undesirable. The usual proposed alternative - intensification with increased resource use - also has negative effects. It is therefore imperative to find ways to achieve global food security without expanding crop or pastureland and without increasing greenhouse gas emissions. Some authors have emphasised a role for sustainable intensification in closing global 'yield gaps' between the currently realised and potentially achievable yields. However, in this paper we use a transparent, data-driven model, to show that even if yield gaps are closed, the projected demand will drive further agricultural expansion. There are, however, options for reduction on the demand side that are rarely considered. In the second part of this paper we quantify the potential for demand-side mitigation options, and show that improved diets and decreases in food waste are essential to deliver emissions reductions, and to provide global food security in 2050.This work was funded by a grant to the University of Cambridge from BP as part of their Energy Sustainability Challenge.This is the accepted manuscript version. The final version is available from Nature Climate Change at http://www.nature.com/nclimate/journal/vaop/ncurrent/full/nclimate2353.html
Reduced-folate carrier (RFC) is expressed in placenta and yolk sac, as well as in cells of the developing forebrain, hindbrain, neural tube, craniofacial region, eye, limb buds and heart
BACKGROUND: Folate is essential for cellular proliferation and tissue regeneration. As mammalian cells cannot synthesize folates de novo, tightly regulated cellular uptake processes have evolved to sustain sufficient levels of intracellular tetrahydrofolate cofactors to support biosynthesis of purines, pyrimidines, and some amino acids (serine, methionine). Though reduced-folate carrier (RFC) is one of the major proteins mediating folate transport, knowledge of the developmental expression of RFC is lacking. We utilized in situ hybridization and immunolocalization to determine the developmental distribution of RFC message and protein, respectively. RESULTS: In the mouse, RFC transcripts and protein are expressed in the E10.0 placenta and yolk sac. In the E9.0 to E11.5 mouse embryo RFC is widely detectable, with intense signal localized to cell populations in the neural tube, craniofacial region, limb buds and heart. During early development, RFC is expressed throughout the eye, but by E12.5, RFC protein becomes localized to the retinal pigment epithelium (RPE). CONCLUSIONS: Clinical studies show a statistical decrease in the number of neural tube defects, craniofacial abnormalities, cardiovascular defects and limb abnormalities detected in offspring of female patients given supplementary folate during pregnancy. The mechanism, however, by which folate supplementation ameliorates the occurrence of developmental defects is unclear. The present work demonstrates that RFC is present in placenta and yolk sac and provides the first evidence that it is expressed in the neural tube, craniofacial region, limb buds and heart during organogenesis. These findings suggest that rapidly dividing cells in the developing neural tube, craniofacial region, limb buds and heart may be particularly susceptible to folate deficiency
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Evolution of DebrisâFlow Initiation Mechanisms and Sediment Sources During a Sequence of Postwildfire Rainstorms
Wildfire alters vegetation cover and soil hydrologic properties, substantially increasing the likelihood of debris flows in steep watersheds. Our understanding of initiation mechanisms of postwildfire debris flows is limited, in part, by a lack of direct observations and measurements. In particular, there is a need to understand temporal variations in debris-flow likelihood following wildfire and how those variations relate to wildfire-induced hydrologic and geomorphic changes. In this study, we use a combination of in situ measurements, hydrologic monitoring equipment, and numerical modeling to assess the impact of wildfire-induced hydrologic and geomorphic changes on debris-flow initiation during seven postwildfire rainstorms. We predict the impact of hillslope erosion on debris-flow initiation by combining terrestrial laser scanning surveys of a hillslope burned during the 2016 Fish Fire with numerical modeling of sediment transport throughout a 0.12-km(2) basin in southern California. We use measurements of sediment thickness within the channel to constrain numerical experiments and to assess the role of channel sediment supply on debris-flow initiation. Results demonstrate that debris flows initiated during rainstorms where hillslopes contributed minimally to the event sediment yield and suggest that large inputs of sediment from rill and gully networks are not essential for runoff-generated debris flows. Simulations suggest that both the gradual entrainment of sediment and the mass failure of channel bed sediment can increase sediment concentration to levels associated with debris flows. Finally, postwildfire debris-flow initiation appears closely linked to the same rainfall intensity-duration threshold despite temporal changes in the sediment source, initiation processes, and hydraulic roughness.U.S. Geological Survey (USGS) Landslide Hazards ProgramPublic domain articleThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
Mesoscale variability in intact and ghost colonies of Phaeocystis antarctica in the Ross Sea : distribution and abundance
