1,903 research outputs found

    Hijacked Consent: Debt Collection and the Telephone Consumer Protection Act

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    Hijacked Consent: Debt Collection and the Telephone Consumer Protection Act

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    Pengaruh Literasi Keuangan, Sosialisasi Keuangan Orang Tua, Teman Sebaya Dan Pengendalian Diri Terhadap Perilaku Menabung Pada Mahasiswa Fakultas Ekonomi Dan Bisnis Universitas Musamus Merauke

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    Penelitian ini bertujuan untuk mengetahui dan menganalisis Pengaruh Literasi Keuangan, Sosialisasi Keuangan Orang Tua, Teman Sebaya dan Pengendalian Diri Terhadap Perilaku Menabung Pada Mahasiswa Fakultas EKonomi dan Bisnis Universitas Musamus Merauke. Populasi dalam penelitian ini adalah mahasiswa Fakultas Ekonomi dan Bisnis Universitas Musamus Merauke yang berjumlah 1.385 mahasiswa. Sampel penelitian ini berjumlah 260 responden. Teknik penentuan sampel dalam penelitian ini adalah dengan menggunakan teknik non-probability sampling (purposive sampling). Sumber data yang digunakan adalah data primer dan data sekunder. Metode analisis data menggunakan regresi linier berganda dengan bantuan aplikasi program Statistical Product and Service Solution (SPSS). Hasil penelitian secara parsial menunjukkan bahwa Sosialisasi Keuangan Orang Tua, Teman Sebaya, dan Pengendalian Diri tidak berpengaruh terhadap Perilaku Menabung Mahasiswa FEB Universitas Musamus, sedangkan Literasi Keuangan berpengaruh terhadap Perilaku Menabung pada Mahasiswa FEB Universitas Musamus. Akan tetapi, secara simultan hasil penelitian menunjukkan bahwa Literasi Keuangan, Sosialisasi Keuangan Orang Tua, Teman Sebaya dan Pengendalian Diri berpengaruh terhadap Perilaku Menabung pada Mahasiswa Fakultas Ekonomi dan Bisnis Universitas Musamus Merauke

    Hijacked Consent: Debt Collection and the Telephone Consumer Protection Act

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    Combined stable isotope and gut contents analysis of food webs in plant-dominated, shallow lakes

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    1. To determine feeding links between primary producers, invertebrates and fish, stable isotope analyses and gut content analyses of fish were conducted on the components of four shallow, eutrophic to hypertrophic, plant-dominated lakes. 2. Although separation of basal resources was possible, the diets of both fish and invertebrates were broad, comprising food from different compartments (planktonic, epiphytic/benthic), as well as from different trophic levels. 3. Mixing models were used to determine the extent to which periphyton production supported higher trophic levels. Only one species of invertebrate relied upon periphyton production exclusively. 4. Fish density affected the diets of invertebrates. The response was different for planktonic and epiphytic/benthic invertebrates. The proportion of periphyton production in the diets of zooplankton appeared to increase with fish density, whilst it decreased for other invertebrates. 5. As all zooplankton samples were collected in the open water at dusk, these results are further evidence for the diurnal horizontal migration of zooplankton. Although not conclusive, they are consistent with a behavioural response by invertebrates and zooplankton in the presence of fish

    Inhibition of Reactive Gliosis Prevents Neovascular Growth in the Mouse Model of Oxygen-Induced Retinopathy

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    Retinal neovascularization (NV) is a major cause of blindness in ischemic retinopathies. Previous investigations have indicated that ischemia upregulates GFAP and PDGF-B expression. GFAP overexpression is a hallmark of reactive gliosis (RG), which is the major pathophysiological feature of retinal damage. In addition, PDGF-B has been implicated in proliferative retinopathies. It was the aim of this study to gain insights on the possible pharmacological interventions to modulate PDGF-B and GFAP expression, and its influence on RG and NV. We used an array of assays to evaluate the effects of YC-1, a small molecule inhibitor of HIF-1 and a novel NO-independent activator of soluble guanylyl cyclase (sGC), on RG and NV, in vivo and in vitro. When compared to the DMSO-treated retinas, dual-intravitreal injections of YC-1, in vivo: (1) suppressed the development and elongation of neovascular sprouts in the retinas of the oxygen-induced retinopathy (OIR) mouse model; and (2) reduced ischemia-induced overexpression of GFAP and PDGF-B at the message (by 64.14±0.5% and 70.27±0.04%) and the protein levels (by 65.52±0.02% and 57.59±0.01%), respectively. In addition, at 100 µM, YC-1 treatment downregulated the hypoxia-induced overexpression of GFAP and PDGF-B at the message level in rMC-1 cells (by 71.42±0.02% and 75±0.03%), and R28 cells (by 58.62±0.02% and 50.00±0.02%), respectively; whereas, the protein levels of GFAP and PDGF-B were reduced (by 78.57±0.02% and 77.55±0.01%) in rMC-1cells, and (by 81.44±0.02% and 79.16±0.01%) in R28 cells, respectively. We demonstrate that YC-1 reversed RG during ischemic retinopathy via impairing the expression of GFAP and PDGF-B in glial cells. This is the first investigation that delves into the reversal of RG during ischemic retinal vasculopathies. In addition, the study reveals that YC-1 may exert promising therapeutic effects in the treatment of retinal and neuronal pathologies
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