Second-Order Multifunction Filter with Fully Differential Current Follower

Abstract This paper describes the design of a multifunction biquad filter that can provide multiple transfer functions according to the input and output current ports selected. The filter design is based on a general circuit with five passive elements (three of them are grounded) and one fully differential current follower. This versatile building block is ready to be manufactured by the ON Semiconductor Company and is expected to have impedance and transfer parameters close to the ideal ones in a wide frequency range. The functionality of the filter designed was verified by computer simulation and experimental measurement. The influence of real properties of the active element on the filter characteristics was ascertained

Optimized fractional-order Butterworth filter design in complex F-plane

This paper introduces a new technique to optimally design the fractional-order Butterworth low-pass filter in the complex F-plane. Design stability is assured by incorporating the critical phase angle as an inequality constraint. The poles of the proposed approximants reside on the unit circle in the stable region of the F-plane. The improved accuracy of the suggested scheme as compared to the recently published literature is demonstrated. A mixed-integer genetic algorithm which considers the parallel combinations of resistors and capacitors for the Valsa network is used to optimize the frequency responses of the fractional-order capacitor emulators as part of the experimental verification using the Sallen–Key filter topology. The total harmonic distortion and spurious-free dynamic range of the practical 1.5th-order Butterwoth filter are measured as 0.13% and 62.18 dBc, respectively; the maximum and mean absolute relative magnitude errors are 0.03929 and 0.02051, respectively.Publisher's VersionQ1WOS:00085474580000

Tunable Fiber‐Cavity Enhanced Photon Emission from Defect Centers in hBN

Realization of quantum photonic devices requires coupling single quantum emitters to the mode of optical resonators. In this work, a hybrid system consisting of defect centers in few-layer hexagonal boron nitride (hBN) grown by chemical vapor deposition and a fiber-based Fabry–Pérot cavity is presented. The sub 10-nm thickness of hBN and its smooth surface enable efficient integration into the cavity mode. This hybrid platform is operated over a broad spectral range larger than 30 nm and its tuneability is used to explore different coupling regimes. Consequently, very large cavity-assisted signal enhancement up to 50-fold and strongly narrowed linewidths are achieved, which is owing to cavity funneling, a record for hBN-cavity systems. Additionally, an excitation and readout scheme is implemented for resonant excitation that allows to establish cavity-assisted photoluminescence excitation (PLE) spectroscopy. This work marks an important milestone for the deployment of 2D materials coupled to fiber-based cavities in practical quantum technologies

A Diamond-Photonics Platform Based on Silicon-Vacancy Centers in a Single Crystal Diamond Membrane and a Fiber-Cavity

We realize a potential platform for an efficient spin-photon interface, namely negatively-charged silicon-vacancy centers in a diamond membrane coupled to the mode of a fully-tunable, fiber-based, optical resonator. We demonstrate that introducing the thin ($\sim 200 \, \text{nm}$), single crystal diamond membrane into the mode of the resonator does not change the cavity properties, which is one of the crucial points for an efficient spin-photon interface. In particular, we observe constantly high Finesse values of up to $3000$ and a linear dispersion in the presence of the membrane. We observe cavity-coupled fluorescence froman ensemble of SiV$^{-}$ centers with an enhancement factor of $\sim 1.9$. Furthermore from our investigations we extract the ensemble absorption and extrapolate an absorption cross section of $(2.9 \, \pm \, 2) \, \cdot \, 10^{-12} \, \text{cm}^{2}$ for a single SiV$^{-}$ center, much higher than previously reported.Comment: 8 pages, 4 figure

Development of the Arizona Robotic Telescope Network

The Arizona Robotic Telescope Network (ARTN) project is a long term effort to develop a system of telescopes to carry out a flexible program of PI observing, survey projects, and time domain astrophysics including monitoring, rapid response, and transient/target-of-opportunity followup. Steward Observatory operates and shares in several 1-3m class telescopes with quality sites and instrumentation, largely operated in classical modes. Science programs suited to these telescopes are limited by scheduling flexibility and people-power of available observers. Our goal is to adapt these facilities for multiple co-existing queued programs, interrupt capability, remote/robotic operation, and delivery of reduced data. In the long term, planning for the LSST era, we envision an automated system coordinating across multiple telescopes and sites, where alerts can trigger followup, classification, and triggering of further observations if required, such as followup imaging that can trigger spectroscopy. We are updating telescope control systems and software to implement this system in stages, beginning with the Kuiper 61'' and Vatican Observatory 1.8-m telescopes. The Kuiper 61'' and its Mont4K camera can now be controlled and queue-scheduled by the RTS2 observatory control software, and operated from a remote room at Steward. We discuss science and technical requirements for ARTN, and some of the challenges in adapting heterogenous legacy facilities, scheduling, data pipelines, and maintaining capabilities for a diverse user base.Comment: Proceedings of SPIE Astronomical Telescopes & Instrumentation 2018, Observatory Operations: Strategies, Processes, and Systems VI

