The KdV/KP-I Limit of the Nonlinear Schrödinger Equation

International audienceWe justify rigorously the convergence of the amplitude of solutions of nonlinear Schrödinger-type equations with nonzero limit at infinity to an asymptotic regime governed by the Korteweg-de Vries (KdV) equation in dimension 1 and the Kadomtsev-Petviashvili I (KP-I) equation in dimensions 2 and greater. We get two types of results. In the one-dimensional case, we prove directly by energy bounds that there is no vortex formation for the global solution of the nonlinear Schrödinger equation in the energy space and deduce from this the convergence toward the unique solution in the energy space of the KdV equation. In arbitrary dimensions, we use a hydrodynamic reformulation of the nonlinear Schrödinger equation and recast the problem as a singular limit for a hyperbolic system. We thus prove that smooth H^s solutions exist on a time interval independent of the small parameter. We then pass to the limit by a compactness argument and obtain the KdV/KP-I equation

Las sentencias judiciales como herramienta para la restricción de derechos

El artículo tiene como objeto de análisis las sentencias como herramientas de restricción de derechos en materia de niñez, específicamente en lo que hace al dictado de penas perpetuas a jóvenes en conflicto con la ley penal. En efecto se analizan los avances y retrocesos en la jurisprudencia local a partir del fallo de la Corte Interamericana de Derechos Humanos “Mendoza y otros contra Argentina". En el apartado referente a los avances se realiza una breve reseña de los antecedentes Ledesma Reche y Arce de la Suprema Corte de Mendoza. Mientras que en el apartado referente a los retrocesos se hace un repaso del antecedente Maldonado de la Corte Suprema de Justicia de la Nación y el reciente fallo en la materia del Tribunal Supremo de Corrientes. En siguiente lugar se hace un examen del caso Fontevechia que fue utilizado por el Tribunal Supremo de Corrientes para fundamentar la sentencia. Finalmente se incluyen una serie de reflexiones.Fil: Rousset Siri, Andrés. Universidad Nacional de Cuyo. Facultad de DerechoFil: Rodriguez Infante, David. Universidad Nacional de Cuyo. Facultad de Derech

Uncertainty-sensitive reasoning for inferring sameAs facts in linked data

albakri2016aInternational audienceDiscovering whether or not two URIs described in Linked Data -- in the same or different RDF datasets -- refer to the same real-world entity is crucial for building applications that exploit the cross-referencing of open data. A major challenge in data interlinking is to design tools that effectively deal with incomplete and noisy data, and exploit uncertain knowledge. In this paper, we model data interlinking as a reasoning problem with uncertainty. We introduce a probabilistic framework for modelling and reasoning over uncertain RDF facts and rules that is based on the semantics of probabilistic Datalog. We have designed an algorithm, ProbFR, based on this framework. Experiments on real-world datasets have shown the usefulness and effectiveness of our approach for data linkage and disambiguation

Addressing the pain-points of single-use intensified multi-product downstream and liquid processing in a dancefloor production room layout

The sales of biologics will reach over $300 billion in 2020 and the market continues to have accelerated double-digit growth under the COVID-19 burden, thus biopharmaceutical companies continue to pipeline biologics for a mounting global patient base. Nevertheless, biologics are changing and the needs of their manufacturing are changing with them. Emerging biologics (e.g., antibody–drug conjugates, viral vectors, mRNA, bi/multi-specifics) are coming with complex or lean manufacturing requirements. Additionally, the global market is searching for more affordable & sustainable biologics and biosimilars, creating an increasingly competitive space within the emerging countries who seek to manufacture locally. The BioPhorum Operations Group (BPOG), a cross-industry organization of biopharmaceutical end users and suppliers collected biopharmaceutical industry drivers stating; - 90% reduction in capital expenditure (CAPEX) and manufacturing costs in the next decade. - reduce product changeover times by 90% to improve responses to variability in demand - drive down new facility build times by 70% The question is, how does this translate to actionable and prioritized points of improvement for a biological implementer & supplier to work on? With this general need in mind, combining Design Thinking methodology and insights from single-use biological manufacturing users were gathered through an extended survey with key biopharma industry companies and institutes representing the various user groups. All interviewee responses were populated, to enable the categorization and sorting of distinct user perceptions of likes, pain-points, and benefits. The outcome of the survey was thestarting point to define what are the critical components for a sustainable technology roadmap to address the needs for the rapidly intensifying biologics manufacturing market. In the presented work will be an overview of these validated pain-points, an explanation of the corresponding technology characteristic which address the underlying user need and a journey along the downstream purification steps. The format will be interactive with feedback questions and presentation of anonymous answers from the audience. The presentation will finish with concluding remarks on how sustainable single use processing could benefit the manufacturing of biologics

