A Inserção da dança no currículo dos Colégios de Aplicação: conquistas, possibilidades e desafios

This paper contextualizes and problematizes the inclusion of Dance in the school curriculum, from experiences in Laboratory Schools in different places in Brazil which have Dance as a mandatory class. Through participant observation it was possible to product data about each one of these school realities and promote discussions that indicate changes or continuities of area problems. It brings a brief history of the specific legislation about the teaching of Arts, and a reflection about the National Common Curricular Base, a document that regulates basic education in Brazil. It is possible to observe advancements in the consolidation of Dance as an autonomous area, although there are still some difficulties that are very similar in the different contexts studied, especially in what concerns the polyvalence in the teaching of Arts and its relation to the field of Physical Education.O trabalho contextualiza e problematiza questões acerca da inserção da Dança no currículo escolar, partindo de experiências de quatro Colégios de Aplicação de diferentes  localidades do Brasil, cujas matrizes curriculares possuem a Dança como componente obrigatório. A partir da observação participante foi possível construir dados acerca de cada uma dessas realidades escolares e promover debates que indicam mudanças ou permanência de problemáticas discutidas na área. O texto faz um breve histórico sobre a legislação específica acerca do ensino da Arte e reflete sobre a Base Nacional Comum Curricular, documento que normatiza o currículo do ensino básico nacional. Observam-se avanços na consolidação da Dança como área autônoma, apesar de ainda existirem dificuldades muito semelhantes nos diferentes contextos estudados, especialmente em se tratando da questão da polivalência no ensino de Arte e da relação com a área da Educação Física

Ethnobotanical survey of medicinal flora in the rural community Rio dos Couros, state of Mato Grosso, Brazil

The aim of this work was to register the traditional knowledge about medicinal plants, as well as raise the socioeconomic profile of the residents from the community Rio dos Couros (Brazil), in order to relate them the level of botanical knowledge. The methodology adopted was the "snowball", through semi-structured interviews. Levels of agreement regarding the main uses (PUC) and use value (UV) were applied, as well as the ICD for classification of health problems. Difference of age, residence time and individual income were elements that interfered in the level of botanical knowledge. We recorded 81 different plants distributed in 38 botanical families, with Fabaceae as the most cited. The highest value for PUCc was attributed to Strychnos pseudoquina (87%), and the respiratory problem was one of the most common diseases among the community

A ozonioterapia como tratamento complementar do pé diabético

The aim of this paper was to present the use of ozone therapy as an adjuvant treatment in cases of diabetic foot ulcers and to compare traditional treatment and traditional treatment associated with ozone therapy. This is an integrative review in which searches were carried out in the PubMed, VHL, ScienceDirect and SciELO databases, without date or language restrictions. The results demonstrate that ozone, as a complementary measure to conventional treatment, has shown promise in the treatment of diabetic foot and ulcers, as it helps with healing, circulation, the immune system and has no adverse effects. Diabetes Mellitus, if left untreated, can lead to complications, such as diabetic foot - a syndrome that causes neuropathy, ischemia and infections that lead to the development of diabetic foot ulcers. Conventional treatment for diabetic foot ulcers consists of the use of antibiotics, debridement of the lesions and, in some cases, amputation of the limbs; therefore, ozone therapy has been used to complement the treatment. The results obtained showed that the use of ozone is promising in patients with diabetic foot ulcers.O objetivo deste trabalho foi apresentar o uso da ozonioterapia como tratamento coadjuvante em casos de úlcera de pé diabético e comparar o tratamento tradicional e o tratamento tradicional associado à ozonioterapia. Trata-se de uma revisão integrativa em que foram realizadas pesquisas nas bases de dados PubMed, BVS, ScienceDirect e SciELO, sem restrições de datas ou idiomas. Os resultados demonstram que o ozônio, como medida complementar ao tratamento convencional, se mostrou promissor no tratamento do pé diabético e das úlceras, por auxiliar na cicatrização, circulação, no sistema imunológico e não apresenta efeitos adversos. A Diabetes Mellitus, se não tratada, pode acarretar complicações, como o pé diabético - uma síndrome que ocasiona neuropatia, isquemia e infecções que cursam com o desenvolvimento das úlceras do pé diabético. O tratamento convencional para as úlceras do pé diabético consiste na utilização de antibióticos, desbridamento das lesões e, em alguns casos, a amputação dos membros, assim, a ozonioterapia vem sendo utilizada para complementar o tratamento. Os resultados obtidos mostraram que o uso do ozônio é promissor nos pacientes portadores de úlcera do pé diabético

Early hematopoietic stem cell transplantation in a patient with severe mucopolysaccharidosis II : 7 years follow-up

