Autonomous Cars, Electric and Hybrid Cars, and Ridesharing: Perceptions vs. Reality

Autonomous Cars, Electric and Hybrid Cars, and Ridesharing are all important new technologies in today\u27s society that can have potentially large impacts on the environment in the future. This study was conducted to determine the differences in perceptions of Gettysburg College students regarding Autonomous Cars, Electric and Hybrid Cars, and Ridesharing and the reality of these topics in the real world. This paper also compares the perceptions of Environmental Studies majors/minors to the perceptions of other majors at Gettysburg College. The primary research was conducted by analyzing questions that were a part of a survey consisting of 16 questions which was administered to Gettysburg College students via Facebook class group pages and the Environmental Studies majors email alias. The study group consisted of 110 students with 31 of them being Environmental Studies majors/minors and 79 of them being non-Environmental Studies majors/minors. It was determined that there were no statistically significant differences between the Environmental Studies majors/minors and students that are other majors/minors at Gettysburg College. From our survey, we found that there is a distinct gap in knowledge on the current and future impacts on the environment from Autonomous Cars, Electric and Hybrid Cars, and Ridesharing. The questions that ask which power method produces more greenhouse gas emissions as well as the questions about the miles per gallon of participants’ personal vehicles were the most accurately answered. Overall, Gettysburg College students regardless of major or minor were found to have mostly inaccurate perceptions on the topics of Autonomous Cars, Electric and Hybrid Cars, and Ridesharing

“All Persons Living and Dead Are Purely Coincidental:” Unity, Dissolution, and the Humanist Wampeter of Kurt Vonnegut’s Universe

Though most critical analyses of Kurt Vonnegut’s work focus on the assertions made in individual texts, Vonnegut’s narratives do not occupy the traditional space of a singular novel. Instead, Vonnegut’s characters and narrative devices appear again and again in multiple, non-sequential works, weaving together otherwise isolated texts. In this thesis, I explore the way reading Vonnegut’s canon as an interconnected whole reshapes the way his novels are perceived individually and forms a larger continuous narrative in which humanist themes are brought into counterpoint with the more nihilistic satire Vonnegut is most known for. Vonnegut uses this unique act of world building as a phenomenological device, dissolving the traditional boundaries within and between texts and revising the role of the author

Technical Considerations of closed containment sea pen production for some life stages of salmonids

We have investigated the technical and economic use of a closed containment sea pen nursery system for production of larger (circa 1 kg) fish for stocking in conventional cage systems with a view to reducing the duration of the marine on-growing phase in conventional open cages. This modified production strategy would reduce the time of exposure to sea lice, allow the capture of some of the solid waste from the culture operation and potentially allow more efficient use of ongrowing sites as the rate of throughput in those sites could be substantially increasedhttp://www.sarf.org.uk/projects

The Effect of Urbanization on Water Quality

The past several decades have seen the proliferation of urban areas around the world (Uitto, 1999). Land-cover change, correlated with different forms of land use, is documented to have significant impact on earth\u27s hydrologic systems (Aichele, 2005). Significant studies point to urbanization as being a key source of pollutants in earth\u27s watersheds and natural hydrologic landscapes(Li et al. 2016; Aichele 2005). This study aims to measure the effect of urbanization on the water quality of Gross Creek. Concentrations of E.coli, phosphorus, nitrogen, and suspended sediments were measured from four sampling sites along Gross Creek in Farmville, Virginia. This process was repeated before and after three major rain events. It is predicted that due to stormwater runoff from rain events, there will be higher concentrations of E.coli, nitrogen, phosphorus, and sediment present in Gross Creek after rain events and in areas of more urban surroundings

Notch activation is required for downregulation of HoxA3-dependent endothelial cell phenotype during blood formation.

