1,405 research outputs found
Momentum Spectra of Electrons Rescattered from Rare-Gas Targets Following Their Extraction by One- and Two-Color Femtosecond Laser Pulses
We have used velocity-map imaging to measure the three-dimensional momenta of electrons rescattered from Xe and Ar following the liberation of the electrons from these atoms by 45 fs, 800 nm intense laser pulses. Strong structure in the rescattering region is observed in both angle and energy, and is interpreted in terms of quantitative rescattering (QRS) theory. Momentum images have also been taken with two-color (800 nm + 400 nm) pulses on Xe targets. A strong dependence of the spectra on the relative phase of the two colors is observed in the rescattering region. Interpretation of the phase dependence using both QRS theory and a full solution to the time-dependent Schrödinger equation shows that the rescattered electrons provide a much more robust method for determining the relative phase of the two colors than do the direct electrons
MPGDs in Compton imaging with liquid-xenon
The interaction of radiation with liquid xenon, inducing both scintillation
and ionization signals, is of particular interest for Compton-sequences
reconstruction. We report on the development and recent results of a
liquid-xenon time-projection chamber, dedicated to a novel nuclear imaging
technique named "3 gamma imaging". In a first prototype, the scintillation is
detected by a vacuum photomultiplier tube and the charges are collected with a
MICROMEGAS structure; both are fully immersed in liquid xenon. In view of the
final large-area detector, and with the aim of minimizing dead-zones, we are
investigating a gaseous photomultiplier for recording the UV scintillation
photons. The prototype concept is presented as well as preliminary results in
liquid xenon. We also present soft x-rays test results of a gaseous
photomultiplier prototype made of a double Thick Gaseous Electron Multiplier
(THGEM) at normal temperature and pressure conditions.Comment: presented at MPGD09, CRETE, June 2009; to be published in JINST
Proceedings, PDF, 10 pages, 11 figure
Orientation Dependence of the Ionization of CO and NO in an Intense Femtosecond Two-Color Laser Field
Two-color (800- and 400-nm) short (45-fs) linearly polarized pulses are used to ionize and dissociate CO and NO. The emission of Cq+, Nq+, and O⁺ fragments indicates that the higher ionization rate occurs when the peak electric field points from C to O in CO and from N to O in NO. This preferred direction is in agreement with that predicted by Stark-corrected strong-field-approximation calculations
Large-Angle Electron Diffraction Structure in Laser-Induced Rescattering from Rare Gases
We have measured full momentum images of electrons rescattered from Xe, Kr, and Ar following the liberation of the electrons from these atoms by short, intense laser pulses. At high momenta the spectra show angular structure (diffraction) which is very target dependent and in good agreement with calculated differential cross sections for the scattering of free electrons from the corresponding ionic cores
Magnetic enhancement of CoZnFeO spinel oxide by mechanical milling
We report the magnetic properties of mechanically milled
CoZnFeO spinel oxide. After 24 hours milling of the
bulk sample, the XRD spectra show nanostructure with average particle size
20 nm. The as milled sample shows an enhancement in magnetization and
ordering temperature compared to the bulk sample. If the as milled sample is
annealed at different temperatures for the same duration, recrystallization
process occurs and approaches to the bulk structure on increasing the annealing
temperatures. The magnetization of the annealed samples first increases and
then decreases. At higher annealing temperature ( 1000C) the system
shows two coexisting magnetic phases {\it i.e.}, spin glass state and
ferrimagnetic state, similar to the as prepared bulk sample. The room
temperature M\"{o}ssbauer spectra of the as milled sample, annealed at
300C for different durations (upto 575 hours), suggest that the observed
change in magnetic behaviour is strongly related with cations redistribution
between tetrahedral (A) and octahedral (O) sites in the spinel structure. Apart
from the cation redistribution, we suggest that the enhancement of
magnetization and ordering temperature is related with the reduction of B site
spin canting and increase of strain induced anisotropic energy during
mechanical milling.Comment: 14 pages LaTeX, 10 ps figure
Antifungal Chromans Inhibiting the Mitochondrial Respiratory Chain of Pea Seeds and New Xanthones from Calophyllum caledonicum
Two new xanthones, caledonixanthone M 1 and caloxanthone L 2, and one new acid, caledonic acid 6 were isolated from the hexane-soluble extract of the stem bark of Calophyllum caledonicum. In the course of this phytochemical study, seven other known compounds - calothwaitesixanthone, calozeyloxanthone, allanxanthone, isoapetalic acid 3, calolongic acid 4, apetalic acid 5 and isocalolongic acid 7 - were isolated. Their antifungal activity against the growth of the human pathogenic fungus Aspergillus fumigatus was then investigated. The results indicated that the crude extract, calolongic acid 4 and isocalolongic acid 7 exhibited strong inhibitory effects with MIC80 values of 8, 4, 2 pg/mL, respectively. Besides, calolongic acid 4, its lactone derivative 4a and isocalolongic acid 7 markedly reduced the respiration of pea seed mitochondria
Coulomb breakup of neutron-rich Na isotopes near the island of inversion
First results are reported on the ground state configurations of the
neutron-rich Na isotopes, obtained via Coulomb dissociation (CD)
measurements as a method of the direct probe. The invariant mass spectra of
those nuclei have been obtained through measurement of the four-momentum of all
decay products after Coulomb excitation on a target at energies of
400-430 MeV/nucleon using FRS-ALADIN-LAND setup at GSI, Darmstadt. Integrated
Coulomb-dissociation cross-sections (CD) of 89 mb and 167 mb up to
excitation energy of 10 MeV for one neutron removal from Na and
Na respectively, have been extracted. The major part of one neutron
removal, CD cross-sections of those nuclei populate core, in its' ground state.