Mucopolysaccharidosis type II (MPS II - Hunter syndrome) is an X-linked lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2 sulfatase (I2S), leading to the accumulation of the glycosaminoglycans, affecting multiple organs and systems. Enzyme replacement therapy does not cross the blood brain barrier, limiting results in neurological forms of the disease. Another option of treatment for severe MPS, hematopoietic stem cell transplantation (HSCT) has become the treatment of choice for the severe form of MPS type I, since it can preserve neurocognition when performed early in the course of the disease. To date, only few studies have examined the long-term outcomes of HSCT in patients with MPS II. We describe the seven-year follow-up of a prenatally diagnosed MPS II boy with positive family history of severe MPS form, submitted to HSCT with umbilical cord blood cells at 70 days of age. Engraftment after 30 days revealed mixed chimerism with 79% donor cells; after 7 years engraftment remains at 80%. I2S activity 30 days post-transplant was low in plasma and normal in leukocytes and the same pattern is observed to date. At age 7 years growth charts are normal and he is very healthy, although mild signs of dysostosis multiplex are present, as well as hearing loss. The neuropsychological evaluation (Wechsler Intelligence Scale for Children - Fourth Edition - WISC-IV), disclosed an IQ of 47. Despite this low measured IQ, the patient continues to show improvements in cognitive, language and motor skills, being quite functional. We believe that HSCT is a therapeutic option for MPS II patients with the severe phenotype, as it could preserve neurocognition or even halt neurodegeneration, provided strict selection criteria are followed

Qualidade microbiológica e caracterização da resistência antimicrobiana de bactérias isoladas de queijos Coalho comercializados em Vitória da Conquista-Bahia

Neste estudo foram determinadas a qualidade higiênico-sanitária, a prevalência e a resistência antimicrobiana de patógenos isolados de 24 amostras de queijo Coalho comercializados em duas feiras livres do município de Vitória da Conquista, Bahia. Foram realizadas análises físico-químicas e microbiológicas através de métodos convencionais interpretados conforme legislação vigente. Identificamos que 75% das amostras eram comercializadas em temperatura inadequada e que 100% apresentaram contagem para coliformes totais acima do limite aceitável.  Staphylococcus coagulase positiva e Escherichia coli foram isolados em 87,5% e 62,5% das amostras, respectivamente. Não foi detectada a presença de Listeria monocytogenes e Salmonella sp. Identificamos 51,1% de resistência a pelo menos um dos sete antimicrobianos testados para Staphylococcus coagulase positiva e 44,4% para pelo menos um dos 11 avaliados para E.coli. As análises realizadas evidenciaram uma precariedade higiênico-sanitária na produção e comercialização de queijo coalho nas feiras livres de Vitória da Conquista. Torna-se também uma preocupação, a presença de bactérias resistentes aos antimicrobianos nestes queijos. Deste modo, ressaltamos a importância do controle de qualidade na produção e comercialização destes produtos, assim como a necessidade das ações da vigilância sanitária para orientação aos manipuladores e produtores de queijo

A Model of DENV-3 Infection That Recapitulates Severe Disease and Highlights the Importance of IFN-γ in Host Resistance to Infection

There are few animal models of dengue infection, especially in immunocompetent mice. Here, we describe alterations found in adult immunocompetent mice inoculated with an adapted Dengue virus (DENV-3) strain. Infection of mice with the adapted DENV-3 caused inoculum-dependent lethality that was preceded by several hematological and biochemical changes and increased virus dissemination, features consistent with severe disease manifestation in humans. IFN-γ expression increased after DENV-3 infection of WT mice and this was preceded by increase in expression of IL-12 and IL-18. In DENV-3-inoculated IFN-γ−/− mice, there was enhanced lethality, which was preceded by severe disease manifestation and virus replication. Lack of IFN-γ production was associated with diminished NO-synthase 2 (NOS2) expression and higher susceptibility of NOS2−/− mice to DENV-3 infection. Therefore, mechanisms of protection to DENV-3 infection rely on IFN-γ-NOS2-NO-dependent control of viral replication and of disease severity, a pathway showed to be relevant for resistance to DENV infection in other experimental and clinical settings. Thus, the model of DENV-3 infection in immunocompetent mice described here represents a significant advance in animal models of severe dengue disease and may provide an important tool to the elucidation of immunopathogenesis of disease and of protective mechanisms associated with infection

Biogeochemical mechanisms controlling trophic state and micropollutant concentrations in a tropical artificial lake

