Suarez resurgitur : adapting the early modern Jus Gentium in contemporary international jurisprudence : on the fourth centenary of' Francisco Suarez's De legibus

Taking its cues from Francisco Suarez's treatise De legibus (1612) and from a recent case before the International Court of Justice, this article examines the parallels between the Spanish philosopher's view of the 'jus gentium', as a law concerning both the relations between states and humanity as a whole, and contemporary trends in international jurisprudence, which reject the exclusively inter-state conception of international law that shaped its underlying philosophy and 'practice for over three centuries after the Treaty of Westphalia (1648). In the context of the gradual recognition of individuals as true subjects of international law, resulting from the rise of humanitarian and human rights law and accelerated by globalisation, Suarez's vision of a strong complementary connection between individuals and states as holders of rights and bearers of obligations may offer some useful insights and perspectives for the philosophical underpinning of future developments in international law.peer-reviewe

‘Un fiume piccolissimo di quel mare immenso’. Universalism, Navigation and the Rethinking of the Mediterranean in Campanella

This contribution offers an intertextual reading of Tommaso Campanella’s early political writings and his utopia, The City of the Sun, with a view of bringing to the fore his stance on the radical shift in early modern maritime geopolitics. Campanella’s proposals for the establishment of world governance were informed by his enthusiasm for inventions such as the navigational compass, and by his emphasis on maritime prowess as a necessary condition for creating a universal monarchy. The dialogical and poetic character of The City of the Sun, and the choice of its imaginary interlocutors, may suggest an interpretation of Campanella’s utopia as a distinctively Mediterranean encounter between the ‘Old World’ and the ‘New World’. The transfer of knowledge and communication thus emerge as crucial lynchpins in Campanella’s project for universal reform and unity

Developing Resistance to Aflatoxin in Maize and Cottonseed

At this time, no “magic bullet” for solving the aflatoxin contamination problem in maize and cottonseed has been identified, so several strategies must be utilized simultaneously to ensure a healthy crop, free of aflatoxins. The most widely explored strategy for the control of aflatoxin contamination is the development of preharvest host resistance. This is because A. flavus infects and produces aflatoxins in susceptible crops prior to harvest. In maize production, the host resistance strategy has gained prominence because of advances in the identification of natural resistance traits. However, native resistance in maize to aflatoxin contamination is polygenic and complex and, therefore, markers need to be identified to facilitate the transfer of resistance traits into agronomically viable genetic backgrounds while limiting the transfer of undesirable traits. Unlike maize, there are no known cotton varieties that demonstrate enhanced resistance to A. flavus infection and aflatoxin contamination. For this reason, transgenic approaches are being undertaken in cotton that utilize genes encoding antifungal/anti-aflatoxin factors from maize and other sources to counter fungal infection and toxin production. This review will present information on preharvest control strategies that utilize both breeding and native resistance identification approaches in maize as well as transgenic approaches in cotton

Micronutrient malnutrition and biofortification: recent advances and future perspectives

Micronutrients malnutrition is of great public health importance in several parts of the world, especially the developing and underdeveloped countries. It has been estimated that about 2 billion people, about one third of the world’s population, are deficient in one or more mineral elements. Although required in traces, these mineral elements are involved in many vital metabolic functions. Micronutrient deficiencies in humans can be remedied through food diversification, mineral supplementation, food fortification, and biofortification. Biofortification is the strategy of increasing the content of bioavailable nutrients in the edible parts of staple food crops for better human nutrition. Staple crops such as maize, rice, and wheat provide most of the calories for low-income families around the globe. However, staple crop-based diets fall far short in providing the required amounts of micronutrients and heavy reliance on staple food is the root cause of micronutrient malnutrition. Biofortification includes the enhanced uptake of such minerals from soils, their transport to edible plant parts, and improving the bioavailability of these minerals. International initiatives have recently released several plant cultivars with increased bioavailable micronutrient concentrations in their edible parts. The use of these biofortified cultivars is expected to mitigate micronutrient malnourishment in large populations especially in Africa. Crop breeding, genetic manipulation, and application of mineral fertilizers are the bases of biofortification strategies and have enormous potential to address micronutrient malnourishment. In this chapter, crop biofortification for zinc, iron, vitamin A, and iodine has been discussed. Biofortification is a proven strategy to combat micronutrient deficiency in large populations, particularly for those living in developing countries. However, to make it more effective, efficient, and acceptable for people, better planning, implementation, monitoring, and evaluation of biofortification programs are needed to produce cost-effective and socially acceptable biofortified food crops. Food safety, quality assurance, and legal framework also need to be considered while developing any biofortification strategy

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Young People and Workplace Discrimination

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The correspondence of Tommaso Campanella [Catalogue]

Early Modern Letters Online is a combined finding aid and editorial interface for basic descriptions of early modern correspondence: a collaboratively populated union catalogue of sixteenth-, seventeenth-, and eighteenth-century letters. http://emlo-portal.bodleian.ox.ac.uk/collections/?page_id=907This is an online tool regarding the correspondence of Tommaso Campanella and can be accessed from the following link: http://emlo-portal.bodleian.ox.ac.uk/collections/?catalogue=tommaso-campanella . The catalogue contains the 172 known extant letters by Campanella. It includes dedicatory letters published in some of his works, as well as fragments of letters that have been indicated as such. The letters are in Italian and Latin, bar one written in Spanish. Addressees include notable scientists and scholars (for example, Galileo, dal Pozzo, Gassendi, Peiresc), popes, cardinals and other prelates, as well as rulers and civil authorities. Campanella’s letters are an especially rich source of biographical information, and an indispensable point of reference for the study of the intricate history of his writings. The subject matter of the correspondence ranges from philosophical, scientific, and political discussions to self-advocacy and lists of completed and projected works.peer-reviewe

Review of Jean-Louis Fournel, La cite du soleil et les territoires des hommes : le savoir du monde chez Campanella

Review of Jean-Louis Fournel, La cité du soleil et les territoires des hommes: Le savoir du monde chez Campanella by Dr. Jean-Paul De Luccapeer-reviewe