Amniotic fluid volume: Rapid MR-based assessment at 28-32 weeks gestation

Objectives: This work evaluates rapid magnetic resonance projection hydrography (PH) based amniotic fluid volume (AFV) estimates against established routine ultrasound single deepest vertical pocket (SDVP) and amniotic fluid index (AFI) measurements, in utero, at 28-32 weeks gestation. Manual multi-section planimetry (MSP) based measurement of AFV is used as a proxy reference standard. Methods: 35 women with a healthy singleton pregnancy (20-41 years) attending routine antenatal ultrasound were recruited. SDVP and AFI were measured using ultrasound, with same day MRI assessing AFV with PH and MSP. The relationships between the respective techniques were assessed using linear regression analysis and Bland-Altman method comparison statistics. Results: When comparing estimated AFV, a highly significant relationship was observed between PH and the reference standard MSP (R2=0.802, p<0.001). For the US measurements, SDVP measurement related most closely to amniotic fluid volume, (R2=0.470, p<0.001), with AFI demonstrating a weaker relationship (R2=0.208, p=0.007). Conclusion: This study shows that rapid MRI based PH measurement is a better predictor of AFV, relating more closely to our proxy standard than established US techniques. Although larger validation studies across a range of gestational ages are required this approach could form part of MR fetal assessment, particularly where poly or oligohydramnios is suspected.This study was supported by the National Institute of Health Research, Cambridge Biomedical Research Centre. The authors also acknowledge the support of Addenbrooke’s Charitable Trust and thank the participants for their contribution to the study.This is the author accepted manuscript. The final version is available from Springer via http://dx.doi.org/10.1007/s00330-015-4179-

The Four Regions in Settlement Space: A Game-Theoretical Approach to Investment Treaty Arbitration Part II: Cases

Following from Part I of this paper, which introduced the notion of decision-modelling for investor-state arbitration, Part II of the paper uses the game theoretic notions developed in Part I to explore the question of why a relatively large fraction of investor-state disputes proceed to arbitration tribunals. Likely explanations are advanced. The detailed mathematical model derived in Part I of the paper is then used to analyse 31 cases where an investor-state dispute has been judged by an arbitration tribunal. Auxiliary mathematics are developed to identify the relevant averages and variances, which are then calculated from the full data set. Three sample cases are analysed in greater detail, with the model results being compared against the actual awards. It is concluded that applying the mathematical model of the international arbitration process developed in Part I together with the data analysis laid out in Part II will provide useful insight and guidance to both parties involved or likely to be involved in a dispute between investor and state

Quantitative BOLD imaging at 3T: Temporal changes in hepatocellular carcinoma and fibrosis following oxygen challenge.

PURPOSE: To evaluate the utility of oxygen challenge and report on temporal changes in blood oxygenation level-dependent (BOLD) contrast in normal liver, hepatocellular carcinoma (HCC) and background fibrosis. MATERIALS AND METHODS: Eleven volunteers (nine male and two female, mean age 33.5, range 27-41 years) and 10 patients (nine male and one female, mean age 68.9, range 56-87 years) with hepatocellular carcinoma on a background of diffuse liver disease were recruited. Imaging was performed on a 3T system using a multiphase, multiecho, fast gradient echo sequence. Oxygen was administered via a Hudson mask after 2 minutes of free-breathing. Paired t-tests were performed to determine if the mean pre- and post-O2 differences were statistically significant. RESULTS: In patients with liver fibrosis (n = 8) the change in T2* following O2 administration was elevated (0.88 ± 0.582 msec, range 0.03-1.69 msec) and the difference was significant (P = 0.004). The magnitude of the BOLD response in patients with HCC (n = 10) was larger, however the response was more variable (1.07 ± 1.458 msec, range -0.93-3.26 msec), and the difference was borderline significant (P = 0.046). The BOLD response in the volunteer cohort was not significant (P = 0.121, 0.59 ± 1.162 msec, range -0.81-2.44 msec). CONCLUSION: This work demonstrates that the BOLD response following oxygen challenge within cirrhotic liver is consistent with a breakdown in vascular autoregulatory mechanisms. Similarly, the elevated BOLD response within HCC is consistent with the abnormal capillary vasculature within tumors and the arterialization of the blood supply. Our results suggest that oxygen challenge may prove a viable BOLD contrast mechanism in the liver. J. Magn. Reson. Imaging 2016;44:739-744.This study was supported by the Addenbrooke’s Charitable Trust, Cambridge’s Experimental Cancer Medicine Centre and a NIHR comprehensive Biomedical Research Centre award to Cambridge University Hospitals NHS Foundation Trust in partnership with the University of Cambridge.This is the final version of the article. It first appeared from Wiley via https://doi.org/10.1002/jmri.2518

