Thermal preferences and cognitive performance estimation via user's physiological responses

This study investigated the relationship between occupants' thermal sensation, physiological responses, and cognitive performance to quantify the priorities of the selected physiological responses for optimal productivity. In order to quantify variables for optimal productivity estimation, this study considered the following factors: 1. Local body skin temperature as an occupant's physiological responses; 2. Participants' individual factors such as gender; 3. Cognitive performance in operation span task; 4. Environmental data such as indoor temperature, wind velocity, CO2 level and indoor humidity; 5. Individual ratings of subjective thermal sensation. A series of human experiments were conducted to collect physiological responses and cognitive performance in a different room temperature conditions. The skin temperatures and environmental data were recorded in every minutes, and thermal sensation was surveyed by the Likert 7 point scale questionnaires. The operation span (OSPAN) task was used to measure working memory as a cognitive performance for occupant's productivity. Total 39 participants' data was collected for comparative analysis. The results revealed significant correlations between overall thermal sensation and local body skin temperatures. Also, the OSPAN score showed that it has a significant correlation with indoor temperature, thermal sensation as well as physiological responses. The OSPAN results were higher when indoor temperature was relatively low or when participant's thermal perception was either slightly cool or cool. Most local body skin temperatures were negatively correlated with the cognitive test scores, therefore it was concluded that a little low temperature has a significant impact to promote occupant's productivity. This study also determined the priority of local skin temperatures and gender by their impact to estimate the occupant's cognitive performance

Maintenance and manipulation of object sequences in working memory: a lifespan study

Many studied reported that working memory components receive remarkable changes during lifespan. In order to better investigate this, we evaluated working memory components on human subjects belonging to five groups (10 subjects each) at different ages 6, 8 and 10 years old, young adult (age) and old adult (age). Our pattern of results shows a major transition in object sequence manipulation performance between ages 8 and 10 years. If related to young adults results, both 10-year-old children and old adults differed in accuracy and RT in both maintenance and manipulation conditions. In particular, young adults and old adults differ in RTs in the manipulation condition. Our results also suggest that a change in response strategy from 6 to 8 years of age, to prioritize accuracy may be present. Our findings appear consistent with recent neuroscientific findings, and lead to novel predictions

Correctional nursing in Liguria, Italy: Examining the ethical challenges

IntroductionCorrectional nursing can involve significant ethical difficulties. This study examined ethical challenges encountered by correctional nurses in the Italian region of Liguria. Empirical data were analyzed in relation to relevant ethical standards. The former involved a study of 75 nurses and managers in the Ligurian correctional system, while the latter involved an analysis of the Italian Code of Ethics for Nurses and related standards for correctional practice. MethodsQuantitative and qualitative methods were used for the empirical study. Questionnaires were administered to collect data on participants’ characteristics and care settings. The Measure of Job Satisfaction (MJS) was also administered. Five focus groups were conducted. ResultsQuantitative Data: Respondents identified factors that mostly impacted on recruitment and retention. Unfavourable factors included: structural, organizational, and relational factors. Favourable factors included: nursing consultation, continuing education activities, and peer support. MJS results were equal to ‘unsatisfied’.Qualitative Data: Five themes were identified through thematic analysis of focus group data: Health needs of incarcerated persons; Negotiation of the boundaries between care and custody; Job satisfaction related to nursing in a correctional setting; Barriers to providing good care; and Security needs. Ten categories of norms were identified in the Code as areas of ethical standards relevant for the empirical data. ConclusionsOur empirical findings demonstrate that these nursing standards can be systematically compromised in correctional settings. Nurses feel compelled to provide ethically-problematic nursing services, with situations of moral distress. This research informs the development of needed policy, educational, and practice changes for nurses in correctional settings

The Morra game as a naturalistic test bed for investigating automatic and voluntary processes in random sequence generation