High content live cell imaging for the discovery of new antimalarial marine natural products

<p>Abstract</p> <p>Background</p> <p>The human malaria parasite remains a burden in developing nations. It is responsible for up to one million deaths a year, a number that could rise due to increasing multi-drug resistance to all antimalarial drugs currently available. Therefore, there is an urgent need for the discovery of new drug therapies. Recently, our laboratory developed a simple one-step fluorescence-based live cell-imaging assay to integrate the complex biology of the human malaria parasite into drug discovery. Here we used our newly developed live cell-imaging platform to discover novel marine natural products and their cellular phenotypic effects against the most lethal malaria parasite, <it>Plasmodium falciparum</it>.</p> <p>Methods</p> <p>A high content live cell imaging platform was used to screen marine extracts effects on malaria. Parasites were grown <it>in vitro </it>in the presence of extracts, stained with RNA sensitive dye, and imaged at timed intervals with the BD Pathway HT automated confocal microscope.</p> <p>Results</p> <p>Image analysis validated our new methodology at a larger scale level and revealed potential antimalarial activity of selected extracts with a minimal cytotoxic effect on host red blood cells. To further validate our assay, we investigated parasite's phenotypes when incubated with the purified bioactive natural product bromophycolide A. We show that bromophycolide A has a strong and specific morphological effect on parasites, similar to the ones observed from the initial extracts.</p> <p>Conclusion</p> <p>Collectively, our results show that high-content live cell-imaging (HCLCI) can be used to screen chemical libraries and identify parasite specific inhibitors with limited host cytotoxic effects. All together we provide new leads for the discovery of novel antimalarials.</p

Natural History of MYH7-Related Dilated Cardiomyopathy

BACKGROUND Variants in myosin heavy chain 7 (MYH7) are responsible for disease in 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history of MYH7-related DCM are poorly described. OBJECTIVES We sought to determine the phenotype and prognosis of MYH7-related DCM. We also evaluated the influence of variant location on phenotypic expression. METHODS We studied clinical data from 147 individuals with DCM-causing MYH7 variants (47.6% female; 35.6 +/- 19.2 years) recruited from 29 international centers. RESULTS At initial evaluation, 106 (72.1%) patients had DCM (left ventricular ejection fraction: 34.5% +/- 11.7%). Median follow-up was 4.5 years (IQR: 1.7-8.0 years), and 23.7% of carriers who were initially phenotype-negative developed DCM. Phenotypic expression by 40 and 60 years was 46% and 88%, respectively, with 18 patients (16%) first diagnosed at <18 years of age. Thirty-six percent of patients with DCM met imaging criteria for LV noncompaction. During follow-up, 28% showed left ventricular reverse remodeling. Incidence of adverse cardiac events among patients with DCM at 5 years was 11.6%, with 5 (4.6%) deaths caused by end-stage heart failure (ESHF) and 5 patients (4.6%) requiring heart transplantation. The major ventricular arrhythmia rate was low (1.0% and 2.1% at 5 years in patients with DCM and in those with LVEF of <= 35%, respectively). ESHF and major ventricular arrhythmia were significantly lower compared with LMNA-related DCM and similar to DCM caused by TTN truncating variants. CONCLUSIONS MYH7-related DCM is characterized by early age of onset, high phenotypic expression, low left ventricular reverse remodeling, and frequent progression to ESHF. Heart failure complications predominate over ventricular arrhythmias, which are rare. (C) 2022 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation

Evidence for a decision variable in the human motor system

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High-Precision Differential-Input Buffered and External Transconductance Amplifier for Low-Voltage Low-Power Applications

Recently, the demand for low-voltage low-power integrated circuits design has grown dramatically. For battery-operated devices both the supply voltage and the power consumption have to be lowered in order to prolong the battery life. This paper presents an attractive approach to designing a low-voltage low-power high-precision differential-input buffered and external transconductance amplifier, DBeTA, based on the bulk-driven technique. The proposed DBeTA possesses rail-to-rail voltage swing capability at a low supply voltage of +/- 400 mV and consumes merely 62 mu W. The proposed circuit is a universal active element that offers more freedom during the design of current-, voltage-, or mixed-mode applications. The proposed circuit is particularly interesting for biomedical applications requiring low-voltage low-power operation capability where the processing signal frequency is limited to a few kilohertz. An oscillator circuit employing a minimum number of active and passive components has been described in this paper as one of many possible applications. The circuit contains only a single active element DBeTA, two capacitors, and one resistor, which is very attractive for integrated circuit implementation. PSpice simulation results using the 0.18 mu m CMOS technology from TSMC are included to prove the unique results