1,719 research outputs found
An acute bout of cycling does not induce compensatory responses in pre-menopausal women not using hormonal contraceptives
There is a clear need to improve understanding of the effects of physical activity and exercise on appetite control. Therefore, the acute and short-term effects (three days) of a single bout of cycling on energy intake and energy expenditure were examined in women not using hormonal contraceptives. Sixteen active (n = 8) and inactive (n = 8) healthy pre-menopausal women completed a randomised crossover design study with two conditions (exercise and control). The exercise day involved cycling for 1 h (50% of maximum oxygen uptake) and resting for 2 h, whilst the control day comprised 3 h of rest. On each experimental day participants arrived at the laboratory fasted, consumed a standardised breakfast and an ad libitum pasta lunch. Food diaries and combined heart rate-accelerometer monitors were used to assess free-living food intake and energy expenditure, respectively, over the subsequent three days. There were no main effects or condition (exercise vs control) by group (active vs inactive) interaction for absolute energy intake (P > 0.05) at the ad libitum laboratory lunch meal, but there was a condition effect for relative energy intake (P = 0.004, ηp2 = 0.46) that was lower in the exercise condition (1417 ± 926 kJ vs. 2120 ± 923 kJ). Furthermore, post-breakfast satiety was higher in the active than in the inactive group (P = 0.005, ηp2 = 0.44). There were no main effects or interactions (P > 0.05) for mean daily energy intake, but both active and inactive groups consumed less energy from protein (14 ± 3% vs. 16 ± 4%, P = 0.016, ηp2 = 0.37) and more from carbohydrate (53 ± 5% vs. 49 ± 7%, P = 0.031, ηp2 = 0.31) following the exercise condition. This study suggests that an acute bout of cycling does not induce compensatory responses in active and inactive women not using hormonal contraceptives, while the stronger satiety response to the standardised breakfast meal in active individuals adds to the growing literature that physical activity helps improve the sensitivity of short-term appetite control
Reverse engineering of logic-based differential equation models using a mixed-integer dynamic optimization approach
9 páginas, 6 figuras.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution LicenseMotivation: Systems biology models can be used to test new hypotheses formulated on the basis of previous knowledge or new experimental data, contradictory with a previously existing model. New hypotheses often come in the shape of a set of possible regulatory mechanisms. This search is usually not limited to finding a single regulation link, but rather a combination of links subject to great uncertainty or no information about the kinetic parameters.
Results: In this work, we combine a logic-based formalism, to describe all the possible regulatory structures for a given dynamic model of a pathway, with mixed-integer dynamic optimization (MIDO). This framework aims to simultaneously identify the regulatory structure (represented by binary parameters) and the real-valued parameters that are consistent with the available experimental data, resulting in a logic-based differential equation model. The alternative to this would be to perform real-valued parameter estimation for each possible model structure, which is not tractable for models of the size presented in this work. The performance of the method presented here is illustrated with several case studies: a synthetic pathway problem of signaling regulation, a two-component signal transduction pathway in bacterial homeostasis, and a signaling network in liver cancer cellsD.H., J.R.B. and J.S.R. acknowledge funding from the EU FP7 projects
‘NICHE’ (ITN Grant number 289384) and ‘BioPreDyn’ (KBBE grant number
289434). J.R.B. also acknowledges funding from the Spanish Ministerio de
EconomÃa y Competitividad (and the FEDER) through the project
MultiScales (DPI2011-28112-C04-03).Peer reviewe
Quantitative adsorbate structure determination under catalytic reaction conditions
Current methods allow quantitative local structure determination of adsorbate geometries on surfaces in ultrahigh vacuum (UHV) but are incompatible with the higher pressures required for a steady-state catalytic reactions. Here we show that photoelectron diffraction can be used to determine the structure of the methoxy and formate reaction intermediates during the steady-state oxidation of methanol over Cu(110) by taking advantage of recent instrumental developments to allow near-ambient pressure x-ray photoelectron spectroscopy. The local methoxy site differs from that under static UHV conditions, attributed to the increased surface mobility and dynamic nature of the surface under reaction conditions
Small-Angle CMB Temperature Anisotropies Induced by Cosmic Strings
We use Nambu-Goto numerical simulations to compute the cosmic microwave
background (CMB) temperature anisotropies induced at arcminute angular scales
by a network of cosmic strings in a Friedmann-Lemaitre-Robertson-Walker (FLRW)
expanding universe. We generate 84 statistically independent maps on a 7.2
degree field of view, which we use to derive basic statistical estimators such
as the one-point distribution and two-point correlation functions. At high
multipoles, the mean angular power spectrum of string-induced CMB temperature
anisotropies can be described by a power law slowly decaying as \ell^{-p}, with
p=0.889 (+0.001,-0.090) (including only systematic errors). Such a behavior
suggests that a nonvanishing string contribution to the overall CMB
anisotropies may become the dominant source of fluctuations at small angular
scales. We therefore discuss how well the temperature gradient magnitude
operator can trace strings in the context of a typical arcminute
diffraction-limited experiment. Including both the thermal and nonlinear
kinetic Sunyaev-Zel'dovich effects, the Ostriker-Vishniac effect, and the
currently favored adiabatic primary anisotropies, we find that, on such a map,
strings should be ``eye visible,'' with at least of order ten distinctive
string features observable on a 7.2 degree gradient map, for tensions U down to
GU \simeq 2 x 10^{-7} (in Planck units). This suggests that, with upcoming
experiments such as the Atacama Cosmology Telescope (ACT), optimal
non-Gaussian, string-devoted statistical estimators applied to small-angle CMB
temperature or gradient maps may put stringent constraints on a possible cosmic
string contribution to the CMB anisotropies.Comment: 17 pages, 9 figures. v2: matches published version, minor
clarifications added, typo in Eq. (8) fixed, results unchange
Exploring Halo Substructure with Giant Stars: Spectroscopy of Stars in the Galactic Anticenter Stellar Structure
To determine the nature of the recently discovered, ring-like stellar
structure at the Galactic anticenter, we have collected spectra of a set of
presumed constituent M giants selected from the 2MASS point source catalog.