Characteristics and Evolution of the Magnetic field and Chromospheric Emission in an Active Region Core Observed by Hinode

We describe the characteristics and evolution of the magnetic field and chromospheric emission in an active region core observed by the Solar Optical Telescope on Hinode. Consistent with previous studies, we find that the moss is unipolar, the spatial distribution of magnetic flux evolves slowly, and the magnetic field is only moderately inclined. We show that the field line inclination and horizontal component are coherent, and that the magnetic field is mostly sheared in the inter-moss regions where the highest magnetic flux variability is seen. Using extrapolations from SP magnetograms we show that the magnetic connectivity in the moss is different than in the quiet Sun because most of the magnetic field extends to significant coronal heights. The magnetic flux, field vector, and chromospheric emission in the moss also appear highly dynamic, but actually show only small scale variations in magnitude on time-scales longer than the cooling times for hydrodynamic loops computed from our extrapolations, suggesting high-frequency (continuous) heating events. Some evidence is found for flux (Ca 2 intensity) changes on the order of 100--200 G (DN) on time-scales of 20--30 mins that could be taken as indicative of low-frequency heating. We find, however, that only a small fraction (10%) of our simulated loops would be expected to cool on these time-scales, and we find no clear evidence that the flux changes consistently produce intensity changes in the chromosphere. The magnetic flux and chromospheric intensity in most individual SOT pixels in the moss vary by less than ~ 20% and ~ 10%, respectively, on loop cooling time-scales. In view of the high energy requirements of the chromosphere, we suggest that these variations could be sufficient for the heating of `warm' EUV loops, but that the high basal levels may be more important for powering the hot core loops rooted in the moss.Comment: Accepted by ApJ, 16 pages, 20 figures. Abridged abstract (original is in PDF file). Figures 1 & 2 are reduced resolution to meet size limit

What is a Paraconsistent Logic?

Paraconsistent logics are logical systems that reject the classical principle, usually dubbed Explosion, that a contradiction implies everything. However, the received view about paraconsistency focuses only the inferential version of Explosion, which is concerned with formulae, thereby overlooking other possible accounts. In this paper, we propose to focus, additionally, on a meta-inferential version of Explosion, i.e. which is concerned with inferences or sequents. In doing so, we will offer a new characterization of paraconsistency by means of which a logic is paraconsistent if it invalidates either the inferential or the meta-inferential notion of Explosion. We show the non-triviality of this criterion by discussing a number of logics. On the one hand, logics which validate and invalidate both versions of Explosion, such as classical logic and Asenjo–Priest’s 3-valued logic LP. On the other hand, logics which validate one version of Explosion but not the other, such as the substructural logics TS and ST, introduced by Malinowski and Cobreros, Egré, Ripley and van Rooij, which are obtained via Malinowski’s and Frankowski’s q- and p-matrices, respectively

Effect of monthly vitamin D3 supplementation in healthy adults on adverse effects of earthquakes: randomised controlled trial