Universidade de Brasília. Instituto de Geociências. Brasília, DF, Brazil.Universidade de Brasília. Instituto de Geociências. Brasília, DF, Brazil.Universidade Federal de Tocantins. Departamento de Química Ambiental. Tocantins, TO, Brazil.Universidade de Brasília. Instituto de Geociências. Brasília, DF, Brazil.Companhia de Saneamento do Distrito Federal. Brasília, Df, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Ananindeua, PA, Brasil.Universidade de Brasília. Instituto de Geociências. Brasília, DF, Brazil.Lake Paranoá is a human-made water reservoir created in 1959 together with the new capital of Brazil (Brasilia). With the demands of urban development, population growth, and land use changes, the lake presented severe deterioration of water quality due to the disposal of wastewater with a high concentration of nutrients. To better elucidate the natural and anthropogenic sources controlling the water quality from Lake Paranoá, this study aimed to (1) investigate the main geochemical processes controlling water quality of the lake and its tributaries; (2) evaluate Lake Paranoá’s trophic state; and (3) determine the occurrence and fate of organic micropollutants in Lake Paranoá waters and WWTPs effluents. The waters from Lake Paranoá tributaries are naturally acidic due to the nature of the extremely weathered ferralsols and the crustal material composition. The main processes linked with anthropogenic activities that affect the water quality from the tributaries are the input of untreated domestic wastewater and the dissolution of carbonate minerals arising from construction material residues. Generally, the waters of Lake Paranoá presented low nutrient and chlorophyll-a concentrations, indicating a low trophic state (oligo-mesotrophic). A significant increase in the trophic state (super-eutrophic) was observed at specific regions of the lake that have high nutrient input from tributaries, caused by the continuous disposal of untreated domestic sewage. In Lake Paranoá waters, the organic micropollutants that were identified and quantified (caffeine, bezafibrate, bisphenol A, diethyl phthalate, and nonylphenol) presented concentrations consistent with previous studies and within the threshold of toxicity, except bisphenol A

Alternatives to antibiotic growth promoters for weanling pigs

An experiment was conducted to evaluate the addition of sodium butyrate, plant extracts and nucleotides on weanling pig performance, digestive content pH, organ morphometry, and intestinal epithelial histology. A total of 90 piglets at 21 days of age and an average initial weight of 6.35±0.34kg were used. The piglets were distributed in a randomized complete block design with five treatments, six replicates, and three animals per experimental unit. The treatments consisted of the following: Control: basal diet without antibiotic; Antibiotic: basal diet with 40mg kg-1 colistin sulfate and Additive: 1000, 1500 and 2000mg kg-1 of a combination of sodium butyrate + plant extracts + nucleotides. The experiment lasted 35 days, at which time one animal was slaughtered to assess pH of the digestive contents, morphometry of the organs and histology of the intestinal epithelium. No differences were found (P>0.05) in the performance, pH of the digestive contents, morphometry of the organs or histology of the intestinal epithelium by the analysis of orthogonal polynomials or contrasts. The combination of sodium butyrate, plant extracts and nucleotides not improved the productive characteristics of weanling pigs

Early hematopoietic stem cell transplantation in a patient with severe mucopolysaccharidosis II: A 7 years follow-up

Mucopolysaccharidosis type II (MPS II - Hunter syndrome) is an X-linked lysosomal storage disorder caused by a deficiency in the enzyme iduronate-2 sulfatase (I2S), leading to the accumulation of the glycosaminoglycans, affecting multiple organs and systems. Enzyme replacement therapy does not cross the blood brain barrier, limiting results in neurological forms of the disease. Another option of treatment for severe MPS, hematopoietic stem cell transplantation (HSCT) has become the treatment of choice for the severe form of MPS type I, since it can preserve neurocognition when performed early in the course of the disease. To date, only few studies have examined the long-term outcomes of HSCT in patients with MPS II. We describe the seven-year follow-up of a prenatally diagnosed MPS II boy with positive family history of severe MPS form, submitted to HSCT with umbilical cord blood cells at 70 days of age. Engraftment after 30 days revealed mixed chimerism with 79% donor cells; after 7 years engraftment remains at 80%. I2S activity 30 days post-transplant was low in plasma and normal in leukocytes and the same pattern is observed to date. At age 7 years growth charts are normal and he is very healthy, although mild signs of dysostosis multiplex are present, as well as hearing loss. The neuropsychological evaluation (Wechsler Intelligence Scale for Children - Fourth Edition - WISC-IV), disclosed an IQ of 47. Despite this low measured IQ, the patient continues to show improvements in cognitive, language and motor skills, being quite functional. We believe that HSCT is a therapeutic option for MPS II patients with the severe phenotype, as it could preserve neurocognition or even halt neurodegeneration, provided strict selection criteria are followed