Under Western Eyes

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Tangential flow filtration and scalability in viral vector purification

Pall Biotech has linearly scalable tangential flow filtration technology that can cover processing volume ranges from less than a liter to over 2000 liters. Manual assemblies can be used with Pall TFF filters in scales under 20L and programmable skids are available for larger scales. In this document TFF linear scalability of up to 200 liters is covered starting from a 7L initial volume and maintaining similar pressures, processing times and yields at all scales. Using this scalable technology Pall biotech can help biologics companies go to clinical trials and to commercial scale manufacturing successfully. Please click Additional Files below to see the full abstract

Leak testing of single-use biocontainer for bulk product storage and transport using flow measurement instrument

For some bulk drug products, the biopharmaceutical industry requires a complex transportation network for global shipping and storage under cold temperatures. With the growing demand for single-use technologies, there is need of an accurate method for assuring that single-use biocontainers remain integral throughout such transport and storage. Please click Additional Files below to see the full abstract

Aggregation-Induced Emission (AIE), Life and Health

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health

Design and Testing of Non-Toxic RCS Thrusters for Second Generation Reusable Launch Vehicle

Under NASA sponsorship, Northrop Grumman Space Technology (NGST) designed, built and tested two non-toxic, reaction control engines, one using liquid oxygen (LOX) and liquid hydrogen (LH2) and the other using liquid oxygen and ethanol. This paper presents the design and testing of the LOX/LH2 thruster. The two key enabling technologies are the coaxial liquid-on-liquid pintle injector and the fuelcooling duct. The workhorse thruster was hotfire tested at the NASA Marshall Space Flight Center Test Stand 500 in March and April of 2002. All tests were performed at sea-level conditions. During the test program, 7 configurations were tested, including 2 combustion chambers, 3 LOX injector pintle tips, and 4 LHp injector settings. The operating conditions surveyed were 70 to 100% thrust levels, mixture ratios from 3.27 to 4.29, and LH2 duct cooling from 18.0 to 25.5% fuel flow. The copper heat sink chamber was used for 16 burns, each burn lasting from 0.4 to 10 seconds, totaling 51.4 seconds, followed by Haynes chamber testing ranging from 0.9 to 120 seconds, totaling 300.9 seconds. The performance of the engine reached 95% C* efficiency. The temperature on the Haynes chamber remained well below established material limits, with the exception of one localized hot spot. These results demonstrate that both the coaxial liquid-on-liquid pintle injector design and fuel duct concepts are viable for the intended application. The thruster headend design maintained cryogenic injection temperatures while firing, which validates the selected injector design approach for minimal heat soak-back. Also, off -nominal operation without adversely impacting the thermal response of the engine showed the robustness of the duct design, a key design feature for this application. By injecting fuel into the duct, the throat temperatures are manageable, yet the split of fuel through the cooling duct does not compromise the overall combstion efficiency, which indicates that, provided proper design refinement, such a concept could be applied to a high-performance version of the thruster

Contribution à l'évaluation stratégique de la recherche par l'étude des temps de premières citations

National audienceL'objectif principal de cette étude était de rechercher la durée moyenne ou médiane que mettait un article de recherche pour être cité par un autre auteur. C'est pourquoi, nous avons relevé les données temporelles correspondant à la durée entre la publication de l'article et la publication du premier article le citant. Sachant que certains articles n'ont pas encore reçu de citation, nous avons donc constitué une base de données temporelles incluant des données censurées. A partir de ce moment, nous avons recherché un modèle mathématique qui correspond à la distribution de ces données en fonction de la quantité d'articles de l'ensemble. En utilisant la loi de hasard, (en particulier la fonction de hasard), il est possible de traiter ces données graphiquement. Très vite nous nous sommes aperçus que ces ensembles semblent suivre une distribution Log-Normal à partir de laquelle il est possible de relever 2 coefficients suffisamment significatifs pour caractériser la distribution. Le coefficient > qui montre l'immédiateté de l'apparition de la première citation : plus il est petit et plus la probabilité instantanée d'apparition de cette citation est forte, ce qui signifie que si > est petit la probabilité d'apparition de première citation d'un article encore non-cité est très forte dans un futur proche. Le coefficient > qui indique le temps médian (pour 50% des articles) de première citation de la base de données étudiées

Aggregation-Induced Emission (AIE), Life and Health.

Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied in imaging of biological structure and dynamic physiological processes, disease diagnosis and treatment, and detection and monitoring of specific analytes, followed by representative works. Discussions on critical issues and perspectives on future directions are also included. This review aims to stimulate the interest of researchers from different fields, including chemistry, biology, materials science, medicine, etc., thus promoting the development of AIE in the fields of life and health