Objective: To determine whether supplementation with vitamin D improves resilience to the adverse effects of earthquakes. Design: Opportunistic addition to an established randomised double blind placebo controlled trial. Setting: Christchurch, New Zealand, where a prolonged series of catastrophic earthquakes beginning on 4 September 2010 occurred, which caused widespread destruction, fatalities, and extensive psychological damage. Participants: 322 healthy adults (241 women; 81 men) aged 18-67 who were already participating in the vitamin D and acute respiratory infections study (VIDARIS) between February 2010 and November 2011. Intervention Participants were randomised to receive an oral dose of either 200 000 IU vitamin D3 monthly for two months then 100 000 IU monthly (n=161) or placebo (n=161) for a total of 18 months. Main outcome measure This is a post hoc analysis from the previously published VIDARIS trial. The primary endpoint in the current analysis was the self reported effects and overall adverse impact of the Christchurch earthquakes as assessed by questionnaire four months after the most destructive earthquake on 22 February 2011, which was used as the index event. The secondary end point was the number of “psychological” adverse events that participants reported at their usual monthly appointments as part of the original VIDARIS trial. Results: 308 participants completed the earthquake impact questionnaire (n=152 in the vitamin D group and 156 in the placebo group). There was no significant difference in the number of self reported adverse effects between those receiving vitamin D supplementation and those receiving placebo. There was also no difference in the overall adverse impact score between treatment groups (χ2 P=0.44). The exception was that those in the vitamin D group experienced more adverse effects on family relationships (22% v 13%; χ2 P=0.03). The number of psychological adverse events—such as fatigue, stress, anxiety, and insomnia—that participants reported at their usual monthly appointments was significantly higher after the earthquake (χ2 P=0.007) but did not differ between treatment groups. Conclusion: In this trial, vitamin D supplementation did not reduce the adverse impact of earthquakes in healthy adults. Trial registration Australian New Zealand Clinical Trials Registry (anzctr.org.au) ACTRN1260900048622

Development and Application of Comparative Gene Co-expression Network Methods in Brachypodium distachyon

Gene discovery and characterization is a long and labor-intensive process. Gene co-expression network analysis is a long-standing powerful approach that can strongly enrich signals within gene expression datasets to predict genes critical for many cellular functions. Leveraging this approach with a large number of transcriptome datasets does not yield a concomitant increase in network granularity. Independently generated datasets that describe gene expression in various tissues, developmental stages, times of day, and environments can carry conflicting co-expression signals. The gene expression responses of the model C3 grass Brachypodium distachyon to abiotic stress is characterized by a co-expression-based analysis, identifying 22 modules of genes, annotated with putative DNA regulatory elements and functional terms. A great deal of co-expression elasticity is found among the genes characterized therein. An algorithm, dGCNA, designed to determine statistically significant changes in gene-gene co-expression relationships is presented. The algorithm is demonstrated on the very well-characterized circadian system of Arabidopsis thaliana, and identifies potential strong signals of molecular interactions between a specific transcription factor and putative target gene loci. Lastly, this network comparison approach based on edge-wise similarities is demonstrated on many pairwise comparisons of independent microarray datasets, to demonstrate the utility of fine-grained network comparison, rather than amassing as large a dataset as possible. This approach identifies a set of 182 gene loci which are differentially expressed under drought stress, change their co-expression strongly under loss of thermocycles or high-salinity stress, and are associated with cell-cycle and DNA replication functions. This set of genes provides excellent candidates for the generation of rhythmic growth under thermocycles in Brachypodium distachyon

