La transfiguración del espacio litúrgico mediante la iconografía de Marko Ivan Rupnik.

Las conexiones que se establecen entre la obra iconográfica de Marko Ivan Rupnik y la manera en que interviene en el espacio litúrgico están fundamentadas en una espiritualidad y una elaboración teológica que, desde la perspectiva occidental, propone una novedad. La tradición oriental y la vocación ecuménica de su arte son el punto de partida de una llamada dirigida a provocar una sinergia entre el icono y la arquitectura. El camino trazado por su taller de arte, el Centro Aletti, que es sólido y evocador, muestra que sus intenciones superan la condición de que sus intervenciones transformen meramente el espacio sagrado. Como heredero de las propuestas iniciadas por Soloviev, Rupnik ha sabido conciliar un lenguaje simbólico que quedó perdido en el discurrir de la cultura moderna y posmoderna, mediante la evocación de lo orgánico y lo dinámico en el arte del mosaico y en su repercusión en el espacio, que demanda a su vez una actitud renovada del artista y el hombre actual. El conocimiento simbólico, que es el garante de la posibilidad de integrar las realidades sensibles y espirituales, se materializa en la obra y propuesta artística de Rupnik desde la génesis del proyecto hasta su finalización, dando como resultado una auténtica transfiguración del espacio cultual.pre-print5437 K

Does the epiphyseal cartilage of the long bones have one or two ossification fronts?

[Abstract] Epiphyseal cartilage is hyaline cartilage tissue with a gelatinous texture, and it is responsible for the longitudinal growth of the long bones in birds and mammals. It is located between the epiphysis and the diaphysis. Epiphyseal cartilage also is called a growth plate or physis. It is protected by three bone components: the epiphysis, the bone bar of the perichondrial ring and the metaphysis. The epiphysis, which lies over the epiphyseal cartilage in the form a cupola, contains a juxtaposed bone plate that is near the epiphyseal cartilage and is in direct contact with the epiphyseal side of the epiphyseal cartilage. The germinal zone corresponds to a group of cells called chondrocytes. These chondrocytes belong to a group of chondral cells, which are distributed in rows and columns; this architecture is commonly known as a growth plate. The growth plate is responsible for endochondral bone growth. The aim of this study was to elucidate the causal relationship between the juxtaposed bone plate and epiphyseal cartilage in mammals. Our hypothesis is that cells from the germinal zone of the epiphyseal side of the epiphyseal cartilage are involved in forming a second ossification front that is responsible for the origin of the juxtaposed bone plate. We report the following: (a) The juxtaposed bone plate has a morphology and function that differs from that of the epiphyseal trabeculae; (b) on the epiphyseal edge of the epiphyseal cartilage, a new ossification front starts on the chondrocytes of the germinal area, which forms the juxtaposed bone plate. This ossification front is formed by chondrocytes from the germinal zone through a process of mineralisation and ossification, and (c) the process of mineralisation and ossification has a certain morphological analogy to the process of ossification in the metaphyseal cartilage of amphibians and differs from the endochondral ossification process in the metaphyseal side of the growth plate. The close relationship between the juxtaposed bone plate and the epiphyseal cartilage, in which the chondrocytes that migrate from the germinal area play an important role in the mineralisation and ossification process of the juxtaposed bone plate, supports the hypothesis of a new ossification front in the epiphyseal layer of the epiphyseal plate. This hypothesis has several implications: (a) epiphyseal cartilage is a morphological entity with two different ossification fronts and two different functions, (b) epiphyseal cartilage may be a morphological structure with three parts: perichondrial ring, metaphyseal ossification front or growth plate, and epiphyseal ossification front, (c) all disease (traumatic or dysplastic) that affects some of these parts can have an impact on the morphology of the epiphyseal region of the bone, (d) there is a certain analogy between metaphyseal cartilage in amphibians and mammalian epiphyseal cartilage, although the former is not responsible for bone growth, (e) comparative histological and anatomy studies are also warranted, to shed light on the phylogenetic study of epiphyseal cartilage throughout the changes that occur in the animal species

Impact of a Multichannel Blocker in Attenuating Intramyocardial Artery Remodeling in Hypertensive Rats through Increased Nitric Oxide Bioavailability.

