2,365 research outputs found
Method and system for an automated tool for en route traffic controllers
A method and system for a new automation tool for en route air traffic controllers first finds all aircraft flying on inefficient routes, then determines whether it is possible to save time by bypassing some route segments, and finally whether the improved route is free of conflicts with other aircraft. The method displays all direct-to eligible aircraft to an air traffic controller in a list sorted by highest time savings. By allowing the air traffic controller to easily identify and work with the highest pay-off aircraft, the method of the present invention contributes to a significant increase in both air traffic controller and aircraft productivity. A graphical computer interface (GUI) is used to enable the air traffic controller to send the aircraft direct to a waypoint or fix closer to the destination airport by a simple point and click action
Method and System for Dynamic Automated Corrections to Weather Avoidance Routes for Aircraft in En Route Airspace
A dynamic weather route system automatically analyzes routes for in-flight aircraft flying in convective weather regions and attempts to find more time and fuel efficient reroutes around current and predicted weather cells. The dynamic weather route system continuously analyzes all flights and provides reroute advisories that are dynamically updated in real time while the aircraft are in flight. The dynamic weather route system includes a graphical user interface that allows users to visualize, evaluate, modify if necessary, and implement proposed reroutes
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High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma.
IntroductionPrognosis after resection of hepatocellular carcinoma (HCC) is highly variable. Compared to clinicopathologic factors, the use of molecular markers to predict outcome has not been well studied. We investigated the prognostic importance of thymidylate synthase (TS) gene expression and polymorphisms in patients after resection of HCC.MethodsPatients who underwent complete resection of HCC for whom tissue was available were identified. TS gene expression level and polymorphisms were determined in HCC specimens. Prognostic factors were evaluated using Kaplan-Meier curves and Cox proportional hazard models.ResultsThe study included 67 patients. In univariate analysis, variables that negatively influenced survival included TNM stage, microvascular invasion, and high TS expression. For the high TS expression group, median survival was 54 months and 5-year actuarial survival was 47%. For the low TS expression group, median survival was not reached and the 5-year actuarial survival was 91%. In multivariate analysis, only high TS expression remained an independent predictor of poor survival (HR = 10.77, 95% CI 1.36-84.91; P = 0.02). TS gene polymorphisms were not associated with TS expression or overall survival.ConclusionsHigh TS expression predicts poor outcome after resection of HCC. Molecular markers might be robust predictors of patient outcome after resection of HCC
The High Resolution Doppler Imager (HRDI) on the Upper Atmosphere Research Satellite
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76425/1/AIAA-1993-123-305.pd
Radio frequency electrical transduction of graphene mechanical resonators
We report radio frequency (rf) electrical readout of graphene mechanical
resonators. The mechanical motion is actuated and detected directly by using a
vector network analyzer, employing a local gate to minimize parasitic
capacitance. A resist-free doubly clamped sample with resonant frequency ~ 34
MHz, quality factor ~ 10000 at 77 K, and signal-to-background ratio of over 20
dB is demonstrated. In addition to being over two orders of magnitude faster
than the electrical rf mixing method, this technique paves the way for use of
graphene in rf devices such as filters and oscillators.Comment: 10 pages, 2 figure
The broad-spectrum antiviral favipiravir protects guinea pigs from lethal Lassa virus infection post-disease onset
With up to 500,000 infections annually, Lassa virus (LASV), the cause of Lassa fever, is one of the most prevalent etiological agents of viral hemorrhagic fever (VHF) in humans. LASV is endemic in several West African countries with sporadic cases and prolonged outbreaks observed most commonly in Sierra Leone, Liberia, Guinea and Nigeria. Additionally several cases of Lassa fever have been imported into North America, Europe and Asia making LASV a global threat to public health. Despite this, currently no approved therapeutic or vaccine exists to treat or prevent LASV infections. Here, using a passaged strain of LASV that is uniformly lethal in Hartley guinea pigs, we demonstrate that favipiravir, a broad-spectrum antiviral agent and leading treatment option for influenza, has potent activity against LASV infection. In this model, once daily treatment with favipiravir significantly reduced viral titers in tissue samples and reduced mortality rates when compared with animals receiving vehicle-only or ribavirin, the current standard of care for Lassa fever. Favipiravir remained highly effective against lethal LASV infection when treatments were initiated nine days post-infection, a time when animals were demonstrating advanced signs of disease. These results support the further preclinical evaluation of favipiravir for Lassa fever and other VHFs
Organizational Mortality of Small Firms: The Effects of Entrepreneurial Age and Human Capital
This paper addresses the issue of internal determination of organizational outcomes. It is argued that in small and simply structured organizations a considerable proportion of the variance in organizational activities and outcomes is associated with individuals. In particular, the paper uses human capital theory to derive hypotheses about individual determinants of organizational mortality. These hypotheses are tested with event-history data of firm registrations and de-registrations in a West German region. The hypotheses are corroborated by the data, but the effects may nonetheless be due to processes linking individual characteristics with organizational performance other than those suggested by the human capital approach
A relationship between AGN jet power and radio power
Using Chandra X-ray and VLA radio data, we investigate the scaling
relationship between jet power, P_jet, and synchrotron luminosity, P_rad. We
expand the sample presented in Birzan et al. (2008) to lower radio power by
incorporating measurements for 21 gEs to determine if the Birzan et al. (2008)
P_jet-P_rad scaling relations are continuous in form and scatter from giant
elliptical galaxies (gEs) up to brightest cluster galaxies (BCGs). We find a
mean scaling relation of P_jet approximately 5.8x10^43 (P_rad/10^40)^(0.70)
erg/s which is continuous over ~6-8 decades in P_jet and P_rad with a scatter
of approximately 0.7 dex. Our mean scaling relationship is consistent with the
model presented in Willott et al. (1999) if the typical fraction of lobe energy
in non-radiating particles to that in relativistic electrons is > 100. We
identify several gEs whose radio luminosities are unusually large for their jet
powers and have radio sources which extend well beyond the densest parts of
their X-ray halos. We suggest that these radio sources are unusually luminous
because they were unable to entrain appreciable amounts of gas.Comment: Accepted for publication in the Astrophysical Journal; 8 pages, 3
color figures, 1 tabl
Spiral-like structure in nearby clusters of galaxies
X-ray data analysis have found that fairly complex structures at cluster
centres are more common than expected. Many of these structures have similar
morphologies, which exhibit spiral-like substructure. It is not yet well known
how these structures formed or are maintained. Understanding the origin of
these spiral-like features at the centre of some clusters is the major
motivation behind this work. We analyse deep \textit{Chandra} observations of
15 nearby galaxy clusters (0.01 0.06), and use X-ray temperature and
substructure maps to detect small features at the cores of the clusters. We
detect spiral-like features at the centre of 7 clusters: A85, A426, A496, Hydra
A cluster, Centaurus, Ophiuchus, and A4059. These patterns are similar to those
found in numerical hydrodynamic simulations of cluster mergers with non-zero
impact parameter. In some clusters of our sample, a strong radio source also
occupies the inner region of the cluster, which indicates a possible connection
between the two. Our investigation implies that these spiral-like structures
may be caused by off-axis minor mergers. Since these features occur in regions
of high density, they may confine radio emission from the central galaxy
producing, in some cases, unusual radio morphology.Comment: 14 pages, 3 figures, accepted for publication in A&A (Nov 17, 2009
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