Intra-fraction motion of pelvic oligometastases and feasibility of PTV margin reduction using MRI guided adaptive radiotherapy

PurposeThis study assesses the impact of intra-fraction motion and PTV margin size on target coverage for patients undergoing radiation treatment of pelvic oligometastases. Dosimetric sparing of the bowel as a function of the PTV margin is also evaluated.Materials and methodsSeven patients with pelvic oligometastases previously treated on our MR-linac (35 Gy in 5 fractions) were included in this study. Retrospective adaptive plans were created for each fraction on the daily MRI datasets using PTV margins of 5 mm, 3 mm, and 2 mm. Dosimetric constraint violations and GTV coverage were measured as a function of PTV margin size. The impact of intra-fraction motion on GTV coverage was assessed by tracking the GTV position on the cine MR images acquired during treatment delivery and creating an intra-fraction dose distribution for each IMRT beam. The intra-fraction dose was accumulated for each fraction to determine the total dose delivered to the target for each PTV size.ResultsAll OAR constraints were achieved in 85.7%, 94.3%, and 100.0% of fractions when using 5 mm, 3 mm, and 2 mm PTV margins while scaling to 95% PTV coverage. Compared to plans with a 5 mm PTV margin, there was a 27.4 ± 12.3% (4.0 ± 2.2 Gy) and an 18.5 ± 7.3% (2.7 ± 1.4 Gy) reduction in the bowel D0.5cc dose for 2 mm and 3 mm PTV margins, respectively. The target dose (GTV V35 Gy) was on average 100.0 ± 0.1% (99.6 – 100%), 99.6 ± 1.0% (97.2 – 100%), and 99.0 ± 1.4% (95.0 – 100%), among all fractions for the 5 mm, 3 mm, and 2 mm PTV margins on the adaptive plans when accounting for intra-fraction motion, respectively.ConclusionA 2 mm PTV margin achieved a minimum of 95% GTV coverage while reducing the dose to the bowel for all patients

Variations in hydrological connectivity of Australian semiarid landscapes indicate abrupt changes in rainfall-use efficiency of vegetation

[1] Dryland vegetation frequently shows self‐organized spatial patterns as mosaic‐like structures of sources (bare areas) and sinks (vegetation patches) of water runoff and sediments with variable interconnection. Good examples are banded landscapes displayed by Mulga in semiarid Australia, where the spatial organization of vegetation optimizes the redistribution and use of water (and other scarce resources) at the landscape scale. Disturbances can disrupt the spatial distribution of vegetation causing a substantial loss of water by increasing landscape hydrological connectivity and consequently, affecting ecosystem function (e.g., decreasing the rainfall‐use efficiency of the landscape). We analyze (i) connectivity trends obtained from coupled analysis of remotely sensed vegetation patterns and terrain elevations in several Mulga landscapes subjected to different levels of disturbance, and (ii) the rainfall‐use efficiency of these landscapes, exploring the relationship between rainfall and remotely sensed Normalized Difference Vegetation Index. Our analyses indicate that small reductions in the fractional cover of vegetation near a particular threshold can cause abrupt changes in ecosystem function, driven by large nonlinear increases in the length of the connected flowpaths. In addition, simulations with simple vegetation‐thinning algorithms show that these nonlinear changes are especially sensitive to the type of disturbance, suggesting that the amount of alterations that an ecosystem can absorb and still remain functional largely depends on disturbance type. In fact, selective thinning of the vegetation patches from their edges can cause a higher impact on the landscape hydrological connectivity than spatially random disturbances. These results highlight surface connectivity patterns as practical indicators for monitoring landscape health

