490 research outputs found
Territorial structure of the denominational space of the South-East Baltic
The South-East Baltic is a meeting place of three branches of Christianity: Orthodoxy, Catholicism, and Lutheranism. Dominant in the Baltic region, these religious confessions define the cultural landscape of the area. At the same time, they have an indirect effect on socio-economic development. In this study, we aim to identify the main components of the territorial structure and the formation and transformation factors of the denominational space in the South-East Baltic. The complexity of the denominational structure of the local population stems from the centuries-long position of this region as a political buffer zone. We calculate the potential denominational structure and the potential religious fractionalisation index at the level of basic territorial units and regions southeast of the Baltic Sea. Based on this, we identify the main components of the territorial structure of the denominational space, which includes three denominational shields and contact zones between them. From a practical viewpoint, these components suggest a new variant of the territorial differentiation of the Baltic region. This variant has only limited relevance to ethnic and socioeconomic zoning
Wave Energy: a Pacific Perspective
This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by The Royal Society and can be found at: http://rsta.royalsocietypublishing.org/.This paper illustrates the status of wave energy development in Pacific Rim countries by characterizing the available resource and introducing the region‟s current and potential future leaders in wave energy converter development. It also describes the existing licensing and permitting process as well as potential environmental concerns. Capabilities of Pacific Ocean testing facilities are described in addition to the region‟s vision of the future of wave energy
Interannual and seasonal variability of atmospheric inhomogeneities from satellite systems data and it's correlation with atmosphere monitoring
© 2016 SPIE.In this paper we presented results long-term experimental study of atmosphere remote sensing by GPS-GLONASS signals and simultaneous near surface atmospheric parameters measurements in Kazan city. During the period of 2010 - 2012. The interannual and seasonal variability of the radiovawes zenith tropospheric delay structure functions was analyzed. The correlation coefficient of the of the time structure function decimeter radio waves zenith tropospheric delay power approximation with surface temperature reaches a value of 0.73 for the fluctuations with time scales up to 8 hours. According to the results it can be assume a strong influence of the synoptic processes and the underlying surface on the formation of mesoscale fluctuations in the satellite navigation systems phase path
Capture of particles of dust by convective flow
Interaction of particles of dust with vortex convective flows is under
theoretical consideration. It is assumed that the volume fraction of solid
phase is small, variations of density due to nonuniform distribution of
particles and those caused by temperature nonisothermality of medium are
comparable. Equations for the description of thermal buoyancy convection of a
dusty medium are developed in the framework of the generalized Boussinesq
approximation taking into account finite velocity of particle sedimentation.
The capture of a cloud of dust particles by a vortex convective flow is
considered, general criterion for the formation of such a cloud is obtained.
The peculiarities of a steady state in the form of a dust cloud and backward
influence of the solid phase on the carrier flow are studied in detail for a
vertical layer heated from the sidewalls. It is shown that in the case, when
this backward influence is essential, a hysteresis behavior is possible. The
stability analysis of the steady state is performed. It turns out that there is
a narrow range of governing parameters, in which such a steady state is stable.Comment: 14 pages, 10 figures, published in Physics of Fluid
In silico assessment of potential druggable pockets on the surface of α1-Antitrypsin conformers
The search for druggable pockets on the surface of a protein is often performed on a single conformer, treated as a rigid body. Transient druggable pockets may be missed in this approach. Here, we describe a methodology for systematic in silico analysis of surface clefts across multiple conformers of the metastable protein α1-antitrypsin (A1AT). Pathological mutations disturb the conformational landscape of A1AT, triggering polymerisation that leads to emphysema and hepatic cirrhosis. Computational screens for small molecule inhibitors of polymerisation have generally focused on one major druggable site visible in all crystal structures of native A1AT. In an alternative approach, we scan all surface clefts observed in crystal structures of A1AT and in 100 computationally produced conformers, mimicking the native solution ensemble. We assess the persistence, variability and druggability of these pockets. Finally, we employ molecular docking using publicly available libraries of small molecules to explore scaffold preferences for each site. Our approach identifies a number of novel target sites for drug design. In particular one transient site shows favourable characteristics for druggability due to high enclosure and hydrophobicity. Hits against this and other druggable sites achieve docking scores corresponding to a Kd in the µM–nM range, comparing favourably with a recently identified promising lead. Preliminary ThermoFluor studies support the docking predictions. In conclusion, our strategy shows considerable promise compared with the conventional single pocket/single conformer approach to in silico screening. Our best-scoring ligands warrant further experimental investigation
An NLO QCD analysis of inclusive cross-section and jet-production data from the ZEUS experiment
The ZEUS inclusive differential cross-section data from HERA, for charged and
neutral current processes taken with e+ and e- beams, together with
differential cross-section data on inclusive jet production in e+ p scattering
and dijet production in \gamma p scattering, have been used in a new NLO QCD
analysis to extract the parton distribution functions of the proton. The input
of jet data constrains the gluon and allows an accurate extraction of
\alpha_s(M_Z) at NLO;
\alpha_s(M_Z) = 0.1183 \pm 0.0028(exp.) \pm 0.0008(model)
An additional uncertainty from the choice of scales is estimated as \pm
0.005. This is the first extraction of \alpha_s(M_Z) from HERA data alone.Comment: 37 pages, 14 figures, to be submitted to EPJC. PDFs available at
http://durpdg.dur.ac.uk/hepdata in LHAPDFv
Measurement of the cross-section ratio sigma_{psi(2S)}/sigma_{J/psi(1S)} in deep inelastic exclusive ep scattering at HERA
The exclusive deep inelastic electroproduction of and
at an centre-of-mass energy of 317 GeV has been studied with the ZEUS
detector at HERA in the kinematic range GeV,
GeV and GeV, where is the photon virtuality, is the
photon-proton centre-of-mass energy and is the squared four-momentum
transfer at the proton vertex. The data for GeV were taken in
the HERA I running period and correspond to an integrated luminosity of 114
pb. The data for GeV are from both HERA I and HERA II
periods and correspond to an integrated luminosity of 468 pb. The decay
modes analysed were and for the
and for the . The cross-section ratio
has been measured as a function of
and . The results are compared to predictions of QCD-inspired
models of exclusive vector-meson production.Comment: 24 pages, 8 figure
Search for lepton-flavor violation at HERA
A search for lepton-flavor-violating interactions and has been performed with the ZEUS detector using the entire HERA I
data sample, corresponding to an integrated luminosity of 130 pb^{-1}. The data
were taken at center-of-mass energies, , of 300 and 318 GeV. No
evidence of lepton-flavor violation was found, and constraints were derived on
leptoquarks (LQs) that could mediate such interactions. For LQ masses below
, limits were set on , where
is the coupling of the LQ to an electron and a
first-generation quark , and is the branching ratio of
the LQ to the final-state lepton ( or ) and a quark . For
LQ masses much larger than , limits were set on the four-fermion
interaction term for LQs that couple to an electron and a quark
and to a lepton and a quark , where and are
quark generation indices. Some of the limits are also applicable to
lepton-flavor-violating processes mediated by squarks in -Parity-violating
supersymmetric models. In some cases, especially when a higher-generation quark
is involved and for the process , the ZEUS limits are the most
stringent to date.Comment: 37 pages, 10 figures, Accepted by EPJC. References and 1 figure (Fig.
6) adde
- …