Dronedarone is recommended for the treatment of atrial fibrillation. However, we do not know its effect on vascular remodeling. This study was designed to assess whether dronedarone has the potential to improve the intramyocardial artery remodeling induced by chronic hypertension. Ten-month-old male spontaneously hypertensive rats (SHR) were randomly assigned to receive dronedarone (100mg/kg) or vehicle. Age-matched maleWistar-Kyoto rats served as controls. After 14 days of treatment, we studied the structure (geometry and fibrosis) of the intramyocardial artery using histological analysis. Nitric oxide (NO) in plasma was analyzed. In the untreated SHR, we observed a significant increase in external diameter, lumen diameter, wall width, cross-sectional area, and collagen volume density, as was expected in the experimental model. Dronedarone induced a significant decrease in wall width, cross-sectional area, and collagen volume density in SHR-D in comparison with untreated SHR. The values obtained in SHR-D were similar in the WKY control group. We found significantly higher NO levels in plasma in SHR-D than in untreated SHR. Dronedarone improves the intramyocardial artery remodeling induced by chronic hypertension in SHR through increased nitric oxide bioavailability.post-print459 K

Exposición Madrid-Río [to be continued]. Propuestas para el Río Manzanares. Proyectos Fin de Grado UFV.

Presentamos esta exposición desde la Universidad Francisco de Vitoria con el objetivo de mostrar el trabajo realizado durante los cursos de Proyectos Arquitectónicos y Urbanos de 5º curso y el Proyecto Fin de Grado con Madrid Río y el Nudo Sur como objeto de estudio específico. Esta propuesta trata de repensar por lo tanto un espacio específico de la ciudad que necesita de nuevas soluciones, y de acercar al visitante una conciencia de la ciudad como ente vivo y en constante transformación, haciéndole finalmente partícipe de su futuro.pre-print941 K

Detection of a Corrugated Velocity Pattern in the Spiral Galaxy NGC 5427

Here we report the detection, in Halpha emission, of a radial corrugation in the velocity field of the spiral galaxy NGC 5427. The central velocity of the Halpha line displays coherent, wavy-like variations in the vicinity of the spiral arms. The spectra along three different arm segments show that the maximum amplitude of the sinusoidal line variations are displaced some 500 pc from the central part of the spiral arms. The peak blueshifted velocities appear some 500 pc upstream the arm, whereas the peak redshifted velocities are located some 500 pc downstream the arm. This kinematical behavior is similar to the one expected in a galactic bore generated by the interaction of a spiral density wave with a thick gaseous disk, as recently modeled by Martos & Cox (1998).Comment: Accepted for publication in Ap

Jornada de Grandes infraestructuras europeas de Ciencias Sociales y Humanidades en el CSIC: DARIAH y CLARÍN en el horizonte (11 de mayo de 2023)

Peer reviewe

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true

El espacio expectante. Un acercamiento al espacio litúrgico como lugar de presencia y de encuentro a través de la obra de Rupnik.

En pleno siglo XXI, el espacio litúrgico cristiano se halla inmerso en un nuevo proceso de inculturación. Las sugerencias postconciliares no han producido un cambio significativo en las propuestas arquitectónicas, si bien algunas iniciativas artísticas, como la obra de Rupnik, han desencadenado una reflexión profunda sobre el sentido estético y teológico de las artes que intervienen en el templo. Se propone un acercamiento metodológico para reformular el espacio litúrgico como espacio simbólicamente expectante. El espacio expectante, tomado como categoría, implica que la presencia del Misterio encarnado se manifieste de forma explícita a través de la arquitectura y el arte que la reviste, propiciando y acompañando el encuentro en el contexto de la celebración de la Liturgia.post-print344 K

Complejidad y contradicción en la representación del sufrimiento en el espacio litúrgico mediante la arquitectura. Una aproximación a través de Raniero Cantalamessa.

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