The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of a
complex object. Among other applications, FD has been used to identify abnormalities of the human brain in
conventional magnetic resonance imaging (MRI), including white matter abnormalities in patients with
Multiple Sclerosis (MS). Extensive grey matter (GM) pathology has been recently identified in MS and it
appears to be a key factor in long-term disability. The aim of the present work was to assess whether FD
measurement of GM in T1 MRI sequences can identify GM abnormalities in patients with MS in the early
phase of the disease. A voxel-based morphometry approach optimized for MS was used to obtain the
segmented brain, where we later calculated the three-dimensional FD of the GM in MS patients and healthy
controls.We found that patients with MS had a significant increase in the FD of the GM compared to controls.
Such differences were present even in patients with short disease durations, including patients with first
attacks of MS. In addition, the FD of the GM correlated with T1 and T2 lesion load, but not with GM atrophy
or disability. The FD abnormalities of the GM here detected differed from the previously published FD of the
white matter in MS, suggesting that different pathological processes were taking place in each structure.
These results indicate that GM morphology is abnormal in patients with MS and that this alteration appears
early in the course of the disease