Characteristics and effects of motivational music in exercise

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The research programme had three principal objectives. First, the evaluation and extension of the extant conceptual framework pertaining to motivational music in exercise settings. Second, the development of a valid instrument for assessing the motivational qualities of music: The Brunel Music Rating Inventory-2 (BMRI-2). Third, to test the effects of motivational and oudeterous (lacking in both motivational and de-motivational qualities) music in an externally-valid setting. These objectives were addressed through 4 studies. First, a series of open-ended interviews were conducted with exercise leaders and participants (N = 13), in order to investigate the characteristics and effects of motivational music in the exercise setting. The data were content analysed to abstract thematic categories of response. These categories were subsequently evaluated in the context of relevant conceptual frameworks. Subsequently, a sample of 532 health-club members responded to a questionnaire that was designed to assess the perceived characteristics of motivational music. The responses were analysed across age groups, gender, frequency of attendance (low, medium, high), and time of attendance (morning, afternoon, evening). The BMRI-2 was developed in order to address psychometric weaknesses that were associated with its forbear, the BMRI. A refined item pool was created which yielded an 8-item instrument that was subjected to confirmatory factor analysis. A single-factor model demonstrated acceptable fit indices across three different pieces of music, two samples of exercise participants, and both sexes. The BMRI-2 was used to select 20 pieces of motivational music, which were delivered in a health club gymnasium. It was found that health club members (N = 112) exercised for longer under the condition of motivational music as opposed to oudeterous music (the club’s typical output); however, no differences were noted in terms of affective response. (Jun 2004)David Lloyd Leisure (part of Whitbread PLC

Redesign and initial validation of an instrument to assess the motivational qualities of music in exercise: The Brunel Music Rating Inventory-2

In the present study, a measure to assess the motivational qualities of music in exercise was redesigned, extending previous research efforts (Karageorghis et al., 1999). The original measure, the Brunel Music Rating Inventory (BMRI), had shown limitations in its factor structure and its applicability to non-experts in music selection. Redesign of the BMRI used in-depth interviews with eight participants (mean age 31.9 years, s¼8.9 years) to establish the initial item pool, which was examined using a series of confirmatory factor analyses. A single-factor model provided a good fit across three musical selections with different motivational qualities (comparative fit index, CFI: 0.95 – 0.98; standardized root mean residual, SRMR: 0.03 – 0.05). The single-factor model also demonstrated acceptable fit across two independent samples and both sexes using one piece of music (CFI: 0.86 – 1.00; SRMR: 0.04 – 0.07). The BMRI was designed for experts in selecting music for exercise (e.g. dance aerobic instructors), whereas the BMRI-2 can be used both by exercise instructors and participants. The psychometric properties of the BMRI-2 are stronger than those of the BMRI and it is easier to use. The BMRI-2 provides a valid and internally consistent tool by which music can be selected to accompany a bout of exercise or a training session. Furthermore, the BMRI-2 enables researchers to standardize music in experimental protocols involving exercise-related tasks

Observations and Interpretation of a Low Coronal Shock Wave Observed in the EUV by the SDO/AIA

Taking advantage of both the high temporal and spatial resolution of the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO), we studied a limb coronal shock wave and its associated extreme ultraviolet (EUV) wave that occurred on 2010 June 13. Our main findings are (1) the shock wave appeared clearly only in the channels centered at 193 \AA and 211 \AA as a dome-like enhancement propagating ahead of its associated semi-spherical CME bubble; (2) the density compression of the shock is 1.56 according to radio data and the temperature of the shockis around 2.8 MK; (3) the shock wave first appeared at 05:38 UT, 2 minutes after the associated flare has started and 1 minute after its associated CME bubble appeared;(4) the top of the dome-like shock wave set out from about 1.23 R\odot and the thickness of the shocked layer is ~ 2\times10^4 km; (5) the speed of the shock wave is consistent with a slight decrease from about 600 km/s to 550 km/s; (6) the lateral expansion of the shock wave suggests a constant speed around 400 km/s, which varies at different heights and directions. Our findings support the view that the coronal shock wave is driven by the CME bubble, and the on-limb EUV wave is consistent with a fast wave or at least includes the fast wave component.Comment: 24 pages,8 Figures and 6 movies. It is scheduled for publication on the Astrophysical Journal on the August 1, 2011, Issue 736 -