7,007 research outputs found

    In Adolescents With Epilepsy, High Scores Of Anxiety And Depression Are Associated With Occurrence Of Seizures In Public Places.

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    Objective To assess depression and anxiety symptoms of adolescents with epilepsy compared with adolescents without epilepsy. Method The study sample consisted of: case participants (50 subjects) attending the pediatric epilepsy clinic of a tertiary hospital and control participants (51 subjects) from public schools. The instruments utilized were: identification card with demographic and epilepsy data, Beck Depression Inventory and State-Trait Anxiety Inventory. Results No significant differences were founded between the groups regarding scores for depression and anxiety symptoms but both groups presented moderate scores of anxiety. A correlation was found between low scores anxiety and not frequent seizures, low scores anxiety and perception of seizure control, high scores of anxiety and depression and occurrence of seizures in public places. Conclusion Low scores of anxiety are associated with not frequent seizures; high scores of anxiety and depression are associated with occurrence of seizures in public places.73205-1

    A genetic network that suppresses genome rearrangements in Saccharomyces cerevisiae and contains defects in cancers.

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    Gross chromosomal rearrangements (GCRs) play an important role in human diseases, including cancer. The identity of all Genome Instability Suppressing (GIS) genes is not currently known. Here multiple Saccharomyces cerevisiae GCR assays and query mutations were crossed into arrays of mutants to identify progeny with increased GCR rates. One hundred eighty two GIS genes were identified that suppressed GCR formation. Another 438 cooperatively acting GIS genes were identified that were not GIS genes, but suppressed the increased genome instability caused by individual query mutations. Analysis of TCGA data using the human genes predicted to act in GIS pathways revealed that a minimum of 93% of ovarian and 66% of colorectal cancer cases had defects affecting one or more predicted GIS gene. These defects included loss-of-function mutations, copy-number changes associated with reduced expression, and silencing. In contrast, acute myeloid leukaemia cases did not appear to have defects affecting the predicted GIS genes

    The scale-free character of the cluster mass function and the universality of the stellar IMF

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    Our recent determination of a Salpeter slope for the IMF in the field of 30 Doradus (Selman and Melnick 2005) appears to be in conflict with simple probabilistic counting arguments advanced in the past to support observational claims of a steeper IMF in the LMC field. In this paper we re-examine these arguments and show by explicit construction that, contrary to these claims, the field IMF is expected to be exactly the same as the stellar IMF of the clusters out of which the field was presumably formed. We show that the current data on the mass distribution of clusters themselves is in excellent agreement with our model, and is consistent with a single spectrum {\it by number of stars} of the type nβn^\beta with beta between -1.8 and -2.2 down to the smallest clusters without any preferred mass scale for cluster formation. We also use the random sampling model to estimate the statistics of the maximal mass star in clusters, and confirm the discrepancy with observations found by Weidner and Kroupa (2006). We argue that rather than signaling the violation of the random sampling model these observations reflect the gravitationally unstable nature of systems with one very large mass star. We stress the importance of the random sampling model as a \emph{null hypothesis} whose violation would signal the presence of interesting physics.Comment: 9 pages emulateap

    Fluctuating Dimension in a Discrete Model for Quantum Gravity Based on the Spectral Principle

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    The spectral principle of Connes and Chamseddine is used as a starting point to define a discrete model for Euclidean quantum gravity. Instead of summing over ordinary geometries, we consider the sum over generalized geometries where topology, metric and dimension can fluctuate. The model describes the geometry of spaces with a countable number nn of points, and is related to the Gaussian unitary ensemble of Hermitian matrices. We show that this simple model has two phases. The expectation value ,theaveragenumberofpointsintheuniverse,isfiniteinonephaseanddivergesintheother.Wecomputethecriticalpointaswellasthecriticalexponentof, the average number of points in the universe, is finite in one phase and diverges in the other. We compute the critical point as well as the critical exponent of . Moreover, the space-time dimension δ\delta is a dynamical observable in our model, and plays the role of an order parameter. The computation of is discussed and an upper bound is found, <2 < 2.Comment: 10 pages, no figures. Third version: This new version emphasizes the spectral principle rather than the spectral action. Title has been changed accordingly. We also reformulated the computation of the dimension, and added a new reference. To appear in Physical Review Letter

    Anatomic Aspects of Inguinal Lymph Nodes Applied to Lymphadenectomy in Penile Cancer