Participation as Post-Fordist Politics: Demos, New Labour, and Science Policy

In recent years, British science policy has seen a significant shift ‘from deficit to dialogue’ in conceptualizing the relationship between science and the public. Academics in the interdisciplinary field of Science and Technology Studies (STS) have been influential as advocates of the new public engagement agenda. However, this participatory agenda has deeper roots in the political ideology of the Third Way. A framing of participation as a politics suited to post-Fordist conditions was put forward in the magazine Marxism Today in the late 1980s, developed in the Demos thinktank in the 1990s, and influenced policy of the New Labour government. The encouragement of public participation and deliberation in relation to science and technology has been part of a broader implementation of participatory mechanisms under New Labour. This participatory program has been explicitly oriented toward producing forms of social consciousness and activity seen as essential to a viable knowledge economy and consumer society. STS arguments for public engagement in science have gained influence insofar as they have intersected with the Third Way politics of post-Fordism

How is the intensity of rainfall events best characterised? A brief critical review and proposed new rainfall intensity index for application in the study of landsurface processes

In many studies of landsurface processes, the intensity of rainfall events is expressed with clock-period indexes such as I30, the wettest 30-minute interval within a rainfall event. Problematically, the value of I30 cannot be estimated for rainfall events shorter than 30 min, excluding many intense convective storms. Further, it represents a diminishing proportion of increasingly long rainfall events, declining to <2% of the duration of a 30-hour event but representing 25% of the duration of a two-hour event. Here, a new index termed EDf5 is proposed: It is the rainfall depth in the wettest 5% of the event duration. This can be derived for events of any duration. Exploratory determinations of EDf5 are presented for two Australian locations with contrasting rainfall climatologies—one arid and one wet tropical. The I30 index was similar at both sites (7.7 and 7.9 mm h−1) and was unable to differentiate between them. In contrast, EDf5 at the arid site was 7.4 mm h−1, whilst at the wet tropical site, it was 3.8 mm h−1. Thus, the EDf5 index indicated a greater concentration of rain at the arid site where convective storms occurred (i.e., the intensity sustained for 5% of event duration at that site is higher). The EDf5 index can be applied to short, intense events that can readily be included in the analysis of event-based rainfall intensity. I30 therefore appears to offer less discriminatory power and consequently may be of less value in the investigation of rainfall characteristics that drive many important landsurface processes

Leaf water shedding: Moving away from assessments based on static contact angles, and a new device for observing dynamic droplet roll‐off behaviour

Abstract Leaf wettability and drainage characteristics of different taxa are often hypothesised to have emerged as a result of evolutionary selection, perhaps to limit the duration of leaf wetness, or to direct water toward efficiently to the soil and root system, rather than suffering loss to evaporation. Methods for quantifying leaf wetting and drainage are however not well‐developed. The present work describes a low‐cost, electro‐mechanical tilting table intended to facilitate precise and reproducible measurements of droplet shedding from leaves, describe by the roll‐off angle αroll. The new tilting table uses widely‐available components (microcontroller, stepper motor and driver, liquid‐crystal display (LCD) and custom operating code) to achieve controlled tilting through the range 0° to >90° at user‐controlled rates of tilting. It is suitable for field use, such that leaf specimens can be tested within minutes of collection. Water shedding tests on juvenile leaves from Homolanthus populifolius, native to the wet tropics of northern Queensland, Australia, show that testing of whole leaves (rather than small excised samples) reveals quite complex behaviour in which the open leaf surface is hydrophobic but major adaxial veins are strongly hydrophilic and can trap droplets. These can remain attached to the leaf at inclinations beyond vertical. Moreover, the apparent droplet roll‐off angles are dependent on the tilt speed applied. Droplet roll‐off tests used to characterise the propensity for leaf wetting or water shedding require controlled and reproducible experimental conditions, and a device suitable for studying the whole intact leaf surface. Preliminary results on H. populifolius show complex adaxial leaf surface characteristics, with mixed hydrophobic and hydrophilic components. This suggests that overall propensity to retain or shed water droplets is likely to depend on the size and intensity of rain or canopy drip from above. This makes the inferring of evolutionary costs or advantages more challenging and more likely to co‐vary with regional environmental conditions

