Death rates from malaria epidemics, Burundi and Ethiopia.

Death rates exceeded emergency thresholds at 4 sites during epidemics of Plasmodium falciparum malaria in Burundi (2000-2001) and in Ethiopia (2003-2004). Deaths likely from malaria ranged from 1,000 to 8,900, depending on site, and accounted for 52% to 78% of total deaths. Earlier detection of malaria and better case management are needed

Développement participatif d'un outil technologique d'aide à la supervision en EHPAD ou de l'importance d'une remontée des besoins des futurs utilisateurs pour une conception plus pertinente

National audienceLe projet e-monitor'age vise à développer un système d'aide à la supervision des résidents en EHPAD (Etablissement d'Hébergement pour Personnes Agées Dépendantes). L'originalité de l'approche est que ce système (multicapteur et logiciel) est développé via une conception participative, c'est-à-dire main dans la main avec les personnels afin de répondre aux vrais besoins des " end users " et que son acceptabilité par ces personnels soit la meilleure possible

Temperature dependence of binding and catalysis for human serum arylesterase/paraoxonase.

International audience: The influence of temperature upon the hydrolysis of phenyl acetate, catalysed by purified human serum arylesterase/paraoxonase (E. C. 3.1.8.1), was studied in the temperature range 10 °C-40 °C by spectrophotometry in TRIS buffer, pH 8.0, using both initial rate analysis and progress curve analysis. The kinetic parameters (catalytic constant kcat; Michaelis constant Km; product inhibition constant Kp) were determined by nonlinear regression. All parameters increased with temperature, but the ratios kcat/Km and Kp/Km remained practically constant. Binding of both substrate and reaction product (phenol) was exothermic. A negative entropic term accounted for about 50% of the enthalpy change for both the binding and catalytic steps. Thermodynamic analysis suggested that: (1) the rate-limiting step is the nucleophilic attack of the carbonyl group of the substrate by a water molecule, (2) the active site is preorganized with no induced fit, (3) the enzyme-bound calcium plays an important role in stabilizing both the substrate and the transition state. The practical implications of these results are discussed

Brain type carnosinase in dementia: a pilot study

Research articl

Prévenir l'hospitalisation des résidents d'EHPAD

National audienc

La musique au cœur du repas. Décideurs en gérontologie.

National audienc

Une expérience pionnière sur la télésurveillance médicale des seniors.

National audienc