251 research outputs found
DEM Simulation of Soil Loosening Process Caused by a Vibrating Subsoiler
Rosana G. Moreira, Editor-in-Chief; Texas A&M UniversityThis is a paper from International Commission of Agricultural Engineering (CIGR, Commission Internationale du Genie Rural) E-Journal Volume 9 (2007): DEM Simulation of Soil Loosening Process Caused by a Vibrating Subsoiler. Manuscript PM 05 010. Vol. IX. November, 2007
“Paradoxical shrinkage” of coronary arterial wall may contribute to luminal narrowing in stable angina but not in acute myocardial infarction
Anti-Colonial Strategies in Cross-cultural Music Science Research
This paper presents a critical analysis of ethical and methodological issues within cross-cultural music science research, including issues around community based research, participation, and data sovereignty. Although such issues have long been discussed in social science fields including anthropology and ethnomusicology, psychology and music cognition are only beginning to take them into serious consideration. This paper aims to fill that gap in the literature, and draw attention to the necessity of critically considering how implicit cultural biases and pure positivist approaches
can mar scientific investigations of music, especially in a cross-cultural context. We focus initially on two previous papers (Jacoby et al., 2020; Savage et al., 2021) before broadening our discussion to critique and provide alternatives to scientific approaches that support assimilation, extractvism, and universalism. We then discuss methodological considerations around crosscultural research ethics, data ownership, and open science and reproducibility. Throughout our critique, we offer many personal recommendations to crosscultural music researchers, and suggest a few larger
systemic changes
Discrete symmetries and models of flavor mixing
Evidences of a discrete symmetry behind the pattern of lepton mixing are
analyzed. The program of "symmetry building" is outlined. Generic features and
problems of realization of this program in consistent gauge models are
formulated. The key issues include the flavor symmetry breaking, connection of
mixing and masses, {\it ad hoc} prescription of flavor charges, "missing"
representations, existence of new particles, possible accidental character of
the TBM mixing. Various ways are considered to extend the leptonic symmetries
to the quark sector and to reconcile them with Grand Unification. In this
connection the quark-lepton complementarity could be a viable alternative to
TBM. Observational consequences of the symmetries and future experimental tests
of their existence are discussed.Comment: 14 pages, 5 figures. Talk given at the Symposium "DISCRETE 2010", 6 -
11 December 2010, La Sapienza, Rome, Ital
<Abstract of published report>The Effect of ONO-3708,a Novel TXA_2 Receptor Antagonist, on U-46619-Induced Contraction of Guinea Pig and Human Tracheal Strips in vitro and on Bronchoconstriction in Guinea Pigs in vivo.
TGF-β-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis
BACKGROUND: Cytoglobin (CYGB) is a respiratory protein that acts as a scavenger of reactive oxygen species. Although CYGB is expressed uniquely in hepatic stellate cells (HSCs) in the liver, the molecular role of CYGB in human HSC activation and human liver disease remains uncharacterised. The aim of this study was to reveal the mechanism by which TGF-β1/SMAD2 pathway regulates human CYGB promoter and the pathophysiological function of CYGB in human non-alcoholic steatohepatitis (NASH). METHODS: Immunohistochemical staining was performed using human NASH biopsy specimens. Molecular and biochemical analysis were performed by western blotting, quantitative PCR, and luciferase and immunoprecipitation assays. Hydroxyl radicals (•OH) and oxidative DNA damage were measured using an •OH-detectable probe and 8-hydroxy-2’-deoxyguanosine (8-OHdG) ELISA. RESULTS: In culture, TGF-β1-pretreated human hepatic stellate cells (HHSteCs) exhibited lowered CYGB levels together with increased NADPH oxidase 4 (NOX4) expression and were primed for H_{2}O_{2}-triggered OH production and 8-OHdG generation. Overexpression of human CYGB in HHSteCs cancelled out those effects of TGF-β1. Electron spin resonance demonstrated direct •OH-scavenging activity of recombinant human CYGB. Mechanistically, pSMAD2 reduced CYGB transcription by recruiting the M1 repressor isoform of SP3 to the human CYGB promoter at nucleotide positions +2–{+}^13 from the transcription start site. The same repression did not occur on the mouse Cygb promoter. TGF-β1/SMAD3 mediated αSMA and collagen expression. Consistent with those observations in cultured HHSteCs, CYGB expression was negligible, but 8-OHdG was abundant, in activated αSMA^{+}pSMAD2^{+}- and αSMA^{+}NOX4^{+}-positive hepatic stellate cells from human NASH patients with advanced fibrosis. CONCLUSIONS: Downregulation of CYGB by the TGF-β1/pSMAD2/SP3-M1 pathway brings about •OH-dependent oxidative DNA damage in activated hepatic stellate cells from human patients with NASH
Bilinear R-parity violation with flavor symmetry
Bilinear R-parity violation (BRPV) provides the simplest intrinsically
supersymmetric neutrino mass generation scheme. While neutrino mixing
parameters can be probed in high energy accelerators, they are unfortunately
not predicted by the theory. Here we propose a model based on the discrete
flavor symmetry with a single R-parity violating parameter, leading to