Morra is a 3,000-years-old hand game of prediction and numbers. The two players reveal their hand simultaneously, presenting a number of fingers between 1 and 5, while calling out a number between 2 and 10. Any player who successfully guesses the summation of fingers revealed by both players scores a point. While the game is extremely fast-paced, making it very difficult for players to achieve a conscious control of their game strategies, expert players regularly outperform non-experts, possibly with strategies residing out of conscious control. In this study, we used Morra as a naturalistic setting to investigate the necessity of attentive control in generation of sequence of items and the ability to proceduralize random number generation, which are both a crucial defensive strategy in Morra and a well-known empirical procedure to test the central executive capacity within the working memory model. We recorded the sequence of numbers generated by expert players in a Morra tournament in Sardinia (Italy) and by undergraduate students enrolled in a course-based research experience (CRE) course at Lawrence Technological University in the United States. Number sequences generated by non-expert and expert players both while playing Morra and in a random number generation task (RNGT) were compared in terms of randomness scores. Results indicate that expert players of Morra largely outperformed non-experts in the randomness scores only within Morra games, whereas in RNGT the two groups were very similar. Importantly, survey data acquired after the games indicate that expert players have very poor conscious recall of their number generation strategies used during the Morra game. Our results indicate that the ability of generating random sequences can be proceduralized and do not necessarily require attentive control. Results are discussed in the framework of the dual processing theory and its automatic-parallel-fast vs.controlled-sequential-slow polarities

Natural language learning and grounding for robotic systems

In many ways, human cognition is importantly predictive. We predict the sensory consequences of our own actions, but we also predict, and react to, the sensory consequences of how others experience their own actions. This ability extends to perceiving the intentions of other humans based on past and current actions. We present research results that show that social aspects and future movement patterns can be predicted from fairly simple kinematic patterns in biological motion sequences. The purpose of this presentation is to demonstrate and discuss the different environmental (gravity and perspective) and bodily constraints on understanding our social and movement-based interactions with others. In a series of experiments, we have used psychophysical methods and recordings from interactions with objects in natural settings. This includes experiments on the incidental processing of biological motion as well as driving simulator studies that examine the role of kinematic patterns of cyclists and driver’s accuracy to predict the cyclist’s intentions in traffic.  The results we present show both clear effects of “low-level” biological motion factors, such as opponent motion, on the incidental triggering of attention in basic perceptual tasks and “higher-lever” top-down guided perception in the intention prediction of cyclist behavior. We propose to use our results to stimulate discussion about the interplay between expectation mediated and stimulus driven effects of visual processing in spatial cognition the context of human interaction. Such discussion will include the role of context in gesture recognition and to what extent our visual system can handle visually complex environments

Proinflammatory and Cancer-Promoting Pathobiont Fusobacterium nucleatum Directly Targets Colorectal Cancer Stem Cells

Intestinal bacterial communities participate in gut homeostasis and are recognized as crucial in bowel inflammation and colorectal cancer (CRC). Fusobacterium nucleatum (Fn), a pathobiont of the oral microflora, has recently emerged as a CRC-associated microbe linked to disease progression, metastasis, and a poor clinical outcome; however, the primary cellular and/or microenvironmental targets of this agent remain elusive. We report here that Fn directly targets putative colorectal cancer stem cells (CR-CSCs), a tumor cell subset endowed with cancer re-initiating capacity after surgery and chemotherapy. A patient-derived CSC line, highly enriched (70%) for the stem marker CD133, was expanded as tumor spheroids, dissociated, and exposed in vitro to varying amounts (range 100-500 MOI) of Fn. We found that Fn stably adheres to CSCs, likely by multiple interactions involving the tumor-associated Gal-GalNac disaccharide and the Fn-docking protein CEA-family cell adhesion molecule 1 (CEACAM-1), robustly expressed on CSCs. Importantly, Fn elicited innate immune responses in CSCs and triggered a growth factor-like, protein tyrosine phosphorylation cascade largely dependent on CEACAM-1 and culminating in the activation of p42/44 MAP kinase. Thus, the direct stimulation of CSCs by Fn may contribute to microbiota-driven colorectal carcinogenesis and represent a target for innovative therapies

brainlife.io: A decentralized and open source cloud platform to support neuroscience research

