The spectroscopic evolution of the γ\gamma-ray emitting classical nova Nova Mon 2012. I. Implications for the ONe subclass of classical novae

Nova Mon 2012 was the first classical nova to be detected as a high energy $\gamma$-ray transient, by Fermi-LAT, before its optical discovery. We study a time sequence of high resolution optical echelle spectra (Nordic Optical Telescope) and contemporaneous NOT, STIS UV, and CHIRON echelle spectra (Nov 20/21/22). We use [O III] and H$\beta$ line fluxs to constrain the properties of the ejecta. We derive the structure from the optical and UV line profiles and compare our measured line fluxes for with predictions using Cloudy with abundances from other ONe novae. Mon 2012 is confirmed as an ONe nova. We find E(B-V)=0.85$\pm$0.05 and hydrogen column density $\approx 5\times 10^{21}$ cm$^{-2}$. The corrected continuum luminosity is nearly the same in the entire observed energy range as V1974 Cyg, V382 Mon, and Nova LMC 2000 at the same epoch after outburst. The distance, about 3.6 kpc, is quite similar to V1974 Cyg. The line profiles can be modeled using an axisymmetric bipolar geometry for the ejecta with various inclinations of the axis to the line of sight, 60 \le i \le 80 degrees, an opening angle of \approx$70 deg, inner radius$\Delta R/R(t)\approx 0.4$for permitted lines and less filled for forbidden lines. The filling factor$f\approx 0.1-0.3$implying M(ejecta)$\leq 6\times 10^{-5}$M$_\odot$. The ONe novae appear to comprise a single physical class with bipolar high mass ejecta, similarly enhanced abundances, and a common spectroscopic evolution within a narrow range of luminosities. The detected$\gamma$-ray emission may be a generic phenomenon, common to all ONe novae, possibly to all classical novae, and connected with acceleration and emission processes within the ejecta (abstract severely truncated).Comment: Submitted to A&A 9/1/2013; Accepted 27/2/2013 (in press

The spectroscopic evolution of the recurrent nova T Pyxidis during its 2011 outburst. II.The optically thin phase and the structure of the ejecta in recurrent novae

We continue our study of the physical properties of the recurrent nova T Pyx, focussing on the structure of the ejecta in the nebular stage of expansion during the 2011 outburst. The nova was observed contemporaneously with the Nordic Optical Telescope (NOT), at high resolution spectroscopic resolution (R ~ 65000) on 2011 Oct. 11 and 2012 Apr. 8 (without absolute flux calibration), and with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope, at high resolution (R ~ 30000) on 2011 Oct. 10 and 2012 Mar. 28 (absolute fluxes). We use standard plasma diagnostics (e.g. [O III] and [N II] line ratios and the H$\beta$ line fluxes) to constrain electron densities and temperatures. Using Monte Carlo modeling of the ejecta, we derive the structure and filling factor from comparisons to the optical and ultraviolet line profiles. The ejecta can be modeled using an axisymmetric conical -- bipolar -- geometry with a low inclination of the axis to the line of sight, i=15+/-5 degrees, compatible with published results from high angular resolution optical spectro-interferometry. The structure is similar to that observed in the other short orbital period recurrent novae during their nebular stages. We show that the electron density scales as $t^{-3}$ as expected from a ballistically ejected constant mass shell; there is no need to invoke a continuing mass outflow following the eruption. The derived mass for the ejecta with filling factor f ~ 3%, M_ej ~ 2E-6$M_sun is similar to that obtained for other recurrent nova ejecta but inconsistent with the previously reported extended optically thick epoch of the explosion. We suggest that the system underwent a common envelope phase following the explosion that produced the recombination event. Implications for the dynamics of the recurrent novae are discussed. (truncated)Comment: accepted for publication in A&A (10 Nov. 2012), 10 pgs, 16 fig

Percutaneous ablation techniques for renal cell carcinoma: current status and future trends

Percutaneous ablation is an increasingly applied technique for the treatment of localized renal tumors, especially for elderly or co-morbid patients, where co-morbidities increase the risk of traditional nephrectomy. Ablative techniques are technically suited for the treatment of tumors generally not exceeding 4 cm, which has been set as general consensus cutoff and is described as the upper threshold of T1a kidney tumors. This threshold cutoff is being challenged, but with still limited evidence. Percutaneous ablation techniques for the treatment of renal cell carcinoma (RCC) include radiofrequency ablation, cryoablation, laser or microwave ablation; the main advantage of all these techniques over surgery is less invasiveness, lower complication rates and better patient tolerability. Currently, international guidelines recommend percutaneous ablation either as intervention for frail patients or as a first line tool, provided that the tumor can be radically ablated. The purpose of this article is to describe the basic concepts of percutaneous ablation in the treatment of RCC. Controversies concerning techniques and products and the need for patient-centered tailored approaches during selection among the different techniques available will be discussed

