Multiple high voltage output DC-to-DC power converter

Disclosed is a multiple output DC-to-DC converter. The DC input power is filtered and passed through a chopper preregulator. The chopper output is then passed through a current source inverter controlled by a squarewave generator. The resultant AC is passed through the primary winding of a transformer, with high voltages induced in a plurality of secondary windings. The high voltage secondary outputs are each solid-state rectified for passage to individual output loads. Multiple feedback loops control the operation of the chopper preregulator, one being responsive to the current through the primary winding and another responsive to the DC voltage level at a selected output

Paleomagnetic evidence for rapid vertical-axis rotation in the Peruvian Cordillera ca. 8 Ma

Paleomagnetic results from 31 Neogene sites in the Peruvian Andes yield primary magnetizations, as demonstrated by positive fold and reversal tests. Strata dated as 18–9 Ma record a significant counterclockwise rotation (−11° ± 5°), whereas unconformably overlying younger strata (7–6 Ma) are not rotated. The age of rotation thus is between 9 and 7 Ma, a period that coincides with the widespread Quechua 2 deformation phase. Moreover, eight independent studies on 107–9 Ma rocks from Peru between 9°S and 15°S reveal similar and significant rotations (−15° ± 6°). This suggests that the region rotated during a 2 m.y. period of deformation ca. 8 Ma, when the Andes underwent rapid uplift and important deformation commenced in the Subandean zone

Uplift of the Bolivian orocline coastal areas based on geomorphologic evolution of marine terraces and abrasion surfaces: preliminary results

The southern Pacific coast morphology and especially the presence of marine surfaces gives information on the dynamics of Andean forearc evolution from the Neogene. Along most of the Southern Peru and Northern Chilean coasts, discontinuous uplifts are recorded by marine terraces and marine abrasion surfaces; they have thus, preserved a record of eustatic sea level changes and the uplift history of the coastal area in the Andean forearc. One approach to study the tectonic history of the Andean forearc is to identify its effects in marine sedimentation or erosion patterns along the coastal area. To investigate these processes, the Neogene marine formations are studied in various coastal sections either in southern Peru, at Chala (15°50'S) and Ilo (17°32'S-17°48'S), situated above a steep subduction segment and at San Juan de Marcona (15°20'S), situated above the southern part of the Nazca ridge; or in Chile, from Tongoy (30°15'S) to Los Vilos (31°55'S), situated above a flat subduction segment (Fig.1). We chose various sites from each branch of the Arica bend in order to sample possibly different time spans during the Neogene and different response of the continental plate to the subduction process. Various studies were already undertaken on such problems either in Peru or Chile but mainly leaded to the datation of the 5th isotopic stage. So, differential GPS and cosmogenic datations are pursued in order to propose robust ages on these sites and subtract the effects of eustatic sea-level changes from local curves, identifying tectonic uplifts

Linking Ecology and Economics for Ecosystem Management

This article outlines an approach, based on ecosystem services, for assessing the trade-offs inherent in managing humans embedded in ecological systems. Evaluating these trade-offs requires an understanding of the biophysical magnitudes of the changes in ecosystem services that result from human actions, and of the impact of these changes on human welfare.We summarize the state of the art of ecosystem services?based management and the information needs for applying it. Three case studies of Long Term Ecological Research (LTER) sites?coastal, urban, and agricultural? illustrate the usefulness, information needs, quantification possibilities, and methods for this approach. One example of the application of this approach, with rigorously established service changes and valuations taken from the literature, is used to illustrate the potential for full economic valuation of several agricultural landscape management options, including managing for water quality, biodiversity, and crop productivity

Forearc deformation along the peruvian margin and the effects of changes in subduction style: quantifying the rates of Quaternary deformation using in situ produced cosmogenic 10Be and 26Al.

The Andes are one ofthe world's two highest mountain ranges and together wíth the westem cordillera of North America they forro an almost a continuous mountaín chain from the tip of Patagonia to the Alaskan peninsula. Common to all the cordillera of westem North and South America is the ín:fluence oflong-lived subduction. Indeed, the style of this subduction process has profoundly modified the margin of both continents. For example, following relatively normal subduction in the Jurassíc and the Cretaceous, the Laramide orogeny of North America is thought to have been produced from effects of extremely flat subduction

Mouse genome-wide association and systems genetics identifies Lhfp as a regulator of bone mass.