Neuroscience research has expanded dramatically over the past 30 years by advancing standardization and tool development to support rigor and transparency. Consequently, the complexity of the data pipeline has also increased, hindering access to FAIR data analysis to portions of the worldwide research community. brainlife.io was developed to reduce these burdens and democratize modern neuroscience research across institutions and career levels. Using community software and hardware infrastructure, the platform provides open-source data standardization, management, visualization, and processing and simplifies the data pipeline. brainlife.io automatically tracks the provenance history of thousands of data objects, supporting simplicity, efficiency, and transparency in neuroscience research. Here brainlife.io's technology and data services are described and evaluated for validity, reliability, reproducibility, replicability, and scientific utility. Using data from 4 modalities and 3,200 participants, we demonstrate that brainlife.io's services produce outputs that adhere to best practices in modern neuroscience research

Acute Delta Hepatitis in Italy spanning three decades (1991–2019): Evidence for the effectiveness of the hepatitis B vaccination campaign

Updated incidence data of acute Delta virus hepatitis (HDV) are lacking worldwide. Our aim was to evaluate incidence of and risk factors for acute HDV in Italy after the introduction of the compulsory vaccination against hepatitis B virus (HBV) in 1991. Data were obtained from the National Surveillance System of acute viral hepatitis (SEIEVA). Independent predictors of HDV were assessed by logistic-regression analysis. The incidence of acute HDV per 1-million population declined from 3.2 cases in 1987 to 0.04 in 2019, parallel to that of acute HBV per 100,000 from 10.0 to 0.39 cases during the same period. The median age of cases increased from 27 years in the decade 1991-1999 to 44 years in the decade 2010-2019 (p < .001). Over the same period, the male/female ratio decreased from 3.8 to 2.1, the proportion of coinfections increased from 55% to 75% (p = .003) and that of HBsAg positive acute hepatitis tested for by IgM anti-HDV linearly decreased from 50.1% to 34.1% (p < .001). People born abroad accounted for 24.6% of cases in 2004-2010 and 32.1% in 2011-2019. In the period 2010-2019, risky sexual behaviour (O.R. 4.2; 95%CI: 1.4-12.8) was the sole independent predictor of acute HDV; conversely intravenous drug use was no longer associated (O.R. 1.25; 95%CI: 0.15-10.22) with this. In conclusion, HBV vaccination was an effective measure to control acute HDV. Intravenous drug use is no longer an efficient mode of HDV spread. Testing for IgM-anti HDV is a grey area requiring alert. Acute HDV in foreigners should be monitored in the years to come

Laparoscopic right hemicolectomy: a SICE (Società Italiana di Chirurgia Endoscopica e Nuove tecnologie) network prospective study on the approach to right colon lymphadenectomy in Italy: is there a standard?—CoDIG 2 (ColonDx Italian Group)

Background: Colon cancer is a disease with a worldwide spread. Surgery is the best option for the treatment of advanced colon cancer, but some aspects are still debated, such as the extent of lymphadenectomy. In Japanese guidelines, the gold standard was D3 dissection to remove the central lymph nodes (203, 213, and 223), but in 2009, Hoenberger et al. introduced the concept of complete mesocolic excision, in which surgical dissection follows the embryological planes to remove the mesentery entirely to prevent leakage of cancer cells and collect more lymph nodes. Our study describes how lymphadenectomy is currently performed in major Italian centers with an unclear indication on the type of lymphadenectomy that should be performed during right hemicolectomy (RH). Methods: CoDIG 2 is an observational multicenter national study that involves 76 Italian general surgery wards highly specialized in colorectal surgery. Each center was asked not to modify their usual surgical and clinical practices. The aim of the study was to assess the preference of Italian surgeons on the type of lymphadenectomy to perform during RH and the rise of any new trends or modifications in habits compared to the findings of the CoDIG 1 study conducted 4 years ago. Results: A total of 788 patients were enrolled. The most commonly used surgical technique was laparoscopic (82.1%) with intracorporeal (73.4%), side-to-side (98.7%), or isoperistaltic (96.0%) anastomosis. The lymph nodes at the origin of the vessels were harvested in an inferior number of cases (203, 213, and 223: 42.4%, 31.1%, and 20.3%, respectively). A comparison between CoDIG 1 and CoDIG 2 showed a stable trend in surgical techniques and complications, with an increase in the robotic approach (7.7% vs. 12.3%). Conclusions: This analysis shows how lymphadenectomy is performed in Italy to achieve oncological outcomes in RH, although the technique to achieve a higher lymph node count has not yet been standardized. Trial registration (ClinicalTrials.gov) ID: NCT05943951