Functional Social Support Moderates Stress on Depression in Individuals with CID during the COVID-19 Pandemic: A Two-Wave Study.

Depression is a common psychological experience for those living with a chronic illness and disease (CID). Social support (SS) can influence psychological health by regulating emotional functioning. The functional domain of SS refers to supportive exchange, including the emotional and instrumental functions. Public health measures during the COVID-19 pandemic include social distancing and isolation, which have impacted functional aspects of SS. The health risks of being isolated are comparable to the risks linked to obesity, blood pressure, and cigarette smoking. PURPOSE: To investigate the moderating effect of functional SS on the stress-depression relationship on individuals with CID during the COVID-19 pandemic. METHODS: Two waves of data were collected from a US sample: Apr. ’20: N = 321; Jun. ’20: N = 238. Participants completed the Patient Health Questionnaire–9 (depression symptoms), the Medical Outcomes Study–Social Support Survey–8 (perceived social support), and the Perceived Stress Scale–10 (perceived stress). For each wave of data, social support was entered as a moderator of the stress-depression relationship via multiple regression. RESULTS: The moderation models were estimated separately by wave. In the first wave, there was a negative but nonsignificant moderating effect (b = -0.19, p = .10) of social support on the stress-depression relationship (R2 = 51). In the second wave, the moderating relationship of social support doubled in magnitude (b = -0.30, p = .03, R2 = .57). During the COVID pandemic, functional social support weakened the association between stress and depression. CONCLUSION: Given the increased risk for social isolation and negative social exchange among people with CID during the COVID-19 pandemic, practitioners in rehabilitation psychology need to be informed about the potential implications of a lack of SS for the psychological health of the CID clients they work with. Drawing from the stress-buffering model and Lazarus et al.’s stress and coping theory (Lazarus, 1966; Lazarus & Folkman, 1984), our findings indicate that increased levels of perceived support can reduce the effects of stress on depression during the pandemic by contributing to fewer negative appraisals. Interventions targeting the particular functions of emotional (e.g., opportunities for emotional expression and venting) and instrumental (e.g., material aid) support could have immediate implications for facilitating rehabilitation outcomes (e.g., quality of life, interpersonal functioning, psychiatric symptomatology) during this public health crisis

Constraints on Supersymmetric Grand Unified Theories from Cosmology

Within the context of SUSY GUTs, cosmic strings are generically formed at the end of hybrid inflation. However, the WMAP CMB measurements strongly constrain the possible cosmic strings contribution to the angular power spectrum of anisotropies. We investigate the parameter space of SUSY hybrid (F- and D- term) inflation, to get the conditions under which theoretical predictions are in agreement with data. The predictions of F-term inflation are in agreement with data, only if the superpotential coupling $\kappa$ is small. In particular, for SUSY SO(10), the upper bound is \kappa\lsim 7\times 10^{-7}. This fine tuning problem can be lifted if we employ the curvaton mechanism, in which case \kappa\lsim 8\times 10^{-3}; higher values are not allowed by the gravitino constraint. The constraint on $\kappa$ is equivalent to a constraint on the SSB mass scale $M$, namely M \lsim 2\times 10^{15} GeV. The study of D-term inflation shows that the inflaton field is of the order of the Planck scale; one should therefore consider SUGRA. We find that the cosmic strings contribution to the CMB anisotropies is not constant, but it is strongly dependent on the gauge coupling $g$ and on the superpotential coupling $\lambda$. We obtain g\lsim 2\times 10^{-2} and \lambda \lsim 3\times 10^{-5}. SUGRA corrections induce also a lower limit for $\lambda$. Equivalently, the Fayet-Iliopoulos term $\xi$ must satisfy \sqrt\xi \lsim 2\times 10^{15} GeV. This constraint holds for all allowed values of $g$.Comment: 32 pages, 7 figures. To match published versio

Averaged Methods for Vortex-String Evolution

We discuss friction-dominated vortex-string evolution using a new analytic model recently developed by the authors. By treating the average string velocity, as well as the characteristic lengthscale, as dynamical variables, we can provide a quantitative picture of the complete evolution of a vortex-string network. Previously known scaling laws are confirmed, and new quantitative predictions regarding loop production and evolution are made.Comment: REVTeX, 21 pages, 23 .eps files included. Submitted to Phys. Rev. B. Minor changes---but some key concepts clarifie