Bone mineral density (BMD) is a strong predictor of osteoporotic fracture. It is also one of the most heritable disease-associated quantitative traits. As a result, there has been considerable effort focused on dissecting its genetic basis. Here, we performed a genome-wide association study (GWAS) in a panel of inbred strains to identify associations influencing BMD. This analysis identified a significant (P = 3.1 x 10-12) BMD locus on Chromosome [email protected] Mbp that replicated in two separate inbred strain panels and overlapped a BMD quantitative trait locus (QTL) previously identified in a F2 intercross. The association mapped to a 300 Kbp region containing four genes; Gm2447, Gm20750, Cog6, and Lhfp. Further analysis found that Lipoma HMGIC Fusion Partner (Lhfp) was highly expressed in bone and osteoblasts. Furthermore, its expression was regulated by a local expression QTL (eQTL), which overlapped the BMD association. A co-expression network analysis revealed that Lhfp was strongly connected to genes involved in osteoblast differentiation. To directly evaluate its role in bone, Lhfp deficient mice (Lhfp-/-) were created using CRISPR/Cas9. Consistent with genetic and network predictions, bone marrow stromal cells (BMSCs) from Lhfp-/- mice displayed increased osteogenic differentiation. Lhfp-/- mice also had elevated BMD due to increased cortical bone mass. Lastly, we identified SNPs in human LHFP that were associated (P = 1.2 x 10-5) with heel BMD. In conclusion, we used GWAS and systems genetics to identify Lhfp as a regulator of osteoblast activity and bone mass

Composition of the Earth's inner core from high-pressure sound velocity measurements in Fe-Ni-Si alloys

Editor: R.D. van der Hilst Keywords: Fe-Ni-Si alloy aggregate compressional and shear sound velocities high pressure inner core light elements We performed room-temperature sound velocity and density measurements on a polycrystalline alloy, Fe 0.89 Ni 0.04 Si 0.07 , in the hexagonal close-packed (hcp) phase up to 108 GPa. Over the investigated pressure range the aggregate compressional sound velocity is ∼ 9% higher than in pure iron at the same density. The measured aggregate compressional (V P ) and shear (V S ) sound velocities, extrapolated to core densities and corrected for anharmonic temperature effects, are compared with seismic profiles. Our results provide constraints on the silicon abundance in the core, suggesting a model that simultaneously matches the primary seismic observables, density, P-wave and S-wave velocities, for an inner core containing 4 to 5 wt.% of Ni and 1 to 2 wt.% of Si

Identification of quantitative trait loci influencing skeletal architecture in mice: Emergence of Cdh11 as a primary candidate gene regulating femoral morphology

Bone strength is influenced by many properties intrinsic to bone, including its mass, geometry, and mineralization. To further advance our understanding of the genetic basis of bone strength-related traits, we utilized a large (N=815), moderately (G4) advanced intercross line (AIL) of mice derived from a high-runner selection line (HR) and the C57BL/6J inbred strain. In total, 16 quantitative trait loci (QTL) were identified that affected areal bone mineral density (aBMD) and femoral length and width. Four significant (P<0.05) and one suggestive (P<0.10) QTL were identified for three aBMD measurements: total body, vertebral and femoral. A QTL on Chromosome (Chr.) 3 influenced all three aBMD measures, while the other four QTL were unique to a single measure. A total of 10 significant and one suggestive QTL were identified for femoral length (FL) and two measures of femoral width, anterior-posterior (AP) and medial-lateral (ML). FL QTL were distinct from loci affecting AP and ML width, and of the seven AP QTL, only three affected ML. A QTL on Chr. 8 that explained 7.1% and 4.0% of the variance in AP and ML, respectively, was mapped to a six megabase (Mb) region harboring 12 protein-coding genes. The pattern of haplotype diversity across the QTL region and expression profiles of QTL genes, suggested that of the 12, cadherin 11 (Cdh11) was most likely the causal gene. These findings, when combined with existing data from gene knockouts, identify Cdh11 as a strong candidate gene within which genetic variation may affect bone morphology