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    Objectives. To provide a better understanding of the distribution of inguinal nodes in order to prevent the complications of unnecessary and extended dissections in penile cancer. Methods. The bilateral inguinal regions of 19 male cadavers were dissected. Nodal distribution was noted and quantified based on anatomical location. The superficial nodes were subdivided into quarters as follows: superomedial, superolateral, inferomedial, and inferolateral. Statistical analysis was performed comparing node distribution between quarters using one-way analysis of variance (ANOVA), and the unpaired T-test was used between superficial and deep nodes. Results. Superficial nodes were found in all inguinal regions studied (mean = 13.60), and their distribution was more prominent in the superomedial quarter (mean = 3.94) and less in the inferolateral quarter (mean = 2.73). There was statistical significance between quarters when comparing the upper group with the lower one (P = 0.02). Nodes were widely distributed in the superficial region compared with deep lymph nodes (mean = 13.60 versus 1.71, P < 0.001). Conclusions. A great number of inguinal lymph nodes are distributed near the classical anatomical landmarks for inguinal lymphadenectomy, more prominent in upper quadrants

    Stellar Population gradients in galaxy discs from the CALIFA survey

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    While studies of gas-phase metallicity gradients in disc galaxies are common, very little has been done in the acquisition of stellar abundance gradients in the same regions. We present here a comparative study of the stellar metallicity and age distributions in a sample of 62 nearly face-on, spiral galaxies with and without bars, using data from the CALIFA survey. We measure the slopes of the gradients and study their relation with other properties of the galaxies. We find that the mean stellar age and metallicity gradients in the disc are shallow and negative. Furthermore, when normalized to the effective radius of the disc, the slope of the stellar population gradients does not correlate with the mass or with the morphological type of the galaxies. Contrary to this, the values of both age and metallicity at \sim2.5 scale-lengths correlate with the central velocity dispersion in a similar manner to the central values of the bulges, although bulges show, on average, older ages and higher metallicities than the discs. One of the goals of the present paper is to test the theoretical prediction that non-linear coupling between the bar and the spiral arms is an efficient mechanism for producing radial migrations across significant distances within discs. The process of radial migration should flatten the stellar metallicity gradient with time and, therefore, we would expect flatter stellar metallicity gradients in barred galaxies. However, we do not find any difference in the metallicity or age gradients in galaxies with without bars. We discuss possible scenarios that can lead to this absence of difference.Comment: 24 pages, 17 figures, accepted for publication in A&

    Fractal dimension analysis of grey matter in multiple sclerosis

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    The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of a complex object. Among other applications, FD has been used to identify abnormalities of the human brain in conventional magnetic resonance imaging (MRI), including white matter abnormalities in patients with Multiple Sclerosis (MS). Extensive grey matter (GM) pathology has been recently identified in MS and it appears to be a key factor in long-term disability. The aim of the present work was to assess whether FD measurement of GM in T1 MRI sequences can identify GM abnormalities in patients with MS in the early phase of the disease. A voxel-based morphometry approach optimized for MS was used to obtain the segmented brain, where we later calculated the three-dimensional FD of the GM in MS patients and healthy controls.We found that patients with MS had a significant increase in the FD of the GM compared to controls. Such differences were present even in patients with short disease durations, including patients with first attacks of MS. In addition, the FD of the GM correlated with T1 and T2 lesion load, but not with GM atrophy or disability. The FD abnormalities of the GM here detected differed from the previously published FD of the white matter in MS, suggesting that different pathological processes were taking place in each structure. These results indicate that GM morphology is abnormal in patients with MS and that this alteration appears early in the course of the disease

    Produção e características morfológicas de capim Marandu em função da face de exposição e distância do renque

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    Diversas plantas forrageiras ainda não possuem respostas conhecidas em sistemas de produção mais complexos, por exemplo, aqueles que utilizam árvores e promovem o sombreamento das gramíneas. O objetivo com este trabalho foi avaliar a produção de forragem e as características morfológicas de capim Marandu (Brachiaria brizantha cv. Marandu) em função da face de exposição (norte e sul) e distância das arvores (3, 6, 10 e 15 metros) no sistema Silvipastoril. O capim Marandu no Sistema Silvipastoril apresentou valores médios massa total de forragem semelhante independente da face de exposição ou distância do renque (P=0,7281). A massa de forragem total foi em média 3741 kg ha -1 . Dosséis manejados no Sistema Silvipastoril com Brachiaria brizantha cv. Marandu não apresentaram diferença nas massas de folha, colmo e morto quando avaliados em função da distância das árvores (3, 6, 9 e 15 m) ou a face (Norte e Sul). Assim como não houve efeito para a proporção de folha, colmo e material morto (P>0,05). Em média, registrou-se 77,1% de folha, 4,9 % de colmo e 14,3 % de material morto. A produção de forragem e as características morfológicas de capim Marandu não foram modificadas em função da face de exposição e distância do renque, enquanto as árvores têm até 9 metros de altura
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