The RadFxSat-2 Mission to Measure SEU Rates in FinFET Microelectronics

The RadFxSat-2 mission was launched January 17, 2021 with Virgin Orbit\u27s LauncherOne under the NASA ELaNa-20 initiative. RadFxSat-2 carries a radiation effects payload designed to investigate single event upsets (SEUs) in sub-65 nm commercial memories, including a FinFET-based memory. Sub-65 nm technologies have demonstrated enhanced sensitivity to low-energy protons, but current models have not considered low-energy protons as a source of SEUs. Missions utilizing the latest commercial technologies could experience a higher error rate than predicted. RadFxSat-2 was designed to assess SEU rates for FinFET SRAMs operated in low-Earth orbit (LEO), a proton-heavy environment. Details of the mission and data collected over the previous two years are presented. Results from RadFxSat-2 suggest that FinFET-based microelectronic technologies are suitable for high-performance, high-density storage in LEO

Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis

Wearable sensor technologies are essential to the realization of personalized medicine through continuously monitoring an individual’s state of health. Sampling human sweat, which is rich in physiological information, could enable non-invasive monitoring. Previously reported sweat-based and other non-invasive biosensors either can only monitor a single analyte at a time or lack on-site signal processing circuitry and sensor calibration mechanisms for accurate analysis of the physiological state. Given the complexity of sweat secretion, simultaneous and multiplexed screening of target biomarkers is critical and requires full system integration to ensure the accuracy of measurements. Here we present a mechanically flexible and fully integrated (that is, no external analysis is needed) sensor array for multiplexed in situ perspiration analysis, which simultaneously and selectively measures sweat metabolites (such as glucose and lactate) and electrolytes (such as sodium and potassium ions), as well as the skin temperature (to calibrate the response of the sensors). Our work bridges the technological gap between signal transduction, conditioning (amplification and filtering), processing and wireless transmission in wearable biosensors by merging plastic-based sensors that interface with the skin with silicon integrated circuits consolidated on a flexible circuit board for complex signal processing. This application could not have been realized using either of these technologies alone owing to their respective inherent limitations. The wearable system is used to measure the detailed sweat profile of human subjects engaged in prolonged indoor and outdoor physical activities, and to make a real-time assessment of the physiological state of the subjects. This platform enables a wide range of personalized diagnostic and physiological monitoring applications

The high-precision, charge-dependent Bonn nucleon-nucleon potential (CD-Bonn)

We present a charge-dependent nucleon-nucleon (NN) potential that fits the world proton-proton data below 350 MeV available in the year of 2000 with a chi^2 per datum of 1.01 for 2932 data and the corresponding neutron-proton data with chi^2/datum = 1.02 for 3058 data. This reproduction of the NN data is more accurate than by any phase-shift analysis and any other NN potential. The charge-dependence of the present potential (that has been dubbed `CD-Bonn') is based upon the predictions by the Bonn Full Model for charge-symmetry and charge-independence breaking in all partial waves with J <= 4. The potential is represented in terms of the covariant Feynman amplitudes for one-boson exchange which are nonlocal. Therefore, the off-shell behavior of the CD-Bonn potential differs in a characteristic and well-founded way from commonly used local potentials and leads to larger binding energies in nuclear few- and many-body systems, where underbinding is a persistent problem.Comment: 69 pages (RevTex) including 20 tables and 9 figures (ps files

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

Peer reviewe

Biological Case Against Downlisting the Whooping Crane and for Improving Implementation under the Endangered Species Act

The Whooping Crane (Grus americana; WHCR) is a large, long-lived bird endemic to North America. The remnant population migrates between Aransas National Wildlife Refuge, USA, and Wood Buffalo National Park, Canada (AWBP), and has recovered from a nadir of 15-16 birds in 1941 to ~540 birds in 2022. Two ongoing reintroduction efforts in Louisiana and the Eastern Flyway together total ~150 birds. Evidence indicates the U.S. Fish and Wildlife Service (USFWS) is strongly considering downlisting the species from an endangered to a threatened status under the Endangered Species Act (ESA). We examined the current status of the WHCR through the lens of ESA threat factors, the USFWS’s Species Status Assessment (SSA) framework, and other avian downlisting actions to determine if the action is biologically warranted. Our research indicates that WHCRs are facing an intensification of most threat drivers across populations and important ranges. The AWBP is still relatively small compared to other crane species and most birds of conservation concern. To date, only one avian species has been downlisted from an endangered status with an estimated population of \u3c3,000 individuals. Representation in terms of WHCRs historic genetic, geographic, and life history variation remains limited. Also, the lack of spatial connectivity among populations, reliance of the reintroduced populations on supplementation, and continued habitat loss suggest that WHCR populations may not be resilient to large stochastic disturbances. Given that reintroduced populations are not self-sustaining, neither supplies true redundancy for the AWBP. Proposed downlisting before recovery plan population criteria have been met is objectively unwarranted 3 and reflects USFWS inconsistency across ESA actions. Only by incorporating basic quantitative criteria and added oversight into ESA listing decisions can we avoid an action as misguided as downlisting the Whooping Crane without consideration of its recovery plan criteria or ostensibly its population ecology