Multicomponent reactions for the synthesis of new cyclopentadienephosphonate derivatives in water

<p>A series of polysubstituted cyclopentadienephosphonate derivatives were synthesized via one-pot multicomponent reactions of primary amines and phosphites with activated acetylenic compounds in water as the solvent at room temperature.</p> <p>Particularly valuable features of this method include high yields of products, broad substrate scope, short reaction time and a straightforward procedure.</p