(i) correct Cabbibo mixing given by the Gatto-Sartori-Tonin formula, and a
successful unification-like b-tau mass relation, and (ii) a correlation between
the lepton mixing angles and in agreement with
recent neutrino oscillation data, as well as a (nearly) massless neutrino,
leading to absence of neutrinoless double beta decay.Comment: 16 pages, 3 figures. Extended version, as published in JHE
Mass bound of the lightest neutral Higgs scalar in the extra U(1) models
The upper mass bound of the lightest neutral Higgs scalar is studied in the
problem solvable extra U(1) models by using the analysis of the
renormalization group equations. In order to restrict the parameter space we
take account of a condition of the radiative symmetry breaking and some
phenomenological constraints. We compare the bound obtained based on this
restricted parameter space with the one of the next to the minimal
supersymmetric standard model (NMSSM). Features of the scalar potential and
renormalization group equations of the Yukawa couplings among Higgs chiral
supermultiplets are rather different between them. They can reflect in this
bound.Comment: 22 pages, latex, 11 eps-figure
CP Violation in Supersymmetric U(1)' Models
The supersymmetric CP problem is studied within superstring-motivated
extensions of the MSSM with an additional U(1)' gauge symmetry broken at the
TeV scale. This class of models offers an attractive solution to the mu problem
of the MSSM, in which U(1)' gauge invariance forbids the bare mu term, but an
effective mu parameter is generated by the vacuum expectation value of a
Standard Model singlet S which has superpotential coupling of the form SH_uH_d
to the electroweak Higgs doublets. The effective mu parameter is thus
dynamically determined as a function of the soft supersymmetry breaking
parameters, and can be complex if the soft parameters have nontrivial
CP-violating phases. We examine the phenomenological constraints on the
reparameterization invariant phase combinations within this framework, and find
that the supersymmetric CP problem can be greatly alleviated in models in which
the phase of the SU(2) gaugino mass parameter is aligned with the soft
trilinear scalar mass parameter associated with the SH_uH_d coupling. We also
study how the phases filter into the Higgs sector, and find that while the
Higgs sector conserves CP at the renormalizable level to all orders of
perturbation theory, CP violation can enter at the nonrenormalizable level at
one-loop order. In the majority of the parameter space, the lightest Higgs
boson remains essentially CP even but the heavier Higgs bosons can exhibit
large CP-violating mixings, similar to the CP-violating MSSM with large mu
parameter.Comment: 29 pp, 3 figs, 2 table
The Global Jukebox: a public database of performing arts and culture
Standardized cross-cultural databases of the arts are critical to a balanced scientific understanding of the performing arts, and their role in other domains of human society. This paper introduces the Global Jukebox as a resource for comparative and cross-cultural study of the performing arts and culture. The Global Jukebox adds an extensive and detailed global database of the performing arts that enlarges our understanding of human cultural diversity. Initially prototyped by Alan Lomax in the 1980s, its core is the Cantometrics dataset, encompassing standardized codings on 37 aspects of musical style for 5,776 traditional songs from 1,026 societies. The Cantometrics dataset has been cleaned and checked for reliability and accuracy, and includes a full coding guide with audio training examples (https://theglobaljukebox.org/?songsofearth). Also being released are seven additional datasets coding and describing instrumentation, conversation, popular music, vowel and consonant placement, breath management, social factors, and societies. For the first time, all digitized Global Jukebox data are being made available in open-access, downloadable format (https://github.com/theglobaljukebox), linked with streaming audio recordings (theglobaljukebox.org) to the maximum extent allowed while respecting copyright and the wishes of culture-bearers. The data are cross-indexed with the Database of Peoples, Languages, and Cultures (D-PLACE) to allow researchers to test hypotheses about worldwide coevolution of aesthetic patterns and traditions. As an example, we analyze the global relationship between song style and societal complexity, showing that they are robustly related, in contrast to previous critiques claiming that these proposed relationships were an artifact of autocorrelation (though causal mechanisms remain unresolved).Introduction Background The Global Jukebox and its data 1. The data 1.1. Datasets of the Global Jukebox 1.2. Comparison with other cross cultural datasets 1.3. Coded performance variables: Selection and reliability 1.4. Performance data sources 1.5. Selection of audio examples 1.6. Availability of audio recordings 1.7. Performance metadata 2. Sampling societies and links to other datasets 2.1. Sampling societies 2.2. Links to other cross-cultural datasets 3. Data curation, cleaning, and validation 4. Coding reliability 5. Is song style correlated with social complexity? An example of hypothesis testing using the Global Jukebox 5.1. Hypothesis testing with the Global Jukebox datasets 5.2. Methods 5.3 Results of reanalysis 5.4 Discussion 6. Ethics, rights and consent 7. Conclusio
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