Climate Change Meets the Law of the Horse

The climate change policy debate has only recently turned its full attention to adaptation - how to address the impacts of climate change we have already begun to experience and that will likely increase over time. Legal scholars have in turn begun to explore how the many different fields of law will and should respond. During this nascent period, one overarching question has gone unexamined: how will the legal system as a whole organize around climate change adaptation? Will a new distinct field of climate change adaptation law and policy emerge, or will legal institutions simply work away at the problem through unrelated, duly self-contained fields, as in the famous Law of the Horse? This Article is the first to examine that question comprehensively, to move beyond thinking about the law and climate change adaptation to consider the law of climate change adaptation. Part I of the Article lays out our methodological premises and approach. Using a model we call Stationarity Assessment, Part I explores how legal fields are structured and sustained based on assumptions about the variability of natural, social, and economic conditions, and how disruptions to that regime of variability can lead to the emergence of new fields of law and policy. Case studies of environmental law and environmental justice demonstrate the model’s predictive power for the formation of new distinct legal regimes. Part II applies the Stationarity Assessment model to the topic of climate change adaptation, using a case study of a hypothetical coastal region and the potential for climate change impacts to disrupt relevant legal doctrines and institutions. We find that most fields of law appear capable of adapting effectively to climate change. In other words, without some active intervention, we expect the law and policy of climate change adaptation to follow the path of the Law of the Horse - a collection of fields independently adapting to climate change - rather than organically coalescing into a new distinct field. Part III explores why, notwithstanding this conclusion, it may still be desirable to seek a different trajectory. Focusing on the likelihood of systemic adaptation decisions with perverse, harmful results, we identify the potential benefits offered by intervening to shape a new and distinct field of climate change adaptation law and policy. Part IV then identifies the contours of such a field, exploring the distinct purposes of reducing vulnerability, ensuring resiliency, and safeguarding equity. These features provide the normative policy components for a law of climate change adaptation that would be more than just a Law of the Horse. This new field would not replace or supplant any existing field, however, as environmental law did with regard to nuisance law, and it would not be dominated by substantive doctrine. Rather, like the field of environmental justice, this new legal regime would serve as a holistic overlay across other fields to ensure more efficient, effective, and just climate change adaptation solutions

Recurrence of chronic venous ulcers on the basis of clinical, etiologic, anatomic, and pathophysiologic criteria and air plethysmography

AbstractIntroduction: Leg ulcers associated with chronic venous insufficiency (CVI) frequently recur after healing. The risk of recurrence has not been well defined for patients in different anatomic and hemodynamic groups. We reviewed the risk of ulcer recurrence on the basis of clinical, etiologic, anatomic, and pathophysiologic criteria and hemodynamic characteristics of the affected limb as assessed with air plethysmography (APG). Methods: Ninety-nine limbs with class 6 CVI were assessed clinically and with standing duplex ultrasound scanning and APG for the definition of clinical, etiologic, anatomic, and pathophysiologic criteria. Leg ulcers were treated with high-pressure compression protocols. Surgical correction of venous abnormalities was offered to patients with appropriate conditions. After ulcer healing, the limbs were placed in compressive garments and followed at 6-month intervals for ulcer recurrence. Results: The mean patient age was 54.3 years, and 46% of the patients were female. Corrective venous surgery was performed in 37 limbs. The mean follow-up time for all 99 limbs was 28 months. The ulcer recurrence rate with life table was 37% ± 6% at 3 years and 48% ± 10% at 5 years. The patients who underwent venous surgery had a significantly lower recurrence rate (27% ± 9% at 48 months) than did those patients who had not undergone surgery (67% ± 8% at 48 months; P =.005). The patients with deep venous insufficiency (DVI; n=51) had significantly higher recurrence rates (66% ± 8% at 48 months) than did the patients without DVI (n = 48; 29% ± 9% at 48 months; P =.006). This difference was significant even after accounting for the effects of surgery (P =.03).The hazard ratio of ulcer recurrence increases by 14% for every unit increase in the venous filling index (VFI; P =.001). This remains significant even after accounting for the effects of surgery (P =.001). The combination of DVI and a VFI of more than 4 mL/s yields a risk of ulcer recurrence of 43% ± 9% at 1 year and 60% ± 10% at 2 years. Conclusion: Leg ulcers associated with CVI have a high rate of recurrence. Ulcer recurrence is significantly increased in patients with DVI and in patients who do not have venous abnormalities corrected surgically. The VFI obtained from APG is useful in the prediction of increased risk for recurrence, particularly in association with anatomic data. (J Vasc Surg 2002;35:723-8.