Sub-Daily Rainfall Intensity Extremes: Evaluating Suitable Indices at Australian Arid and Wet Tropical Observing Sites

Rainfall intensity extremes are relevant to many aspects of climatology, climate change, and landsurface processes. Intensity is described and analysed using a diversity of approaches, reflecting its importance in these diverse areas. The characteristics of short-interval intensity extremes, such as the maximum 5-min intensity, are explored here. It is shown that such indices may have marked diurnal cycles, as well as seasonal variability. Some indices of intensity, such as the SDII (simple daily intensity index), provide too little information for application to landsurface processes. Upper percentiles of the intensity distribution, such as the 95th and 99th percentiles (Q95 and Q99) are used as indices of extreme intensity, but problematically are affected by changes in intensity below the nominated threshold, as well as above it, making the detection of secular change, and application to sites with contrasting rainfall character, challenging. For application to landsurface processes, a new index is introduced. This index (RQ95), is that intensity or rainfall rate above which 5% of the total rainfall is delivered. This index better reflects intense rainfall than does Q95 of even 5-min accumulation duration (AD) rainfall depths. Such an index is helpful for detecting secular change at an observing station, but, like Q95, remains susceptible to the effects of change elsewhere in the distribution of intensities. For understanding impacts of climate and climate change on landsurface processes, it is argued that more inclusive indices of intensity are required, including fixed intensity criteria

Sub-daily rainfall intensity extremes:Evaluating suitable indices at Australian arid and wet tropical observing sites

Rainfall intensity extremes are relevant to many aspects of climatology, climate change, and landsurface processes. Intensity is described and analysed using a diversity of approaches, reflecting its importance in these diverse areas. The characteristics of short-interval intensity extremes, such as the maximum 5-min intensity, are explored here. It is shown that such indices may have marked diurnal cycles, as well as seasonal variability. Some indices of intensity, such as the SDII (simple daily intensity index), provide too little information for application to landsurface processes. Upper percentiles of the intensity distribution, such as the 95th and 99th percentiles (Q95 and Q99) are used as indices of extreme intensity, but problematically are affected by changes in intensity below the nominated threshold, as well as above it, making the detection of secular change, and application to sites with contrasting rainfall character, challenging. For application to landsurface processes, a new index is introduced. This index (RQ95), is that intensity or rainfall rate above which 5% of the total rainfall is delivered. This index better reflects intense rainfall than does Q95 of even 5-min accumulation duration (AD) rainfall depths. Such an index is helpful for detecting secular change at an observing station, but, like Q95, remains susceptible to the effects of change elsewhere in the distribution of intensities. For understanding impacts of climate and climate change on landsurface processes, it is argued that more inclusive indices of intensity are required, including fixed intensity criteria

Recording Rainfall Intensity: Has an Optimum Method Been Found?

Many design principles for rain gauges that have the capacity to record rainfall intensity have been proposed or developed. These are here grouped into 15 categories, and the abilities and limitations of each are discussed. No standard or optimum method has emerged, despite more than 80 years of effort in the last two centuries, together with prior work from the 17th C onwards. Indeed, new methods continue to be explored for both point-based and area-wide collections of intensity data. Examples include the use of signal attenuation by rain along the tower-to-tower links of cellular phone networks, monitoring the speed of vehicle windscreen wipers, and exploiting the sound or vision from security and traffic-monitoring cameras. Many of these approaches have the potential to provide vastly more observation sites than conventional meteorological stations equipped with rain gauges. Some of these contemporary approaches seek to harness the potential of crowdsourced or citizen-science data. It is hoped that the present overview of methods will provide a guide for those wishing to collect or analyses rainfall intensity data for application in areas such as soil erosion processes, ecohydrology, agrochemical washoff, or urban flash flooding. Because rainfall intensity is one of the key aspects of the hydrologic cycle likely to respond as climate change and variability proceed, the choice of appropriate data collection methods has additional contemporary importance for the monitoring of regional and global precipitation changes