A quelles conditions les lieux virtuels peuvent-ils être des espaces de formation ?

Texte de l\u27intervention de Nathalie Deschryver, responsable TICE IFeL, à l\u27occasion des 9es Rencontres Formist

À quelles conditions les lieux virtuels peuvent-ils être des espaces de formation ?

Diaporama de l\u27intervention de Nathalie Deschryver, à l\u27occasion des 9es Rencontres Formist

Environmental Fit: A Model for Assessing and Treating Problem Behavior Associated with Curricular Difficulties in Children with Autism Spectrum Disorders

Theoretical considerations suggest that problem behavior should increase when a child’s competency does not match the curricular demands of the environment (i.e., when there is poor environmental fit). In the present study, environmental fit was examined for six children with autism spectrum disorders. Results indicated that the children exhibited high rates of problem behavior associated with poor motor or academic competency. Curricular modifications resulted in (a) a decrease in the level of problem behavior, (b) an increase in the percentage of task steps completed correctly, and (c) improved affect. Adults who worked with the children reported ease of intervention techniques. The concept of environmental fit and its usefulness in guiding both assessment of and intervention for problem behavior are discussed

Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts

Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up from the Translational Breast Cancer Research Consortium 038 study and the Resource of Archival Breast Tissue cohorts. We identify 812 genes associated with ipsilateral recurrence within 5 years from treatment and develop a classifier that predicts DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression patterns and immune cell compositions are identified. Our multiscale approach employed in situ methods to generate a spatially resolved atlas of breast precancers, where complementary modalities can be directly compared and correlated with conventional pathology findings, disease states, and clinical outcome

IntersTICES, a Swiss Virtual Campus support mandate to foster a richer eLearning pedagogy in higher education and to set a general evaluation framework assessing innovative pedagogy

Abstract : The TECFA unit of the University of Geneva received from a major federal initiative, the Swiss Virtual Campus, a 3 years mandate entitled «Pedagogical support and evaluation »

9es Rencontres Formist - 2009 : La bibliothèque, lieu de formation ?

Programme, textes et diaporama des interventions qui se sont tenues à l\u27enssib le 18 juin 2009, à l\u27occasion des 9es Rencontres Formist sur le thème : "La bibliothèque, lieu de formation ?

Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers

Resistance to oestrogen-deprivation therapy is common in oestrogen-receptor-positive (ER+) breast cancer. To better understand the contributions of tumour heterogeneity and evolution to resistance, here we perform comprehensive genomic characterization of 22 primary tumours sampled before and after 4 months of neoadjuvant aromatase inhibitor (NAI) treatment. Comparing whole-genome sequencing of tumour/normal pairs from the two time points, with coincident tumour RNA sequencing, reveals widespread spatial and temporal heterogeneity, with marked remodelling of the clonal landscape in response to NAI. Two cases have genomic evidence of two independent tumours, most obviously an ER− ‘collision tumour', which was only detected after NAI treatment of baseline ER+ disease. Many mutations are newly detected or enriched post treatment, including two ligand-binding domain mutations in ESR1. The observed clonal complexity of the ER+ breast cancer genome suggests that precision medicine approaches based on genomic analysis of a single specimen are likely insufficient to capture all clinically significant information