A comparison with the direct breakup model, suggests the predominant occupation
of the valence neutron in the ground state of Na and
Na is the orbital with small contribution in the
-orbital which are coupled with ground state of the core. The ground state
configurations of these nuclei are as Na_{gs (1^+)\otimes\nu_{s,d} and
Na, respectively. The ground state spin
and parity of these nuclei, obtained from this experiment are in agreement with
earlier reported values. The spectroscopic factors for the valence neutron
occupying the and orbitals for these nuclei in the ground state have
been extracted and reported for the first time. A comparison of the
experimental findings with the shell model calculation using MCSM suggests a
lower limit of around 4.3 MeV of the sd-pf shell gap in Na.Comment: Modified version of the manuscript is accepted for publication in
Journal of Physics G, Jan., 201
Symptoms and quality of life in late stage Parkinson syndromes: a longitudinal community study of predictive factors
BACKGROUND
Palliative care is increasingly offered earlier in the cancer trajectory but rarely in Idiopathic Parkinson's Disease(IPD), Progressive Supranuclear Palsy(PSP) or Multiple System Atrophy(MSA). There is little longitudinal data of people with late stage disease to understand levels of need. We aimed to determine how symptoms and quality of life of these patients change over time; and what demographic and clinical factors predicted changes.
METHODS
We recruited 82 patients into a longitudinal study, consenting patients with a diagnosis of IPD, MSA or PSP, stages 3-5 Hoehn and Yahr(H&Y). At baseline and then on up to 3 occasions over one year, we collected self-reported demographic, clinical, symptom, palliative and quality of life data, using Parkinson's specific and generic validated scales, including the Palliative care Outcome Scale (POS). We tested for predictors using multivariable analysis, adjusting for confounders.
FINDINGS
Over two thirds of patients had severe disability, over one third being wheelchair-bound/bedridden. Symptoms were highly prevalent in all conditions - mean (SD) of 10.6(4.0) symptoms. More than 50% of the MSA and PSP patients died over the year. Over the year, half of the patients showed either an upward (worsening, 24/60) or fluctuant (8/60) trajectory for POS and symptoms. The strongest predictors of higher levels of symptoms at the end of follow-up were initial scores on POS (AOR 1.30; 95%CI:1.05-1.60) and being male (AOR 5.18; 95% CI 1.17 to 22.92), both were more predictive than initial H&Y scores.
INTERPRETATION
The findings point to profound and complex mix of non-motor and motor symptoms in patients with late stage IPD, MSA and PSP. Symptoms are not resolved and half of the patients deteriorate. Palliative problems are predictive of future symptoms, suggesting that an early palliative assessment might help screen for those in need of earlier intervention
The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster
The regulatory protein NsrR, a member of the Rrf2 family of transcription repressors, is specifically dedicated to sensing nitric oxide (NO) in a variety of pathogenic and non-pathogenic bacteria. It has been proposed that NO directly modulates NsrR activity by interacting with a predicted [Fe-S] cluster in the NsrR protein, but no experimental evidence has been published to support this hypothesis. Here we report the purification of NsrR from the obligate aerobe Streptomyces coelicolor. We demonstrate using UV-visible, near UV CD and EPR spectroscopy that the protein contains an NO-sensitive [2Fe-2S] cluster when purified from E. coli. Upon exposure of NsrR to NO, the cluster is nitrosylated, which results in the loss of DNA binding activity as detected by bandshift assays. Removal of the [2Fe-2S] cluster to generate apo-NsrR also resulted in loss of DNA binding activity. This is the first demonstration that NsrR contains an NO-sensitive [2Fe-2S] cluster that is required for DNA binding activity
Conformational Instability of Rodlike Polyelectrolytes due to Counterion Fluctuations
The effective elasticity of highly charged stiff polyelectrolytes is studied
in the presence of counterions, with and without added salt. The rigid polymer
conformations may become unstable due to an effective attraction induced by
counterion density fluctuations. Instabilities at the longest, or intermediate
length scales may signal collapse to globule, or necklace states, respectively.
In the presence of added-salt, a generalized electrostatic persistence length
is obtained, which has a nontrivial dependence on the Debye screening length.
It is also found that the onset of conformational instability is a re-entrant
phenomenon as a function of polyelectrolyte length for the unscreened case, and
the Debye length or salt concentration for the screened case. This may be
relevant in understanding the experimentally observed re-entrant condensation
of DNA.Comment: 8 pages, 4 figure
- …