2,244 research outputs found
The role of plant species in biomass production and response to elevated CO 2 and N
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72902/1/j.1461-0248.2003.00467.x.pd
Range contraction enables harvesting to extinction
Economic incentives to harvest a species usually diminish as its abundance
declines, because harvest costs increase. This prevents harvesting to
extinction. A known exception can occur if consumer demand causes a declining
species' harvest price to rise faster than costs. This threat may affect rare
and valuable species, such as large land mammals, sturgeons, and bluefin tunas.
We analyze a similar but underappreciated threat, which arises when the
geographic area (range) occupied by a species contracts as its abundance
declines. Range contractions maintain the local densities of declining
populations, which facilitates harvesting to extinction by preventing abundance
declines from causing harvest costs to rise. Factors causing such range
contractions include schooling, herding, or flocking behaviors--which,
ironically, can be predator-avoidance adaptations; patchy environments; habitat
loss; and climate change. We use a simple model to identify combinations of
range contractions and price increases capable of causing extinction from
profitable overharvesting, and we compare these to an empirical review. We find
that some aquatic species that school or forage in patchy environments
experience sufficiently severe range contractions as they decline to allow
profitable harvesting to extinction even with little or no price increase; and
some high-value declining aquatic species experience severe price increases.
For terrestrial species, the data needed to evaluate our theory are scarce, but
available evidence suggests that extinction-enabling range contractions may be
common among declining mammals and birds. Thus, factors causing range
contraction as abundance declines may pose unexpectedly large extinction risks
to harvested species.Comment: 25 pages total, 8 pages main text, 17 pages supporting informatio
How Acute and Chronic Alcohol Consumption Affects Brain Networks: Insights from Multimodal Neuroimaging
Background—
Multimodal imaging combining 2 or more techniques is becoming increasingly
important because no single imaging approach has the capacity to elucidate all clinically relevant
characteristics of a network.
Methods—
This review highlights recent advances in multimodal neuroimaging (i.e., combined
use and interpretation of data collected through magnetic resonance imaging [MRI], functional
MRI, diffusion tensor imaging, positron emission tomography, magnetoencephalography, MR
perfusion, and MR spectroscopy methods) that leads to a more comprehensive understanding of
how acute and chronic alcohol consumption affect neural networks underlying cognition, emotion,
reward processing, and drinking behavior.
Results—
Several innovative investigators have started utilizing multiple imaging approaches
within the same individual to better understand how alcohol influences brain systems, both during
intoxication and after years of chronic heavy use.
Conclusions—
Their findings can help identify mechanism-based therapeutic and
pharmacological treatment options, and they may increase the efficacy and cost effectiveness of
such treatments by predicting those at greatest risk for relapse
The recovery of plant community composition following passive restoration across spatial scales
Human impacts have led to dramatic biodiversity change which can be highly scale-dependent across space and time. A primary means to manage these changes is via passive (here, the removal of disturbance) or active (management interventions) ecological restoration. The recovery of biodiversity, following the removal of disturbance, is often incomplete relative to some kind of reference target. The magnitude of recovery of ecological systems following disturbance depends on the landscape matrix and many contingent factors. Inferences about recovery after disturbance and biodiversity change depend on the temporal and spatial scales at which biodiversity is measured. We measured the recovery of biodiversity and species composition over 33 years in 17 temperate grasslands abandoned after agriculture at different points in time, collectively forming a chronosequence since abandonment from 1 to 80 years. We compare these abandoned sites with known agricultural land-use histories to never-disturbed sites as relative benchmarks. We specifically measured aspects of diversity at the local plot-scale (α-scale, 0.5 m2) and site-scale (γ-scale, 10 m2), as well as the within-site heterogeneity (β-diversity) and among-site variation in species composition (turnover and nestedness). At our α-scale, sites recovering after agricultural abandonment only had 70% of the plant species richness (and ~30% of the evenness), compared to never-ploughed sites. Within-site β-diversity recovered following agricultural abandonment to around 90% after 80 years. This effect, however, was not enough to lead to recovery at our γ-scale. Richness in recovering sites was ~65% of that in remnant never-ploughed sites. The presence of species characteristic of the never-disturbed sites increased in the recovering sites through time. Forb and legume cover declines in years since abandonment, relative to graminoid cover across sites. Synthesis. We found that, during the 80 years after agricultural abandonment, old fields did not recover to the level of biodiversity in remnant never-ploughed sites at any scale. β-diversity recovered more than α-scale or γ-scale. Plant species composition recovered, but not completely, over time, and some species groups increased their cover more than others. Patterns of ecological recovery in degraded ecosystems across space and long time-scales can inform targeted active restoration interventions and perhaps, lead to better outcomes
Genomic transmission analysis of multidrug-resistant Gram-negative bacteria within a newborn unit of a Kenyan tertiary hospital: A four-month prospective colonization study
Objective:Â Multidrug-resistant organisms (MDRO), especially carbapenem-resistant organisms (CRO), represent a threat for newborns. This study investigates the colonization prevalence of these pathogens in a newborn unit at a Kenyan tertiary hospital in an integrated approach combining routine microbiology, whole genome sequencing (WGS) and hospital surveillance data.