Hemogenic endothelium (HE) undergoes endothelial-to-hematopoietic transition (EHT) to generate blood, a process that requires progressive down-regulation of endothelial genes and induction of hematopoietic ones. Previously, we have shown that the transcription factor HoxA3 prevents blood formation by inhibiting Runx1 expression, maintaining endothelial gene expression and thus blocking EHT. In the present study, we show that HoxA3 also prevents blood formation by inhibiting Notch pathway. HoxA3 induced upregulation of Jag1 ligand in endothelial cells, which led to cis-inhibition of the Notch pathway, rendering the HE nonresponsive to Notch signals. While Notch activation alone was insufficient to promote blood formation in the presence of HoxA3, activation of Notch or downregulation of Jag1 resulted in a loss of the endothelial phenotype which is a prerequisite for EHT. Taken together, these results demonstrate that Notch pathway activation is necessary to downregulate endothelial markers during EHT

Differential impact of mass and targeted praziquantel delivery on schistosomiasis control in school-aged children: A systematic review and meta-analysis.

Schistosomiasis is a widespread public health concern in the poorest regions of the world. The principal control strategy is regular praziquantel administration to school-aged children in endemic areas. With calls for the elimination of schistosomiasis as a public health problem, expanding praziquantel delivery to all community members has been advocated. This systematic review and meta-analysis compares the impact of community-wide and child-targeted praziquantel distribution on schistosomiasis prevalence and intensity in school-aged children. We searched MEDLINE, Embase and Web of Science to identify papers that reported schistosome prevalence before and after praziquantel administration, either to children only or to all community members. Extracted data included Schistosoma species, drug administration strategy, number of treatment rounds, follow-up interval and prevalence and intensity before and after treatment. We used inverse variance weighted generalised linear models to examine the impact of mass versus targeted drug administration on prevalence reduction, and weighted boxplots to examine the impact on infection intensity reduction. This study is registered with PROSPERO, number CRD42018095377. In total, 34 articles were eligible for systematic review and 28 for meta-analysis. Schistosoma mansoni was reported in 20 studies; Schistosoma haematobium in 19 studies, and Schistosoma japonicum in two studies. Results of generalised linear models showed no detectable difference between mass and targeted treatment strategies on prevalence reduction in school-aged children for S. mansoni (odds ratio 0.47, 95%CI 0.13-1.68, p = 0.227) and S. haematobium (0.41, 95%CI 0.06-3.03, p = 0.358). Box plots also showed no apparent differences in intensity reduction between the two treatment strategies. The results of this meta-analysis do not support the hypothesis that community-wide treatment is more effective than targeted treatment at reducing schistosomiasis infections in children. This may be due to the relatively small number of included studies, insufficient treatment coverage, persistent infection hotspots and unmeasured confounders. Further field-based studies comparing mass and targeted treatment are required

Work hard, party harder:drug use and sexual behaviour in young British casual workers in Ibiza, Spain

Background: Every summer, young people flock to nightlife-focused holiday resorts around the world to find casual work. Despite being exposed to hedonistic environments, often for several months, little is known about their substance use, sexual activity and health service needs over this extended amount of time abroad. Methods: A short anonymous questionnaire examining alcohol and drug use, sexual behaviour and use of health services was administered to young British casual workers aged 16–35 in San Antonio, Ibiza (n = 171). Results: 97.7% of casual workers used alcohol in Ibiza, and the majority (85.3%) used drugs. Almost half (43.5%) of all participants used a drug in Ibiza that they had never used in the UK. Most casual workers arrived in Ibiza without a partner or spouse (86.5%). Of these, 86.9% had sex during their stay and 50.0% had unprotected sex; often while under the influence of alcohol. Only 14.3% of those having unprotected sex with a new partner sought a sexual health check-up in Ibiza, although 84.1% intended to do this on their return to the UK. Conclusion: Substance use and sexual risk taking is widespread among young British casual workers in Ibiza. Such international nightlife resorts represent key settings for substance-related health and social problems, and for the international spread of sexually transmitted infections. Addressing the health needs of casual workers and the environments that permit and promote their excessive behaviour requires collaboration between authorities in home and destination countries and the tourism industry

