Synthesis, characterization and cyclization reactions of some new bisthiosemicarbazones

The reaction of trans-1, 4-dichloro-2-butene 1 with selected phenols affords (E)-1, 4-bis(aryloxy)-2-butenes 2a-d which are converted into bis-thiosemicarbazones 3a-h via the reactions with thiosemicarbazide and 4-methyl thiosemicarbazide, respectively. Similarly, 4-methyl-5-ethoxycarbonyl- 2, 3-dihydro-1, 3-thiazoles 4a-h are synthesized via the reaction of bis-thiosemicarbazones 3a-h with ethyl 2-chloroacetoacetate. trans-1, 4-Dithiocyanato-2-butene 5 is obtained from the reaction of KSCN and trans-1, 4-dichloro-2-butene 1. Furthermore, the bis-2-amino-1, 3, 4-thiadiazoles 6k and l are obtained from the reaction of trans-1, 4-dithiocyanato-2-butene 5 with thiosemicarbazide and 4-methyl thiosemicarbazide, respectively. These compounds are characterized by elemental analyses, infrared, 1H-, 13C-NMR and mass spectrometry. Finally, the microbial features of all compounds are determined. Some of them exhibited microbial activities at low level, and the electronic absorption spectra of the compounds 3b, d, f and h are measured in organic solvents (MeOH, DMF, DMSO and 1, 4-dioxane) with various polarities

Effect of The Atherogenic Index of Plasma on Microvascular Complications Associated with Type 2 Diabetes Mellitus

Objective: The aim of this study was to evaluate the effects of the atherogenic index of plasma (AIP) on the microvascular complications of type 2 diabetes mellitus (DM) patients who applied to our internal medicine clinic. Methods: The study included 212 type 2 DM patients and 34 healthy controls who were compatible according to age and sex. Age, sex, duration of illness, treatment for diabetes and other illnesses associated with diabetes, height, weight, retinopathy, nephropathy, neuropathy, hypertension, and hyperlipidemia were recorded at the beginning of the study. AIP is calculated as the logarithm of the ratio between the triglyceride value and high density lipoprotein value (in mg/dL). Results: AIP and triglyceride levels of the type 2 DM patients were higher than those of the control group. Also, the study determined that 25.7% of the patients have retinopathy, 31.6% have neuropathy, 29.1% have microalbuminuria, and 3.9% have macroalbuminuria. If we accept that there is a complications who have one of these complications in this three, there is 62.6% of the patients have complications. A statistically significant correlation was determined with these complications and lipid subgroups such as AIP and low density lipoprotein (LDL). Conclusion: The relationship between AIP and only nephropathy, which is a complication in type 2 DM patients, was determined

Effect of the Atherogenic Index of Plasma on Microvascular Complications Associated with Type 2 Diabetes Mellitus

Amaç: İç hastalıkları polikliniğimize başvuran tip 2 diyabet mellituslu hastalarda plazma aterojenik indeksin (AİP) mikrovasküler komplikasyonlar olan etkisini değerlendirmeyi amaçlanmıştır. Yöntemler: Çalışmaya 212 Tip 2 Diyabet Mellitus (DM) tanılı hasta ile yaş ve cinsiyet uyumlu 34 sağlıklı kişi olmak üzere toplam 246 kişi katıldı. Çalışma başlangıcında hastaların yaş, cinsiyet, hastalık yaşı, diyabete ve eşlik eden hastalıklara yönelik aldığı tedavi, boy-kilo, retinopati, nefropati, nöropati, hipertansiyon, hiperlipidemi varlığı kaydedildi. Plazma aterojenik indeksi desilitrede miligram olarak ölçülen plazma trigliserid düzeyinin yüksek dansiteli lipoprotein (HDL) düzeyine oranının 10 tabanındaki logaritması olarak hesaplandı. Bulgular: Çalışmamızda tip 2 DM hastalarda kontrol grubuna göre trigliserid ve plazma aterojenik indeksin daha yüksek olduğu görüldü. Ayrıca Tip 2 DM olgularında %25,7'sinde retinopati, %31,6'sında nöropati, %29,1'inde mikroalbüminüri, %3,9 makroalbüminüri olduğu saptanmıştır. Bu üç komplikasyondan herhangi birini gösterenlere komplikasyon var dersek olguların %62,6'sında komplikasyon olduğu görülmüştür. Çalışmamızda mikrovasküler komplikasyonlarla lipid alt grupları arasındaki ilişkiye baktığımızda mikroalbüminüri ile AİP ve düşük dansiteli lipoprotein (LDL) arasında istatistiksel anlamlı korelasyon saptanmıştır. Sonuç: Tip 2 diyabet hastaların mikrovasküler komplikasyonlarından sadece nefropati ile plazma aterojenik indeks arasında ilişki saptanmıştır.Objective: The aim of this study was to evaluate the effects of the atherogenic index of plasma (AIP) on the microvascular complications of type 2 diabetes mellitus (DM) patients who applied to our internal medicine clinic. Methods: The study included 212 type 2 DM patients and 34 healthy controls who were compatible according to age and sex. Age, sex, duration of illness, treatment for diabetes and other illnesses associated with diabetes, height, weight, retinopathy, nephropathy, neuropathy, hypertension, and hyperlipidemia were recorded at the beginning of the study. AIP is calculated as the logarithm of the ratio between the triglyceride value and high density lipoprotein value (in mg/dL). Results: AIP and triglyceride levels of the type 2 DM patients were higher than those of the control group. Also, the study determined that 25.7% of the patients have retinopathy, 31.6% have neuropathy, 29.1% have microalbuminuria, and 3.9% have macroalbuminuria. If we accept that there is a complications who have one of these complications in this three, there is 62.6% of the patients have complications. A statistically significant correlation was determined with these complications and lipid subgroups such as AIP and low density lipoprotein (LDL). Conclusion: The relationship between AIP and only nephropathy, which is a complication in type 2 DM patients, was determined

