Salvage radiotherapy for patients with PSA relapse after radical prostatectomy: a single institution experience

<p>Abstract</p> <p>Background</p> <p>To assess the efficacy of salvage radiotherapy (RT) for persistent or rising PSA after radical prostatectomy and to determine prognostic factors identifying patients who may benefit from salvage RT.</p> <p>Methods</p> <p>Between 1990 and 2003, 59 patients underwent RT for PSA recurrence after radical prostatectomy. Patients received a median of 66 Gy to the prostate bed with 3D or 2D RT. The main end point was biochemical failure after salvage RT, defined as an increase of the serum PSA value >0.2 ng/ml confirmed by a second elevation.</p> <p>Results</p> <p>Median follow-up was 38 months. The 3-year and 5-year bDFS rates were 56.1% and 41.2% respectively. According to multivariate analysis, only preRT PSA ≥1 ng/ml was associated with biochemical relapse.</p> <p>Conclusion</p> <p>When delivered early, RT is an effective treatment after radical prostatectomy. Only preRT PSA ≥1 ng/ml predicted relapse.</p

ALTIROC0, a 20 pico-second time resolution ASIC for the ATLAS High Granularity Timing Detector (HGTD)

International audienceALTIROC0 is an 8-channel ASIC prototype designed to readout 1x1 or 2x2 mm2 50 µm thick Low Gain Avalanche Diodes (LGAD) of the ATLAS High Granularity Timing Detector (HGTD). The targeted combined time resolution of the sensor and the readout electronics is 30 ps for one MIP. Each analog channel of the ASIC must exhibit an extremely low jitter to ensure this challenging time resolution, while keeping a low power consumption of 2 mW/channel. A “Time Over Threshold” and a “Constant Fraction Discriminator” architecture are integrated to correct for the time walk. Test bench measurements performed on the ASIC received in April 2017 are presented

PMm2: R&D on triggerless acquisition for next generation neutrino experiments

The next generation of proton decay and neutrino experiments, the post-SuperKamiokande detectors, such as those that will take place in megaton size water tanks, will require very large surfaces of photo-detection and will produce a large volume of data. Even with large hemispherical photomultiplier tubes (PMTs), the expected number of channels should reach hundreds of thousands. An ANR funded R&D program to implement a solution is presented here. The very large surface of photo-detection is segmented in macro pixels consisting of an array (2 × 2 m2) of 16 hemispherical 12-inch PMTs connected to autonomous underwater front-end electronics working in a triggerless data acquisition mode. The array is powered by a common high voltage and only one data cable allows the connection by network to the surface controller. This architecture allows a considerable reduction of the cost and facilitates the industrialization. This paper presents the complete architecture of the prototype system and tests results with 16 8-inch PMTs, validating the whole electronics, the built-in gain adjustment and the calibration principle. © 2011 IOP Publishing Ltd and SISSA.SCOPUS: cp.jinfo:eu-repo/semantics/publishe

Damping signatures at JUNO, a medium-baseline reactor neutrino oscillation experiment

Abstract We study damping signatures at the Jiangmen Underground Neutrino Observatory (JUNO), a medium-baseline reactor neutrino oscillation experiment. These damping signatures are motivated by various new physics models, including quantum decoherence, nu(3) decay, neutrino absorption, and wave packet decoherence. The phenomenological effects of these models can be characterized by exponential damping factors at the probability level. We assess how well JUNO can constrain these damping parameters and how to disentangle these different damping signatures at JUNO. Compared to current experimental limits, JUNO can significantly improve the limits on tau(3)/m(3) in the nu(3) decay model, the width of the neutrino wave packet sigma(x), and the intrinsic relative dispersion of neutrino momentum sigma(rel)

JUNO sensitivity to the annihilation of MeV dark matter in the galactic halo

International audienceWe discuss JUNO sensitivity to the annihilation of MeV dark matter in the galactic halo via detecting inverse beta decay reactions of electron anti-neutrinos resulting from the annihilation. We study possible backgrounds to the signature, including the reactor neutrinos, diffuse supernova neutrino background, charged- and neutral-current interactions of atmospheric neutrinos, backgrounds from muon-induced fast neutrons and cosmogenic isotopes. A fiducial volume cut, as well as the pulse shape discrimination and the muon veto are applied to suppress the above backgrounds. It is shown that JUNO sensitivity to the thermally averaged dark matter annihilation rate in 10 years of exposure would be significantly better than the present-day best limit set by Super-Kamiokande and would be comparable to that expected by Hyper-Kamiokande