729 research outputs found
In vivo detection and treatment of ischemia-induced cardiac apoptosis using an MRI-detectable molecular probe and an alpha-adrenergic receptor agonist
The lesson of causal discovery algorithms for quantum correlations: Causal explanations of Bell-inequality violations require fine-tuning
An active area of research in the fields of machine learning and statistics
is the development of causal discovery algorithms, the purpose of which is to
infer the causal relations that hold among a set of variables from the
correlations that these exhibit. We apply some of these algorithms to the
correlations that arise for entangled quantum systems. We show that they cannot
distinguish correlations that satisfy Bell inequalities from correlations that
violate Bell inequalities, and consequently that they cannot do justice to the
challenges of explaining certain quantum correlations causally. Nonetheless, by
adapting the conceptual tools of causal inference, we can show that any attempt
to provide a causal explanation of nonsignalling correlations that violate a
Bell inequality must contradict a core principle of these algorithms, namely,
that an observed statistical independence between variables should not be
explained by fine-tuning of the causal parameters. In particular, we
demonstrate the need for such fine-tuning for most of the causal mechanisms
that have been proposed to underlie Bell correlations, including superluminal
causal influences, superdeterminism (that is, a denial of freedom of choice of
settings), and retrocausal influences which do not introduce causal cycles.Comment: 29 pages, 28 figs. New in v2: a section presenting in detail our
characterization of Bell's theorem as a contradiction arising from (i) the
framework of causal models, (ii) the principle of no fine-tuning, and (iii)
certain operational features of quantum theory; a section explaining why a
denial of hidden variables affords even fewer opportunities for causal
explanations of quantum correlation
Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1
The mechanisms underlying the Hepatitis C virus (HCV) resistance to interferon alpha (IFN-α) are not fully understood. We used IFN-α resistant HCV replicon cell lines and an infectious HCV cell culture system to elucidate the mechanisms of IFN-α resistance in cell culture. The IFN-α resistance mechanism of the replicon cells were addressed by a complementation study that utilized the full-length plasmid clones of IFN-α receptor 1 (IFNAR1), IFN-α receptor 2 (IFNAR2), Jak1, Tyk2, Stat1, Stat2 and the ISRE- luciferase reporter plasmid. We demonstrated that the expression of the full-length IFNAR1 clone alone restored the defective Jak-Stat signaling as well as Stat1, Stat2 and Stat3 phosphorylation, nuclear translocation and antiviral response against HCV in all IFN-α resistant cell lines (R-15, R-17 and R-24) used in this study. Moreover RT-PCR, Southern blotting and DNA sequence analysis revealed that the cells from both R-15 and R-24 series of IFN-α resistant cells have 58 amino acid deletions in the extracellular sub domain 1 (SD1) of IFNAR1. In addition, cells from the R-17 series have 50 amino acids deletion in the sub domain 4 (SD4) of IFNAR1 protein leading to impaired activation of Tyk2 kinase. Using an infectious HCV cell culture model we show here that viral replication in the infected Huh-7 cells is relatively resistant to exogenous IFN-α. HCV infection itself induces defective Jak-Stat signaling and impairs Stat1 and Stat2 phosphorylation by down regulation of the cell surface expression of IFNAR1 through the endoplasmic reticulum (ER) stress mechanisms. The results of this study suggest that expression of cell surface IFNAR1 is critical for the response of HCV to exogenous IFN-α
The cancer translational research informatics platform
<p>Abstract</p> <p>Background</p> <p>Despite the pressing need for the creation of applications that facilitate the aggregation of clinical and molecular data, most current applications are proprietary and lack the necessary compliance with standards that would allow for cross-institutional data exchange. In line with its mission of accelerating research discoveries and improving patient outcomes by linking networks of researchers, physicians, and patients focused on cancer research, caBIG (cancer Biomedical Informatics Grid™) has sponsored the creation of the caTRIP (Cancer Translational Research Informatics Platform) tool, with the purpose of aggregating clinical and molecular data in a repository that is user-friendly, easily accessible, as well as compliant with regulatory requirements of privacy and security.</p> <p>Results</p> <p>caTRIP has been developed as an N-tier architecture, with three primary tiers: domain services, the distributed query engine, and the graphical user interface, primarily making use of the caGrid infrastructure to ensure compatibility with other tools currently developed by caBIG. The application interface was designed so that users can construct queries using either the Simple Interface via drop-down menus or the Advanced Interface for more sophisticated searching strategies to using drag-and-drop. Furthermore, the application addresses the security concerns of authentication, authorization, and delegation, as well as an automated honest broker service for deidentifying data.</p> <p>Conclusion</p> <p>Currently being deployed at Duke University and a few other centers, we expect that caTRIP will make a significant contribution to further the development of translational research through the facilitation of its data exchange and storage processes.</p
Manganese-enhanced MRI detects live human amnion-derived mesenchymal stem cells in vivo after transplantation and restoration of myocardial function in a pig ischemia-reperfusion injury model
Studying Parton Energy Loss in Heavy-Ion Collisions via Direct-Photon and Charged-Particle Azimuthal Correlations
Charged-particle spectra associated with direct photon () and
are measured in + and Au+Au collisions at center-of-mass energy
GeV with the STAR detector at RHIC. A hower-shape
analysis is used to partially discriminate between and .