Radial velocities have been obtained for stars spanning ~100 degrees,
exhibiting a trend in velocity with Galactic longitude and an estimated
dispersion of 20 +/- 4 km/sec. A mean metallicity [Fe/H] = -0.4 +/- 0.3
measured for these stars combines with previous evidence from the literature to
suggest a population with a significant metallicity spread. In addition, a
curious alignment of at least four globular clusters of lower mean metallicity
is noted to be spatially and kinematically consistent with this stellar
distribution. We interpret the M giant sample position and velocity variation
with Galactic longitude as suggestive of a satellite galaxy currently
undergoing tidal disruption in a non-circular, prograde orbit about the Milky
Way.Comment: (1) University of Virginia, 4 pages, 3 figures, accepted for
publication in The Astrophysical Journal Letter
Structure-Dependent Fluorescence Efficiencies of Individual Single-Walled Carbon Nanotubes
Single-nanotube photometry was used to measure the product of absorption
cross-section and fluorescence quantum yield for 12 (n,m) structural species of
semiconducting SWNTs in aqueous SDBS suspension. These products ranged from 1.7
to 4.5 x 10(-19) cm2/C atom, generally increasing with optical band gap as
described by the energy gap law. The findings suggest fluorescent quantum
yields of ~8% for the brightest, (10,2) species and introduce the empirical
calibration factors needed to deduce quantitative (n,m) distributions from bulk
fluorimetric intensities
Selection and photometric properties of K+A galaxies
Two different simple measurements of galaxy star formation rate with
different timescales are compared empirically on fiber spectra of
galaxies with mag taken from the Sloan Digital Sky Survey in the
redshift range : a ratio \Aamp / \Kamp found by fitting a linear
sum of an average old stellar poplulation spectrum (\Kamp) and average A-star
spectrum (\Aamp) to the galaxy spectrum, and the equivalent width (EW) of the
\Halpha emission line. The two measures are strongly correlated, but there is
a small clearly separated population of outliers from the median correlation
that display excess \Aamp /\Kamp relative to \Halpha EW. These ``K+A'' (or
``E+A'') galaxies must have dramatically decreased their star-formation rates
over the last Gyr. The K+A luminosity distribution is very similar to
that of the total galaxy population. The K+A population appears to be
bulge-dominated, but bluer and higher surface-brightness than normal
bulge-dominated galaxies; it appears that K+A galaxies will fade with time into
normal bulge-dominated galaxies. The inferred rate density for K+A galaxy
formation is at redshift .
These events are taking place in the field; K+A galaxies don't primarily lie in
the high-density environments or clusters typical of bulge-dominated
populations.Comment: submitted to Ap
Dark spinor models in gravitation and cosmology
We introduce and carefully define an entire class of field theories based on
non-standard spinors. Their dominant interaction is via the gravitational field
which makes them naturally dark; we refer to them as Dark Spinors. We provide a
critical analysis of previous proposals for dark spinors noting that they
violate Lorentz invariance. As a working assumption we restrict our analysis to
non-standard spinors which preserve Lorentz invariance, whilst being non-local
and explicitly construct such a theory. We construct the complete
energy-momentum tensor and derive its components explicitly by assuming a
specific projection operator. It is natural to next consider dark spinors in a
cosmological setting. We find various interesting solutions where the spinor
field leads to slow roll and fast roll de Sitter solutions. We also analyse
models where the spinor is coupled conformally to gravity, and consider the
perturbations and stability of the spinor.Comment: 43 pages. Several new sections and details added. JHEP in prin
- …