Evolution of A Peculiar Type Ibn Supernova SN 2019wep

We present a high-cadence short term photometric and spectroscopic monitoring campaign of a type Ibn SN 2019wep, which is one of the rare SN Ibn after SNe 2010al and 2019uo to display signatures of flash ionization (\ion{He}{2}, \ion{C}{3}, \ion{N}{3}). We compare the decline rates and rise time of SN 2019wep with other SNe Ibn and fast transients. The post-peak decline in all bands (0.1 mag d$^{-1}$) are consistent with SNe Ibn but less than the fast transients. On the other hand, the $\Delta$m$_{15}$ values are slightly lower than the average values for SNe Ibn but consistent with the fast transients. The rise time is typically shorter than SNe Ibn but longer than fast transients. SN 2019wep lies at the fainter end of SNe Ibn but possesses an average luminosity amongst the fast transients sample. The peculiar color evolution places it between SNe Ib and the most extreme SNe Ibn. The bolometric light curve modelling shows resemblance with SN 2019uo with ejecta masses consistent with SNe Ib. SN 2019wep belongs to the "P cygni" sub-class of SNe Ibn and shows faster evolution in line velocities as compared to the "emission" sub-class. The post-maximum spectra show close resemblance with ASASSN-15ed hinting it to be of SN Ib nature. The low \ion{He}{1} CSM velocities and residual H$\alpha$ further justifies it and gives evidence of an intermittent progenitor between WR and LBV star.Comment: 19 pages, 14 figures, 2 Tables, Accepted for publication in ApJ main journa

sj-pdf-1-ojs-10.1177_23259671241229079 – Supplemental material for Association of Head-Neck Rotation With History of Pitching-Related Elbow Pain in Youth Baseball Players

Supplemental material, sj-pdf-1-ojs-10.1177_23259671241229079 for Association of Head-Neck Rotation With History of Pitching-Related Elbow Pain in Youth Baseball Players by Masumi Yoshimoto, Masashi Kawabata, Toru Miyata, Yosuke Sato, Daichi Naoi, Mitsuaki Ashihara, Nobuyuki Suzuki, Chihiro Ikoma, Hiroaki Tatsuki, Ryota Kuratsubo, Hiroyuki Watanabe, Yohei Kusaba and Daiki Watanabe in Orthopaedic Journal of Sports Medicine</p

Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

The emergence of the Omicron variant of SARS-CoV-2 is an urgent global health concern(1). In this study, our statistical modelling suggests that Omicron has spread more rapidly than the Delta variant in several countries including South Africa. Cell culture experiments showed Omicron to be less fusogenic than Delta and than an ancestral strain of SARS-CoV-2.Although the spike (S) protein of Delta is efficiently cleaved into two subunits, which facilitates cell-cell fusion(2,3), the Omicron S protein was less efficiently cleaved compared to the S proteins of Delta and ancestral SARS-CoV-2. Furthermore, in a hamster model, Omicron showed decreased lung infectivity and was less pathogenic compared to Delta and ancestral SARS-CoV-2. Our multiscale investigations reveal the virological characteristics of Omicron, including rapid growth in the human population, lower fusogenicity and attenuated pathogenicity