63 research outputs found
Stratified analyses for selecting appropriate target patients with diabetic peripheral neuropathy for long-term treatment with an aldose reductase inhibitor, epalrestat
Mexiletine for HIV-Infected Patients With Painful Peripheral Neuropathy: A Double-Blind, Placebo-Controlled, Crossover Treatment Trial
Subanesthetic concentrations of lidocaine selectively inhibit a nociceptive response in the isolated rat spinal cord
Physiological Effects of Mental Stress and Orthostasis in Young Insulin-Dependent Diabetic Patients
Experience with oral mexiletine in primary erythromelalgia in children
Primary erythromelalgia is characterized by burning pain, redness, and warmth in the extremities. We present two cases of primary erythromelalgia both of whom presented with a history of several months of severe burning pain in both hands and feet. Both patients had received multiple pain medications with no improvement in symptoms. Pain was relieved by putting affected parts in ice cold water, which resulted in immersion injury of the affected parts. Both patients stopped taking part in school and social activities. We tried oral mexiletine, a class Ib antiarrythmic agent, in view of its reported role in various chronic painful conditions. Dramatic improvement was observed with its use. Both patients improved after several weeks of use, and there were fewer soaking episodes. We observed no adverse effects with mexilitine therapy
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