A minimum-dissipation time-integration strategy for large-eddy simulation of incompressible turbulent flows

Adaptive time stepping can significantly enhance the accuracy and the efficiency of computational methods. In this work, a time-integration strategy with adaptive time step control is proposed for large-eddy simulation of turbulent flows. The algorithm is based on Runge-Kutta methods and consists in adjusting the time-step size dynamically to ensure that the numerical dissipation rate due to the temporal scheme is smaller than the molecular and subgrid-scale ones within a desired tolerance. The effectiveness of the method, as compared to standard CFL-like criteria, is assessed by large-eddy simulations of the three-dimensional Taylor-Green Vortex

Modularity and Optimality in Social Choice

Marengo and the second author have developed in the last years a geometric model of social choice when this takes place among bundles of interdependent elements, showing that by bundling and unbundling the same set of constituent elements an authority has the power of determining the social outcome. In this paper we will tie the model above to tournament theory, solving some of the mathematical problems arising in their work and opening new questions which are interesting not only from a mathematical and a social choice point of view, but also from an economic and a genetic one. In particular, we will introduce the notion of u-local optima and we will study it from both a theoretical and a numerical/probabilistic point of view; we will also describe an algorithm that computes the universal basin of attraction of a social outcome in O(M^3 logM) time (where M is the number of social outcomes).Comment: 42 pages, 4 figures, 8 tables, 1 algorithm

Atmospheric particulate matter (PM) effect on the growth of Solanum lycopersicum cv. Roma plants

This study shows the direct effect of atmospheric particulate matter on plant growth. Tomato (Solanum lycopersicum L.) plants were grown for 18. d directly on PM10 collected on quartz fiber filters. Organic and elemental carbon and polycyclic aromatic hydrocarbons (PAHs) contents were analyzed on all the tested filters. The toxicity indicators (i.e., seed germination, root elongation, shoot and/or fresh root weight, chlorophyll and carotenoids content) were quantified to study the negative and/or positive effects in the plants via root uptake. Substantial differences were found in the growth of the root apparatus with respect to that of the control plants. A 17-58% decrease of primary root elongation, a large amount of secondary roots and a decrease in shoot (32%) and root (53-70%) weights were found. Quantitative analysis of the reactive oxygen species (ROS) indicated that an oxidative burst in response to abiotic stress occurred in roots directly grown on PM10, and this detrimental effect was also confirmed by the findings on the chlorophyll content and chlorophyll-to-carotenoid ratio

Revived Fossil Plasma Sources in Galaxy Clusters

© 2020 ESO.It is well established that particle acceleration by shocks and turbulence in the intra-cluster medium can produce cluster-scale synchrotron emitting sources. However, the detailed physics of these particle acceleration processes is still not well understood. One of the main open questions is the role of fossil relativistic electrons that have been deposited in the intracluster medium (ICM) by radio galaxies. These synchrotron-emitting electrons are very difficult to study as their radiative lifetime is only tens of Myr at gigahertz frequencies, and they are therefore a relatively unexplored population. Despite the typical steep radio spectrum due to synchrotron losses, these fossil electrons are barely visible even at radio frequencies well below the gigahertz level. However, when a pocket of fossil radio plasma is compressed, it boosts the visibility at sub-gigahertz frequencies, creating what are known as radio phoenices. This compression can be the result of bulk motion and shocks in the ICM due to merger activity. In this paper we demonstrate the discovery potential of low-frequency radio sky surveys to find and study revived fossil plasma sources in galaxy clusters. We used the 150 MHz TIFR GMRT Sky Survey and the 1.4 GHz NVSS sky survey to identify candidate radio phoenices. A subset of three candidates was studied in detail using deep multi-band radio observations (LOFAR and GMRT), X-ray obserations (Chandra or XMM-Newton), and archival optical observations. Two of the three sources are new discoveries. Using these observations, we identified common observational properties (radio morphology, ultra-steep spectrum, X-ray luminosity, dynamical state) that will enable us to identify this class of sources more easily, and will help us to understand the physical origin of these sources.Peer reviewedFinal Accepted Versio

Surgical Treatment Following Failed Medical Treatment of an Interstitial Pregnancy

