Three steps to maintain predictable interdental papilla and gingiva emergence profiles in immediate implant placement. A 3-year follow-up case report

We present a case that describes a three-step clinical technique to provide guidelines to replace fractured teeth with immediate implant placement using the same dental structure as a temporary crown and a regenerative approach. This approach predictably maintains the interdental papilla and gingiva emergence profile to ensure a favorable cosmetic result. A 3-year follow-up has shown good clinical outcomes and stability in crestal bone levels. Consequently, this is an innovative way to do temporary crown and design restorations in everyday clinical practice

Selective generation of local ferromagnetism in austenitic stainless steel using nanoindentation

This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.Periodic arrays of magnetic structures with micrometrer and submicrometer lateral sizes have been prepared at the surface of an austenitic stainless steel by means of local deformation using a nanoindenter. This method takes advantage of the phase transformation (from nonmagnetic fcc austenite to ferromagnetic bct martensite) which occurs in this material upon plastic deformation. The local character of the induced ferromagnetism is confirmed by magneto-optical Kerr effect measurements together with magnetic force microscopy imaging. The generated ferromagnetism can be subsequently erased by subjecting the deformed steel to annealing processes at temperatures above the reverse, martensite-to-austenite, phase transformation temperature

Oxaliplatin-Related Ocular Toxicity

We report the case of a 52-year-old woman with advanced colorectal cancer who was treated with oxaliplatin on a FOLFOX schedule. After 3 cycles of chemotherapy, she started to complain of visual loss, altered color vision and neurological symptoms. Due to the suspicion of ocular and neurological toxicity, antineoplastic treatment was stopped. Her visual field showed a concentric bilateral scotoma and the electrooculogram test revealed severe impairment of the retinal pigment epithelium. Visual acuity, color vision and visual field recovered completely 8 months later, although electrooculogram remained abnormal. Ocular toxicity has been reported as an infrequent adverse event of oxaliplatin. Findings in this case indicate toxicity of this chemotherapeutic agent on the retinal pigment epithelium, which has not been reported before. This damage could be permanent, and it thus differs from previously described oxaliplatin-induced ocular toxicities, which are usually transient and reversible. With increasing use of oxaliplatin as first-line treatment in advanced colorectal cancer, we have to be aware of this possible toxicity

O mapeamento das competências dos técnicos administrativos em educação da FACH/UFMS e a necessidade de treinamento = Mapping the skills of administrative technicians in education at FACH/UFMS and the need for training = Mapeo de las competencias de los técnicos administrativos en educación de la FACH/UFMS y la necesidad de capacitación

DOI: 10.30612/videre.v14i30.1612

Disentangling Highly Asymmetric Magnetoelectric Effects in Engineered Multiferroic Heterostructures

One of the main strategies to control magnetism by voltage is the use of magnetostrictive-piezoelectric hybrid materials, such as ferromagnetic-ferroelectric heterostructures. When such heterostructures are subjected to an electric field, piezostrain-mediated effects, electronic charging, and voltage-driven oxygen migration (magnetoionics) may simultaneously occur, making the interpretation of the magnetoelectric effects not straightforward and often leading to misconceptions. Typically, the strain-mediated magnetoelectric response is symmetric with respect to the sign of the applied voltage because the induced strain (and variations in the magnetization) depends on the square of the ferroelectric polarization. Conversely, asymmetric responses can be obtained from electronic charging and voltage-driven oxygen migration. By engineering a ferromagnetic-ferroelectric hybrid consisting of a magnetically soft 50-nm thick Fe75Al25 (at. %) thin film on top of a (110)-oriented Pb(Mg1/3Nb2/3)O3-32PbTiO3 ferroelectric crystal, a highly asymmetric magnetoelectric response is obtained and the aforementioned magnetoelectric effects can be disentangled. Specifically, the large thickness of the Fe75Al25 layer allows dismissing any possible charge accumulation effect, whereas no evidence of magnetoionics is observed experimentally, as expected from the high resistance to oxidation of Fe75Al25, leaving strain as the only mechanism to modulate the asymmetric magnetoelectric response. The origin of this asymmetric strain-induced magnetoelectric effect arises from the asymmetry of the polarization reversal in the particular crystallographic orientation of the ferroelectric substrate. These results are important to optimize the performance of artificial multiferroic heterostructures

HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease

We investigated the associations with HLA and microtubule-associated protein tau (MAPT) H1 haplotype in anti-IgLON5 disease, a recently identified disorder characterized by gait instability, brainstem dysfunction, and a prominent sleep disorder in association with IgLON5 antibodies and pathologic findings of a novel neuronal-specific tauopathy. We compared the HLA alleles and MAPT H1/H1 genotype of 35 patients with anti-IgLON5 with healthy controls. The on-line server tool NetMHCIIpan 3.1 was used to predict the IgLON5 peptide binding to HLA Class II molecules. The HLA-DRB1*10:01-DQB1*05:01 haplotype was overrepresented in patients with anti-IgLON5 disease (OR = 54.5; 95% CI: 22.2-133.9, p < 0.0001). In addition, HLA-DQA was genotyped in 27 patients, and 25 (92.6%) of them had DQ molecules composed by DQA1*01 and DQB1*05 chains compared with 148/542 (27.3%) controls (OR = 43.9; 95% CI: 10.4-185.5, p < 0.0001). Patients DRB1*10:01 positive developed more frequently sleep or bulbar symptoms than those carrying other HLA alleles (70.0% vs 26.7%; p = 0.011). Prediction algorithms identified 2 IgLON5 peptides (1 located in the signal sequence) that showed strong binding to HLA-DRB1*10:01 and other HLA-DRB1, but not to HLA-DQA and HLA-DQB molecules. The MAPT H1/H1 homozygous genotype was present in 20/24 (83.3%) anti-IgLON5 Caucasian patients compared with 54/116 (46.5%) healthy controls (p = 0.0007). The robust association of anti-IgLON5 disease with distinct HLA Class II molecules supports a primary autoimmune origin. The significant association of MAPT H1 haplotype also suggests that an underlying neurodegenerative process could be involved in anti-IgLON5 disease

The multiple sclerosis visual pathway cohort: understanding neurodegeneration in MS

BACKGROUND: Multiple Sclerosis (MS) is an immune-mediated disease of the Central Nervous System with two major underlying etiopathogenic processes: inflammation and neurodegeneration. The latter determines the prognosis of this disease. MS is the main cause of non-traumatic disability in middle-aged populations. FINDINGS: The MS-VisualPath Cohort was set up to study the neurodegenerative component of MS using advanced imaging techniques by focusing on analysis of the visual pathway in a middle-aged MS population in Barcelona, Spain. We started the recruitment of patients in the early phase of MS in 2010 and it remains permanently open. All patients undergo a complete neurological and ophthalmological examination including measurements of physical and disability (Expanded Disability Status Scale; Multiple Sclerosis Functional Composite and neuropsychological tests), disease activity (relapses) and visual function testing (visual acuity, color vision and visual field). The MS-VisualPath protocol also assesses the presence of anxiety and depressive symptoms (Hospital Anxiety and Depression Scale), general quality of life (SF-36) and visual quality of life (25-Item National Eye Institute Visual Function Questionnaire with the 10-Item Neuro-Ophthalmic Supplement). In addition, the imaging protocol includes both retinal (Optical Coherence Tomography and Wide-Field Fundus Imaging) and brain imaging (Magnetic Resonance Imaging). Finally, multifocal Visual Evoked Potentials are used to perform neurophysiological assessment of the visual pathway. DISCUSSION: The analysis of the visual pathway with advance imaging and electrophysilogical tools in parallel with clinical information will provide significant and new knowledge regarding neurodegeneration in MS and provide new clinical and imaging biomarkers to help monitor disease progression in these patients

Mortality Attributable to Environmental Tobacco Smoke Exposure in Spain in 2020

Introduction and objectives: Exposure to environmental tobacco smoke (ETS) is associated with increased mortality and morbidity. The objective of this study was to estimate the impact of ETS exposure in Spain on mortality in 2020 in the population aged 35 years and over. Methods: A method of estimating attributable mortality (AM) based on the prevalence of ETS exposure was applied. Prevalence data were obtained from a representative study conducted in Spain and the relative risks were derived from a meta-analysis. AM point estimates are presented along with 95% confidence intervals (95% CI), calculated using a bootstrap naive procedure. AM, both overall and by smoking habit, was estimated for each combination of sex, age group, and cause of death (lung cancer and ischemic heart disease). A sensitivity analysis was performed. Results: A total of 747 (95% CI 676–825) deaths were attributable to ETS exposure, of which 279 (95% CI 256–306) were caused by lung cancer, and 468 (95% CI 417–523) by ischemic heart disease. Three quarters (75.1%) of AM occurred in men and 60.9% in non-smokers. When chronic obstructive pulmonary disease and cerebrovascular disease are included, the burden of AM is estimated at 2242 deaths. Conclusions: ETS exposure is associated with 1.5% of all deaths from lung cancer and ischemic heart disease in the population aged 35 and over. These data underline the need for health authorities to focus on reducing exposure to ETS in all settings and environmentsInstituto de Salud Carlos III (ISCIII), reference: PI22/00727, co-funded by the European UnionS