© The Author(s), 2016. This is the author's version of the work and is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Journal of Marine Systems 166 (2017): 97-107, doi:10.1016/j.jmarsys.2016.05.007.Phaeocystis, a genus with a cosmopolitan distribution and a polymorphic life cycle, was observed during summer in the Ross Sea, Antarctica, where large blooms of this haptophyte regularly occur. The mesoscale vertical and horizontal distributions of colonies of P. antarctica were assessed using a towed Video Plankton Recorder (VPR). The mean size of colonies was 1.20 mm, and mean abundances within the three VPR surveys were 4.86, 1.96, and 11.5 mL-1. In addition to the typical spherical, transparent colonies, the VPR quantified an optically dissimilar form of colony that had a distinctive translucent appearance. It also measured the abundance of collapsed colonies, similar to those observed previously from cultures and mesocosms, which we called âghost coloniesâ. The translucent colonial form had a different distribution than the more common colonial form, and at times was more abundant. Relative to intact colonies, the ghost colonies occurred less frequently, with mean abundances in the three surveys being 0.01, 0.08, and 0.0004 mL-1. Ghost colonies generally were found below the euphotic zone, where they often were in greater abundance than intact colonies. However, the relationship of ghost colonies to intact P. antarctica colonies was not direct or consistent, suggesting that the formation of ghost colonies from living colonies and their appearance within the water column were not tightly coupled. Given their relative scarcity and low carbon content, it is unlikely that ghost colonies contribute substantially to vertical flux; however, it is possible that we did not sample periods of major flux events, and as a result minimized the importance of ghost colonies to vertical flux. They do, however, represent a poorly documented feature of polar haptophyte life cycles.This research was supported by grants from the National Science Foundation (ANT-0944254 and ANT-0944165). HMS and EEP acknowledge support of the Gordon and Betty Moore Foundation (Grant #2649) for image informatics development.2018-06-0
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Momentum Spectra of Charged Pions Produced in Proton-ProtonInteractions between 13 and 28.5 GeV/c
Proton-proton interactions with four or more charged particles in the final state are studied over a range of incident momenta between 13 and 28.5 GeV/c. Topology cross sections are presented. The center-of-mass momentum distributions of {pi}{sup +} and {pi}{sup -} are determined and are successfully parameterized. The {pi}{sup +} and {pi}{sup -} momentum spectra are found to have approximately the same shape. Multiple fireball production is not required by our data
Accelerated Turnover of Taste Bud Cells in Mice Deficient for the Cyclin-Dependent Kinase Inhibitor p27\u3csup\u3ekip1\u3c/sup\u3e
Background: Mammalian taste buds contain several specialized cell types that coordinately respond to tastants and communicate with sensory nerves. While it has long been appreciated that these cells undergo continual turnover, little is known concerning how adequate numbers of cells are generated and maintained. The cyclin-dependent kinase inhibitor p27Kip1 has been shown to influence cell number in several developing tissues, by coordinating cell cycle exit during cell differentiation. Here, we investigated its involvement in the control of taste cell replacement by examining adult mice with targeted ablation of the p27Kip1 gene.Results: Histological and morphometric analyses of fungiform and circumvallate taste buds reveal no structural differences between wild-type and p27Kip1-null mice. However, when examined in functional assays, mutants show substantial proliferative changes. In BrdU incorporation experiments, more S-phase-labeled precursors appear within circumvallate taste buds at 1 day post-injection, the earliest time point examined. After 1 week, twice as many labeled intragemmal cells are present, but numbers return to wild-type levels by 2 weeks. Mutant taste buds also contain more TUNEL-labeled cells and 50% more apoptotic bodies than wild-type controls. In normal mice, p27 Kip1 is evident in a subset of receptor and presynaptic taste cells beginning about 3 days post-injection, correlating with the onset of taste cell maturation. Loss of gene function, however, does not alter the proportions of distinct immunohistochemically-identified cell types.Conclusions: p27Kip1 participates in taste cell replacement by regulating the number of precursor cells available for entry into taste buds. This is consistent with a role for the protein in timing cell cycle withdrawal in progenitor cells. The equivalence of mutant and wild-type taste buds with regard to cell number, cell types and general structure contrasts with the hyperplasia and tissue disruption seen in certain developing p27Kip1-null sensory organs, and may reflect a compensatory capability inherent in the regenerative taste system
Instrumental oscillations in RHESSI count rates during solar flares
Aims: We seek to illustrate the analysis problems posed by RHESSI spacecraft
motion by studying persistent instrumental oscillations found in the
lightcurves measured by RHESSI's X-ray detectors in the 6-12 keV and 12-25 keV
energy range during the decay phase of the flares of 2004 November 4 and 6.
Methods: The various motions of the RHESSI spacecraft which may contribute to
the manifestation of oscillations are studied. The response of each detector in
turn is also investigated. Results: We find that on 2004 November 6 the
observed oscillations correspond to the nutation period of the RHESSI
instrument. These oscillations are also of greatest amplitude for detector 5,
while in the lightcurves of many other detectors the oscillations are small or
undetectable. We also find that the variation in detector pointing is much
larger during this flare than the counterexample of 2004 November 4.
Conclusions: Sufficiently large nutation motions of the RHESSI spacecraft lead
to clearly observable oscillations in count rates, posing a significant hazard
for data analysis. This issue is particularly problematic for detector 5 due to
its design characteristics. Dynamic correction of the RHESSI counts, accounting
for the livetime, data gaps, and the transmission of the bi-grid collimator of
each detector, is required to overcome this issue. These corrections should be
applied to all future oscillation studies.Comment: 8 pages, 10 figure
Experimental support of the scaling rule for demographic stochasticity
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73613/1/j.1461-0248.2006.00903.x.pd
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