Interstitial pregnancy (IP) is a type of ectopic pregnancy in which the embryo implants in the interstitial part of the Fallopian tube. It accounts for 2% of all ectopic pregnancies. Signs and symptoms appear later than the other forms of ectopic pregnancies because of its peculiar location. The gold standard for its diagnosis is transvaginal ultrasound. The treatment can be medical or surgical. Medical treatment is based on the systemic or local injection of methotrexate (MTX); a dose of mifepristone can be added with a reported 85-90% success rate. The surgical option is laparoscopic unilateral cornuostomy or unilateral salpingectomy. The therapeutic choice is based on symptoms, serum β-human chorionic gonadotropin (β-hCG) values, and sonographic features. Furthermore, the patient's fertility perspectives should be considered. We report a case of IP in a Caucasian woman of 29 years old, with a previous salpingectomy for ectopic pregnancy medically treated by a double dose of intramuscular MTX 50 mg/m2 combined with a single dose of leucovorin 15 mg and a single dose of mifepristone 600 mg orally. Medical therapy failed as suggested by the sudden onset of intense pelvic pain after 10 days. Because of the clinical symptoms and the sonographic suspicious of pregnancy rupture due to the modest amount of fluid in the pouch of Douglas, clinicians decided on an urgent unilateral laparoscopic salpingectomy. The hemoperitoneum was drained. The patient was discharged two days later and β-hCG serum levels became negative after 45 days. The advantages of fertility sparing should be weighted according to the patient's reproductive perspectives. Appropriate counseling is therefore key in managing the treatment of interstitial pregnancy

D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study

D-dimer assay is used to stratify patients with unprovoked venous thromboembolism (VTE) for the risk of recurrence. However, this approach was never evaluated since direct oral anticoagulants are available. With this multicenter, prospective cohort study, we aimed to assess the value of an algorithm incorporating serial D-dimer testing and administration of reduced-dose apixaban (2.5 mg twice daily) only to patients with a positive test. A total of 732 outpatients aged 18 to 74 years, anticoagulated for ≥12 months after a first unprovoked VTE, were included. Patients underwent D-dimer testing with commercial assays and preestablished cutoffs. If the baseline D-dimer during anticoagulation was negative, anticoagulation was stopped and testing repeated after 15, 30, and 60 days. Patients with serially negative results (286 [39.1%]) were left without anticoagulation. At the first positive result, the remaining 446 patients (60.9%) were given apixaban for 18 months. All patients underwent follow-up planned for 18 months. The study was interrupted after a planned interim analysis for the high rate of primary outcomes (7.3%; 95% confidence interval [CI], 4.5-11.2), including symptomatic proximal deep vein thrombosis (DVT) or pulmonary embolism (PE) recurrence, death for VTE, and major bleeding occurring in patients off anticoagulation vs that in those receiving apixaban (1.1%; 95% CI, 0.4-2.6; adjusted hazard ratio [HR], 8.2; 95% CI, 3.2-25.3). In conclusion, in patients anticoagulated for ≥1 year after a first unprovoked VTE, the decision to further extend anticoagulation should not be based on D-dimer testing. The results confirmed the high efficacy and safety of reduced-dose apixaban against recurrences. This trial was registered at www.clinicaltrials.gov as #NCT03678506

Infodemiological patterns in searching medication errors: Relationship with risk management and shift work

INTRODUCTION: Western world health care systems have been trying to improve their efficiency and effectiveness in order to respond properly to population aging and non-communicable diseases epidemic. Treatment of the elderly population is becoming complex due to the high number of prescribed drugs because of multimorbidity. Errors in drugs administration in different health care related settings are an actual important issue due to different causes. Aim of this observational study is to measure the online interest in seeking medication errors information related to risk management and shift work. MATERIALS AND METHODS: We investigated Google Trends® for popular search relating to medication errors, risk management and shift work. Relative search volumes (RSVs) were evaluated from 2008 to 2018. A comparison between RSV curves related to medication errors, risk management and shift work was carried out. Then, we compared the world to Italian search. RESULTS: RSVs were persistently higher for risk management than for medication errors (mean RSVs 069 vs. 48%) and RSVs were stably higher for medication errors than shift work (mean RSVs 48 vs. 22%). In Italy, RSVs were much lower compared to the rest of the world, and RSVs for medication errors during the study period were negligible. Mean RSVs for risk management and shift work were 3 and 25%, respectively. RSVs related to medication errors and clinical risk management were correlated (r=0.520, p<0.0001). CONCLUSIONS: Google Trends® search query volumes related to medication errors, risk management and shift work are different. RSVs for risk management are higher, and they are correlated with medication errors. Also, shift work search appears to be lower. These results should be interpreted in order to correctly evaluate how to decrease the number of medication errors in different health care related setting