Methods:Â The study was performed in the Kenyatta National Hospital (KNH) in 2019 over a four-month period and included 300 mother-baby pairs. A total of 1,097 swabs from newborns (weekly), mothers (once) and the hospital environment were taken. Routine clinical microbiology methods were applied for surveillance. Of the 288 detected MDRO, 160 isolates were analyzed for antimicrobial resistance genes and phylogenetic relatedness using whole genome sequencing (WGS) and bioinformatic analysis.
Results: In maternal vaginal swabs, MDRO detection rate was 15% (n=45/300), including 2% CRO (n=7/300). At admission, MDRO detection rate for neonates was 16% (n=48/300), including 3% CRO (n=8/300) with a threefold increase for MDRO (44%, n=97/218) and a fivefold increase for CRO (14%, n=29/218) until discharge. Among CRO, K. pneumoniae harboring blaNDM-1 (n=20) or blaNDM-5 (n=16) were most frequent. WGS analysis revealed 20 phylogenetically related transmission clusters (including five CRO clusters). In environmental samples, the MDRO detection rate was 11% (n=18/164), including 2% CRO (n=3/164).
Conclusion:Â Our study provides a snapshot of MDRO and CRO in a Kenyan NBU. Rather than a large outbreak scenario, data indicate several independent transmission events. The CRO rate among newborns attributed to the spread of NDM-type carbapenemases is worrisome
Clinical relevance of biomarkers of oxidative stress
SIGNIFICANCE
Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids. Recent Advances: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance.
CRITICAL ISSUES
The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use.
FUTURE DIRECTIONS
Several markers of oxidative stress still represent a viable biomarker opportunity for clinical use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker. Antioxid. Redox Signal. 00, 000-000
MadGraph/MadEvent v4: The New Web Generation
We present the latest developments of the MadGraph/MadEvent Monte Carlo event
generator and several applications to hadron collider physics. In the current
version events at the parton, hadron and detector level can be generated
directly from a web interface, for arbitrary processes in the Standard Model
and in several physics scenarios beyond it (HEFT, MSSM, 2HDM). The most
important additions are: a new framework for implementing user-defined new
physics models; a standalone running mode for creating and testing matrix
elements; generation of events corresponding to different processes, such as
signal(s) and backgrounds, in the same run; two platforms for data analysis,
where events are accessible at the parton, hadron and detector level; and the
generation of inclusive multi-jet samples by combining parton-level events with
parton showers. To illustrate the new capabilities of the package some
applications to hadron collider physics are presented:
1) Higgs search in pp \to H \to W^+W^-: signal and backgrounds.
2) Higgs CP properties: pp \to H jj$in the HEFT.
3) Spin of a new resonance from lepton angular distributions.
4) Single-top and Higgs associated production in a generic 2HDM.
5) Comparison of strong SUSY pair production at the SPS points.
6) Inclusive W+jets matched samples: comparison with the Tevatron data.Comment: 38 pages, 15 figure
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Range area matters, and so does spatial configuration: predicting conservation status in vertebrates
The current rapid loss of biodiversity globally calls for improved tools to predict conservation status. Conservation status varies among taxa and is influenced by intrinsic species’ traits and extrinsic factors. Among these predictors, the most consistently recognized and widely available is geographic range area. However, ranges of equal area can have diverse spatial configurations that reflect variation in threatening processes and species’ characteristics (e.g., dispersal ability), and can affect local and regional population dynamics. The aim of this study is to assess if and how the spatial configuration of a species’ range relates to its conservation status. We obtained range maps and two descriptors of conservation status: extinction risk and population trend, from the IUCN for 11,052 species of amphibians, non-marine birds, and terrestrial mammals distributed across the World. We characterized spatial configuration using descriptors of shape and fragmentation (fragment number and size heterogeneity) and used regression analysis to evaluate their role in explaining current extinction risk and population trend. The most important predictor of conservation status was range area, but our analyses also identified shape and fragmentation as valuable predictors. We detected complex relationships, revealed by multiple interaction terms, e.g. more circular shapes were negatively correlated with population trend, and heterogeneity was positively correlated with extinction risk for small range areas but negatively for bigger ranges. Considering descriptors of spatial configuration beyond size improves our understanding of conservation status among vertebrates. The metrics we propose are relatively easy to define (although values can be sensitive to data quality), and unlike other correlates of status, like species’ traits, are readily available for many species (all of those with range maps). We argue that considering spatial configuration predictors is a straightforward way to improve our capacity to predict conservation status and thus, can be useful to promote more effective conservation
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