Long-term follow-up of beryllium sensitized workers from a single employer

<p>Abstract</p> <p>Background</p> <p>Up to 12% of beryllium-exposed American workers would test positive on beryllium lymphocyte proliferation test (BeLPT) screening, but the implications of sensitization remain uncertain.</p> <p>Methods</p> <p>Seventy two current and former employees of a beryllium manufacturer, including 22 with pathologic changes of chronic beryllium disease (CBD), and 50 without, with a confirmed positive test were followed-up for 7.4 +/-3.1 years.</p> <p>Results</p> <p>Beyond predicted effects of aging, flow rates and lung volumes changed little from baseline, while D_LCO dropped 17.4% of predicted on average. Despite this group decline, only 8 subjects (11.1%) demonstrated physiologic or radiologic abnormalities typical of CBD. Other than baseline status, no clinical or laboratory feature distinguished those who clinically manifested CBD at follow-up from those who did not.</p> <p>Conclusions</p> <p>The clinical outlook remains favorable for beryllium-sensitized individuals over the first 5-12 years. However, declines in D_LCO may presage further and more serious clinical manifestations in the future. These conclusions are tempered by the possibility of selection bias and other study limitations.</p

An Inside Look at Sunspot Oscillations with Higher Azimuthal Wavenumbers

Solar chromospheric observations of sunspot umbrae offer an exceptional view of magneto-hydrodynamic wave phenomena. In recent years, a wealth of wave signatures related to propagating magneto-acoustic modes have been presented, which demonstrate complex spatial and temporal structuring of the wave components. Theoretical modelling has demonstrated how these ubiquitous waves are consistent with an m=0 slow magneto-acoustic mode, which are excited by trapped sub-photospheric acoustic (p-mode) waves. However, the spectrum of umbral waves is broad, suggesting that the observed signatures represent the superposition of numerous frequencies and/or modes. We apply Fourier filtering, in both spatial and temporal domains, to extract chromospheric umbral wave characteristics consistent with an m=1 slow magneto-acoustic mode. This identification has not been described before. Angular frequencies of 0.037 +/- 0.007 rad/s (2.1 +/- 0.4 deg/s), corresponding to a period approximately 170 s for the m=1 mode are uncovered for spatial wavenumbers in the range of 0.45<k<0.90 arcsec^-1 (5000-9000 km). Theoretical dispersion relations are solved, with corresponding eigenfunctions computed, which allows the density perturbations to be investigated and compared with our observations. Such magnetohydrodynamic modelling confirms our interpretation that the identified wave signatures are the first direct observations of an m=1 slow magneto-acoustic mode in the chromospheric umbra of a sunspot

Migration of Beryllium via Multiple Exposure Pathways among Work Processes in Four Different Facilities

<div><p>Inhalation of beryllium is associated with the development of sensitization; however, dermal exposure may also be important. The primary aim of this study was to elucidate relationships among exposure pathways in four different manufacturing and finishing facilities. Secondary aims were to identify jobs with increased levels of beryllium in air, on skin, and on surfaces; identify potential discrepancies in exposure pathways, and determine if these are related to jobs with previously identified risk.</p><p>Beryllium was measured in air, on cotton gloves, and on work surfaces. Summary statistics were calculated and correlations among all three measurement types were examined at the facility and job level. Exposure ranking strategies were used to identify jobs with higher exposures.</p><p>The highest air, glove, and surface measurements were observed in beryllium metal production and beryllium oxide ceramics manufacturing jobs that involved hot processes and handling powders. Two finishing and distribution facilities that handle solid alloy products had lower exposures than the primary production facilities, and there were differences observed among jobs. For all facilities combined, strong correlations were found between air-surface (rp ≥ 0.77), glove-surface (rp ≥ 0.76), and air-glove measurements (rp ≥ 0.69). In jobs where higher risk of beryllium sensitization or disease has been reported, exposure levels for all three measurement types were higher than in jobs with lower risk, though they were not the highest. Some jobs with low air concentrations had higher levels of beryllium on glove and surface wipe samples, suggesting a need to further evaluate the causes of the discrepant levels.</p><p>Although such correlations provide insight on where beryllium is located throughout the workplace, they cannot identify the direction of the pathways between air, surface, or skin. Ranking strategies helped to identify jobs with the highest combined air, glove, and/or surface exposures. All previously identified high-risk jobs had high air concentrations, dermal mass loading, or both, and none had low dermal and air. We have found that both pathways are relevant.</p><p>[Supplementary materials are available for this article. Go to the publisher's online edition of <i>Journal of Occupational and Environmental Hygiene</i> for the following free supplemental resource: a file describing the forms of beryllium materials encountered during production and characteristics of the aerosols by process areas.]</p></div