Extragalactic Fields Optimized for Adaptive Optics

In this paper we present the coordinates of 67 55' x 55' patches of sky which have the rare combination of both high stellar surface density (>0.5 arcmin^{-2} with 13<R<16.5 mag) and low extinction (E(B-V)<0.1). These fields are ideal for adaptive-optics based follow-up of extragalactic targets. One region of sky, situated near Baade's Window, contains most of the patches we have identified. Our optimal field, centered at RA: 7h24m3s, Dec: -1deg27'15", has an additional advantage of being accessible from both hemispheres. We propose a figure of merit for quantifying real-world adaptive optics performance, and use this to analyze the performance of multi-conjugate adaptive optics in these fields. We also compare our results to those that would be obtained in existing deep fields. In some cases adaptive optics observations undertaken in the fields given in this paper would be orders of magnitude more efficient than equivalent observations undertaken in existing deep fields.Comment: 28 pages, 15 figures, 1 table; accepted for publication in PAS

Combined Thoracic Ultrasound Assessment during a Successful Weaning Trial Predicts Postextubation Distress

International audienceBackground: Recent studies suggest that isolated sonographic assessment of the respiratory, cardiac, or neuromuscular functions in mechanically ventilated patients may assist in identifying patients at risk of postextubation distress. The aim of the present study was to prospectively investigate the value of an integrated thoracic ultrasound evaluation, encompassing bedside respiratory, cardiac, and diaphragm sonographic data in predicting postextubation distress.Methods: Longitudinal ultrasound data from 136 patients who were extubated after passing a trial of pressure support ventilation were measured immediately after the start and at the end of this trial. In case of postextubation distress (31 of 136 patients), an additional combined ultrasound assessment was performed while the patient was still in acute respiratory failure. We applied machine-learning methods to improve the accuracy of the related predictive assessments.Results: Overall, integrated thoracic ultrasound models accurately predict postextubation distress when applied to thoracic ultrasound data immediately recorded before the start and at the end of the trial of pressure support ventilation (learning sample area under the curve: start, 0.921; end, 0.951; test sample area under the curve: start, 0.972; end, 0.920). Among integrated thoracic ultrasound data, the recognition of lung interstitial edema and the increased telediastolic left ventricular pressure were the most relevant predictive factors. In addition, the use of thoracic ultrasound appeared to be highly accurate in identifying the causes of postextubation distress.Conclusions: The decision to attempt extubation could be significantly assisted by an integrative, dynamic, and fully bedside ultrasonographic assessment of cardiac, lung, and diaphragm functio

TSF Experiment for comparision of high Reynold's number turbulence in He I and He II : first results

International audienceSuperfluid turbulence (TSF) project uses liquid helium for the fundamental study of turbulent phenomena behind a passive grid and is able to work both in HeI and in HeII. Local and semi-local instrumentation was developed specifically for the purpose of this experiment(e.g. sub-micrometer anemometer, total head pressure tube and second sound tweezer). The difficulties encountered with this local and fragile instrumentation are discussed. Global characterization of the flow is presented including velocity, pressure, temperature stability and turbulence intensity. Finally, first results obtained with semi local measurements (total head pressure tube and second sound tweezer) both in the two phases of helium are presented

Molecular techniques reveal cryptic life history and demographic processes of a critically endangered marine turtle

The concept of ‘effective population size’ (Ne), which quantifies how quickly a population will lose genetic variability, is one of the most important contributions of theoretical evolutionary biology to practical conservation management. Ne is often much lower than actual population size: how much so depends on key life history and demographic parameters, such as mating systems and population connectivity, that often remain unknown for species of conservation concern. Molecular techniques allow the indirect study of these parameters, as well as the estimation of current and historical Ne. Here, we use genotyping to assess the genetic health of an important population of the critically endangered hawksbill turtle (Eretmochelys imbricata), a slow-to-mature, difficult-to-observe species with a long history of severe overhunting. Our results were surprisingly positive: we found that the study population, located in the Republic of Seychelles, Indian Ocean, has a relatively large Ne, estimated to exceed 1000, and showed no evidence of a recent reduction in Ne (i.e. no genetic bottleneck). Furthermore, molecular inferences suggest the species' mating system is conducive to maintaining a large Ne, with a relatively large and widely distributed male population promoting considerable gene flow amongst nesting sites across the Seychelles area. This may also be reinforced by the movement of females between nesting sites. Our study underlines how molecular techniques can help to inform conservation biology. In this case our results suggest that this important hawksbill population is starting from a relatively strong position as it faces new challenges, such as global climate change

Preliminary genetic evidence of two different populations of Opisthorchis viverrini in Lao PDR

Opisthorchis viverrini is a major public health concern in Southeast Asia. Various reports have suggested that this parasite may represent a species complex, with genetic structure in the region perhaps being dictated by geographical factors and different species of intermediate hosts. We used four microsatellite loci to analyze O. viverrini adult worms originating from six species of cyprinid fish in Thailand and Lao PDR. Two distinct O. viverrini populations were observed. In Ban Phai, Thailand, only one subgroup occurred, hosted by two different fish species. Both subgroups occurred in fish from That Luang, Lao PDR, but were represented to very different degrees among the fish hosts there. Our data suggest that, although geographical separation is more important than fish host specificity in influencing genetic structure, it is possible that two species of Opisthorchis, with little interbreeding, are present near Vientiane in Lao PDR