Characterizing Australia's east coast cyclones (1950–2019)

East coast cyclones (ECCs) provide an essential reprieve from dry periods across eastern Australia. They also deliver flood‐producing rains with significant economic, social and environmental impacts. Assessing and comparing the influence of different types of cyclones is hindered by an incomplete understanding of ECC typology, given their widely variable spatial and temporal characteristics. This study employs a track‐clustering method (probabilistic curve‐aligned regression model) to identify key cyclonic pathways for ECCs from 1950 to 2019. Six spatially independent clusters were successfully distinguished and further sub‐classified (coastal, continental and tropical) based on their genesis location. The seasonality and long‐term variability, intensity (maximum Laplacian value ± two days) and event‐based rainfall were then evaluated for each cluster to quantify the impact of these storms on Australia. The highest quantity of land‐based rainfall per event is associated with the tropical cluster (Cluster 6), whereas widespread rainfall was also found to occur in the two continental lows (Cluster 4 and 5). Cyclone tracks orientated close to the coast (clusters 1, 2 and 3) were determined to be the least impactful in terms of rainfall and intensity, despite being the most common cyclone type. In terms of interannual variability, sea surface temperature anomalies suggest an increased cyclone frequency for clusters 1 (austral winter) and 4 (austral spring) during a central Pacific El Niño. Further, cyclone incidence during IOD‐negative conditions was more pronounced in winter for clusters 1, 2, 3 – and clusters 4 and 5 in spring. All cyclones also predominantly occurred in SAM‐positive conditions. However, winter ECCs for clusters 1 and 3 had a higher frequency in SAM‐negative. This new typology of ECCs via spatial clustering provides crucial insights into the systems that produce extreme rainfall across eastern Australia and should be used to inform future hazard management of cyclone events. This article is protected by copyright. All rights reserved

Cost-effectiveness of peer-supported self-management for people discharged from a mental health crisis team: methodological challenges and recommendations

Background Mental health acute crisis episodes are associated with high inpatient costs. Self-management interventions may reduce readmission by enabling individuals to manage their condition. Delivery of such interventions by Peer Support Workers (PSWs) may be cost-effective. CORE, a randomized control trial of a PSW self-management intervention compared to usual care, found a significant reduction in admissions to acute mental healthcare for participants receiving the intervention. This paper aims to evaluate the cost-effectiveness of the intervention over 12 months from a mental health service perspective. Analysis methods of increasing complexity were used to account for data missingness and distribution. Methods Participants were recruited from six crisis resolution teams in England from 12 March 2014 to 3 July 2015 (trial registration ISRCTN: 01027104). Resource use was collected from patient records at baseline and 12 months. The EQ-5D-3L was collected at baseline and 4 and 18 months, and linear interpolation was used to calculate 12-month values for quality-adjusted life-years (QALYs). The primary analysis of adjusted mean incremental costs and QALYs for complete cases are calculated separately using OLS regression. Secondly, a complete-case non-parametric two-stage bootstrap (TSB) was performed. The impacts of missing data and skewed cost data were explored using multiple imputation using chained equations and general linear models, respectively. Results Four hundred and forty-one participants were recruited to CORE; 221 randomized to the PSW intervention and 220 to usual care plus workbook. The probability that the PSW intervention was cost-effective compared with the workbook plus usual care control at 12 months varied with the method used, and ranged from 57% to 96% at a cost-effectiveness threshold of £20,000 per QALY gained. Discussion There was a minimum 57% chance that the intervention was cost-effective compared to the control using 12-month costs and QALYs. The probability varied by 40% when methods were employed to account for the relationship between costs and QALYs, but which restricted the sample to those who provided both complete cost and utility data. Caution should therefore be applied when selecting methods for the evaluation of healthcare interventions that aim to increase precision but may introduce bias if missing data are heavily unbalanced between costs and outcomes