Effect of the Atherogenic Index of Plasma on Microvascular Complications Associated with Type 2 Diabetes Mellitus

Objective: The aim of this study was to evaluate the effects of the atherogenic index of plasma (AIP) on the microvascular complications of type 2 diabetes mellitus (DM) patients who applied to our internal medicine clinic. Methods: The study included 212 type 2 DM patients and 34 healthy controls who were compatible according to age and sex. Age, sex, duration of illness, treatment for diabetes and other illnesses associated with diabetes, height, weight, retinopathy, nephropathy, neuropathy, hypertension, and hyperlipidemia were recorded at the beginning of the study. AIP is calculated as the logarithm of the ratio between the triglyceride value and high density lipoprotein value (in mg/dL). Results: AIP and triglyceride levels of the type 2 DM patients were higher than those of the control group. Also, the study determined that 25.7% of the patients have retinopathy, 31.6% have neuropathy, 29.1% have microalbuminuria, and 3.9% have macroalbuminuria. If we accept that there is a complications who have one of these complications in this three, there is 62.6% of the patients have complications. A statistically significant correlation was determined with these complications and lipid subgroups such as AIP and low density lipoprotein (LDL). Conclusion: The relationship between AIP and only nephropathy, which is a complication in type 2 DM patients, was determined

Use of azomethine-bridged phenolic metallophthalocyanines for sensitization of TiO2

KOC KESIR, Melek/0000-0001-8905-2664WOS: 000403563700023A group of novel azomethine-bridged phenolic metallophtalocyanines (substituted at -nonperipheral position, MPc) were synthesized, characterized and used as sensitizer. Phthalocyanine derivatives (containing TiO(II), Fe(II), Co(II), Ni(II) and Zn(II) ions in the center of phtalocyanine) were immobilized on TiO2 photocatalyst using a wet deposition method. MPc/TiO2 nanocomposites have been tested for their photocatalytic reduction ability of Cr(VI) ions in aqueous solution under near visible light irradiation. The results demonstrated that the presence of the sensitizer is certainly beneficial for the photocatalytic activity of TiO2, confirming the significant role of substitution and metal-co-ordination in the center of the phthalocyanine ring. Photoreduction results show that the all composite materials exposed significantly higher Cr(VI) removal performance than bare TiO2-Consequently, MPc sensitized TiO2 nanocomposites may be good alternatives for efficient photocatalysis that can be used for wastewater treatment processes.Turkish Scientific Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z308]The authors gratefully appreciate the financial support from Turkish Scientific Research Council (TUBITAK, Project No.: 113Z308). The authors declare that there is no conflict of interest

Suboptimal use of non-vitamin K antagonist oral anticoagulants: Results from the RAMSES study

WOS: 000384041400052PubMed ID: 27583892This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians' adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study).RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression.Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included >65 years of age, creatinine clearance 50mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of <3, whereas that of OT were creatinine clearance <50mL/min, ongoing rivaroxaban treatment, and HAS-BLED score of 3.The suboptimal use of NOACs is common because of physicians' poor compliance to the guideline recommendations in patients with nonvalvular atrial fibrillation (NVAF). Older patients who were on dabigatran treatment with good renal functions and low risk of bleeding were at risk of UT, whereas patients who were on rivaroxaban treatment with renal impairment and high risk of bleeding were at risk of OT. Therefore, a greater emphasis should be given to prescribe the recommended dose for the specified patients