Assuming no associated charged particles in the direction (near
side) and small contribution from fragmentation photons (), the
associated charged-particle yields opposite to (away side) are
extracted. At mid-rapidity () in central Au+Au collisions,
charged-particle yields associated with and at high
transverse momentum ( GeV/) are suppressed by a factor
of 3-5 compared with + collisions. The observed suppression of the
associated charged particles, in the kinematic range and GeV/, is similar for and , and
independent of the energy within uncertainties. These
measurements indicate that the parton energy loss, in the covered kinematic
range, is insensitive to the parton path length.Comment: submitted to Phys. Rev. Lett, 6 pages, 4 figure
Measurements of meson production in relativistic heavy-ion collisions at RHIC
We present results for the measurement of meson production via its
charged kaon decay channel in Au+Au collisions at
, 130, and 200 GeV, and in and +Au collisions
at GeV from the STAR experiment at the BNL Relativistic
Heavy Ion Collider (RHIC). The midrapidity () meson transverse
momentum () spectra in central Au+Au collisions are found to be well
described by a single exponential distribution. On the other hand, the
spectra from , +Au and peripheral Au+Au collisions show power-law tails
at intermediate and high and are described better by Levy
distributions. The constant yield ratio vs beam species, collision
centrality and colliding energy is in contradiction with expectations from
models having kaon coalescence as the dominant mechanism for production
at RHIC. The yield ratio as a function of is consistent
with a model based on the recombination of thermal quarks up to GeV/, but disagrees at higher transverse momenta. The measured nuclear
modification factor, , for the meson increases above unity at
intermediate , similar to that for pions and protons, while is
suppressed due to the energy loss effect in central Au+Au collisions. Number of
constituent quark scaling of both and for the meson
with respect to other hadrons in Au+Au collisions at =200 GeV
at intermediate is observed. These observations support quark
coalescence as being the dominant mechanism of hadronization in the
intermediate region at RHIC.Comment: 22 pages, 21 figures, 4 table
Observation of charge-dependent azimuthal correlations and possible local strong parity violation in heavy ion collisions
Parity-odd domains, corresponding to non-trivial topological solutions of the
QCD vacuum, might be created during relativistic heavy-ion collisions. These
domains are predicted to lead to charge separation of quarks along the orbital
momentum of the system created in non-central collisions. To study this effect,
we investigate a three particle mixed harmonics azimuthal correlator which is a
\P-even observable, but directly sensitive to the charge separation effect. We
report measurements of this observable using the STAR detector in Au+Au and
Cu+Cu collisions at =200 and 62~GeV. The results are presented
as a function of collision centrality, particle separation in rapidity, and
particle transverse momentum. A signal consistent with several of the
theoretical expectations is detected in all four data sets. We compare our
results to the predictions of existing event generators, and discuss in detail
possible contributions from other effects that are not related to parity
violation.Comment: 17 pages, 14 figures, as accepted for publication in Physical Review
C
Charged and strange hadron elliptic flow in Cu+Cu collisions at = 62.4 and 200 GeV
We present the results of an elliptic flow analysis of Cu+Cu collisions
recorded with the STAR detector at 62.4 and 200GeV. Elliptic flow as a function
of transverse momentum is reported for different collision centralities for
charged hadrons and strangeness containing hadrons , ,
, in the midrapidity region . Significant reduction in
systematic uncertainty of the measurement due to non-flow effects has been
achieved by correlating particles at midrapidity, , with those at
forward rapidity, . We also present azimuthal correlations in
p+p collisions at 200 GeV to help estimating non-flow effects. To study the
system-size dependence of elliptic flow, we present a detailed comparison with
previously published results from Au+Au collisions at 200 GeV. We observe that
() of strange hadrons has similar scaling properties as were
first observed in Au+Au collisions, i.e.: (i) at low transverse momenta,
, scales with transverse kinetic energy, , and
(ii) at intermediate , , it scales with the number of
constituent quarks, . We have found that ideal hydrodynamic calculations
fail to reproduce the centrality dependence of () for
and . Eccentricity scaled values, , are larger
in more central collisions, suggesting stronger collective flow develops in
more central collisions. The comparison with Au+Au collisions which go further
in density shows depend on the system size, number of
participants . This indicates that the ideal hydrodynamic limit is
not reached in Cu+Cu collisions, presumably because the assumption of
thermalization is not attained.Comment: 18 pages, 14 figure
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