DnaSP 6 : DNA sequence polymorphism analysis of large data sets

We present version 6 of the DnaSP (DNA Sequence Polymorphism) software, a new version of the popular tool for performing exhaustive population genetic analyses on multiple sequence alignments. This major upgrade incorporates novel functionalities to analyse large datasets, such as those generated by high-throughput sequencing (HTS) technologies. Among other features, DnaSP 6 implements: i) modules for reading and analysing data from genomic partitioning methods, such as RADseq or hybrid enrichment approaches, ii) faster methods scalable for HTS data, and iii) summary statistics for the analysis of multi-locus population genetics data. Furthermore, DnaSP 6 includes novel modules to perform single- and multi-locus coalescent simulations under a wide range of demographic scenarios. The DnaSP 6 program, with extensive documentation, is freely available at http://www.ub.edu/dnasp

Adaptation of HIV-1 Depends on the Host-Cell Environment

Many viruses have the ability to rapidly develop resistance against antiviral drugs and escape from the host immune system. To which extent the host environment affects this adaptive potential of viruses is largely unknown. Here we show that for HIV-1, the host-cell environment is key to the adaptive potential of the virus. We performed a large-scale selection experiment with two HIV-1 strains in two different T-cell lines (MT4 and C8166). Over 110 days of culture, both virus strains adapted rapidly to the MT4 T-cell line. In contrast, when cultured on the C8166 T-cell line, the same strains did not show any increase in fitness. By sequence analyses and infections with viruses expressing either yellow or cyan fluorescent protein, we were able to show that the absence of adaptation was linked to a lower recombination rate in the C8166 T-cell line. Our findings suggest that if we can manipulate the host-cellular factors that mediate viral evolution, we may be able to significantly retard viral adaptability

Psychological development which experienced the survivors to trafficking for the purposes of sexual exploitation

[ES] Vídeo de 22:55 minutos que muestra la charla de investigación titulada "Acercamiento a la exploración del desarrollo psicológico que experimentan las supervivientes a la trata con fines de explotación sexual", que se realizó en el salón de actos del Instituto de Investigaciones Agrobiológicas de Galicia (IIAG), el 01-03-2016 en Santiago de Compostela. La ponente es Elena DelBarrio-Alvarez, psicóloga y técnico de investigación del Incipit, CSIC.[EN] 22:55 minutes video showing the talk of research study entitled "Approach to the exploration of psychological development which experienced the survivors to trafficking for the purposes of sexual exploitation", held in the assembly room of the Institute of Agrobiological Research from Galicia (IIAG), on March 01, 2016, in Santiago de Compostela. The speaker is Elena DelBarrio-Alvarez, a psychologist and a technician of research of the Institute of Heritage Sciencies (Incipit), Spanish National Research Council (CSIC).N

Gazed Pottery: an Archaeometric-Cognitive Approach to Material Culture Visuality

This draft is currently on peer review.This research was funded by the Spanish Ministry of Economics and Competitiviness, Program Consolider-Ingenio 2010, as part of the “Research Program on Technologies for conservation and valorization of Cultural Heritage” (CSD2007-00058). Work in the laboratory of LMM was supported by the Spanish Ministry of Economy and Competitiveness (Grant BFU2014-58776-r), co-financed by the European Regional Development Fund (ERDF), and the Severo Ochoa Program for Centers of Excellence in R&D (SEV-2013-0317).N

DnaSP 6 : DNA sequence polymorphism analysis of large data sets

We present version 6 of the DnaSP (DNA Sequence Polymorphism) software, a new version of the popular tool for performing exhaustive population genetic analyses on multiple sequence alignments. This major upgrade incorporates novel functionalities to analyse large datasets, such as those generated by high-throughput sequencing (HTS) technologies. Among other features, DnaSP 6 implements: i) modules for reading and analysing data from genomic partitioning methods, such as RADseq or hybrid enrichment approaches, ii) faster methods scalable for HTS data, and iii) summary statistics for the analysis of multi-locus population genetics data. Furthermore, DnaSP 6 includes novel modules to perform single- and multi-locus coalescent simulations under a wide range of demographic scenarios. The DnaSP 6 program, with extensive documentation, is freely available at http://www.ub.edu/dnasp

Time Trend in Psychotropic Medication Use in Spain: A Nationwide Population-Based Study

Background: We performed an epidemiologic study to analyze nationwide time trends in adult psychotropic drug use over a period from 2006 to 2012, and to identify those factors associated with the likelihood of consumption of these drugs during the study period; Methods: Cross-sectional study on psychotropic medication in the Spanish adult population. We used secondary individualized data drawn from the 2006 and 2012 Spanish National Health Surveys (SNHS). The dependent variable was the use of psychotropic drugs in the previous two weeks. Independent variables included socio-demographic characteristics, comorbidity, lifestyles and healthcare resource utilization. Using logistic multivariate regression models, we analyzed the temporal evolution of psychotropic medication consumption between 2006 and 2012 in both sexes; Results: The prevalence of psychotropic drug use was significantly greater in women (18.14% vs. 8.08% in 2012 (p < 0.05). In Spanish women, the variables associated with a greater probability of psychotropic use were, age, unemployment (adjusted odds ratio (AOR), 1.60; 95% CI, 1.24–2.07), negative perception of health or taking non-psychotropic drugs. Among men, psychotropic use is associated with presence of chronic disease, negative perception of health (AOR, 3.27; 95% CI, 2.62–4.07 in 2012) or inactive status; Conclusions: Between 2006 and 2012, the probability of having taken psychotropic drugs increased by 16% among women. Unemployed women aged ≥45 years with a negative perception of their health constitute a clear risk profile in terms of psychotropic drug use. Inactive men who have a negative perception of their health are the group most likely to consume psychotropic drugs